リソソーム膜タンパク質2
- 関
- LAMP-2、LAMP2、lysosomal-associated membrane protein 2
WordNet
- having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"
- a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"
- a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"
- any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"
- make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all" (同)tie_in, relate, link, colligate, link up, connect
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- a thin pliable sheet of material
- a pliable sheet of tissue that covers or lines or connects the organs or cells of animals or plants (同)tissue layer
- an organelle found in the cytoplasm of most cells (especially in leukocytes and liver and kidney cells)
PrepTutorEJDIC
- 〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…
- 蛋白(たんばく)質
- (生物の)膜,皮膜
UpToDate Contents
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English Journal
- Cellular immunogenicity of novel gene immunogens in mice monitored by in vivo imaging.
- Starodubova E, Krotova O, Hallengärd D, Kuzmenko Y, Engström G, Legzdina D, Latyshev O, Eliseeva O, Karin Maltais A, Tunitskaya V, Karpov V, Bråve A, Isaguliants M.AbstractAbstractThe efficient cell-mediated immune response clears cells expressing deoxyribonucleic acid (DNA) immunogens, but there are no methods to monitor this in vivo. We hypothesized that immune-mediated clearance can be monitored in vivo if DNA immunogens are coexpressed with reporter(s). To test this, we designed genes encoding human immunodeficiency virus 1 (HIV-1) reverse transcriptase (RT) fused via its N- or C-terminus to 30-amino acid-long Gly-Ala-repeat of Epstein-Barr virus nuclear antigen 1 or via the N-terminus to the transport signal of invariant chain/Ii or inserted between the cytoplasmic and luminal domains of lysosome-associated membrane protein I (LAMP). DNA immunogens mixed with luciferase gene were injected into BALB/c mice with subsequent electroporation. Reporter expression seen as luminescence was monitored by in vivo imaging. When luminescence faded, mice were sacrificed, and their splenocytes were stimulated with RT-derived antigens. Fading of luminescence correlated with the RT-specific secretion of interferon-γ and interleukin-2. Both immune and in vivo imaging techniques concordantly demonstrated an enhanced immunogenicity of RT-LAMP and of the N-terminal Gly-Ala-RT fusion genes. In vivo imaging performed as an animal-sparing method to estimate the overall performance of DNA immunogens, predicting it early in the experiment. So far, in vivo imaging cannot be a substitute for conventional immune assays, but it is supplementary to them. Further experiments are needed to identify which arms of cellular immune response in vivo imaging monitors best.
- Molecular imaging.Mol Imaging.2012 Dec 1;11(6):471-86.
- AbstractThe efficient cell-mediated immune response clears cells expressing deoxyribonucleic acid (DNA) immunogens, but there are no methods to monitor this in vivo. We hypothesized that immune-mediated clearance can be monitored in vivo if DNA immunogens are coexpressed with reporter(s). To test th
- PMID 23084248
- Functional Analysis of Lysosomes During Mouse Preimplantation Embryo Development.
- Tsukamoto S, Hara T, Yamamoto A, Ohta Y, Wada A, Ishida Y, Kito S, Nishikawa T, Minami N, Sato K, Kokubo T.SourceLaboratory Animal and Genome Sciences Section, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
- The Journal of reproduction and development.J Reprod Dev.2012 Oct 19. [Epub ahead of print]
- Lysosomes are acidic and highly dynamic organelles that are essential for macromolecule degradation and many other cellular functions. However, little is known about lysosomal function during early embryogenesis. Here, we found that the number of lysosomes increased after fertilization. Lysosomes we
- PMID 23080372
Japanese Journal
- Constitutive expression of a COOH-terminal leucine mutant of lysosome-associated membrane protein-1 causes its exclusive localization in low density intracellular vesicles
- ACAT1-associated Late Endosomes/Lysosomes Significantly Improve Impaired Intracellular Cholesterol Metabolism and the Survival of Niemann-Pick Type C Mice
- Functional Analysis of Lysosomes During Mouse Preimplantation Embryo Development
- The Journal of reproduction and development 59(1), 33-39, 2013-02-01
- NAID 10031156809
Related Links
- Lysosome-associated membrane protein (LAMP2) cardiomyopathy is an X-linked and highly progressive myocardial storage disorder associated with diminished survival, which clinically resembles sarcomeric hypertrophic ...
- "An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner." Konecki D.S., Foetisch K., Zimmer K.P., Schlotter M., Lichter-Konecki U. Biochem. Biophys [] ...
★リンクテーブル★
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- 関
- LAMP2、lysosomal-associated membrane protein 2、lysosome-associated membrane protein 2
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- 英
- lysosome-associated membrane protein 2、lysosomal-associated membrane protein 2、LAMP-2、LAMP2
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- 同
- LAMP-2＆autophagy
- 同
- LAMP-2＆autophagy
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- 結合する、連合させる。連想によって結びつける。(人を)仲間/友達などとしての関係に置く。(化)会合させる
- 仲間/友人などとして交際する(with)。一つにまとめる、連合する
- 仕事仲間、提携者、同僚。友人、朋友。準会員。従業員、社員
- 密接な蒸す偽付きのある物、付随する物、つきもの。準国家
- 連想によって心に浮かぶ言葉/思い、連想物
- 仲間の、同僚の。製紙機械員に次ぐ資格の
- 付随する、連想される
- 関
- accompany、association、associative、attach、bearing、bind、binding、bond、bonding、coassemble、colleague、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、correlate、correlation、couple、dock、engage、engagement、federation、implication、join、joint、ligate、link、linkage、peer、pertinent、reference、relate、relation、relationship、relative、relevance、relevant、symphysial、union
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- 関
- concomitant、erratic、erratically
- associate
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