A selection of various kinds of alcoholic beverage.
An alcoholic beverage is a drink that contains ethanol. Alcoholic beverages are divided into three general classes for taxation and regulation of production: beers, wines, and spirits (distilled beverages). They are legally consumed in most countries around the world. More than 100 countries have laws regulating their production, sale, and consumption.[1]
Alcoholic beverages have been consumed by humans since the Neolithic era; the earliest evidence of alcohol was discovered in Jiahu, dating from 7000–6600 BC.[2] The production and consumption of alcohol occurs in most cultures of the world, from hunter-gatherer peoples to nation-states.[3]
Alcoholic beverages are a source of food energy. The USDA uses a figure of 6.93 kcal per gram of alcohol (5.47 kcal per ml) for calculating food energy.[4]
Contents
- 1 Fermented beverages
- 2 Distilled beverages
- 3 Congeners
- 3.1 Furfural
- 3.2 Fusel alcohols
- 3.3 Tannins
- 4 History
- 5 Standards
- 5.1 Alcohol concentration
- 5.2 Alcohol-free beverage definition controversy
- 5.3 Standard drinks
- 5.4 Serving sizes
- 6 Usage
- 6.1 Apéritif and digestif
- 6.2 Sensation of warmth
- 6.3 Flavoring
- 6.4 Hydration
- 7 Alcohol and health
- 8 Legal status
- 9 Religious aspects
- 10 Alcoholic beverages listed by type of base material
- 11 See also
- 12 References
- 13 External links
Fermented beverages[edit]
Beer[edit]
Main article: Beer
See also: Beer styles and List of beer styles
Kriek, a variety of beer brewed with cherries
Beer is at present the most consumed alcoholic beverage in the world,....[5]
Beer is a beverage fermented from grain mash. It is made from barley or a blend of several grains. If the fermented mash is distilled, then the beverage is a spirit.
Wine[edit]
Main article: Wine
See also: Wine and health
Wine is a fermented beverage produced from grapes. Wine involves a longer fermentation process than beer and also a long aging process (months or years), resulting in an alcohol content of 9%–16% ABV. Sparkling wine can be made by means of a secondary fermentation.
Beverages called "fruit wines" are made from fruits such as plums, cherries, or apples. The kind of fruit must be specified on the label.
Fortified wine is wine, such as port or sherry, to which a distilled beverage (usually brandy) has been added.[6] Fortified wine is distinguished from spirits made from wine in that spirits are produced by means of distillation, while fortified wine is simply wine that has had a spirit added to it. Many different styles of fortified wine have been developed, including port, sherry, madeira, marsala, commandaria, and the aromatized wine vermouth.[7]
Distilled beverages[edit]
Main article: Distilled beverage
These flaming cocktails illustrate that a distilled beverage will readily catch fire and burn.
A distilled beverage, spirit, or liquor is an alcoholic beverage produced by distilling (i.e., concentrating by distillation) ethanol produced by means of fermenting grain, fruit, or vegetables.[8] Unsweetened, distilled, alcoholic beverages that have an alcohol content of at least 20% ABV are called spirits.[9] For the most common distilled beverages, such as whiskey and vodka, the alcohol content is around 40%. The term hard liquor is used in North America to distinguish distilled beverages from undistilled ones (implicitly weaker). Vodka, gin, baijiu, tequila, whiskey, brandy, and soju are examples of distilled beverages. Distilling concentrates the alcohol and eliminates some of the congeners. Freeze distillation concentrates ethanol along with methanol and fusel alcohols (fermentation by-products partially removed by distillation) in applejack. Paracelsus gave alcohol its modern name, which is derived from an Arabic word that means “finely divided” (a reference to distillation).
Rectified spirit[edit]
Rectified spirit, also called "neutral grain spirit," is alcohol which has been purified by means of "rectification" (i.e., repeated distillation). The term "neutral" refers to the spirit's lacking the flavor that would have been present if the mash ingredients had been distilled to a lower level of alcoholic purity. Rectified spirit also lacks any flavoring added to it after distillation (as is done, for example, with gin). Other kinds of spirits, such as whiskey, are distilled to a lower alcohol percentage in order to preserve the flavor of the mash.
Rectified spirit is a clear, colorless, flammable liquid that may contain as much as 95% ABV. It is often used for medicinal purposes. It may be a grain spirit or it may be made from other plants. It is used in mixed drinks, in liqueurs, in tinctures, and as a household solvent.
Congeners[edit]
See also: Congener (alcohol), Wine chemistry, and Hangover
In the alcoholic beverages industry, congeners are substances produced during fermentation. These substances include small amounts of chemicals such as other alcohols (known as fusel alcohols), acetone, acetaldehyde, esters, and aldehydes (e.g., propanol, glycols, ethyl acetate). Congeners are responsible for most of the taste and aroma of distilled alcoholic beverages, and contribute to the taste of non-distilled drinks.[10] It has been suggested that these substances contribute to the symptoms of a hangover.[11]
Furfural[edit]
Furfural is a congener that inhibits yeast metabolism. It may be added to alcoholic beverages during the fermentation stage. Although it occurs in many foods and flavorants, furfural is toxic with an LD50 of 65 mg/kg (oral, rat).[12]
Fusel alcohols[edit]
Main article: Fusel alcohol
The term fusel is German for "bad liquor".[13] Methanol and isopropanol are fusel alcohols.
