- adv.
- 潜在的に
WordNet
- existing in possibility; "a potential problem"; "possible uses of nuclear power" (同)possible
- the inherent capacity for coming into being (同)potentiality, potency
- with a possibility of becoming actual; "he is potentially dangerous"; "potentially useful"
- potentially existing but not presently evident or realized; "a latent fingerprint"; "latent talent"
- (pathology) not presently active; "latent infection"; "latent diabetes"
PrepTutorEJDIC
- 可能性のある,潜在的な / 可能性,潜在力 / 電位
- 可能性を秘めて,潜在的に
- 潜在(潜伏)している,隠れている
UpToDate Contents
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- 1. エプスタインバーウイルス（EBウイルス）のウイルス学 virology of epstein barr virus
- 2. 単純ヘルペスウイルス1型感染の病因 pathogenesis of herpes simplex virus type 1 infection
- 3. Bウイルス感染 b virus infection
- 4. HIVの進行に影響を与える因子 factors affecting hiv progression
- 5. Virology, epidemiology, and pathogenesis of JC polyomavirus, BK polyomavirus, and other human polyomaviruses
English Journal
- Small molecule inhibition of Epstein-Barr virus nuclear antigen-1 DNA binding activity interferes with replication and persistence of the viral genome.
- Lee EK1, Kim SY1, Noh KW1, Joo EH1, Zhao B2, Kieff E2, Kang MS3.Author information 1Samsung Advanced Institute for Health Sciences and Technology (SAIHST) and Samsung Biomedical Research Institute (SBRI), Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea.2Infectious Diseases Division, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, United States; Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, United States.3Samsung Advanced Institute for Health Sciences and Technology (SAIHST) and Samsung Biomedical Research Institute (SBRI), Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea; Infectious Diseases Division, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, United States; Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, United States. Electronic address: mkang@skku.edu.AbstractThe replication and persistence of extra chromosomal Epstein-Barr virus (EBV) episome in latently infected cells are primarily dependent on the binding of EBV-encoded nuclear antigen 1 (EBNA1) to the cognate EBV oriP element. In continuation of the previous study, herein we characterized EBNA1 small molecule inhibitors (H20, H31) and their underlying inhibitory mechanisms. In silico docking analyses predicted that H20 fits into a pocket in the EBNA1 DNA binding domain (DBD). However, H20 did not significantly affect EBNA1 binding to its cognate sequence. A limited structure-relationship study of H20 identified a hydrophobic compound H31, as an EBNA1 inhibitor. An in vitro EBNA1 EMSA and in vivo EGFP-EBNA1 confocal microscopy analysis showed that H31 inhibited EBNA1-dependent oriP sequence-specific DNA binding activity, but not sequence-nonspecific chromosomal association. Consistent with this, H31 repressed the EBNA1-dependent transcription, replication, and persistence of an EBV oriP plasmid. Furthermore, H31 induced progressive loss of EBV episome. In addition, H31 selectively retarded the growth of EBV-infected LCL or Burkitt's lymphoma cells. These data indicate that H31 inhibition of EBNA1-dependent DNA binding decreases transcription from and persistence of EBV episome in EBV-infected cells. These new compounds might be useful probes for dissecting EBNA1 functions in vitro and in vivo.
- Antiviral research.Antiviral Res.2014 Apr;104:73-83. doi: 10.1016/j.antiviral.2014.01.018. Epub 2014 Jan 31.
- The replication and persistence of extra chromosomal Epstein-Barr virus (EBV) episome in latently infected cells are primarily dependent on the binding of EBV-encoded nuclear antigen 1 (EBNA1) to the cognate EBV oriP element. In continuation of the previous study, herein we characterized EBNA1 small
- PMID 24486954
- Biology and host response to Cyprinid herpesvirus 3 infection in common carp.
