WordNet

an essential amino acid found in proteins; occurs especially in gelatin and casein
any substance (such as an antibody) or agent that can cause lysis

PrepTutorEJDIC

リジン(細胞溶解素), = lysine

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/15 12:37:28」(JST)

wiki ja

[Wiki ja表示]

この項目では、アミノ酸のリシン（lysine）について説明しています。蛋白質のリシン（ricin）については「リシン (毒物)」をご覧ください。

リシン（英: lysine）はα-アミノ酸のひとつで側鎖に 4-アミノブチル基を持つ。リジンと表記あるいは音読する場合もある。タンパク質構成アミノ酸で、必須アミノ酸である。略号は Lys あるいは K である。側鎖にアミノ基を持つことから、塩基性アミノ酸に分類される。リシンは、クエン酸回路に取り込まれてエネルギーを生み出すケト原性アミノ酸である。

栄養学

必須アミノ酸であるが、植物性蛋白質における含量が低く、動物性蛋白質摂取量の少ない地域での栄養学上の大きな問題となっている。3大穀物である米、小麦、トウモロコシともリシン含有量が少ないので、リシンを豊富に含む副食（肉、魚、豆など）を必要とする。サプリメントとしてヘルペスの予防にも利用される。

WHOによるリシンの成人向け一日当たり推奨摂取量は2.1グラムである^[1]。

穀物中には豊富には含まれないが、豆類には豊富である。肉、魚にも多く含まれる。多量のリシンを含む植物には以下のようなものがある。

バッファロー・ゴーアド（Buffalo Gourd, ウリ科の植物）の種 - 10,130–33,000 ppm
クレソン（オランダガラシ） - 1,340–26,800 ppm
ダイズの種 - 24,290–26,560 ppm
イナゴマメの種 - 26,320 ppm
インゲンマメの芽 - 2,390–25,700 ppm
モリンガの芽 - 5,370–25,165 ppm
レンズマメの芽 - 27,120–23,735 ppm
シカクマメの種 - 21,360–23,304 ppm
アカザの種 - 3,540–22,550 ppm
レンズマメの種 - 19,570–22,035 ppm
ルピナスの種 - 19,330–21,585 ppm
キャラウェイの種 - 16,200–20,700 ppm
ホウレンソウ - 1,740–20,664 ppm

生化学

リシンは蛋白質分子に対してメチル化やアセチル化による翻訳後修飾を行う。コラーゲンはリシンの誘導体であるヒドロキシリシンを含む。細胞から分泌が行われる際に、小胞体またはゴルジ体におけるリシン残基のO-グリコシル化が特定の蛋白質に印を付けるのに使われる。

代謝

哺乳類においてはα-ケトグルタル酸とのアミノ基転移反応を経てアセチルCoAへと代謝されクエン酸回路に入る。バクテリアにおいては脱炭酸によりカダベリンとなる。

生合成

リシンの生合成はアスパラギン酸→β-アスパルチルリン酸→アスパラギン酸セミアルデヒド→ジアミノピメリン酸の順に行われる。カビ類においては、α-ジアミノピメリン酸を経由する。

脚注

^ FAO/WHO/UNU (2007年). “PROTEIN AND AMINO ACID REQUIREMENTS IN HUMAN NUTRITION (PDF)”. WHO Press. 2009年12月3日閲覧。, page 150

外部リンク

リシン（リジン） - 「健康食品」の安全性・有効性情報（国立健康・栄養研究所）

wiki en

[Wiki en表示]

Lysine (abbreviated as Lys or K)^[1] is an α-amino acid with the chemical formula HO₂CCH(NH₂)(CH₂)₄NH₂. It is an essential amino acid for humans. Lysine's codons are AAA and AAG.

Lysine is a base, as are arginine and histidine. The ε-amino group often participates in hydrogen bonding and as a general base in catalysis. (The ε-amino group (NH₃⁺) is attached to the fifth carbon beginning from the α-carbon, which is attached to the carboxyl (C=OOH) group.^[2])

Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications at lysine residues include acetylation, sumoylation, and ubiquitination. Collagen contains hydroxylysine, which is derived from lysine by lysyl hydroxylase. O-Glycosylation of hydroxylysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.

