| Hypersensitivity pneumonitis |
| Classification and external resources |
Micrograph of hypersensitivity pneumonitis. Lung biopsy. Trichrome stain. |
| ICD-10 |
J67 |
| ICD-9 |
495 |
| DiseasesDB |
4630 |
| MedlinePlus |
000109 |
| eMedicine |
med/1103 ped/2577 |
| MeSH |
D000542 |
Hypersensitivity pneumonitis (HP; also called extrinsic allergic alveolitis, EAA) is an inflammation of the alveoli within the lung caused by hypersensitivity to inhaled organic dusts. Sufferers are commonly exposed to the dust by their occupation or hobbies.
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Contents
- 1 Pathophysiology
- 2 Symptoms
- 2.1 Acute
- 2.2 Subacute
- 2.3 Chronic
- 3 Diagnosis
- 3.1 Lung biopsy
- 3.2 Types
- 4 Treatment
- 5 Additional images
- 6 References
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Pathophysiology
Hypersensitivity pneumonitis involves inhalation of an antigen. This leads to an exaggerated immune response (hypersensitivity). Type III hypersensitivity and type IV hypersensitivity occur in hypersensitivity pneumonitis.[1]
Symptoms
Hypersensitivity pneumonitis (HP) is categorized as acute, subacute, and chronic based on the duration of the illness.[2]
Acute
In the acute form of HP, symptoms may develop 4–6 hours following heavy exposure to the provoking antigen. Symptoms include fever, chills, malaise, cough, chest tightness, dyspnea, and headache. Symptoms resolve within 12 hours to several days upon cessation of exposure.[3]
Acute HP is characterized by poorly formed noncaseating interstitial granulomas and mononuclear cell infiltration in a peribronchial distribution with prominent giant cells.[3]
On chest radiographs, a diffuse micronodular interstitial pattern (at times with ground-glass density in the lower and middle lung zones) may be observed. Findings are normal in approximately 10% of patients." In high-resolution CT scans, ground-glass opacities or diffusely increased radiodensities are present. Pulmonary function tests show reduced diffusion capacity of lungs for carbon monoxide (DLCO). Many patients have hypoxemia at rest, and all patients desaturate with exercise.[3]
Subacute
Patients with subacute HP gradually develop a productive cough, dyspnea, fatigue, anorexia, weight loss, and pleurisy. Symptoms are similar to the acute form of the disease, but are less severe and last longer. On chest radiographs, micronodular or reticular opacities are most prominent in mid-to-lower lung zones.[3] Findings may be present in patients who have experienced repeated acute attacks.
The subacute, or intermittent, form produces more well-formed noncaseating granulomas, bronchiolitis with or without organizing pneumonia, and interstitial fibrosis.[3]
Chronic
In chronic HP, patients often lack a history of acute episodes. They have an insidious onset of cough, progressive dyspnea, fatigue, and weight loss. This is associated with partial to complete but gradual reversibility. Avoiding any further exposure is recommended. Clubbing is observed in 50% of patients. Tachypnea, respiratory distress, and inspiratory crackles over lower lung fields often are present.[3]
On chest radiographs, progressive fibrotic changes with loss of lung volume particularly affect the upper lobes. Nodular or ground-glass opacities are not present. Features of emphysema are found on significant chest films and CT scans.[3]
Chronic forms reveal additional findings of chronic interstitial inflammation and alveolar destruction (honeycombing) associated with dense fibrosis. Cholesterol clefts or asteroid bodies are present within or outside granulomas.[3]
In addition, many patients have hypoxemia at rest, and all patients desaturate with exercise.
Diagnosis
The diagnosis is based upon a history of symptoms after exposure to the allergen and clinical tests. A physician may take blood tests, seeking signs of inflammation, a chest X-ray and lung function tests. The sufferer shows a restrictive loss of lung function.