Excessive concentrations of alcohols other than ethanol may cause off-flavors, sometimes described as "spicy", "hot", or "solvent-like". Some beverages, such as rum, whisky (especially Bourbon), incompletely rectified vodka (e.g., Siwucha), and traditional ales and ciders, are expected to have relatively high concentrations of non-hazardous alcohols as part of their flavor profile. However, in other beverages, such as Korn, vodka, and lagers, the presence of alcohols other than ethanol is considered a fault.[14]
Tannins[edit]
See also: Tannins in wine
Tannins are congeners found in wine in the presence of phenolic compounds. Wine tannins add bitterness, has a drying sensation, tastes herbaceous and is often described as astringent. Wine tannins adds balance, complexity, structure and makes a wine last longer so it plays an important role in the aging of wine.[15]
History[edit]
The interior of a liquor store in the United States that sells alcoholic beverages.
Main articles: History of alcoholic beverages and Drinking culture
Since ancient times, people around the world have been drinking alcoholic beverages. Reasons for drinking alcoholic beverages vary and include:
- Being part of a standard diet
- Medical purposes
- Relaxant effects
- Euphoric effects
- Recreational purposes
- Artistic inspiration
- Putative aphrodisiac effects
- Happiness[16]
Examination and analysis of ancient pottery jars from the neolithic village of Jiahu in the Henan province of northern China revealed residue left behind by the alcoholic beverages they had once contained. According to a study published in the Proceedings of the National Academy of Sciences, chemical analysis of the residue confirmed that a fermented drink made from fruit, rice and honey was being produced in 7000–6600 BC.[2][17] The results of this analysis were published in December 2004.[18] This drink, as of now, precedes the evidence of grape wine from the Middle East by more than 500 years.[17] Wine's first appearance dates from 6000 BC in Georgia.[19] Evidence of alcoholic beverages has also been found dating from 3150 BC in ancient Egypt,[20] 3000 BC in Babylon,[21] 2000 BC in pre-Hispanic Mexico,[21] and 1500 BC in Sudan.[22] Distilled alcoholic beverages were first recorded in Europe in the mid-12th century. By the early 14th century, they had spread throughout the European continent.[23]
Standards[edit]
Alcohol concentration[edit]
Main articles: Alcohol by volume and Alcohol proof
The concentration of alcohol in a beverage is usually stated as the percentage of alcohol by volume (ABV, the number of ml of pure ethanol in 100 ml of beverage) or as proof. In the United States, proof is twice the percentage of alcohol by volume at 60 degrees Fahrenheit (e.g. 80 proof = 40% ABV). Degrees proof were formerly used in the United Kingdom, where 100 degrees proof was equivalent to 57.1% ABV. Historically, this was the most dilute spirit that would sustain the combustion of gunpowder.
Ordinary distillation cannot produce alcohol of more than 95.6% ABV (191.2 proof) because at that point alcohol is an azeotrope with water. A spirit which contains a very high level of alcohol and does not contain any added flavoring is commonly called a neutral spirit. Generally, any distilled alcoholic beverage of 170 proof or higher is considered to be a neutral spirit.[24]
Most yeasts cannot reproduce when the concentration of alcohol is higher than about 18%, so that is the practical limit for the strength of fermented beverages such as wine, beer, and sake. However, some strains of yeast have been developed that can reproduce in solutions of up to 25% ABV.[citation needed]
Alcohol-free beverage definition controversy[edit]
The term alcohol-free (e.g. alcohol-free beer) is often used to describe a product that contains 0.0% ABV. Such products are permitted by Islam and are popular in countries that enforce alcohol prohibition, such as Saudi Arabia, Kuwait and Iran.
However, alcohol is legal in most countries of the world where alcohol culture also is prevalent. Laws vary in countries when beverages must indicate the strength but also what they define as alcohol-free.
In the EU the labeling of beverages containing more than 1.2% by volume of alcohol must indicate the actual alcoholic strength by volume, i.e., show the word "alcohol" or the abbreviation "alc." followed by the symbol "% vol."[25]
Most of the alcohol-free drinks sold in Sweden's state-run liquor store monopoly Systembolaget actually contain alcohol, with experts calling the label "misleading" and a threat to recovering alcoholics.[26] Systembolaget defines alcohol-free as a drink that contains a maximum of 0.5 percent alcohol by volume.[27]
Standard drinks[edit]
Main articles: Standard drink#Pure alcohol measure, Alcohol equivalence, and Unit of alcohol
A "standard drink" of hard liquor does not necessarily reflect a typical serving size, such as seen here
A standard drink is a notional drink that contains a specified amount of pure alcohol. The standard drink is used in many countries to quantify alcohol intake. It is usually expressed as a measure of beer, wine, or spirits. One standard drink always contains the same amount of alcohol regardless of serving size or the type of alcoholic beverage.
The standard drink varies significantly from country to country. For example, it is 7.62 ml (6 grams) of alcohol in Austria, but in Japan it is 25 ml (19.75 grams).
In the United Kingdom, there is a system of units of alcohol which serves as a guideline for alcohol consumption. A single unit of alcohol is defined as 10 ml. The number of units present in a typical drink is sometimes printed on bottles. The system is intended as an aid to people who are regulating the amount of alcohol they drink; it is not used to determine serving sizes.
In the United States, the standard drink contains 0.6 US fluid ounces (18 ml) of alcohol. This is approximately the amount of alcohol in a 12-US-fluid-ounce (350 ml) glass of beer, a 5-US-fluid-ounce (150 ml) glass of wine, or a 1.5-US-fluid-ounce (44 ml) glass of a 40% ABV (80 US proof) spirit.