- Adamek M1, Steinhagen D2, Irnazarow I3, Hikima J4, Jung TS4, Aoki T5.Author information 1Fish Disease Research Unit, Centre of Infectious Diseases, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany.2Fish Disease Research Unit, Centre of Infectious Diseases, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany. Electronic address: Dieter.Steinhagen@tiho-hannover.de.3Polish Academy of Sciences, Institute of Ichthyobiology and Aquaculture in Gołysz, Kalinowa 2, 43-520 Chybie, Poland.4Aquatic Biotechnology Center of WCU Project, College of Veterinary Medicine, Gyeongsang National University, 900 Gajwa-dong, Jinju, Gyeongnam 660-710, South Korea.5Aquatic Biotechnology Center of WCU Project, College of Veterinary Medicine, Gyeongsang National University, 900 Gajwa-dong, Jinju, Gyeongnam 660-710, South Korea; Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513, Wasedatsurumaki-cho, Shinjuku-ku, Tokyo 162-0041, Japan.AbstractViruses from the family Alloherpesviridae form an aquatic clade of herpesviruses infecting fish and amphibia. Diseases caused by these herpesviruses are of increasing importance because of the high morbidity and mortality associated with the infection, and the difficulties in diagnosing latently infected carriers. Cyprinid herpesvirus 3 (CyHV-3) induces a severe disease and mortality in common carp and thus greatly affects carp aquaculture and trade. This review summarises advancements in the understanding of the infection process and the current knowledge on immune responses of carp to CyHV-3. A focus is laid on host genetics and immunity responsible for resistance/survival from the disease and on the viral mechanisms accountable for evasion of carp immune responses. As current knowledge of immune responses to CyHV-3 is still limited, perspectives for future studies are outlined. Analysing CyHV-3 fish-host interactions will be useful and thought-provoking for a basic understanding of fish immune responses.
- Developmental and comparative immunology.Dev Comp Immunol.2014 Apr;43(2):151-9. doi: 10.1016/j.dci.2013.08.015. Epub 2013 Aug 24.
- Viruses from the family Alloherpesviridae form an aquatic clade of herpesviruses infecting fish and amphibia. Diseases caused by these herpesviruses are of increasing importance because of the high morbidity and mortality associated with the infection, and the difficulties in diagnosing latently inf
- PMID 23981329
- The role of fish movements and the spread of infectious salmon anemia virus (ISAV) in Chile, 2007-2009.
- Mardones FO1, Martinez-Lopez B2, Valdes-Donoso P3, Carpenter TE4, Perez AM5.Author information 1Center for Animal Disease Modeling and Surveillance (CADMS), Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA; EpiVet Consulting, Santiago, Chile. Electronic address: fomardones@ucdavis.edu.2Center for Animal Disease Modeling and Surveillance (CADMS), Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.3Center for Animal Disease Modeling and Surveillance (CADMS), Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA; Department of Agricultural and Resource Economics, University of California, Davis, CA 95616, USA.4Center for Animal Disease Modeling and Surveillance (CADMS), Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA; EpiCentre, Massey University, Palmerston North 4442, New Zealand.5Center for Animal Disease Modeling and Surveillance (CADMS), Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA; CONICET and Facultad de Ciencias Veterinarias UNR, Argentina.AbstractInfectious salmon anemia virus (ISAV) infection is a constant major threat to farmed and wild Atlantic salmon worldwide. Many epidemics have recently been reported in the most important salmon farming regions of the world, including Chile (2007-2009), where ISAV generated the most important disease and economic crisis in history of the salmon industry of the country. The spread of ISAV within a region is most likely by local or neighborhood spread from an infected farm; however, there is evidence that anthropogenic activities, such as movement of live or harvested fish or their byproduct, may have played a more important role than environmental or passive transmission in the 2007-2009 outbreak. Atlantic salmon farms (n=421) were retrospectively followed from stocking to harvesting in southern Chile at the time of the ISAV epidemic (2007-2009). The effect of husbandry and spatial risk factors, in addition to contact-network risk factors, which were obtained from the social network analyses, on time to first ISAV infection was estimated using a multivariable Cox proportional hazards model. Five variables were retained in the final fitted model: co-existing multiple generations on a farm (hazard ratio [HR]=2.585), mean smolt weight at stocking greater than 120g (HR=1.165), farm area (perkm(2)) (HR=1.005), and increased number of shipments entering a farm, i.e. the farm input degree (HR=1.876) were associated with reduced time to infection; whereas time-to-infection was longer for farms located farther from an ongoing ISAV outbreak (HR=0.943). It was demonstrated that movements of latently infected fish resulted in approximately 7 outbreaks, and potentially explain about 6% of the total number of cases during the epidemic. Results from this study provide new information about the mechanisms of spread of ISAV in one the largest documented ISAV epidemics in the world. Findings may be used to support the design and implementation of risk-based surveillance and control programs that may help to prevent, detect and control future ISAV outbreaks.