Biosynthesis

As an essential amino acid, lysine is not synthesized in animals, hence it must be ingested as lysine or lysine-containing proteins. In plants and bacteria, it is synthesized from aspartic acid (aspartate):^[3]

L-aspartate is first converted to L-aspartyl-4-phosphate by aspartokinase (or Aspartate kinase). ATP is needed as an energy source for this step.
β-Aspartate semialdehyde dehydrogenase converts this into β-aspartyl-4-semialdehyde (or β-aspartate-4-semialdehyde). Energy from NADPH is used in this conversion.
Dihydrodipicolinate synthase adds a pyruvate group to the β-aspartyl-4-semialdehyde, and two water molecules are removed. This causes cyclization and gives rise to 2,3-dihydrodipicolinate.
This product is reduced to 2,3,4,5-tetrahydrodipicolinate (or Δ¹-piperidine-2,6-dicarboxylate, in the figure: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate) by dihydrodipicolinate reductase. This reaction consumes a NADPH molecule.
Tetrahydrodipicolinate N-acetyltransferase opens this ring and gives rise to N-succinyl-L-2-amino-6-oxoheptanedionate (or N-acyl-2-amino-6-oxopimelate). Two water molecules and one acyl-CoA (succinyl-CoA) enzyme are used in this reaction.
N-succinyl-L-2-amino-6-oxoheptanedionate is converted into N-succinyl-LL-2,6-diaminoheptanedionate (N-acyl-2,6-diaminopimelate). This reaction is catalyzed by the enzyme succinyl diaminopimelate aminotransferase. A glutamic acid molecule is used in this reaction and an oxoacid is produced as a byproduct.
N-succinyl-LL-2,6-diaminoheptanedionate (N-acyl-2,6-diaminopimelate)is converted into LL-2,6-diaminoheptanedionate (L,L-2,6-diaminopimelate) by succinyl diaminopimelate desuccinylase (acyldiaminopimelate deacylase). A water molecule is consumed in this reaction and a succinate is produced a byproduct.
LL-2,6-diaminoheptanedionate is converted by diaminopimelate epimerase into meso-2,6-diamino-heptanedionate (meso-2,6-diaminopimelate).
Finally, meso-2,6-diamino-heptanedionate is converted into L-lysine by diaminopimelate decarboxylase.

Enzymes involved in this biosynthesis include:^[4]

Aspartokinase
β-Aspartate semialdehyde dehydrogenase
Dihydropicolinate synthase
Δ¹-Piperidine-2,6-dicarboxylate dehydrogenase
N-succinyl-2-amino-6ketopimelate synthase
Succinyl diaminopimelate aminotransferase
Succinyl diaminopimelate desuccinylase
Diaminopimelate epimerase
Diaminopimelate decarboxylase.

It is worthwhile to note, however, that in fungi, euglenoids and some prokaryotes lysine is synthesized via the alpha-aminoadipate pathway.

Metabolism

Lysine is metabolised in mammals to give acetyl-CoA, via an initial transamination with α-ketoglutarate. The bacterial degradation of lysine yields cadaverine by decarboxylation.

Allysine is a derivative of lysine, used in the production of elastin and collagen. It is produced by the actions of the enzyme lysyl oxidase on lysine in the extracellular matrix and is essential in the crosslink formation that stabilizes collagen and elastin.

Synthesis

Synthetic, racemic lysine has long been known.^[5] A practical synthesis starts from caprolactam.^[6] Industrially, L-lysine is usually manufactured by a fermentation process using Corynebacterium glutamicum; production exceeds 600,000 tons a year.^[7]

Dietary sources

The nutritional requirement per day, in milligrams of lysine per kilogram of body weight, is: infants (3–4 months) 103, children (2 years) 64, older children (10–12 years) 60 to 44, adults 12.^[8] For a 70 kg adult, 12 milligrams of lysine per kilogram of body weight is 0.84 grams of lysine. Note that recommendations were subsequently revised upwards, e.g. 30 mg/kg for adults.^[9]

Good sources of lysine are high-protein foods such as eggs, meat (specifically red meat, lamb, pork, and poultry), soy, beans and peas, cheese (particularly Parmesan), and certain fish (such as cod and sardines).^[10]