Serving sizes[edit]
See also: Shot glass#Sizes
In the United Kingdom, serving size in licensed premises is regulated under the Weights and Measures Act (1985). Spirits (gin, whisky, rum, and vodka) are sold in 25 ml or 35 ml quantities or multiples thereof.[28] Beer is typically served in pints (568 ml), but is also served in half-pints or third-pints.
In Ireland, the serving size of spirits is 35.5 ml or 71 ml. Beer is usually served in pints or half-pints ("glasses"). In the Netherlands and Belgium, standard servings are 250 and 500 ml for pilsner; 300 and 330 ml for ales.
The shape of a glass can have a significant effect on how much one pours. A Cornell University study of students and bartenders' pouring showed both groups pour more into short, wide glasses than into tall, slender glasses.[29] Aiming to pour one shot of alcohol (1.5 ounces or 44.3 ml), students on average poured 45.5 ml & 59.6 ml (30% more) respectively into the tall and short glasses. The bartenders scored similarly, on average pouring 20.5% more into the short glasses. More experienced bartenders were more accurate, pouring 10.3% less alcohol than less experienced bartenders. Practice reduced the tendency of both groups to over pour for tall, slender glasses but not for short, wide glasses. These misperceptions are attributed to two perceptual biases: (1) Estimating that tall, slender glasses have more volume than shorter, wider glasses; and (2) Over focusing on the height of the liquid and disregarding the width.
Usage[edit]
2004 data of alcohol consumption per capita (age 15 or older), per year, by country, in liters of pure alcohol.
[30]
Apéritif and digestif[edit]
An apéritif is any alcoholic beverage usually served before a meal to stimulate the appetite while a digestif is any alcoholic beverage served after a meal, in theory to aid digestion. Fortified wine, liqueur, and dry champagne are common apéritifs. Because apéritifs are served before dining, the emphasis is usually on dry rather than sweet.
Sensation of warmth[edit]
In cold climates, potent alcoholic beverages such as vodka are popularly seen as a way to “warm up” the body, possibly because alcohol is a quickly absorbed source of food energy and because it dilates peripheral blood vessels (peripherovascular dilation). This is a misconception because the “warmth” is actually caused by a transfer of heat from the body’s core to its extremities, where it is quickly lost to the environment. However, the perception alone may be welcomed when only comfort, rather than hypothermia, is a concern.
Flavoring[edit]
A row of alcoholic beverages – in this case, spirits – in a bar
Alcohol is a moderately good solvent for many fatty substances and essential oils. This attribute facilitates the use of flavoring and coloring compounds in alcoholic beverages, especially distilled beverages. Flavors may be naturally present in the beverage’s base material. Beer and wine may be flavored before fermentation. Spirits may be flavored before, during, or after distillation.
Sometimes flavor is obtained by allowing the beverage to stand for months or years in oak barrels, usually American or French oak.
A few brands of spirits have fruit or herbs inserted into the bottle at the time of bottling.
Hydration[edit]
|
|
This section needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (March 2013) |
At times and places of poor public sanitation (such as Medieval Europe), the consumption of alcoholic drinks was a way of avoiding water-borne diseases such as cholera. Small beer and faux wine, in particular, were used for this purpose. Although alcohol kills bacteria, its low concentration in these beverages would have had only a limited effect. More important was that the boiling of water (required for the brewing of beer) and the growth of yeast (required for fermentation of beer and wine) would kill dangerous microorganisms.
The alcohol content of these beverages allowed them to be stored for months or years in simple wood or clay containers without spoiling. For this reason, they were commonly kept aboard sailing vessels as an important (or even the sole) source of hydration for the crew, especially during the long voyages of the early modern period.
Alcohol and health[edit]
Main article: Alcohol and health
members of a German student corps drinking, Duchy of Brunswick, 1837
Short-term effects of alcohol consumption include intoxication and dehydration. Long-term effects of alcohol include alcoholism, malnutrition, chronic pancreatitis, alcoholic liver disease, cancer and damage to the central nervous system and peripheral nervous system.[31][32][33] Alcohol is converted to the carcinogen acetaldehyde by the liver.[34]
Drinking small amounts of alcohol can offer some protection for people at risk of heart disease, but large amounts can increase the risk of stroke, high blood pressure, and other conditions.[34]
Alcoholic beverages contain calories, which may contribute to an increase in body weight (see beer belly). Each gram of alcohol provides 7.1 kcal, and each milliliter provides 5.6 kcal.[35]
In addition to alcohol, many alcoholic beverages contain carbohydrates. For example, beer usually contains 10-15 g of carbohydrates (40-60 kcal) per 12 fl.oz. Aside from the direct effect of its caloric content, alcohol is known to potentiate the insulin response of the human body to glucose, which, in essence, "instructs" the body to convert consumed carbohydrates into fat and to suppress carbohydrate and fat oxidation.[36][37]
Psychoactive drug[edit]
Alcohol (ethanol) is a psychoactive drug.[38][39] In countries that have a drinking culture, social stigma may cause many people not to view alcohol as a drug because it is an important part of social events. In these countries, many young binge drinkers prefer to call themselves hedonists rather than binge drinkers[40] or recreational drug users.
Undergraduate students often position themselves outside the categories of "serious" or "anti-social" drinkers.[41] However, about 40 percent of college students in the United States[42] could be considered alcoholics according to new criteria in Diagnostic and Statistical Manual of Mental Disorders 5.
