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1. ループ利尿剤：最大有効量および主な副作用loop diuretics maximum effective dose and major side effects [show details]
… given at equipotent doses. Going above these maximum doses will produce little or no further diuresis but may increase the risk of side effects. The maximum effective diuretic dose differs in patients …
2. 小児や青年の不安障害への薬物療法pharmacotherapy for anxiety disorders in children and adolescents [show details]
…initial therapeutic dose. If symptoms do not remit after six to eight weeks, the dose is increased incrementally and tested, until the maximum dose is reached or side effects are not tolerable. Antidepressants …
3. 分化型甲状腺癌：放射性ヨード治療differentiated thyroid cancer radioiodine treatment [show details]
…ascertain their safety. Empiric dosing regimens may exceed the maximum tolerable doses as predicted by dosimetry, especially in older adults . As an example, in one study, a dose of 200 mCi (7.5 GBq) exceeded …
4. 切除可能な食道胃接合部癌および胃噴門部腺癌の集学的アプローチmultimodality approaches to potentially resectable esophagogastric junction and gastric cardia adenocarcinomas [show details]
… response for a tolerable level of radiation dose. Thus, 3D conformal techniques should be used for modern treatment planning to minimize toxicities to adjacent vital organs. A standard dose of radiation… offer dose-volume histogram of tumor volume as well as normal organs at risk such as lung, heart, and spinal cord. Thus, it is feasible to deliver an optimized RT that offers the maximum tumor response…
5. 鉄キレート薬：選択肢、投与量、副作用iron chelators choice of agent dosing and adverse effects [show details]
…iron overload – 14 mg/kg daily (maximum dose 28 mg/kg daily) NTDT syndromes – 7 mg/kg daily (maximum dose 14 mg/kg daily) Deferasirox has monitoring of (and potential dose adjustments based on) serum ferritin …

English Journal

Molecular mechanistic insight into the anti-hyperuricemic effect of Eucommia ulmoides in mice and rats.

Fang C, Chen L, He M, Luo Y, Zhou M, Zhang N, Yuan J, Wang H, Xie Y.
Pharmaceutical biology. 2019 Dec;57(1)112-119.
Eucommia ulmoides Oliver (Eucommiaceae) has various medicinal properties. Our previous studies revealed that Eucommia ulmoides has a protective effect on hyperuricaemia. This study investigates the effect of Eucommia ulmoides cortex ethanol extract (EU) on hyperuricaemia and explores the underlying
PMID 30843748

Disentanglement of the secrets of aluminium in acidophilic tea plant (Camellia sinensis L.) influenced by organic and inorganic amendments.

Bora K, Sarkar D, Konwar K, Payeng B, Sood K, Paul RK, Datta R, Das S, Khare P, Karak T.
Food research international (Ottawa, Ont.). 2019 Jun;120()851-864.
Field experiment was carried out for four years in mature tea (Camellia sinensis L.) growing plot to investigate the impacts of different doses of inorganic and organic fertilizers on aluminium (Al) distribution pattern in soil and different parts of tea plant, leaf pigment concentration, gas exchan
PMID 31000306

Human health risk assessment for the occurrence of enteric viruses in drinking water from wells: Role of flood runoff injections.

Masciopinto C, De Giglio O, Scrascia M, Fortunato F, La Rosa G, Suffredini E, Pazzani C, Prato R, Montagna MT.
The Science of the total environment. 2019 May;666()559-571.
We demonstrated that floods can induce severe microbiological contamination of drinking water from wells and suggest strategies to better address water safety plans for groundwater drinking supplies. Since 2002, the Italian Water Research Institute (IRSA) has detected hepatitis A virus, adenovirus,
PMID 30807946

Japanese Journal

A phase I study of single-agent BEZ235 special delivery system sachet in Japanese patients with advanced solid tumors

Toyoda Masanori,Watanabe Koichiro,Amagasaki Taro,Natsume Kazuto,Takeuchi Hiromi,Quadt Cornelia,Shirao Kuniaki,Minami Hironobu
Cancer Chemotherapy and Pharmacology 83(2), 289-299, 2019-02
… This was an open-label, multicenter, dose-escalation, phase I study of single-agent BEZ235 in Japanese oncology patients to determine the maximum tolerated dose (MTD) of BEZ235 based on dose-limiting toxicities (DLTs). … Methods Dose escalation was guided by a standard 3+3 method and was based on DLTs observed in Cycle 1 and other safety, pharmacokinetic, and pharmacodynamic information. …
NAID 120006599080

Combining Fulvestrant with Low-Dose Capecitabine is Effective and Tolerable in Woman with Metastatic Breast Cancer

Nakai Maki,Takei Hiroyuki,Yanagihara Keiko,Yamashita Koji,Uchida Eiji
日本医科大学雑誌 83(2), 81-86, 2016
… Pathologically invasive lobular carcinoma, with a maximum diameter of 28 mm, had been diagnosed in the left breast. … Because anastrozole had not been effective, fulvestrant (500 mg) and low-dose capecitabine (500 mg) were administered for the first 21 days of a 28-day cycle; … this regimen had been shown by a phase 2 trial to be effective and tolerable in patients with metastatic breast cancer. …
NAID 130005151336

BNCTの臨床：皮膚悪性黒色腫

平塚純一,神谷伸彦,笹岡俊輔,桑原千晶
ＲＡＤＩＯＩＳＯＴＯＰＥＳ 64(1), 115-121, 2015
BPAは皮膚悪性黒色腫BNCTのために採用されたホウ素キャリアーである。BPAは必須アミノ酸のチロシンにホウ素原子が結合したもので，チロシンがメラニン合成の前駆物質であることから，メラニン合成能の亢進している黒色腫で選択的集積性を認めている。黒色腫BNCTは，1987年神戸大学の三嶋豊らのグループによりその臨床研究が始まった。川崎医科大学でも2003年から皮膚悪性黒色腫BNCTを10例に実施してき …
NAID 130004803061