リジンカルボキシペプチダーゼ
WordNet
- any substance (such as an antibody) or agent that can cause lysis
- an essential amino acid found in proteins; occurs especially in gelatin and casein
PrepTutorEJDIC
- リジン(細胞溶解素), = lysine
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/07/04 01:13:43」(JST)
[Wiki en表示]
| Lysine carboxypeptidase |
| Identifiers |
| EC number |
3.4.17.3 |
| CAS number |
9013-89-2 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
Lysine carboxypeptidase (EC 3.4.17.3, carboxypeptidase N, arginine carboxypeptidase, kininase I, anaphylatoxin inactivator, plasma carboxypeptidase B, creatine kinase conversion factor, bradykinase, kininase Ia, hippuryllysine hydrolase, bradykinin-decomposing enzyme, protaminase, CPase N, creatinine kinase convertase, peptidyl-L-lysine(-L-arginine) hydrolase, CPN) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Release of a C-terminal basic amino acid, preferentially lysine
This is a zinc enzyme found in plasma. It inactivates bradykinin and anaphylatoxins.
References
- ^ Plummer, T.H. Jr.; Erdös, E.G. (1981). "Human plasma carboxypeptidase N". Methods Enzymol. 80: 442–449. PMID 7341915. doi:10.1016/s0076-6879(81)80038-9.
- ^ Levin, Y.; Skidgel, R.A.; Erdös, E.G. (1982). "Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase I)". Proc. Natl. Acad. Sci. USA. 79: 4618–4622. PMC 346726 . PMID 6750606. doi:10.1073/pnas.79.15.4618.
- ^ Skidgel, R.A. (1988). "Basic carboxypeptidases: regulators of peptide hormone activity". Trends Pharmacol. Sci. 9: 301–303. PMID 3074547. doi:10.1016/0165-6147(88)90015-6.
External links
- Lysine carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Hydrolase: proteases (EC 3.4)
|
| 3.4.11-19: Exopeptidase |
| 3.4.11 |
- Aminopeptidase
- Alanine
- Arginyl
- Aspartyl
- Cystinyl
- Leucyl
- Glutamyl
- Methionyl
- O
|
| 3.4.13 |
|
| 3.4.14 |
- Dipeptidyl peptidase
- Cathepsin C
- Dipeptidyl peptidase-4
- Tripeptidyl peptidase
- Tripeptidyl peptidase I
- Tripeptidyl peptidase II
|
| 3.4.15 |
- Angiotensin-converting enzyme
|
| 3.4.16 |
- Serine type carboxypeptidases: Cathepsin A
- DD-transpeptidase
|
| 3.4.17 |
- Metalloexopeptidases
- Carboxypeptidase
- A
- A2
- B
- C
- E
- Glutamate II
|
| Other/ungrouped |
|
|
| 3.4.21-25: Endopeptidase |
- Serine protease
- Cysteine protease
- Aspartic acid protease
- Metalloendopeptidase
- Threonine endopeptidase
- Proteasome endopeptidase complex
- HslU—HslV peptidase
- Other/ungrouped: Amyloid precursor protein secretase
- Alpha secretase
- Beta-secretase 1
- Beta-secretase 2
- Gamma secretase
|
| 3.4.99: Unknown |
|
|
Enzymes
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
| Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
| Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
|
UpToDate Contents
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English Journal
- Imaging analyses of coagulation-dependent initiation of fibrinolysis on activated platelets and its modification by thrombin-activatable fibrinolysis inhibitor.
- Brzoska T, Suzuki Y, Sano H, Suzuki S, Tomczyk M, Tanaka H, Urano T1.
- Thrombosis and haemostasis.Thromb Haemost.2017 Apr 3;117(4):682-690. doi: 10.1160/TH16-09-0722. Epub 2017 Feb 2.
- PMID 28150854
- Clinical Experience with 18F-Labeled Small Molecule Inhibitors of Prostate-Specific Membrane Antigen.
- Rowe SP1, Gorin MA2, Salas Fragomeni RA3, Drzezga A4, Pomper MG3.
- PET clinics.PET Clin.2017 Apr;12(2):235-241. doi: 10.1016/j.cpet.2016.12.006. Epub 2017 Jan 23.
- PMID 28267456
- Activated thrombin-activatable fibrinolysis inhibitor attenuates the angiogenic potential of endothelial cells: potential relevance to the breast tumour microenvironment.
- Bazzi ZA1,2, Balun J1, Cavallo-Medved D3, Porter LA3, Boffa MB4.
- Clinical & experimental metastasis.Clin Exp Metastasis.2017 Feb;34(2):155-169. doi: 10.1007/s10585-017-9837-y. Epub 2017 Jan 25.
- PMID 28124276
Japanese Journal
- <b>Nicotianamine is a novel angiotensin-converting enzyme 2 inhibitor in soy</b><b>bean </b>
- Novel internally quenched fluorogenic substrates for angiotensin I-converting enzyme and carboxypeptidase Y
- トロンビン活性化線溶阻害因子による線溶活性調節機構
Related Links
- Lysine Carboxypeptidase information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Lysine Carboxypeptidase Description of Lysine Carboxypeptidase Lysine ...
- "Lysine Carboxypeptidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors ... A metallocarboxypeptidase that removes C-terminal basic amino acid ...
★リンクテーブル★
[★]
- 英
- lysine carboxypeptidase
[★]
カルボキシペプチダーゼ