Legal status[edit]
Main article: Alcohol laws
See also: Legality of home brewing in different countries
Alcohol laws are laws in relation to the manufacture, use, influence and sale of ethanol or alcoholic beverages that contain ethanol. Alcohol laws often seek to reduce the availability of alcoholic beverages, often with the stated purpose of reducing the health and social side effect of their consumption. In particular, such laws specify the legal drinking age which usually varies between 16 and 25 years, depending upon the country and the type of drink. Some nations do not have a legal drinking or purchasing age, but most set the age at 18 years.[1] This can also take the form of distribution only in licensed stores or in monopoly stores. Often, this is combined with some form of alcohol taxation. In some jurisdictions alcoholic beverages have been totally prohibited for reasons of religion (e.g., Islamic countries with certain interpretations of sharia law) or perceived public morals and health (e.g., Prohibition in the United States from 1920 to 1933).
Religious aspects[edit]
See also: Entheogen#Religion and alcohol
Some religions forbid, discourage, or restrict the drinking of alcoholic beverages for various reasons. These include Islam, Jainism, Sikhism, the Bahá'í Faith, the Church of God In Christ, The Church of Jesus Christ of Latter-day Saints, the Seventh-day Adventist Church, the Church of Christ, Scientist, the United Pentecostal Church International, Theravada, most Mahayana schools of Buddhism, some Protestant denominations of Christianity, some sects of Taoism (Five Precepts (Taoism) and Ten Precepts (Taoism)), and some sects of Hinduism. In some regions with a dominant religion the production, sale, and consumption of alcoholic beverages is forbidden to everybody, regardless of religion. For instance, some Islamic states, including member states of the Organisation of Islamic Cooperation, such as Afghanistan, Bangladesh, Brunei, Iran, Kuwait, Libya, Saudi Arabia, Sudan, and Yemen, prohibit alcoholic beverages because they are forbidden by Islam.[43]
In some religions alcoholic beverages are used for ritual purposes. For example, the Roman Catholic Church uses wine in the celebration of the Eucharist; in Judaism kosher wine is used in holidays and rituals.
Carnival in the Netherlands is historically a Roman Catholic feast which is well known for its excessive drinking of alcohol.
Alcoholic beverages listed by type of base material[edit]
For micro-organisms, see List of microorganisms used in food and beverage preparation and yeast in winemaking.
The names of some alcoholic beverages are determined by their base material.
| Grains |
Name of fermented beverage |
Name of distilled beverage |
| barley |
beer, ale, barley wine |
Scotch whisky, Irish whiskey, shōchū (mugijōchū) (Japan) |
| rye |
rye beer, kvass |
rye whiskey, vodka (Poland), Korn (Germany) |
| corn |
chicha, corn beer, tesguino |
Bourbon whiskey; and vodka (rarely) |
| sorghum |
burukutu (Nigeria), pito (Ghana), merisa (southern Sudan), bilibili (Chad, Central African Republic, Cameroon) |
maotai, gaoliang, certain other types of baijiu (China). |
| wheat |
wheat beer |
horilka (Ukraine), vodka, wheat whiskey, weizenkorn (Germany) |
| rice |
beer, brem (Bali), huangjiu and choujiu (China), Ruou gao (Vietnam), sake (Japan), sonti (India), makgeolli and chungju (Korea), tuak (Borneo Island), thwon (Nepal) |
aila (Nepal), rice baijiu (China), shōchū (komejōchū) and awamori (Japan), soju (Korea) |
| millet |
millet beer (Sub-Saharan Africa), tongba (Nepal, Tibet), boza (the Balkans, Turkey) |
|
| buckwheat |
|
shōchū (sobajōchū) (Japan) |
| Fruit juice |
Name of fermented beverage |
Name of distilled beverage |
| juice of grapes |
wine |
brandy, Cognac (France), Vermouth, Armagnac (France), Branntwein (Germany), pisco (Peru, Chile), (Grozdova) Rakia (The Balkans, Turkey), singani (Bolivia), Arak (Syria, Lebanon, Jordan), törkölypálinka (Hungary) |
| juice of apples |
cider (U.S.: "hard cider"), Apfelwein |
applejack (or apple brandy), calvados, cider |
| juice of pears |
perry, or pear cider; poiré (France) |
Poire Williams, pear brandy, Eau-de-vie (France), pálinka (Hungary), Krushova rakia / Krushevitsa (Bulgaria) |
| juice of plums |
plum wine |
slivovitz, țuică, umeshu, pálinka, Slivova rakia / Slivovitsa (Bulgaria) |
| juice of apricots |
|
Kaisieva rakia (Bulgaria), pálinka (Hungary) |
| juice of pineapples |
tepache (Mexico), Pineapple Wine (Hawaii) |
|
| juniper berries |
|
gin, borovička (Slovakia) |
| bananas or plantains |
Chuoi hot (Vietnam), Cauim (Kuna Indians of Panama), urgwagwa (Uganda, Rwanda), mbege (with millet malt; Tanzania), kasikisi (with sorghum malt; Democratic Republic of the Congo) |
| gouqi |
gouqi jiu (China) |
gouqi jiu (China) |
| coconut |
Toddy (Sri Lanka, India) |
arrack, lambanog (Sri Lanka, India, Philippines) |
| ginger with sugar, ginger with raisins |
ginger ale, ginger beer, ginger wine |
| Myrica rubra |
yangmei jiu (China) |
yangmei jiu (China) |
| pomace |
pomace wine |
Raki/Ouzo/Pastis/Sambuca (Turkey/Greece/France/Italy), tsipouro/tsikoudia (Greece), grappa (Italy), Trester (Germany), marc (France), orujo (Spain), zivania (Cyprus), Bagaço (Portugal), tescovină (Romania), Arak (Iraq) |
| Vegetables |
Name of fermented beverage |
Name of distilled beverage |
| cassava |
Saliva-fermented beverages:
- Cauim
- chicha: Throughout the Amazon Basin, including the interiors of Brazil, Ecuador, Peru, and Venezuela, chicha is made most often with cassava). in Peruvian Amazonia chichia is known as masato.