Lysine is the limiting amino acid (the essential amino acid found in the smallest quantity in the particular foodstuff) in most cereal grains, but is plentiful in most pulses (legumes).^[11] Consequently, meals that combine cereal grains and legumes, such as the Indian dal with rice, Middle Eastern hummus, ful medames, falafel with pita bread, the Mexican beans with rice or tortilla have arisen to provide complete protein in diets that are, by choice or by necessity, vegetarian. A food is considered to have sufficient lysine if it has at least 51 mg of lysine per gram of protein (so that the protein is 5.1% lysine).^[12]

Foods containing significant proportions of lysine include:

Food	Lysine (% of protein)	Notes
Catfish, channel, farmed, raw	9.19%^[13]	Bluefish, burbot, mahi-mahi, grouper, lingcod, mackerel, pike, salmon, scup, trout, tuna, and yellowtail also have lysine content of nearly 9.2%^[14]
Beef, ground, 90% lean/10% fat, cooked	8.31%^[15]
Chicken, roasting, meat and skin, cooked, roasted	8.11%^[16]
Lentil, sprouts, raw	7.95%^[17]	Sprouting increases the lysine content.^{[citation needed]}
Parmesan cheese, grated	7.75%^[18]
Azuki bean (adzuki beans), mature seeds, raw	7.53%^[19]
Milk, non-fat	7.48%^[20]
Soybean, mature seeds, raw	7.42%^[21]
Pumpkin Seed, dried	7.4%^[22]
Egg, whole, raw	7.27%^[23]
Pea, split, mature seeds, raw	7.22%^[24]
Winged bean (aka Goa Bean or Asparagus Pea), mature seeds, raw	7.20%^[25]
Lentil, pink, raw	6.97%^[26]
Kidney bean, mature seeds, raw	6.87%^[27]
Chickpea, (garbanzo beans, Bengal gram), mature seeds, raw	6.69%^[28]
Soybean, mature seeds, sprouts	5.74%^[29]	Sprouting decreases the lysine content.^{[citation needed]}
Navy bean, mature seeds, raw	5.73%^[30]
Amaranth, grain, uncooked	5.17%^[31]
Quinoa	5%^[32]

Properties

L-Lysine is a necessary building block for all protein in the body. L-Lysine plays a major role in calcium absorption; building muscle protein; recovering from surgery or sports injuries; and the body's production of hormones, enzymes, and antibodies.

Modifications

Lysine can be modified through acetylation (acetyllysine), methylation (methyllysine), ubiquitination, sumoylation, neddylation, biotinylation, pupylation, and carboxylation, which tends to modify the function of the protein of which the modified lysine residue(s) are a part.^[33]

Clinical significance

Some studies have found that lysine may be beneficial for those with herpes simplex infections.^[34] One small randomized, controlled study found that it reduced outbreaks by 2.4 per year.^[35] Other studies found no benefit.^[36]^[37] Lysine has not been approved by the FDA for herpes simplex suppression. ^[38]

Lysine has a anxiolytic action through its effects on serotonin receptors in the intestinal tract, and is also hypothesized to reduce anxiety through serotonin regulation in the amygdala.^[39] One study on rats^[40] showed that overstimulation of the 5-HT4 receptors in the gut are associated with anxiety-induced intestinal pathology. Lysine, acting as a serotonin antagonist and therefore reducing the overactivity of these receptors, reduced signs of anxiety and anxiety-induced diarrhea in the sample population. Another study showed that lysine deficiency leads to a pathological increase in serotonin in the amygdala, a brain structure that is involved in emotional regulation and the stress response.^[39] Human studies have also shown correlations between reduced lysine intake and anxiety. A population-based study in Syria included 93 families whose diet is primarily grain-based and therefore likely to be deficient in lysine. Fortification of grains with lysine was shown to reduce markers of anxiety, including cortisol levels; Smiriga and colleagues concluded that anxiety reduction from lysine occurs through mechanism of serotonin alterations in the central amygdala; older primary research reports hypothesized lysine to reduce anxiety through the potentiation of benzodiazepine receptors (common targets of anxiolytic drugs such as Xanax and Ativan).^[41] (Note that all of these studies were funded by Ajinomoto, Co. Inc., an industrial manufacturer of lysine.)

