- 関
- alpha-interferon、interferon alfa-n1、interferon-alpha
WordNet
- a form of interferon that is produced endogenously and commercially for its pharmacological effects (including regulation of the immune system and antiviral and antineoplastic effects)
- an antiviral protein produced by cells that have been invaded by a virus; inhibits replication of the virus
PrepTutorEJDIC
- インターフェロン(ウイルス増殖抑制物質)
- インターフェロン (virusの増殖を抑制する)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/10/31 23:35:44」(JST)
[Wiki en表示]
Interferon alfa
| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
Pregnancy
category |
- US: C (Risk not ruled out)
|
Routes of
administration |
Subcutaneous, intramuscular |
| ATC code |
|
| Identifiers |
| ChemSpider |
|
| NY (what is this?) (verify) |
Interferon alfa (INN) or HuIFN-alpha-Le, trade name Multiferon, is a pharmaceutical drug composed of natural interferon alpha (IFN-α) obtained from the leukocyte fraction of human blood following induction with Sendai virus. Interferon alfa contains several naturally occurring IFN-α subtypes and is purified by affinity chromatography. Although the pharmaceutical product is often simply called "interferon alpha" or "IFN-α" like its endogenous counterpart, the product's INN is interferon alfa (the spelling of 'alfa' with 'f' reflects INN naming conventions).
Composition
Interferon alfa contains a mixture of several proteins, all with structural, serological, and functional properties typical for natural interferon alpha (IFN α). The major subtypes identified are IFN-α1, IFN-α2, IFN-α8, IFN-α10, IFN-α14 and IFN-α21. Of these, IFN-α2 and IFN-α14 are glycosylated. The IFN-α content is expressed in International Units per milliliter, and the drug product is formulated in isotonic phosphate buffer solution at pH = 7.2, and supplemented with human albumin at 1.5 mg/ml. The albumin used is a medicinal product approved in several countries, and is indicated for subcutaneous injection therapy.
Pharmacology
IFN-α8 enhances the proliferation of human B cells, as well as being able to activate NK cells. The subtypes α10 and α2, along with α8, are the most efficient and powerful NK cell activators. Subtypes α21 and α2 enhance the expression of IFN-gamma-inducible protein-10 (IP-10) in dendritic cells. Activated dendritic cells initiate immune responses and induce the expression of IP-10, a chemokine which promotes a Th1 inflammatory response.
IFN-α1 causes increased HLA-II expression, and can directly inhibit tumor cell growth in vitro. However, it is a poor activator of NK cells, has relatively little antiviral activity, does not induce B cell proliferation, and does not enhance HLA-I or tumor antigen expression. Despite its apparent inactivity, it is still used clinically in the treatment of metastatic renal cell carcinoma, with a reported lower toxicity than the recombinant IFN-α2. Overall, IFN-α has a general inflammatory action which skews the immune response towards a Th1 profile.
Subtype α2 increases the expression of HLA-I molecules, which correlates with IFN-α-mediated activation of memory CD8 cells and increased cytolytic action against virally infected cells and tumor cells (via cytotoxic CD8 cells).