- kasiri (Sub-Saharan Africa)
- nihamanchi (South America) aka nijimanche (Ecuador and Peru)
- Parakari (Guyana)
- Sakurá (Brazil, Surinam)
|
tiquira (Brazil) |
| juice of ginger root |
ginger beer (Botswana) |
| potato |
potato beer |
horilka (Ukraine), vodka (Poland and Germany), akvavit (Scandinavia), poitín (poteen) (Ireland), tuzemák (Czech Republic) |
| sweet potato |
soju (Korea) |
shōchū (imojōchū) (Japan) |
| juice of sugarcane, or molasses |
basi, betsa-betsa (regional) |
rum (Caribbean), Venezuela, Colombia, Nicaragua, pinga or cachaça (Brasil), aguardiente, guaro, Gongo, Konyagi (Tanzania) |
| juice of agave |
pulque |
tequila, mezcal, raicilla |
| Other base materials |
Name of fermented beverage |
Name of distilled beverage |
| sap of palm |
coyol wine (Central America), tembo (Sub-Saharan Africa), toddy (Indian subcontinent) |
| sap of Arenga pinnata, Coconut, Borassus flabellifer |
Tuak (Indonesia) |
Arrack |
| honey |
mead, horilka (Ukraine), tej (Ethiopia) |
distilled mead, honey-flavored liqueur |
| milk |
kumis, kefir, blaand |
arkhi (Mongolia) |
| sugar |
kilju and mead or sima (Finland) |
shōchū (kokutō shōchū): made from brown sugar (Japan) |
See also[edit]
- Alcoholic beverages by alcohol type
- Alternative psychoactive alcohol use
- Beer and breweries by region
- Chinese alcoholic beverages
- Cooking with alcohol
- Home brewing
- List of alcoholic beverages
- Mixed drink
- Moonshine
References[edit]
- ^ a b "Minimum Age Limits Worldwide". International Center for Alcohol Policies. Retrieved 2009-09-20.
- ^ a b McGovern, P. E.; Zhang, J.; Tang, J.; Zhang, Z.; Hall, G. R.; Moreau, R. A.; Nunez, A.; Butrym, E. D.; Richards, M. P.; Wang, C. -S.; Cheng, G.; Zhao, Z.; Wang, C. (2004). "Fermented beverages of pre- and proto-historic China". Proceedings of the National Academy of Sciences 101 (51): 17593–17598. doi:10.1073/pnas.0407921102. PMC 539767. PMID 15590771. edit
- ^ Arnold, John P (2005). Origin and History of Beer and Brewing: From Prehistoric Times to the Beginning of Brewing Science and Technology. Cleveland, Ohio: Reprint Edition by BeerBooks. ISBN 0-9662084-1-2.
- ^ "Composition of Foods Raw, Processed, Prepared USDA National Nutrient Database for Standard Reference, Release 26 Documentation and User Guide". USDA. Aug. 2013. p. 14.
- ^ Nelson, Max (2005). The Barbarian's Beverage: A History of Beer in Ancient Europe. Abingdon, Oxon: Routledge. p. 1. ISBN 0-415-31121-7. Retrieved 21 September 2010.
- ^ Lichine, Alexis (1987). Alexis Lichine's New Encyclopedia of Wines & Spirits (5th ed.). New York: Alfred A. Knopf. p. 236. ISBN 0-394-56262-3.
- ^ Robinson, J., ed. (2006). The Oxford Companion to Wine (3rd ed.). New York: Oxford University Press. p. 279. ISBN 0-19-860990-6.
- ^ "Distilled spirit/distilled liquor". Britannica.com. Retrieved 2013-02-05.
- ^ Lichine, Alexis. Alexis Lichine’s New Encyclopedia of Wines & Spirits (5th edition) (New York: Alfred A. Knopf, 1987), 707–709.
- ^ Understanding Congeners in Wine, Wines & Vines. Accessed 2011-4-20
- ^ Whisky hangover 'worse than vodka, a study suggests', BBC News. Accessed 2009-12-19
- ^ "ChemIDplus Advanced". Chem.sis.nlm.nih.gov. Retrieved 2013-02-05.
- ^ Hazelwood, Lucie A.; Daran, Jean-Marc; van Maris, Antonius J. A.; Pronk, Jack T.; Dickinson, J. Richard (2008). "The Ehrlich Pathway for Fusel Alcohol Production: A Century of Fesearch on Saccharomyces cerevisiae Metabolism". Appl. Environ. Microbiol. 74 (8): 2259–66. doi:10.1128/AEM.02625-07. PMC 2293160. PMID 18281432.
- ^ Aroma of Beer, Wine and Distilled Alcoholic Beverages
- ^ http://winefolly.com/review/wine-characteristics/
- ^ Harter, Pascale (2013-07-01). "BBC News - Can we make ourselves happier?". Bbc.co.uk. Retrieved 2013-09-17.
- ^ a b "The Earliest Alcoholic Beverage in the World". Penn Museum. University of Pennsylvania Museum of Archaeology and Anthropology. Retrieved 9 June 2013.
