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English Journal

Serine protease inhibitors interact with IFN-γ through up-regulation of FasR; a novel therapeutic strategy against cancer.

Shadrin N1, Shapira MG1, Khalfin B2, Uppalapati L3, Parola AH4, Nathan I5.
Experimental cell research.Exp Cell Res.2015 Jan 15;330(2):233-9. doi: 10.1016/j.yexcr.2014.11.005. Epub 2014 Nov 18.
Among the many immunomodulatory and anti-tumor activities, IFN-γ up-regulates tumor cell death mediated by Fas receptor (FasR). Our and several other studies have demonstrated the involvement of trypsin-like proteases (TLPs) in the mode of action of IFN-γ. In the present study, we tried to unravel
PMID 25449698

Protease in sturgeon sperm and the effects of protease inhibitors on sperm motility and velocity.

Alavi SM1, Postlerová-Maňásková P, Hatef A, Pšenička M, Pěknicová J, Inaba K, Ciereszko A, Linhart O.
Fish physiology and biochemistry.Fish Physiol Biochem.2014 Oct;40(5):1393-8. doi: 10.1007/s10695-014-9933-8. Epub 2014 Mar 28.
In mammals, proteases are present in sperm acrosome and play key role in fertilization. Sturgeon sperm has an acrosome, but its physiology, biochemistry, and potential role in fertilization are unknown. In the present study, we have observed high protease activity in acidic extract of intact sperm c
PMID 24677048

Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin.

Simard M1, Hill LA, Underhill CM, Keller BO, Villanueva I, Hancock RE, Hammond GL.
Endocrinology.Endocrinology.2014 Aug;155(8):2900-8. doi: 10.1210/en.2014-1055. Epub 2014 May 21.
The serine protease inhibitor (SERPIN) family member corticosteroid-binding globulin (CBG) is the main carrier of glucocorticoids in plasma. Human CBG mediates the targeted release of cortisol at sites of inflammation through cleavage of its reactive center loop (RCL) by neutrophil elastase. The RCL
PMID 24848868

木付和幸,守屋寛
Chemical & pharmaceutical bulletin 30(6), 2241-2244, 1982-06-25
… The enzymatic activity of this enzyme was inhibited by mercurials, diisopropyl-fluorophosphate (DFP) and a high concentration of ethylenediaminetetraacetic acid (EDTA), but tosyllysine chloromethyl ketone (TLCK), tosylphenylalanine chloromethyl ketone (TPCK), iodoacetic acid, Trasylol and sodium tetrathionate had no detectable effect. …
NAID 110003634586