References
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Immunostimulants (L03)
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| Endogenous |
| Cytokines |
| Colony-stimulating factors |
- G-CSF
- Filgrastim / Pegfilgrastim
- Lenograstim
- GM-CSF
- Molgramostim
- Sargramostim
- SCF
|
| Interferons |
- alpha:
- Albinterferon
- Interferon alfa natural
- Interferon alfa 2a / Peginterferon alfa-2a
- Interferon alfa 2b / Peginterferon alfa-2b
- Interferon alfa n1
- Interferon alfacon-1
- Interferon alpha-n3
- beta:
- Interferon beta natural
- Interferon beta 1a
- Interferon beta 1b
- Interferon gamma
|
| Interleukins |
|
|
| Other protein / peptide |
- Growth hormone
- Immunocyanin
- Pegademase
- Prolactin
- Tasonermin
|
| Other |
- Female sex steroids
- Histamine dihydrochloride
- Poly ICLC
- Vitamin D
|
|
| Exogenous |
- beta-glucan
- heterocyclic compound
- hydroxyquinoline
- Mifamurtide
- oligopeptides
- Glatiramer acetate
- Thymopentin
- Thymosin α1
- Thymulin
- polyribonucleotide
- Polyinosinic:polycytidylic acid
- thiazolidine
- vaccines
- Bacillus Calmette–Guérin
- Melanoma vaccine
- Sipuleucel-T
|
|
Cytokine receptor modulators
|
| Chemokine |
|
| CSF |
| Erythropoietin |
- Agonists: ARA-290
- Asialo erythropoietin
- Carbamylated erythropoietin
- CNTO-530
- Darbepoetin alfa
- Epoetin alfa
- Epoetin beta
- Epoetin delta
- Epoetin epsilon
- Epoetin gamma
- Epoetin kappa
- Epoetin omega
- Epoetin theta
- Epoetin zeta
- Erythropoietin (EPO)
- Erythropoietin-Fc
- Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
- Peginesatide
- Pegol sihematide (EPO-018B)
|
| G-CSF (CSF3) |
- Agonists: Filgrastim
- Granulocyte colony-stimulating factor
- Lenograstim
- Leridistim
- Lipegfilgrastim
- Nartograstim
- Pegfilgrastim
- Pegnartograstim
|
| GM-CSF (CSF2) |
- Agonists: Ecogramostim
- Granulocyte macrophage colony-stimulating factor
- Milodistim
- Molgramostim
- Regramostim
- Sargramostim
- Antibodies: Mavrilimumab
- MOR103
- Namilumab
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| M-CSF (CSF1) |
- Agonists: Cilmostim
- Interleukin-34
- Lanimostim
- Macrophage colony-stimulating factor
- Mirimostim
- Kinase inhibitors: Agerafenib
|
| SCF (c-Kit) |
|
| Thrombopoietin |
- Agonists: Eltrombopag
- Pegacaristim
- Promegapoietin
- Romiplostim
- Thrombopoietin (THPO, MGDF)
|
|
| Interferon |
| IFNAR (α/β, I) |
- Agonists: Albinterferon
- Interferon alpha (interferon alfa, IFN-α)
- Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21)
- Interferon alfa 2a
- Interferon alfa 2b
- Interferon alfa n1
- Interferon alfacon-1
- Interferon alpha-n3
- Interferon beta (IFN-β) (IFNB1, IFNB3)
- Interferon beta 1a
- Interferon beta 1b
- Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
- Interferon omega (IFN-ω, IFNW1)
- Peginterferon alfa-2a
- Peginterferon alfa-2b
- Antibodies: Anifrolumab
- Faralimomab
- MEDI-545
- Rontalizumab
- Sifalimumab
- Decoy receptors: Bifarcept
|
| IFNGR (γ, II) |
- Agonists: Interferon gamma (IFN-γ)
- Interferon gamma 1b
- Antibodies: Emapalumab
- Fontolizumab
|
| IFNLR (λ, III) |
- See IL-28R (IFNLR) here instead.
|
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| Interleukin |
|
| TGFβ |
|
| TNF |
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| Others |
JAK
(inhibitors) |
| JAK1 |
- Baricitinib
- Filgotinib
- Momelotinib
- Oclacitinib
- Ruxolitinib
- Tofacitinib (tasocitinib, CP-690550)
- Upadacitinib
|
| JAK2 |
- AG-490
- Atiprimod
- AZD-1480
- Baricitinib
- CHZ868
- Cucurbitacin I (elatericin B, JSI-124)
- CYT387
- Lestaurtinib
- NSC-7908
- NSC-33994
- Pacritinib
- Ruxolitinib
- SD-1008
- Tofacitinib (tasocitinib, CP-690550)
|
| JAK3 |
- AG-490
- Cercosporamide
- TCS-21311
- Tofacitinib (tasocitinib, CP-690550)
- WHI-P 154
- ZM-39923
- ZM-449829
|
|
| Others |
- Additional cytokines: Cardiotrophin 1 (CT-1)
- FMS-like tyrosine kinase 3 ligand (FLT3L)
- Leukemia/leukocyte inhibitory factor (LIF)
- Oncostatin M (OSM)
- Thymic stromal lymphopoietin (TSLP)
- Additional cytokine receptor modulators: Emfilermin
- Lestaurtinib
- Midostaurin
- Quizartinib
- Sorafenib
- Sunitinib
|
|
- See also
- Receptor/signaling modulators
- Signaling peptide/protein receptor modulators
- Growth factor receptor modulators
|
UpToDate Contents
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English Journal
- Blocking autophagy flux promotes interferon-alpha-mediated apoptosis in head and neck squamous cell carcinoma.
