Statistical thermodynamics for functionally rotating mechanism of the multidrug efflux transporter AcrB.
Mishima H1, Oshima H, Yasuda S, Kinoshita M.
The journal of physical chemistry. B.J Phys Chem B.2015 Feb 26;119(8):3423-33. doi: 10.1021/jp5120724. Epub 2015 Feb 12.
AcrB, a homotrimer, is the pivotal part of a multidrug efflux pump. A "functionally rotating" picture has been proposed for the drug transport by AcrB, but its mechanism remains unresolved. Here, we investigate the energetics of the whole functional rotation cycle using our theoretical methods. We f
Exploring a new SPION-based MRI contrast agent with excellent water-dispersibility, high specificity to cancer cells and strong MR imaging efficacy.
Ma X1, Gong A1, Chen B2, Zheng J2, Chen T1, Shen Z3, Wu A4.
Colloids and surfaces. B, Biointerfaces.Colloids Surf B Biointerfaces.2015 Feb 1;126:44-9. doi: 10.1016/j.colsurfb.2014.11.045. Epub 2014 Dec 6.
Advances in contrast agents have greatly enhanced the sensitivity of magnetic resonance imaging (MRI) technique for early diagnosis of cancer. However, the commercial superparamagnetic iron oxide nanoparticles (SPION)-based contrast agents synthesized by co-precipitation method are not monodisperse
Mo- and W-based organic nanostructures prepared from bulk crystal isomorphs consisted of [(CH3CH2)3NH)]2[MO2(C14H6O4)2] (M = Mo, W).
Zhang B1, Du SZ, Lu XM, Wang G, Fen J.
Inorganic chemistry.Inorg Chem.2013 Aug 19;52(16):9470-8. doi: 10.1021/ic401125e. Epub 2013 Aug 5.
Two new crystal isomorphs consisting of complexes [(CH3CH2)3NH)]2[MoO2(C14H6O4)2] (1) and [(CH3CH2)3NH)]2[WO2(C14H6O4)2] (2) have been synthesized, respectively, and from which Mo-based flexible and durable nanopipes with diameters of 16 nm and lengths of hundreds of micrometers and W-based rigid an
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