浸潤性眼症
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/18 22:40:04」(JST)
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Infiltrative ophthalmopathy is found in Graves disease and resembles exophthalmos, except that the blurry or double vision is acquired because of weakness in the ocular muscles of the eye. In addition, there is no known correlation with the patient's thyroid levels. Exophthalmos associated with Grave's disease disappears when the thyrotoxicosis is corrected. Infiltrative ophthalmopathy at times may not be cured. The current hypothesis is that infiltrative ophthalmopathy may be autoimmune in nature targeting retrobulbar tissue.
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English Journal
- Single unit filter-aided method for fast proteomic analysis of tear fluid.
- Aass C1, Norheim I2, Eriksen EF2, Thorsby PM3, Pepaj M3.
- Analytical biochemistry.Anal Biochem.2015 Jul 1;480:1-5. doi: 10.1016/j.ab.2015.04.002. Epub 2015 Apr 8.
- Human tear fluid is a complex mixture containing high concentrations of proteins and is increasingly becoming an important source for studying protein biomarkers of eye-related diseases such as Graves' ophthalmopathy. Today, the Schirmer tear test is the most widely used technique for tear collectio
- PMID 25862084
- Smoking was associated with poor response to intravenous steroids therapy in Graves' ophthalmopathy.
- Xing L1, Ye L1, Zhu W1, Shen L1, Huang F1, Jiao Q2, Zhou X1, Wang S1, Wang W1, Ning G3.
- The British journal of ophthalmology.Br J Ophthalmol.2015 Jun 10. pii: bjophthalmol-2014-306463. doi: 10.1136/bjophthalmol-2014-306463. [Epub ahead of print]
- BACKGROUND: Previous studies have shown that smoking is closely related to the occurrence, severity and response to orbital radiation in Graves' ophthalmopathy (GO). The aim of this study was to investigate whether smoking impacts the response to intravenous 4.5 g methylprednisolone therapy in pat
- PMID 26061160
- Circulating microRNA predicts insensitivity to glucocorticoid therapy in Graves' ophthalmopathy.
- Shen L1, Huang F, Ye L, Zhu W, Zhang X, Wang S, Wang W, Ning G.
- Endocrine.Endocrine.2015 Jun;49(2):445-56. doi: 10.1007/s12020-014-0487-4. Epub 2015 Jan 15.
- Glucocorticoid (GC) insensitivity occurs commonly in Graves' ophthalmopathy (GO), and GC therapy is associated with major adverse effects. A reliable and easily accessible biomarker is required to predict the outcome of GC therapy. This study aimed to evaluate the performance of circulating microRNA
- PMID 25588771
Japanese Journal
- <研究資料>病気の顔貌と容貌(5) : バセドウ病(Basedow's disease)について
- 佐々木 悠,二宮 寛,二田 哲博,川崎 晃一,奥村 恂
- 健康科学 13, 153-163, 1991-02-08
- … Basedow's disease is a multisystem disease characterized by diffuse goiter, thyrotoxicosis and infiltrative ophthalmopathy. …
- NAID 110000407250
- 著明な外眼筋肥大を伴いthyroid-stimulating antibody (TSAb)高値を示した甲状腺機能低下症の1例
- 板橋 秀雄,内藤 毅嗣,佐藤 晁,竹村 喜弘
- 日本内科学会雑誌 77(5), 695-699, 1988
- … CTスキャンにて著明な外眼筋肥大とそれによる視神経圧迫像を認め, infiltrative ophthalmopathyの存在が明らかであった. …
- NAID 130000901244
Related Links
- ophthalmopathy /oph·thal·mop·a·thy/ (of″thal-mop´ah-the) any disease of the eye. oph·thal·mop·a·thy (f th l-m p-th, -th l-, p-) n. A disease of the eyes. ... Extrathyroidal Manifestations of Graves' Disease Clinically evident infiltrative ...
- Der Begriff Infiltrative ophthalmopathy ist im englisch-sprachigen Wikipedia aufgeführt. Dort heißt es dazu: Infiltrative ophthalmopathy is found in Graves disease and resembles exophthalmos, except that the blurry or double vision is ...
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★リンクテーブル★
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- 英
- Basedow ophthalmopathy
- 同
- グレーブズ病眼症 Graves眼症 Graves ophthalmopathy Graves' ophthalmopathy, 甲状腺機能亢進性眼病変 thyrotoxic ophthalmopathy, 甲状腺眼症状 甲状腺眼症 dysthyroid ophthalmopathy thyroid associated ophthalmopathy thyroid-associated ophthalmopathy TAO、浸潤性眼症 infiltrative ophthalmopathy
- 関
- グレーブス病
概念
- 眼球突出、眼球運動障害、眼瞼浮腫、結膜充血、視神経障害などの眼病変がバセドウ病患者にみられることをいう。
病態生理
- 眼窩内組織(外眼筋、球後結合組織)にTSH受容体を介する自己免疫機序を開始、外眼筋肥厚、脂肪組織増生、涙腺肥大を生じ、結果として眼窩内圧が上昇する。これにより眼球突出をきたす。
症状
- SOP. 184
- 眼窩脂肪織・外眼筋の肥大 → 眼窩内容増大
徴候
参考
- 1. [charged] Pathogenesis and clinical features of Graves' ophthalmopathy (orbitopathy) - uptodate [1]
- 2. [charged] Treatment of Graves' orbitopathy (ophthalmopathy) - uptodate [2]
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- 英
- infiltrative ophthalmopathy
- 関
- 甲状腺眼症、グレーブス眼症、悪性眼球突出症
- (see.→バセドウ病眼症)
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- 英
- malignant exophthalmos
- 同
- 浸潤性眼症 infiltrative ophthalmopathy
- 関
- バセドウ病眼症
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- 関
- invasive
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- 関
- eye disease、eye disorder