- ^ Roach, John. "Cheers! Eight ancient drinks uncorked by science". http://www.nbcnews.com (Nbc News). Retrieved 9 June 2013.
- ^ Vouillamoz, J. F.; McGovern, P. E.; Ergul, A.; Söylemezoğlu, G. K.; Tevzadze, G.; Meredith, C. P.; Grando, M. S. (2006). "Genetic characterization and relationships of traditional grape cultivars from Transcaucasia and Anatolia". Plant Genetic Resources: characterization and utilization 4 (2): 144. doi:10.1079/PGR2006114. edit
- ^ Cavalieri, D; McGovern P.E., Hartl D.L., Mortimer R., Polsinelli M. (2003). "Evidence for S. cerevisiae fermentation in ancient wine.". Journal of Molecular Evolution. 57 Suppl 1: S226–32. doi:10.1007/s00239-003-0031-2. PMID 15008419. 15008419. Archived from the original on April 17, 2007. Retrieved 2007-01-28.
- ^ a b "Fermented fruits and vegetables. A global perspective". FAO Agricultural Services Bulletins - 134. Archived from the original on January 19, 2007. Retrieved 2007-01-28.
- ^ Dirar, H., (1993), The Indigenous Fermented Foods of the Sudan: A Study in African Food and Nutrition, CAB International, UK
- ^ Forbes, Robert James (1970). A Short History of the Art of Distillation: From the Beginnings up to the Death of Cellier Blumenthal. BRILL. ISBN 978-90-04-00617-1. Retrieved 28 June 2010.
- ^ Lichine, Alexis. Alexis Lichine’s New Encyclopedia of Wines & Spirits (5th edition) (New York: Alfred A. Knopf, 1987), 365.
- ^ "Beverage Alcohol Labeling Requirements by Country". Icap.org. Retrieved 2013-02-05.
- ^ "Sweden's alcohol-free drink label 'misleading'". Thelocal.se. 29 October 2012. Retrieved 2013-02-05.
- ^ "Alcohol-free products". Systembolaget.se. 2011-03-11. Retrieved 2013-02-05.
- ^ "fifedirect - Licensing & Regulations - Calling Time on Short Measures!". Fifefire.gov.uk. 2008-07-29. Retrieved 2010-02-11.
- ^ Wansink, Brian; van Ittersum, Koert (2005). "Shape of glass and amount of alcohol poured: comparative study of effect of practice and concentration". BMJ 331 (7531): 1512–14. doi:10.1136/bmj.331.7531.1512.
- ^ "Global Status Report on Alcohol 2004" (PDF). 2004. Retrieved 2013-04-02.
- ^ Müller D, Koch RD, von Specht H, Völker W, Münch EM (March 1985). "[Neurophysiologic findings in chronic alcohol abuse]". Psychiatr Neurol Med Psychol (Leipz) (in German) 37 (3): 129–32. PMID 2988001.
- ^ Testino G (2008). "Alcoholic diseases in hepato-gastroenterology: a point of view". Hepatogastroenterology 55 (82–83): 371–7. PMID 18613369.
- ^ Caan, Woody; Belleroche, Jackie de, eds. (11 April 2002). Drink, Drugs and Dependence: From Science to Clinical Practice (1st ed.). Routledge. pp. 19–20. ISBN 978-0-415-27891-1.
- ^ a b Cancer research UK: Alcohol and cancer "There is no doubt that alcohol can cause seven types of cancer"
- ^ Nielsen, S.J. et al. (2012). Calories Consumed from Alcoholic Beverages by U.S. Adults, 2007-2010. Hyattsville, Md.: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics.
- ^ Robert Metz et.al. (1969). "Potentiation of the Plasma Insulin Response to Glucose by Prior Administration of Alcohol". Diabetes.
- ^ "Ethanol Causes Acute Inhibition of Carbohydrate, Fat, and Protein Oxidation and Insulin Resistance". J.Clin.Invest. 1988.
- ^ USA (2013-03-25). "Disparity between tonic and phasic ethanol-induced dopamine increases in the nucleus accumbens of rats". Ncbi.nlm.nih.gov. Retrieved 2013-09-17.
- ^ Drugs and society - Page 189, Glen (Glen R.) Hanson, Peter J. Venturelli, Annette E. Fleckenstein - 2006
- ^ Szmigin, I.; Griffin, C.; Mistral, W.; Bengry-Howell, A.; Weale, L.; Hackley, C. (2008). "Re-framing 'binge drinking' as calculated hedonism: Empirical evidence from the UK". International Journal of Drug Policy 19 (5): 359–366. doi:10.1016/j.drugpo.2007.08.009. PMID 17981452. edit
- ^ Guise, J. M. F.; Gill, J. S. (2006). "'Binge drinking? It's good, it's harmless fun': A discourse analysis of accounts of female undergraduate drinking in Scotland". Health Education Research 22 (6): 895–906. doi:10.1093/her/cym034. PMID 17675648. edit
- ^ Time: DSM-5 Could Categorize 40% of College Students as Alcoholics, 14 May 2012 The article reports that the new DSM-5 criteria could increase the number of people diagnosed as alcoholics by 60%
- ^ "Saudi Arabia". Travel.state.gov. Retrieved 2012-10-22.
External links[edit]
- Emerald Media Group: About 37 percent of college students could now be considered alcoholics
- Alcohol, Health-EU Portal
- International Center for Alcohol Policies — Website
- International Center for Alcohol Policies — List of Tables
- National Institute on Alcohol Abuse and Alcoholism - What Is a Standard Drink?