Although overlapping in many cases, hypersensitivity pneumonitis may be distinguished from occupational asthma in that it is not restricted to only occupational exposure, and that asthma generally is classified as a type I hypersensitivity.[4][5] Unlike asthma, hypersensitivity pneumonitis targets lung alveoli rather than bronchi.[6]
Lung biopsy
Low magnification micrograph of
hypersensitivity pneumonitis showing multinucleated giant cells and a centrilobular fibrosis. Trichrome stain.
Lung biopsies are rarely diagnostic, but may help intensify the search for an allergen, as certain characteristics may suggest the diagnosis.
The differential diagnosis of hypersensitivity pneumonitis is, primarily, a group of diseases known as idiopathic interstitial pneumonias.[7] This group of diseases includes idiopathic pulmonary fibrosis (IPF) (which manifests histologically as usual interstitial pneumonia (UIP)), idiopathic non-specific interstitial pneumonia (NSIP) and cryptogenic organizing pneumonia, among others.
Hypersensitivity pneumonitis may manifest, histologically, as usual interstitial pneumonia, i.e. it looks like idiopathic pulmonary fibrosis under the microscope; however, certain features may suggest it is a hypersensitivity pneumonitis. UIP does not typically have multinucleated giant cells, nor does it typically have a centrilobular distribution;[7] the presence of these features suggest the diagnosis of hypersensitivity pneumonitis.
The prognosis of some idiopathic interstitial pneumonias, e.g. idiopathic usual interstitial pneumonia (i.e. idiopathic pulmonary fibrosis), are very poor and the treatments of little help. This contrasts the prognosis (and treatment) for hypersensitivity pneumonitis, which is generally fairly good if the allergen is identified and exposures to it significantly reduced or eliminated. Thus, a lung biopsy, in some cases, may make a decisive difference.
Types
Hypersensitivity pneumonitis may also be called many different names, based on the provoking antigen. These include:
| Type[8] |
Specific antigen |
Exposure |
Bird fancier's lung
Also called bird breeder's lung, pigeon breeder's lung, and poultry worker's lung |
Avian proteins |
Feathers and bird droppings [9] |
| Bagassosis |
Thermophilic actinomycetes[9] |
Moldy bagasse (pressed sugarcane) |
| Cephalosporium HP |
Cephalosporium |
Contaminated basements (from sewage) |
| Cheese-washer's lung |
Penicillum casei[9] or P. roqueforti |
Cheese casings |
| Chemical worker’s lung - Isocyanate HP |
Toluene diisocyanate (TDI), Hexamethylene diisocyanate (HDI), or Methylene bisphenyl isocyanate (MDI) |
Paints, resins, and polyurethane foams |
| Chemical worker's lung[9] - Trimellitic anhydride (TMA) HP |
Trimellitic anhydride[9] |
Plastics, resins, and paints |
| Coffee worker's lung |
Coffee bean protein |
Coffee bean dust |
| Compost lung |
Aspergillus |
Compost |
| Detergent worker's disease |
Bacillus subtilis enzymes |
Detergent |
Familial HP
Also called Domestic HP
|
Bacillus subtilis, puffball spores |
Contaminated walls |
| Farmer's lung |
The molds
- Thermophilic actinomycetes[9]
- Aspergillus species
- Saccharopolyspora rectivirgula, and
- Micropolyspora faeni
|
Moldy hay |
| Hot tub lung |
Mycobacterium avium complex |
Mist from hot tubs |
| Humidifier lung |
The bacteria
- Thermoactinomyces candidus
- Bacillus subtilis
- Bacillus cereus, and Klebsiella oxytoca;
- Thermophilic actinomycetes[9]
the fungi
- Aureobasidium pullulans;[9]
and the amoebae
- Naegleria gruberi,
- Acanthamoeba polyhaga, and
- Acanthamoeba castellani.