There are lysine conjugates that show promise in the treatment of cancer, by causing cancerous cells to destroy themselves when the drug is combined with the use of phototherapy, while leaving non-cancerous cells unharmed.^[42]

While chemically insignificant to lysine itself, it is worth noting that lysine is attached to dextroamphetamine to form the prodrug lisdexamfetamine (Vyvanse). In the gastrointestinal tract, the lysine molecule is cleaved from the dextroamphetamine, thereby making oral administration necessary.

Lysine deficiency causes immunodeficiency in chickens.^[43] One cause of relative lysine deficiency is cystinuria, where there is impaired hepatic resorption of basic, or positively charged amino acids, including lysine. The accompanying urinary cysteine results because the same deficient amino acid transporter is normally present in the kidney as well.

Limited studies suggest that a high-lysine diet or L-lysine monochloride supplements may have a moderating effect on blood pressure and the incidence of stroke.^[44]

Use of lysine in animal feed

Lysine production for animal feed is a major global industry, reaching in 2009 almost 700,000 tonnes for a market value of over €1.22 billion.^[45] Lysine is an important additive to animal feed because it is a limiting amino acid when optimizing the growth of certain animals such as pigs and chickens for the production of meat. Lysine supplementation allows for the use of lower-cost plant protein (maize, for instance, rather than soy) while maintaining high growth rates, and limiting the pollution from nitrogen excretion.^[46] In turn, however, phosphate pollution is a major environmental cost when corn is used as feed for poultry and swine.^[47]

Lysine is industrially produced by microbial fermentation, from a base mainly of sugar. Genetic engineering research is actively pursuing bacterial strains to improve the efficiency of production and allow lysine to be made from other substrates.^[45]

In popular culture

The 1993 film Jurassic Park (based on the 1990 Michael Crichton novel of the same name) features dinosaurs that were genetically altered so that they could not produce lysine.^[48] This was known as the "lysine contingency" and was supposed to prevent the cloned dinosaurs from surviving outside the park, forcing them to be dependent on lysine supplements provided by the park's veterinary staff. In reality, most vertebrates cannot produce lysine (it is an essential amino acid).^{[citation needed]}

In 1996, lysine became the focus of a price-fixing case, the largest in United States history. The Archer Daniels Midland Company paid a fine of US$100 million, and three of its executives were convicted and served prison time. Also found guilty in the price-fixing case were two Japanese firms (Ajinomoto, Kyowa Hakko) and a South Korean firm (Sewon).^[49] Secret video recordings of the conspirators fixing lysine's price can be found online or by requesting the video from the U.S. Department of Justice, Antitrust Division. This case served as the basis of the movie The Informant!, and a book of the same title.^[50]