- Most Widely Consumed Alcoholic Beverages
|
Alcoholic beverages
|
|
|
History and production
|
|
| History of alcohol |
- History of alcoholic beverages
- History of beer
- History of wine
- History of Bordeaux wine
- History of Champagne
- History of Chianti
- History of French wine
- History of Portuguese wine
- History of Rioja wine
- History of Sherry
- History of South African wine
|
|
|
| Production |
- Alcohol industry
- Brewing
- Distillation
- Drinking establishments
- Fermentation
- Winemaking
|
|
|
|
|
Alcoholic beverages
|
|
| Fermented beverage |
- Beer
- Cider
- Mead
- Rice wine
- Sake
- Wine
- Other fermented beverages
|
|
|
| Distilled beverage |
- Brandy
- Gin
- Horilka
- Liqueur
- Rum
- Tequila
- Vodka
- Whisky
- Other distilled beverages
|
|
| Fortified wine |
- Madeira wine
- Marsala wine
- Port wine
- Sherry
- Vermouth
- Other fortified wines
|
|
|
|
|
Distilled beverages by ingredients
|
|
| Fruit |
- Apple
- Applejack
- Calvados
- Cashew apple
- Feni
- Coconut
- Arrack
- Grape
- Arak
- Armagnac
- Brandy
- Cognac
- Pisco
- Plum
- Slivovitz
- Ţuică
- Pomace
- Chacha
- Grappa
- Marc
- Orujo
- Tsikoudia
- Tsipouro
- Zivania
- Various fruits
- Eau de vie
- Kirschwasser
- Nalewka
- Pálinka
- Rakia
- Schnaps
|
|
|
| Grain |
- Barley
- Irish whiskey
- Japanese whisky
- Scotch whisky
- Maize
- Bourbon whiskey
- Corn whiskey
- Tennessee whiskey
- Rice
- Awamori
- Cheongju
- Rice baijiu
- Soju
- Rye
- Korn
- Rye whiskey
- Starka
- Sorghum
- Baijiu (Kaoliang)
- Multiple grains
- American whiskey
- Canadian whisky
|
|
| Other |
- Agave
- Mezcal
- Tequila
- Sugarcane or molasses
- Aguardiente
- Arak
- Cachaça
- Clairin
- Guaro
- Rum
- Seco Herrerano
- Tharra
- Various starches
- Akvavit
- Horilka
- Poitín
- Shōchū
- Vodka
|
|
|
|
|
Liqueurs and infused distilled beverages by ingredients
|
|
- Almond
- Amaretto
- Crème de Noyaux
- Anise
- Absinthe
- Arak
- Ouzo
- Pastis
- Rakı
- Sambuca
- Chocolate
- Chocolate liqueur
- Cinnamon
- Tentura
- Cloudberry
- Lakka
- Coconut
- Malibu
- Coffee
- Kahlua
- Tia Maria
- Egg
- Advocaat
- Hazelnut
- Frangelico
- Herbs
- Aquavit
- Bénédictine
- Brennivín
- Crème de menthe
- Metaxa
- Minttu
- Honey
- Bärenjäger
- Drambuie
- Glayva
- Krupnik
- Juniper
- Gin
- Jenever
- Orange
- Campari
- Curaçao
- Triple sec
- Peppers
- Pertsivka
- Star anise
- Sassolino
- Sugarcane/molasses
- Charanda
- Various fruits
- Crème de banane
- Crème de cassis
- Limoncello
- Schnapps
- Sloe gin
|
|
|
- Category
- Portals
- Beer
- Drink
- Wine
- WikiProjects
- Beer
- Spirits
- Wine
|
|
|
Alcohols
|
|
Straight-chain
primary
alcohols (1°) |
- Methanol (C
1)
- Ethanol (C
2)
- 1-Propanol (C
3)
- n-Butanol (C
4)
- 1-Pentanol (C
5)
- 1-Hexanol (C
6)
- 1-Heptanol (C
7)
- 1-Octanol (C
8)
- 1-Nonanol (C
9)
- 1-Decanol (C
10)
- Undecanol (C
11)
- Dodecanol (C
12)
- Tridecan-1-ol (C
13)
- 1-Tetradecanol (C
14)
- Pentadecan-1-ol (C
15)
- Cetyl alcohol (C
16)
- Heptadecan-1-ol (C
17)
- Stearyl alcohol (C
18)
- Nonadecan-1-ol (C
19)
- Arachidyl alcohol (C
20)
- Heneicosan-1-ol (C
21)
- Docosanol (C
22)
- Tricosan-1-ol (C
23)
- 1-Tetracosanol (C
24)
- Pentacosan-1-ol (C
25)
- 1-Hexacosanol (C
26)
- 1-Heptacosanol (C
27)
- 1-Octacosanol (C
28)
- 1-Nonacosanol (C
29)
- Triacontanol (C
30)
- Policosanol
|
|
Other primary
alcohols |
- Isobutanol (C
4)
- Isoamyl alcohol (C
5)
|
|
Secondary
alcohols (2°) |
- Isopropanol (C
3)
- 2-Butanol (C
4)
- 2-Pentanol (C
5)
- 2-Hexanol (C
6)
- 2-Heptanol (C
7)
- 2-Methyl-1-butanol (C
5)
- Cyclohexanol (C
6)
|
|
Tertiary
alcohols (3°) |
- tert-Butyl alcohol (C
4)
- tert-Amyl alcohol (C
5)
- 2-Methyl-2-pentanol (C
6)
- 2-Methylhexan-2-ol (C
7)
- 2-Methylheptan-2-ol (C
8)
- 3-Methyl-3-pentanol (C
6)
- 3-Methyloctan-3-ol (C
9)
|
|
- Biochemical families: carbohydrates
- alcohols
- glycoproteins
- glycosides
- lipids
- eicosanoids
- fatty acids / intermediates
