宿主因子1タンパク質

WordNet

be the host of or for; "We hosted 4 couples last night"
an animal or plant that nourishes and supports a parasite; it does not benefit and is often harmed by the association
the owner or manager of an inn (同)innkeeper, boniface
archaic terms for army (同)legion
(medicine) recipient of transplanted tissue or organ from a donor
a person who invites guests to a social event (such as a party in his or her own home) and who is responsible for them while they are there
any organization that provides resources and facilities for a function or event; "Atlanta was chosen to be host for the Olympic Games"
be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

PrepTutorEJDIC

(…の)大群,大勢《+『of』+『名』》(multitude)
(客を接待する)『主人』,『主人役』;(…の)主人[役]《+『to』+『名』》 / (旅館の)主人 / 寄生動(植)物の宿主 / 〈晩餐会など〉‘の'主人役を務める,‘を'主催する
(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
蛋白(たんばく)質
ほう(驚き・賞賛・冷笑などの発声);お‐い(呼びかけ・注意などの発声)
娼婦・売春婦：（whoreの発音をくずしたもの）

UpToDate Contents

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1. 第V因子ライデンおよび活性化プロテインC抵抗性：臨床症状および診断 factor v leiden and activated protein c resistance clinical manifestations and diagnosis
2. 抗酸菌易感染性を示すメンデル型遺伝性疾患：特異的な遺伝子異常 mendelian susceptibility to mycobacterial diseases specific defects
3. 血友病患者における第VIIIおよび第IX因子阻害物質 factor viii and factor ix inhibitors in patients with hemophilia
4. 止血の概要 overview of hemostasis
5. 急性移植片対宿主病の治療 treatment of acute graft versus host disease

English Journal

Acidic Residues in the Hfq Chaperone Increase the Selectivity of sRNA Binding and Annealing.

Panja S1, Santiago-Frangos A2, Schu DJ3, Gottesman S3, Woodson SA4.
Journal of molecular biology.J Mol Biol.2015 Nov 6;427(22):3491-500. doi: 10.1016/j.jmb.2015.07.010. Epub 2015 Jul 18.
Hfq facilitates gene regulation by small non-coding RNAs (sRNAs), thereby affecting bacterial attributes such as biofilm formation and virulence. Escherichia coli Hfq recognizes specific U-rich and AAN motifs in sRNAs and target mRNAs, after which an arginine patch on the rim promotes base pairing b
PMID 26196441

Alternative Hfq-sRNA interaction modes dictate alternative mRNA recognition.

Schu DJ1, Zhang A2, Gottesman S3, Storz G4.
The EMBO journal.EMBO J.2015 Oct 14;34(20):2557-73. doi: 10.15252/embj.201591569. Epub 2015 Sep 15.
Many bacteria use small RNAs (sRNAs) and the RNA chaperone Hfq to regulate mRNA stability and translation. Hfq, a ring-shaped homohexamer, has multiple faces that can bind both sRNAs and their mRNA targets. We find that Hfq has at least two distinct ways in which it interacts with sRNAs; these diffe
PMID 26373314

Paradoxical suppression of small RNA activity at high Hfq concentrations due to random-order binding.

Sagawa S1, Shin JE1, Hussein R1, Lim HN2.
Nucleic acids research.Nucleic Acids Res.2015 Sep 30;43(17):8502-15. doi: 10.1093/nar/gkv777. Epub 2015 Aug 10.
Small RNAs (sRNAs) are important regulators of gene expression during bacterial stress and pathogenesis. sRNAs act by forming duplexes with mRNAs to alter their translation and degradation. In some bacteria, duplex formation is mediated by the Hfq protein, which can bind the sRNA and mRNA in each pa
PMID 26261213

Japanese Journal

Co-expression of a heat shock transcription factor to improve conformational quality of recombinant protein in Escherichia coli(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)

Hsu Shao-Yen,Lin Yu-Sheng,Li Shu-Jyuan,Lee Wen-Chien
Journal of bioscience and bioengineering 118(3), 242-248, 2014-09
… A co-expression system was established in Escherichia coli for enhancing the cellular expression of heat shock transcription factor, sigma 32 (σ^<32>). … After the IPTG induction, a substantially higher level of sigma 32 was observed up to 3 h in the co-expression cells, but an enhancement in the solubility of target protein was manifest only in the first hour. …
NAID 110009857351

Persistent prion infection disturbs the function of Oct-1, resulting in the down-regulation of murine interferon regulatory factor-3

Homma Takujiro,Ishibashi Daisuke,Nakagaki Takehiro,Fuse Takayuki,Sano Kazunori,Satoh Katsuya,Atarashi Ryuichiro,Nishida Noriyuki
Scientific Reports 4, 6006, 2014-08-08
… As a prompt response against invasion of various viruses, interferon regulatory factor-3 (IRF-3) is initially phosphorylated to become activated and upregulates mainly Type I Interferons (IFN-I) in most cell types. … We previously reported that IRF-3-dependent host innate immune responses partially interfere in infection of prions. … Intriguingly, Oct-1 protein was significantly reduced in prion-infected cells and mice brains compared with uninfected groups. …
NAID 120005477044

MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.

Horie Takahiro,Nishino Tomohiro,Baba Osamu,Kuwabara Yasuhide,Nakao Tetsushi,Nishiga Masataka,Usami Shunsuke,Izuhara Masayasu,Nakazeki Fumiko,Ide Yuya,Koyama Satoshi,Sowa Naoya,Yahagi Naoya,Shimano Hitoshi,Nakamura Tomoyuki,Hasegawa Koji,Kume Noriaki,Yokode Masayuki,Kita Toru,Kimura Takeshi,Ono Koh
Scientific reports 4, 2014-06-16
… 2014-06-17.MicroRNAs (miRs) are small non-protein-coding RNAs that bind to specific mRNAs and inhibit translation or promote mRNA degradation. … Recent reports, including ours, indicated that miR-33a located within the intron of sterol regulatory element-binding protein (SREBP) 2 controls cholesterol homeostasis and can be a possible therapeutic target for treating atherosclerosis. …
NAID 120005447499