- Yang W, Jiang C, Xia W, Ju H, Jin S, Liu S, Zhang L, Ren G, Ma H, Ruan M, Hu J.
- Cancer letters. 2019 Jun;451()34-47.
- Despite multiple antitumor activities, interferon-alpha (IFNα) therapy alone is less effective in solid tumors. Autophagy has been reported to play a key role in tumor chemoresistance. Therefore, it is meaningful to explore whether autophagy can be activated by IFNα in head and neck squamous cell
- PMID 30862487
- Imbalance in the ratio of CpG and polyG contributes to impaired interferon-α expression.
- Lv S, Li S, Wang Z, Xia J.
- Journal of medical virology. 2019 Jun;91(6)1148-1157.
- The secretion of interferon-α (IFN-α) is impaired during hepatitis B virus (HBV) infection. DNA sequences purified from distinct viruses, for example, HBV versus members of Herpesviridae, have been shown to differ in their IFN-α signaling properties. The present study found that DNA from HBV inhi
- PMID 30701565
- Monitoring Disease Activity in Systemic Lupus Erythematosus With Single-Molecule Array Digital Enzyme-Linked Immunosorbent Assay Quantification of Serum Interferon-α.
- Mathian A, Mouries-Martin S, Dorgham K, Devilliers H, Barnabei L, Ben Salah E, Cohen-Aubart F, Garrido Castillo L, Haroche J, Hie M, Pineton de Chambrun M, Miyara M, Sterlin D, Pha M, Lê Thi Huong D, Rieux-Laucat F, Rozenberg F, Gorochov G, Amoura Z.
- Arthritis & rheumatology (Hoboken, N.J.). 2019 May;71(5)756-765.
- No simple or standardized assay is available to quantify interferon-α (IFNα) in routine clinical practice. Single-molecule array (Simoa) digital enzyme-linked immunosorbent assay (ELISA) technology enables direct IFNα quantification at attomolar (femtogram per milliliter [fg/ml]) concentrations.
- PMID 30507062
Japanese Journal
- C型慢性肝炎に対するpegylated interferon α-2b/ribavirin併用療法の無効・再燃例におけるpegylated interferon α-2a/ribavirin併用療法の効果
- 腎がん--小分子物質との比較,単剤投与の意義 (特集 血管新生阻害剤の効果と功罪) -- (Bevacizumab)
★リンクテーブル★
[★]
- 英
- interferon-α interferon-alpha interferon alfa IFN-α
- 同
- インターフェロンアルファ、インターフェロン-α, αインターフェロン α-interferon alpha-interferon
- 商
- スミフェロン(インターフェロンアルファ(NAMALWA))、オーアイエフ(インターフェロン アルファ（BALL-1）)
- 関
- インターフェロン、インターフェロンアルファコン-1(アドバフェロン)、インターフェロンα-2a、インターフェロンα-2b
- 白血球やリンパ芽球が産生する抗ウイルス性タンパク質
適応
[★]
インターフェロンアルファ-n1、インターフェロンアルファn1
- 関
- alpha-interferon、interferon alfa、interferon-alpha
[★]
ペグインターフェロンアルファ-2b、ペグインターフェロンアルファ2b
[★]
インターフェロンアルファ-2a、インターフェロンアルファ2a
[★]
インターフェロンアルファ-2b、インターフェロンアルファ2b
[★]
インターフェロンアルファコン-1
[★]
インターフェロンアルファコン
[★]
- 関
- alpha
[★]
インターフェロン