|
Mist generated by a machine from standing water |
Japanese summer house HP Also called Japanese summer-type HP
|
Trichosporon cutaneum |
Damp wood and mats |
| Laboratory worker's lung |
Male rat urine protein |
Laboratory rats |
| Lycoperdonosis |
Puffball spores |
Spore dust from mature puffballs[10] |
| Malt worker's lung |
Aspergillus clavatus[9] |
Moldy barley |
| Maple bark disease |
Cryptostroma corticale[9] |
Moldy maple bark |
| Metalworking fluids HP |
Nontuberculous mycobacteria |
Mist from metalworking fluids |
| Miller's lung |
Sitophilus granarius (wheat weevil)[9] |
Dust-contaminated grain[9] |
| Mollusc shell HP |
Aquatic animal proteins |
Mollusc shell dust |
| Mushroom worker's lung |
Thermophilic actinomycetes |
Mushroom compost |
| Peat moss worker's lung |
Caused by Monocillium sp. and Penicillium citreonigrum |
Peat moss |
| Pituitary snuff taker's lung |
Pituitary snuff |
Medication |
| Sauna worker's lung |
Aureobasidium, Graphium spp |
Contaminated sauna water |
| Sequoiosis |
Aureobasidium, Graphium spp |
Redwood bark, sawdust |
| Streptomyces HP |
Streptomyces albus |
Contaminated fertilizer |
| Suberosis |
Penicillium glabrum (formerly known as Penicillium frequentans) |
Moldy cork dust |
| Tap water HP |
Unknown |
Contaminated tap water |
| Thatched roof disease |
Saccharomonospora viridis |
Dried grass |
| Tobacco worker's lung |
Aspergillus spp |
Moldy tobacco |
| Wine-grower's lung |
Botrytis cinerea mold |
Moldy grapes |
| Woodworker's lung |
Alternaria, Penicillium spp |
Wood pulp, dust |
Of these types, Farmer's Lung and Bird-Breeder's Lung are the most common. "Studies document 8-540 cases per 100,000 persons per year for farmers and 6000-21,000 cases per 100,000 persons per year for pigeon breeders. High attack rates are documented in sporadic outbreaks. Prevalence varies by region, climate, and farming practices. HP affects 0.4-7% of the farming population. Reported prevalence among bird fanciers is estimated to be 20-20,000 cases per 100,000 persons at risk." [3]
Treatment
The best treatment is to avoid the provoking allergen, as chronic exposure can cause permanent damage. Corticosteroids such as prednisolone may help to control symptoms but may produce side-effects.[11]
Additional images
-
High magnification micrograph of hypersensitivity pneumonitis showing granulomatous inflammation. Trichrome stain.
References
- ^ Mohr LC (September 2004). "Hypersensitivity pneumonitis". Curr Opin Pulm Med 10 (5): 401–11. doi:10.1097/01.mcp.0000135675.95674.29. PMID 15316440. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1070-5287&volume=10&issue=5&spage=401.
- ^ http://www.ucsfhealth.org/adult/medical_services/pulmonary/ild/conditions/hp/signs.html signs and symptoms
- ^ a b c d e f g h i Sharma, Sat. Hypersensitivity Pneumonitis. eMedicine, June 1, 2006.
- ^ "Lecture 14: Hypersensitivity". http://www-immuno.path.cam.ac.uk/~immuno/part1/lec13/lec13_97.html. Retrieved 2008-09-18.
- ^ "Allergy & Asthma Disease Management Center: Ask the Expert". http://www.aaaai.org/aadmc/ate/category.asp?cat=1008. Retrieved 2008-09-18.
- ^ Page 503 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007). Robbins Basic Pathology (8th ed.). Philadelphia: Saunders. ISBN 1-4160-2973-7.
- ^ a b Ohtani Y, Saiki S, Kitaichi M, et al. (August 2005). "Chronic bird fancier's lung: histopathological and clinical correlation. An application of the 2002 ATS/ERS consensus classification of the idiopathic interstitial pneumonias". Thorax 60 (8): 665–71. doi:10.1136/thx.2004.027326. PMC 1747497. PMID 16061708. http://thorax.bmj.com/cgi/pmidlookup?view=long&pmid=16061708.