References

^ IUPAC-IUBMB Joint Commission on Biochemical Nomenclature. "Nomenclature and Symbolism for Amino Acids and Peptides". Recommendations on Organic & Biochemical Nomenclature, Symbols & Terminology etc. Retrieved 2007-05-17.
^ Lysine. The Biology Project, Department of Biochemistry and Molecular Biophysics, University of Arizona.
^ Lysine biosynthesis and catabolism, Purdue University
^ Nelson, D. L.; Cox, M. M. "Lehninger, Principles of Biochemistry" 3rd Ed. Worth Publishing: New York, 2000. ISBN 1-57259-153-6.
^ Braun, J. V. "Synthese des inaktiven Lysins aus Piperidin" Berichte der deutschen chemischen Gesellschaft 1909, Volume 42, p 839-846. doi:10.1002/cber.190904201134.
^ Eck, J. C.; Marvel, C. S. "dl-Lysine Hydrochlorides" Organic Syntheses, Collected Volume 2, p.374 (1943). http://www.orgsyn.org/orgsyn/pdfs/CV2P0374.pdf
^ Pfefferle, W.; Möckel, B.; Bathe, B.; Marx, A. (2003). "Biotechnological manufacture of lysine". Advances in biochemical engineering/biotechnology. Advances in Biochemical Engineering/Biotechnology 79: 59–112. doi:10.1007/3-540-45989-8_3. ISBN 978-3-540-43383-5. PMID 12523389. edit
^ United Nations Food and Agriculture Organization: Agriculture and Consumer Protection. "Energy and protein requirements: 5.6 Requirements for essential amino acids". Retrieved 2010-10-10.
^ FAO/WHO/UNU (2007). "PROTEIN AND AMINO ACID REQUIREMENTS IN HUMAN NUTRITION". WHO Press. , page 150-152
^ University of Maryland Medical Center. "Lysine". Retrieved 2009-12-30.
^ Young VR, Pellett PL (1994). "Plant proteins in relation to human protein and amino acid nutrition" (PDF). American Journal of Clinical Nutrition 59 (5 Suppl): 1203S–1212S. PMID 8172124.
^ Institute of Medicine of the National Academies. "Dietary Reference Intakes for Macronutrients". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, catfish farmed". Retrieved 2010-10-10.
^ http://ndb.nal.usda.gov/ndb/nutrients/report/nutrientsfrm?max=25&offset=0&totCount=0&nutrient1=505&nutrient2=203&nutrient3=&subset=1&fg=&sort=c&measureby=g
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, beef ground 90 10 cooked". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, chicken roasting meat skin". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, lentils sprouted". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, parmesan cheese". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, adzuki bean". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, milk nonfat". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, soybean seeds". Retrieved 2010-10-10.
^ title=Nutrition Data url=http://nutritiondata.self.com/facts/nut-and-seed-products/3066/2
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, egg whole". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, pea split". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, winged bean seeds". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, lentils". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, kidney bean". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, chickpea". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, soybeans sprouted". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, navy bean". Retrieved 2010-10-10.
^ Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, amaranth". Retrieved 2010-10-10.
^ Oelke, E.A.; Putnam, D.H.; Teynor, T.M.; Oplinger, E.S. "Quinoa". Alternative Field Crops Manual. University of Wisconsin Cooperative Extension. Retrieved 11 September 2012.
^ Sadoul K, Boyault C, Pabion M, Khochbin S (February 2008). "Regulation of protein turnover by acetyltransferases and deacetylases". Biochimie 90 (2): 306–12. doi:10.1016/j.biochi.2007.06.009. PMID 17681659.
^ Griffith RS, Norins AL, Kagan C. (1978). "A multicentered study of lysine therapy in Herpes simplex infection". Dermatologica 156 (5): 257–267. doi:10.1159/000250926. PMID 640102.
^ St Pierre SA, Bartlett BL, Schlosser BJ (2009). "Practical management measures for patients with recurrent herpes labialis". Skin Therapy Lett. 14 (8): 1–3. PMID 20054504.
^ Milman N, Scheibel J, Jessen O. (1978). "Failure of lysine treatment in recurrent herpes simplex labialis". The Lancet. doi:10.1016/S0140-6736(78)91658-6.
^ DiGiovanna JJ, Blank H. (1984). "Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis.". Archives of dermatology 120 (1): 48–51. PMID 6419679.
^ Drugs.com. "Herpes Simplex, Suppression Medications". Retrieved 2014-05-19.
^ ^a ^b Smriga, Kameishi, Uneyama, and Torii (December 2002). "Dietary L-Lysine Deficiency Increases Stress-Induced Anxiety and Fecal Excretion in Rats". The Journal of Nutrition 132 (12): 3744–6. PMID 12468617.
^ Smriga and Torii; Torii, K (2003). "l-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats". PNAS 100 (26): 15370–5. doi:10.1073/pnas.2436556100. PMC 307574. PMID 14676321.
^ Smriga, Ghosh, Mouneimne, Pellett, and Scrimshaw (May 2004). "Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria". Proceedings of the National Academy of Sciences 101 (22): 8285–8288. doi:10.1073/pnas.0402550101.
^ ScienceDaily. "Chemists Kill Cancer Cells With Light-activated Molecules". Retrieved 2008-01-24.
^ Chen C, Sander JE, Dale NM (2003). "The effect of dietary lysine deficiency on the immune response to Newcastle disease vaccination in chickens". Avian Dis. 47 (4): 1346–51. doi:10.1637/7008. PMID 14708981.
^ Flodin 1997^{[clarification needed]}
^ ^a ^b "Norwegian granted for improving lysine production process"
^ Toride Y. "Lysine and other amino acids for feed: production and contribution to protein utilization in animal feeding". Retrieved 2011-01-25.
^ Abelson, Philip (March 1999). "A Potential Phosphate Crisis". Science 283 (5410): 2015. doi:10.1126/science.283.5410.2015.
^ Coyne, Jerry A. (October 10, 1999). "The Truth Is Way Out There". The New York Times. Retrieved 2008-04-06.
^ Connor, J.M.; "Global Price Fixing" 2nd Ed. Springer-Verlag: Heidelberg, 2008. ISBN 978-3-540-78669-6.
^ Eichenwald, Kurt.; "The Informant: a true story" Broadway Books: New York, 2000. ISBN 0-7679-0326-9.

