linoleoyl-CoA desaturase

• リノレオイルCoA不飽和化酵素

関

delta-6-desaturase

WordNet

1. the 3rd letter of the Roman alphabet (同)c
2. (music) the keynote of the scale of C major
3. a general-purpose programing language closely associated with the UNIX operating system

PrepTutorEJDIC

1. carbonの化学記号
2. cobaltの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/25 05:07:06」(JST)

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[Wiki en表示]

linoleoyl-CoA desaturase
Identifiers
EC number	1.14.19.3
CAS number	9014-34-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a linoleoyl-CoA desaturase (EC 1.14.19.3) is an enzyme that catalyzes the chemical reaction

linoleoyl-CoA + AH₂ + O₂ gamma-linolenoyl-CoA + A + 2 H₂O

The 3 substrates of this enzyme are linoleoyl-CoA, an electron acceptor AH₂, and O₂, whereas its 3 products are gamma-linolenoyl-CoA, the reduction product A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with oxidation of a pair of donors resulting in the reduction of O to two molecules of water. The systematic name of this enzyme class is linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase. Other names in common use include Delta6-desaturase, Delta6-fatty acyl-CoA desaturase, Delta6-acyl CoA desaturase, fatty acid Delta6-desaturase, fatty acid 6-desaturase, linoleate desaturase, linoleic desaturase, linoleic acid desaturase, linoleoyl CoA desaturase, linoleoyl-coenzyme A desaturase, and long-chain fatty acid Delta6-desaturase. This enzyme participates in linoleic acid metabolism. It employs one cofactor, iron.

References

• Okayasu T, Nagao M, Ishibashi T, Imai Y (1981). "Purification and partial characterization of linoleoyl-CoA desaturase from rat liver microsomes". Arch. Biochem. Biophys. 206 (1): 21–8. doi:10.1016/0003-9861(81)90061-8. PMID 7212717. 

UpToDate Contents

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English Journal

• Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases.

• Watanabe K1, Ohno M1, Taguchi M1, Kawamoto S1, Ono K1, Aki T2.
• Journal of lipid research.J Lipid Res.2015 Nov 20. pii: jlr.M064121. [Epub ahead of print]
• Membrane-bound desaturases are physiologically and industrially important enzymes that are involved in the production of diverse fatty acids such as polyunsaturated fatty acids and their derivatives. Here, we identified amino acid residues that determine the substrate specificity of rat ∆6 desatur
• PMID 26590171

• Evaluation of various biomarkers as potential mediators of the association between Δ5 desaturase, Δ6 desaturase, and stearoyl-CoA desaturase activity and incident type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition-Potsdam Study.

• Jacobs S1, Schiller K1, Jansen EH2, Boeing H3, Schulze MB1, Kröger J4.
• The American journal of clinical nutrition.Am J Clin Nutr.2015 Jul;102(1):155-64. doi: 10.3945/ajcn.114.102707. Epub 2015 May 13.
• BACKGROUND: An association between desaturase activity and risk of type 2 diabetes (T2D) has been found in epidemiologic studies, but little is known about potential mediators of this association.OBJECTIVE: We aimed to investigate the potential role of diabetes-related biomarkers as mediators of the
• PMID 25971719

• Identification of polyunsaturated fatty acid and diterpenoid biosynthesis pathways from draft genome of Aureispira sp. CCB-QB1.

• Furusawa G1, Lau NS2, Shu-Chien AC3, Jaya-Ram A4, Amirul AA3.
• Marine genomics.Mar Genomics.2015 Feb;19:39-44. doi: 10.1016/j.margen.2014.10.006. Epub 2014 Nov 11.
• The genus Aureispira consisting of two species, Aureispira marina and Aureispira maritima is an arachidonic acid-producing bacterium and produces secondary metabolites. In this study, we isolated a new Aureispira strain, Aureispira sp. CCB-QB1 from coastal area of Penang, Malaysia and the genome seq
• PMID 25468060

Japanese Journal

• Purification and partial characterization of linoleoyl-CoA desaturase from rat liver microsomes

• OKAYASU T.
• Arch Biochem Biophys 206, 21-28, 1981
• NAID 10010558073

Related Links

• Linoleoyl-CoA desaturase - Springer

EC number 1.14.19.3 Systematic name linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase Recommended name ... Synonyms Δ 6 CoA desaturase Δ 6-desaturase Δ 6-fatty acyl-CoA desaturase EC 1.4.99.25 (formerly) ...

• Linoleoyl-CoA Desaturase | Profiles RNS

"Linoleoyl-CoA Desaturase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). ... This graph shows the total number of publications written about "Linoleoyl-CoA ...

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★リンクテーブル★

リンク元	「リノレオイルCoA不飽和化酵素」「delta-6-desaturase」
関連記事	「C」「CoA」「desaturase」「COA」「Co」

「リノレオイルCoA不飽和化酵素」

　　[★]

英

linoleoyl-CoA desaturase

関

Δ6不飽和化酵素

「delta-6-desaturase」

　　[★]

Δ6不飽和化酵素

関

linoleoyl-CoA desaturase

「C」

　　[★]

• 炭素 carbon
• シトシン cytosine
• システイン cysteine
• シチジン
• セルシウス度 摂氏 degrees Celsius degree C
• 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語

　 　 　 　

「CoA」

　　[★]

• 大動脈縮窄症 coactation of the aorta
• 補酵素A coenzyme A

「desaturase」

　　[★]

不飽和化酵素、脱飽和酵素、デサチュラーゼ

「COA」

　　[★] 補酵素A coenzyme A CoA

「Co」

　　[★] コバルト cobalt