- ^ Enelow, RI (2008). Fishman's Pulmonary Diseases and Disorders (4th ed.). McGraw-Hill. pp. 1161–72. ISBN 0-07-145739-9.
- ^ a b c d e f g h i j k l Kumar 2007, Table 13-5
- ^ Munson EL, Panko DM, Fink JG. (1997). "Lycoperdonosis: Report of two cases and discussion of the disease". Clinical Microbiology Newsletter 19 (3): 17–24. doi:10.1016/S0196-4399(97)89413-5.
- ^ [1]
- Oxford Handbook of Clinical Medicine
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Pathology of respiratory system (J, 460–519), respiratory diseases
|
|
Upper RT
(including URTIs,
Common cold) |
|
Head
|
- sinuses
- Sinusitis
- nose
- Rhinitis
- Vasomotor rhinitis
- Atrophic rhinitis
- Hay fever
- Nasal polyp
- Rhinorrhea
- nasal septum
- Nasal septum deviation
- Nasal septum perforation
- Nasal septal hematoma
- tonsil
- Tonsillitis
- Adenoid hypertrophy
- Peritonsillar abscess
|
|
|
Neck
|
- pharynx
- Pharyngitis
- Strep throat
- Laryngopharyngeal reflux (LPR)
- Retropharyngeal abscess
- larynx
- Croup
- Laryngitis
- Laryngopharyngeal reflux (LPR)
- Laryngospasm
- vocal folds
- Laryngopharyngeal reflux (LPR)
- Vocal fold nodule
- Vocal cord paresis
- Vocal cord dysfunction
- epiglottis
- Epiglottitis
- trachea
- Tracheitis
- Tracheal stenosis
|
|
|
Lower RT/lung disease
(including LRTIs) |
|
Bronchial/
obstructive
|
- acute
- Acute bronchitis
- chronic
- COPD
- Chronic bronchitis
- Acute exacerbations of chronic bronchitis
- Acute exacerbation of COPD
- Emphysema)
- Asthma (Status asthmaticus
- Aspirin-induced
- Exercise-induced
- Bronchiectasis
- unspecified
- Bronchitis
- Bronchiolitis
- Bronchiolitis obliterans
- Diffuse panbronchiolitis
|
|
Interstitial/
restrictive
(fibrosis) |
External agents/
occupational
lung disease |
- Pneumoconiosis
- Asbestosis
- Baritosis
- Bauxite fibrosis
- Berylliosis
- Caplan's syndrome
- Chalicosis
- Coalworker's pneumoconiosis
- Siderosis
- Silicosis
- Talcosis
- Byssinosis
- Hypersensitivity pneumonitis
- Bagassosis
- Bird fancier's lung
- Farmer's lung
- Lycoperdonosis
|
|
|
Other
|
- ARDS
- Pulmonary edema
- Löffler's syndrome/Eosinophilic pneumonia
- Respiratory hypersensitivity
- Allergic bronchopulmonary aspergillosis
- Hamman-Rich syndrome
- Idiopathic pulmonary fibrosis
- Sarcoidosis
|
|
|
|
Obstructive or
restrictive
|
|
Pneumonia/
pneumonitis
|
|
By pathogen
|
- Viral
- Bacterial
- Atypical bacterial
- Mycoplasma
- Legionnaires' disease
- Chlamydiae
- Fungal
- Parasitic
- noninfectious
- Chemical/Mendelson's syndrome
- Aspiration/Lipid
|
|
|
By vector/route
|
- Community-acquired
- Healthcare-associated
- Hospital-acquired
|
|
|
By distribution
|
|
|
|
IIP
|
|
|
|
|
Other
|
- Atelectasis
- circulatory
- Pulmonary hypertension
- Pulmonary embolism
- Lung abscess
|
|
|
|
Pleural cavity/
mediastinum |
|
Pleural disease
|
- Pneumothorax/Hemopneumothorax
- Pleural effusion
- Hemothorax
- Hydrothorax
- Chylothorax
- Empyema/pyothorax
- Malignant