Sources

Much of the information in this article has been translated from German Wikipedia.
Lide, D. R., ed. (2002). CRC Handbook of Chemistry and Physics (83rd ed.). Boca Raton, FL: CRC Press. ISBN 0-8493-0483-0.

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Japanese Journal

The Arabidopsis thaliana SET-domain-containing protein ASHH1/SDG26 interacts with itself and with distinct histone lysine methyltransferases

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NAID 40019407044

Related Pictures

★リンクテーブル★

リンク元	「リジン」「lysine hydrochloride」「L-lysine hydrochloride」「L-lysine」「リシン」
拡張検索	「lysine-tRNA ligase」「tosyllysine chloromethyl ketone」「lysine carboxypeptidase」「polylysine」

「リジン」

Lysine
	IUPAC name Lysine
	Other names 2,6-Diaminohexanoic acid; 2,6-Diammoniohexanoic acid
Identifiers
CAS number	70-54-2 DL , 56-87-1 L, 923-27-3 D
PubChem	866
ChemSpider	843 , 5747 L
KEGG	C16440
ChEBI	CHEBI:25094
ChEMBL	CHEMBL28328
IUPHAR ligand	724
ATC code	B05XB03
Jmol-3D images	Image 1
	SMILES C(CCN)CC(C(=O)O)N ;
	InChI InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10) ; Key: KDXKERNSBIXSRK-UHFFFAOYSA-N InChI=1/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10); Key: KDXKERNSBIXSRK-UHFFFAOYAY ;
Properties
Molecular formula	C6H14N2O2
Molar mass	146.19 g mol−1
Solubility in water	1.5kg/L @ 25 °C
Supplementary data page
Structure and; properties	n, εr, etc.
Thermodynamic; data	Phase behaviour; Solid, liquid, gas
Spectral data	UV, IR, NMR, MS
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	(verify) (what is: /?)
	Infobox references

リシン
	IUPAC名 Lysine
	別称 2,6-diaminohexanoic acid
識別情報
CAS登録番号	70-54-2, 56-87-1 L, 923-27-3 D
PubChem	866
ChemSpider	843 , 5747 L
KEGG	C16440
ChEMBL	CHEMBL28328
IUPHARリガンド	724
	SMILES C(CCN)CC(C(=O)O)N;
	InChI InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10) ; Key: KDXKERNSBIXSRK-UHFFFAOYSA-N InChI=1/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10); Key: KDXKERNSBIXSRK-UHFFFAOYAY;
特性
化学式	C6H14N2O2
モル質量	146.19 g mol−1
	特記なき場合、データは常温 (25 °C)・常圧 (100 kPa) におけるものである。

　　[★]

英: lysine, Lys, K　≠ ricin
同: リシン
関: アミノ酸、アルギニン、ヒスチジン

極性、塩基性
側鎖

　-CH2-CH2-CH2-CH2-NH2
   α  β  γ  ε ＞εアミノ基を有する。即ち、側鎖には炭素が４つ含まれる。

ヒストンにLysが豊富なこと、Lysのεアミノ基がアセチル化を受けると正電荷が失われる。-NH-CO-CH3

「lysine hydrochloride」

　　[★]

塩酸リジン

関: K、L-lysine、L-lysine hydrochloride、Lys、lysine、ricin

「L-lysine hydrochloride」

　　[★]

塩酸L-リジン

関: K、Lys、lysine、lysine hydrochloride

「L-lysine」

　　[★]

L-リジン

関: lysine、lysine hydrochloride、ricin

「リシン」

　　[★]

英: ricin　≠ lysine
関: 植物性毒素

「lysine-tRNA ligase」

　　[★]

リジンtRNAリガーゼ

関: lysyl-tRNA synthetase

「tosyllysine chloromethyl ketone」

　　[★]

