無効造血
WordNet
- not producing an intended effect; "an ineffective teacher"; "ineffective legislation" (同)uneffective, ineffectual
- lacking in power or forcefulness; "an ineffectual ruler"; "like an unable phoenix in hot ashes" (同)ineffectual, unable
- lacking the ability or skill to perform effectively; inadequate; "an ineffective administration"; "inefficient workers" (同)inefficient
- the process of producing red blood cells by the stem cells in the bone marrow
PrepTutorEJDIC
- 効果のない,むだな / 役に立たない,無能の,無力の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/26 09:10:13」(JST)
[Wiki en表示]
Ineffective erythropoiesis is active erythropoiesis with premature death of red blood cells, a decreased output of RBCs from the bone marrow, and, consequently, anemia.[1]
See also
- List of hematologic conditions
- Congenital Dyserythropoietic Anemias
References
- ^ Nelson Textbook of Pediatrics, 18th ed
UpToDate Contents
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English Journal
- Factors associated with hematopoietic cell transplantation (HCT) among patients in a population-based study of myelodysplastic syndrome (MDS) in Minnesota.
- Smith AR1, Warlick ED, Roesler MA, Poynter JN, Richardson M, Nguyen P, Cioc A, Hirsch B, Ross JA.
- Annals of hematology.Ann Hematol.2015 Oct;94(10):1667-75. doi: 10.1007/s00277-015-2422-z. Epub 2015 Jun 11.
- Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder characterized by dysplastic changes in the bone marrow, ineffective erythropoiesis, and an increased risk of developing acute myeloid leukemia. Treatment planning for patients with MDS is a complex process, and we sought to
- PMID 26063191
- A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis.
- Liang R1, Campreciós G2, Kou Y3, McGrath K4, Nowak R5, Catherman S4, Bigarella CL2, Rimmelé P2, Zhang X2, Gnanapragasam MN2, Bieker JJ6, Papatsenko D2, Ma'ayan A3, Bresnick E7, Fowler V5, Palis J4, Ghaffari S8.
- PLoS genetics.PLoS Genet.2015 Oct 9;11(10):e1005526. doi: 10.1371/journal.pgen.1005526. eCollection 2015.
- Circulating red blood cells (RBCs) are essential for tissue oxygenation and homeostasis. Defective terminal erythropoiesis contributes to decreased generation of RBCs in many disorders. Specifically, ineffective nuclear expulsion (enucleation) during terminal maturation is an obstacle to therapeutic
- PMID 26452208
- Anemia as the Main Manifestation of Myelodysplastic Syndromes.
- Santini V1.
- Seminars in hematology.Semin Hematol.2015 Oct;52(4):348-56. doi: 10.1053/j.seminhematol.2015.06.002. Epub 2015 Jun 30.
- Myelodysplastic syndromes (MDS) are a constellation of different diseases sharing anemia in the great majority of cases, and this cytopenia defines these pathologies and their most dramatic clinical manifestations. Anemia in MDS is due to ineffective erythropoiesis, with a high degree of apoptosis o
- PMID 26404446
Japanese Journal
- Red Blood Cell Distribution Width as a Link Between Ineffective Erythropoiesis and Chronic Inflammation in Heart Failure
- 高容量の赤血球造血刺激因子製剤が必要な血液透析患者に対するL-カルニチン補充療法の効果(赤血球寿命への効果も含めて)
- 脾摘により輸血依存から脱した congenital dyserythropoietic anemia (CDA) II 型の1例
- 日本小児外科学会雑誌 = Journal of the Japanese Society of Pediatric Surgery 49(2), 261-265, 2013-04-20
- NAID 10031173657
Related Links
- Definition of ineffective erythropoiesis in the Medical Dictionary. ineffective erythropoiesis explanation. Information about ineffective erythropoiesis in Free online English dictionary. What is ineffective erythropoiesis? Meaning of ...
- e·ryth·ro·poi·e·sis (ĭ-rĭth′rō-poi-ē′sĭs) n. The formation or production of red blood cells. e·ryth′ro·poi·et′ic (-ĕt′ĭk) adj. erythropoiesis (ɪˌrɪθrəʊpɔɪˈiːsɪs) n 1. (Physiology) physiol the formation of red blood cells [C19: from erythro- + Greek poiēsis ...
Related Pictures
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★リンクテーブル★
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- 英
- ineffective erythropoiesis
- 関
- [[]]
まとめ
- 骨髄内で造血が亢進しているものの、末梢に出現する前に細胞死が生じている病態であり、サラセミア、巨赤芽球性貧血、鉄芽球性貧血、骨髄異形成症候群などでみられる。検査上、細胞死に至った細胞からの鉄の漏出による血清鉄の上昇、これにともない不飽和鉄結合能の低下がみられる。
定義
- 血球前駆細胞が成熟血球に分化する過程で細胞死が生じている病態を指す。
- 骨髄所見と末梢血所見に乖離がみられ、骨髄中の細胞は十分に存在するが、末梢血では血球減少を示す
検査
無効造血を呈する疾患
- サラセミア:赤芽球系の細胞の内に異常ヘモグロビンが沈殿することによる?
- 巨赤芽球性貧血:全ての血球において、核酸合成が十分に行われず細胞質分裂が起こりにくくなっているため核が巨大化?
- 鉄芽球性貧血:ヘムの合成異常。原因は多様
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- 関
- helplessness、inability、ineffectiveness、ineffectual、inefficacious、inefficiency、invalid、powerless
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