- Preventive veterinary medicine.Prev Vet Med.2014 Apr 1;114(1):37-46. doi: 10.1016/j.prevetmed.2014.01.012. Epub 2014 Jan 20.
- Infectious salmon anemia virus (ISAV) infection is a constant major threat to farmed and wild Atlantic salmon worldwide. Many epidemics have recently been reported in the most important salmon farming regions of the world, including Chile (2007-2009), where ISAV generated the most important disease
- PMID 24485704
Japanese Journal
- Accumulation of Somatic Mutations in TP53 in Gastric Epithelium With Helicobacter pylori Infection.
- Shimizu Takahiro,Marusawa Hiroyuki,Matsumoto Yuko,Inuzuka Tadashi,Ikeda Atsuyuki,Fujii Yosuke,Minamiguchi Sachiko,Miyamoto Shin'ichi,Kou Tadayuki,Sakai Yoshiharu,Crabtree Jean E,Chiba Tsutomu
- Gastroenterology 147(2), 407-417.e3, 2014-08
- … To explore the genetic basis of gastric cancer that develops in inflamed gastric mucosa, we investigated genetic aberrations that latently accumulate in nontumorous gastric epithelium with H pylori infection. …
- NAID 120005466713
- Virology : Analysis of the Mechanism of Reactivation of Latently Infecting Pseudorabies Virus by Acetylcholine
- TANAKA Seiichi,MANNEN Kazuaki
- The journal of veterinary medical science 76(5), 719-722, 2014-05
- NAID 40020110921
- 口腔内短鎖脂肪酸の歯周組織と全身疾患に及ぼす影響
- 落合 邦康,今井 健一,落合（栗田） 智子
- 腸内細菌学雑誌 28(3), 111-120, 2014
- 全ての腸内フローラ構成細菌と食物は，口腔を経由して腸管に至り，複雑な腸内フローラが形成される．腸管の生理作用と恒常性維持における腸内フローラの有益性，そして，食物繊維やオリゴ糖の生理作用の本体が短鎖脂肪酸（SCFA）であることは広く知られている．一方，慢性炎症性疾患・歯周病は，糖尿病や動脈硬化などさまざまな全身疾患の誘因となることがさまざまな分野で報告され，口腔と全身疾患との関わりが広く注目されて …
- NAID 130004678111
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Related Pictures
★リンクテーブル★
| リンク元 | 「potential」「potentially」「潜在的」 |
| 関連記事 | 「latent」 |
「potential」
- n.
- adj.
- 潜在的な、可能な、有望な
- 関
- capability、capable、electric potential、electrical potential、feasibility、feasible、latently、likelihood、odds、possibility、possible、potentiality、potentially、probability、promising、voltage
「potentially」
- adv.
- 潜在的に、強力に
- 関
- high-potency、high-power、intensive、intensively、latently、massive、potent、potential、potently、powerful、powerfully
「潜在的」
「latent」
- adj.
- 不顕性の、潜在型の、潜在性の、潜伏した、潜在した