トシルリジンクロロメチルケトン

「lysine carboxypeptidase」

　　[★]

リジンカルボキシペプチダーゼ

「polylysine」

　　[★] ポリリジン

関: poly-Lys

[1] FAO/WHO/UNU (2007年). “PROTEIN AND AMINO ACID REQUIREMENTS IN HUMAN NUTRITION (PDF)”. WHO Press. 2009年12月3日閲覧。, page 150

[1] IUPAC-IUBMB Joint Commission on Biochemical Nomenclature. "Nomenclature and Symbolism for Amino Acids and Peptides". Recommendations on Organic & Biochemical Nomenclature, Symbols & Terminology etc. Retrieved 2007-05-17.

[2] Lysine. The Biology Project, Department of Biochemistry and Molecular Biophysics, University of Arizona.

[3] Lysine biosynthesis and catabolism, Purdue University

[4] Nelson, D. L.; Cox, M. M. "Lehninger, Principles of Biochemistry" 3rd Ed. Worth Publishing: New York, 2000. ISBN 1-57259-153-6.

[5] Braun, J. V. "Synthese des inaktiven Lysins aus Piperidin" Berichte der deutschen chemischen Gesellschaft 1909, Volume 42, p 839-846. doi:10.1002/cber.190904201134.

[6] Eck, J. C.; Marvel, C. S. "dl-Lysine Hydrochlorides" Organic Syntheses, Collected Volume 2, p.374 (1943). http://www.orgsyn.org/orgsyn/pdfs/CV2P0374.pdf

[7] Pfefferle, W.; Möckel, B.; Bathe, B.; Marx, A. (2003). "Biotechnological manufacture of lysine". Advances in biochemical engineering/biotechnology. Advances in Biochemical Engineering/Biotechnology 79: 59–112. doi:10.1007/3-540-45989-8_3. ISBN 978-3-540-43383-5. PMID 12523389. edit

[8] United Nations Food and Agriculture Organization: Agriculture and Consumer Protection. "Energy and protein requirements: 5.6 Requirements for essential amino acids". Retrieved 2010-10-10.

[WHO-9] FAO/WHO/UNU (2007). "PROTEIN AND AMINO ACID REQUIREMENTS IN HUMAN NUTRITION". WHO Press. , page 150-152

[10] University of Maryland Medical Center. "Lysine". Retrieved 2009-12-30.

[VRYoung-11] Young VR, Pellett PL (1994). "Plant proteins in relation to human protein and amino acid nutrition" (PDF). American Journal of Clinical Nutrition 59 (5 Suppl): 1203S–1212S. PMID 8172124.

[12] Institute of Medicine of the National Academies. "Dietary Reference Intakes for Macronutrients". Retrieved 2010-10-10.

[13] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, catfish farmed". Retrieved 2010-10-10.

[14] ttp://ndb.nal.usda.gov/ndb/nutrients/report/nutrientsfrm?max=25&offset=0&totCount=0&nutrient1=505&nutrient2=203&nutrient3=&subset=1&fg=&sort=c&measureby=g

[15] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, beef ground 90 10 cooked". Retrieved 2010-10-10.

[16] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, chicken roasting meat skin". Retrieved 2010-10-10.

[17] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, lentils sprouted". Retrieved 2010-10-10.

[18] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, parmesan cheese". Retrieved 2010-10-10.

[19] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, adzuki bean". Retrieved 2010-10-10.

[20] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, milk nonfat". Retrieved 2010-10-10.

[21] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, soybean seeds". Retrieved 2010-10-10.

[22] title=Nutrition Data url=http://nutritiondata.self.com/facts/nut-and-seed-products/3066/2

[23] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, egg whole". Retrieved 2010-10-10.

[24] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, pea split". Retrieved 2010-10-10.

[25] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, winged bean seeds". Retrieved 2010-10-10.

[26] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, lentils". Retrieved 2010-10-10.

[27] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, kidney bean". Retrieved 2010-10-10.

[28] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, chickpea". Retrieved 2010-10-10.

[29] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, soybeans sprouted". Retrieved 2010-10-10.

[30] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, navy bean". Retrieved 2010-10-10.

[31] Helena Kloosterman; USDA National Nutrient Database for Standard Reference. "Essential Amino Acids Search, amaranth". Retrieved 2010-10-10.