- Fibrothorax
|
|
|
Mediastinal disease
|
- Mediastinitis
- Mediastinal emphysema
|
|
|
| Other/general |
- Respiratory failure
- Influenza
- SARS
- Idiopathic pulmonary haemosiderosis
- Pulmonary alveolar proteinosis
|
|
|
|
anat (n, x, l, c)/phys/devp
|
noco (c, p)/cong/tumr, sysi/epon, injr
|
proc, drug (R1/2/3/5/6/7)
|
|
|
|
|
Health science – Medicine – Allergic conditions
|
|
| Respiratory system |
- Allergic rhinitis
- Asthma
- Hypersensitivity pneumonitis
- Eosinophilic pneumonia
- Churg-Strauss syndrome
- Allergic bronchopulmonary aspergillosis
- Farmer's lung
- Laboratory animal allergy
|
|
| Skin |
- Angioedema
- Urticaria
- Atopic dermatitis
- Allergic contact dermatitis
- Hypersensitivity vasculitis
|
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| Blood and immune system |
|
|
| Circulatory system |
|
|
| Digestive system |
- Coeliac disease
- Eosinophilic gastroenteritis
- Eosinophilic esophagitis
- Food allergy
- Milk intolerance
|
|
| Nervous system |
|
|
| Genitourinary system |
- Acute interstitial nephritis
|
|
| Other conditions |
- Drug allergy
- Allergic conjunctivitis
- Latex allergy
|
|
|
|
cell/phys/auag/auab/comp, igrc
|
|
|
|
|
|
|
Immune disorders: hypersensitivity and autoimmune diseases (279.5–6)
|
|
Type I/allergy/atopy
(IgE) |
|
Foreign
|
Atopic dermatitis · Allergic urticaria · Hay fever · Allergic asthma · Anaphylaxis · Food allergy (Milk, Egg, Peanut, Tree nut, Seafood, Soy, Wheat), Penicillin allergy
|
|
|
Autoimmune
|
none
|
|
|
Type II/ADCC
(IgM, IgG) |
|
Foreign
|
Pernicious anemia · Hemolytic disease of the newborn
|
|
|
Autoimmune
|
|
Cytotoxic
|
Autoimmune hemolytic anemia · Idiopathic thrombocytopenic purpura · Bullous pemphigoid · Pemphigus vulgaris · Rheumatic fever · Goodpasture's syndrome
|
|
|
"Type 5"/receptor
|
Graves' disease · Myasthenia gravis
|
|
|
|
Type III
(Immune complex) |
|
Foreign
|
Henoch–Schönlein purpura · Hypersensitivity vasculitis · Reactive arthritis · Farmer's lung · Post-streptococcal glomerulonephritis · Serum sickness · Arthus reaction
|
|
|
Autoimmune
|
Systemic lupus erythematosus · Subacute bacterial endocarditis · Rheumatoid arthritis
|
|
|
Type IV/cell-mediated
(T-cells) |
|
Foreign
|
Allergic contact dermatitis · Mantoux test
|
|
|
Autoimmune
|
Diabetes mellitus type 1 · Hashimoto's thyroiditis · Guillain–Barré syndrome · Multiple sclerosis · Coeliac disease · Giant-cell arteritis
|
|
|
GVHD
|
Transfusion-associated graft versus host disease
|
|
|
Unknown/
multiple |
|
Foreign
|
Hypersensitivity pneumonitis (Allergic bronchopulmonary aspergillosis) · Transplant rejection · Latex allergy (I+IV)
|
|
|
Autoimmune
|
Sjögren's syndrome · Autoimmune hepatitis · Autoimmune polyendocrine syndrome (APS1, APS2) · Autoimmune adrenalitis · Systemic autoimmune disease
|
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cell/phys/auag/auab/comp, igrc
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