WordNet
- the set of all points or lines that satisfy or are determined by specific conditions; "the locus of points equidistant from a given point is a circle"
- the specific site of a particular gene on its chromosome
- the quality of being diverse and not comparable in kind (同)heterogeneousness
PrepTutorEJDIC
- (法律用語で)場所,位置 / (数学で,点が描く)軌跡)
- 異種,異種混成
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/09/28 09:34:19」(JST)
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Locus heterogeneity is a single disorder, trait, or pattern of traits caused by mutations in genes at different chromosomal loci. For example, retinitis pigmentosa has autosomal dominant, autosomal recessive, and X-linked origins. However, only one mutant locus is needed for the phenotype to manifest.
Another example is hypertrophic cardiomyopathy by Faris Mdanat
See also
- Allelic heterogeneity
- List of cutaneous conditions caused by mutations in keratins
UpToDate Contents
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English Journal
- Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations.
- Mancikova V1, Cruz R2,3, Inglada-Pérez L1,3, Fernández-Rozadilla C2,4, Landa I5, Cameselle-Teijeiro J6, Celeiro C2,6, Pastor S7,8, Velázquez A7,8, Marcos R7,8, Andía V9, Álvarez-Escolá C10, Meoro A11, Schiavi F12, Opocher G12,13, Quintela I14, Ansede-Bermejo J14, Ruiz-Ponte C2,3, Santisteban P15, Robledo M1,3, Carracedo A2,3,14.
- International journal of cancer. Journal international du cancer.Int J Cancer.2015 Oct 15;137(8):1870-8. doi: 10.1002/ijc.29557. Epub 2015 Apr 22.
- Thyroid cancer is the most heritable cancer of all those not displaying typical Mendelian inheritance. However, most of the genetic factors that would explain the high heritability remain unknown. Our aim was to identify additional common genetic variants associated with susceptibility to this disea
- PMID 25855579
- Chromosome dynamics and folding in eukaryotes: Insights from live cell microscopy.
- Bystricky K1.
- FEBS letters.FEBS Lett.2015 Oct 7;589(20 Pt A):3014-22. doi: 10.1016/j.febslet.2015.07.012. Epub 2015 Jul 17.
- How chromosomes are folded and how this folding relates to function remain fundamental questions. Answering them is rendered difficult by the stochasticity of chromatin fiber motion which inevitably results in heterogeneity of the populations analyzed. Even if single cell analyses are beginning to y
- PMID 26188544
Japanese Journal
- Isoenzyme Diversity and Differentiation of Marsh Scotch pine (Pinus sylvestris L.) Populations in The Western Siberia
- Larionova Albina Ya.,Ekart Alexander K.
- Eurasian Journal of Forest Research 14(1), 21-28, 2011-08
- … The mean number of alleles per locus, the mean observed heterozygosity, the mean expected heterozygosity and the effective number of alleles were equal to 2.63, 0.217, 0.212 and 1.37, respectively. … The obtained results testify to considerable genetic heterogeneity studied in Tomsk region of marsh populations of Scotch pine. …
- NAID 80022023413
Related Links
- Locus heterogeneity Definition(s) A single disorder, trait, or pattern of traits caused by mutations in genes at different chromosomal loci Definition from: GeneReviews from the University of Washington and the National Center for . ...
- Locus heterogeneity refers to mutations in different genes at different chromosomal loci that cause an identical phenotype. Chromosomal Instability Syndromes ... Editors Prof. Detlev Ganten Prof. Ruckpaul Klaus Free Articles ...
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- 関
- biologic characteristics、biological characteristics、heterogeneous、heterogenic、heterogenous、heterogenously、heterologous、heterologously、nonuniform、nonuniformity、population characteristics、ununiform、ununiformity
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- 関
- gene loci、gene locus、lie、locate、location、loci、map、position、rank、sit、site、sitting position、situated、situation、stand、topo