[32] Oelke, E.A.; Putnam, D.H.; Teynor, T.M.; Oplinger, E.S. "Quinoa". Alternative Field Crops Manual. University of Wisconsin Cooperative Extension. Retrieved 11 September 2012.

[pmid17681659-33] Sadoul K, Boyault C, Pabion M, Khochbin S (February 2008). "Regulation of protein turnover by acetyltransferases and deacetylases". Biochimie 90 (2): 306–12. doi:10.1016/j.biochi.2007.06.009. PMID 17681659.

[Griffith2-34] Griffith RS, Norins AL, Kagan C. (1978). "A multicentered study of lysine therapy in Herpes simplex infection". Dermatologica 156 (5): 257–267. doi:10.1159/000250926. PMID 640102.

[35] St Pierre SA, Bartlett BL, Schlosser BJ (2009). "Practical management measures for patients with recurrent herpes labialis". Skin Therapy Lett. 14 (8): 1–3. PMID 20054504.

[36] Milman N, Scheibel J, Jessen O. (1978). "Failure of lysine treatment in recurrent herpes simplex labialis". The Lancet. doi:10.1016/S0140-6736(78)91658-6.

[37] DiGiovanna JJ, Blank H. (1984). "Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis.". Archives of dermatology 120 (1): 48–51. PMID 6419679.

[38] Drugs.com. "Herpes Simplex, Suppression Medications". Retrieved 2014-05-19.

[Smriga2-39] Smriga, Kameishi, Uneyama, and Torii (December 2002). "Dietary L-Lysine Deficiency Increases Stress-Induced Anxiety and Fecal Excretion in Rats". The Journal of Nutrition 132 (12): 3744–6. PMID 12468617.

[Smriga1-40] Smriga and Torii; Torii, K (2003). "l-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats". PNAS 100 (26): 15370–5. doi:10.1073/pnas.2436556100. PMC 307574. PMID 14676321.

[Smriga3-41] Smriga, Ghosh, Mouneimne, Pellett, and Scrimshaw (May 2004). "Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria". Proceedings of the National Academy of Sciences 101 (22): 8285–8288. doi:10.1073/pnas.0402550101.

[lysineconjugates-42] ScienceDaily. "Chemists Kill Cancer Cells With Light-activated Molecules". Retrieved 2008-01-24.

[43] Chen C, Sander JE, Dale NM (2003). "The effect of dietary lysine deficiency on the immune response to Newcastle disease vaccination in chickens". Avian Dis. 47 (4): 1346–51. doi:10.1637/7008. PMID 14708981.

[44] Flodin 1997^{[clarification needed]}

[lysineanimalfeed1-45] "Norwegian granted for improving lysine production process"

[lysineanimalfeed-46] Toride Y. "Lysine and other amino acids for feed: production and contribution to protein utilization in animal feeding". Retrieved 2011-01-25.

[47] Abelson, Philip (March 1999). "A Potential Phosphate Crisis". Science 283 (5410): 2015. doi:10.1126/science.283.5410.2015.

[48] Coyne, Jerry A. (October 10, 1999). "The Truth Is Way Out There". The New York Times. Retrieved 2008-04-06.

[49] Connor, J.M.; "Global Price Fixing" 2nd Ed. Springer-Verlag: Heidelberg, 2008. ISBN 978-3-540-78669-6.

[50] Eichenwald, Kurt.; "The Informant: a true story" Broadway Books: New York, 2000. ISBN 0-7679-0326-9.

リシン

IUPAC名 Lysine
別称 2,6-diaminohexanoic acid
識別情報
CAS登録番号	70-54-2, 56-87-1 L, 923-27-3 D
PubChem	866
ChemSpider	843, 5747 L
KEGG	C16440
ChEMBL	CHEMBL28328
IUPHARリガンド	724
SMILES C(CCN)CC(C(=O)O)N
InChI InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10) Key: KDXKERNSBIXSRK-UHFFFAOYSA-N InChI=1/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10) Key: KDXKERNSBIXSRK-UHFFFAOYAY
特性
化学式	C₆H₁₄N₂O₂
モル質量	146.19 g mol⁻¹
特記なき場合、データは常温 (25 °C)・常圧 (100 kPa) におけるものである。

匿名

検索

案内

lysine