- phospholipids
- sphingolipids
- steroids
- nucleic acids
- constituents / intermediates
- proteins
- Amino acids / intermediates
- tetrapyrroles / intermediates
|
|
Consumption of ethanol
|
Psychoactive substance-related disorder (F10–F19, 291–292; 303–305)
|
|
| General |
- SID
- Substance intoxication / Drug overdose
- Withdrawal
- Substance-induced psychosis
- SUD
- Substance abuse
- Physical dependence / Substance dependence
|
|
| Alcohol |
|
SID
|
|
Diseases
|
|
Neurological
disorders
|
- Alcoholic hallucinosis
- Alcohol withdrawal
- Fetal alcohol spectrum disorder (FASD)
- Fetal alcohol syndrome (FAS)
- Korsakoff's syndrome
- Wernicke–Korsakoff syndrome
- Wernicke's encephalopathy
|
|
|
Digestive
system
|
- Alcohol flush reaction
- Alcoholic hepatitis
- Alcoholic liver disease
|
|
|
Nervous
system
|
- Alcohol dementia
- Alcoholic hallucinosis
- Hangover
|
|
|
Cardiovascular
system
|
|
|
|
|
|
SUD
|
- Alcoholism
- Alcohol dependence
- Alcohol abuse
|
|
|
| Opioids |
|
|
| Caffeine |
- SID
- Effect of caffeine on memory
- Caffeine-induced sleep disorder
- SUD
|
|
| Cannabis |
- SID
- Effects of cannabis
- Long-term effects of cannabis
- SUD
|
|
Sedative /
hypnotic |
- benzodiazepine: SID
- Benzodiazepine overdose
- Benzodiazepine withdrawal
- SUD
- Benzodiazepine misuse
- Benzodiazepine dependence
- barbiturate: SID
- SUD
|
|
| Cocaine |
|
|
| Stimulants |
|
|
| Hallucinogen |
- SID
- Hallucinogen persisting perception disorder
|
|
| Tobacco |
- SID
- Nicotine poisoning
- Nicotine withdrawal
|
|
Volatile
solvent |
- Inhalant abuse: Toluene toxicity
|
|
| Multiple |
|
|
|
|
|
dsrd (o, p, m, p, a, d, s), sysi/epon, spvo
|
proc (eval/thrp), drug (N5A/5B/5C/6A/6B/6D)
|
|
|
|
|
Alcohol and health
|
|
Ethanol
classifications |
|
Dependency
and harm
|
- Physical dependence
- ISCD harm and damaging rating: 72/100
- IARC Group 1 carcinogen
- Neurotoxin
|
|
|
Pathophysiology
|
- Anxiolytic
- Depressant
- Euphoriant
- Hypnotic / sedative
|
|
|
Pharmacology
|
- Glutamatergic: NMDA antagonist
Serotonergic: 5-HT3 agonist responsible for GABAergic (GABAA receptor PAM), glycinergic, and cholinergic (nAChR agonist) effects
Research: Adenosinergic: ENT inhibitor. Dopaminergic: Reversible MAO-B inhibitor. Norepinephrine reuptake inhibitor. Opioid
|
|
|
Specific
interactions |
- Note: see Template:Psychoactive substance use for diagnoses
- Aging
- Alcohol-induced mood disorders
- Brain
- Cancer
- Sleep
- Tolerance
- Weight
|
|
Substance
abuse
prevention |
|
Sobriety
|
- Alcohol detoxification
- Alcohol rehabilitation
- Alcoholics Anonymous
- Sober companion
|
|
|
Alcohol
limitation
|
- 0-0-1-3
- Alcohol education
- Alcohol server training
- Recommended maximum intake of alcoholic beverages
|
|
|
Addiction medicine
|
Anti-addictive entheogens: Ibogaine, Salvia divinorum
|
|
|
Religion and alcohol
|
- Christian views on alcohol
- Islam and alcohol
|
|
|
| Social issues |
- Alcohol advertising
- Alcohol-free beverage definition controversy
- Alcohol self-medication
- American Indian alcoholism
- Binge drinking
- Blackout (alcohol-related amnesia)
- College student alcoholism
- Domestic violence
- Drinking games / pregaming
- Driving under the influence
- Drunkorexia
- Adult Children of Alcoholics
- Family systems
- French paradox
- High-functioning alcoholic (HFA)
- Impure alcohol
- methanol outbreaks
- moonshine contamination
- Rum-running
- Sex
- Sin tax / Pigovian tax
|
|
| General |
- Alternative psychoactive alcohol use
- Short-term effects of alcohol
- Long-term effects of alcohol
|
|
Patophysiology of ethanol
|
Antidotes (V03AB)
|
|
Nervous
system |
Nerve agent /
Organophosphate
poisoning |
- Atropine#
- Biperiden
- Diazepam#
- Oximes
- see also: Cholinesterase
|
|
|
Barbiturate
overdose
|
|
|
|
Benzodiazepine
overdose
|
|
|
|
GHB overdose
|
|
|
|
Opioid overdose
|
- Diprenorphine
- Doxapram
- Nalmefene
- Nalorphine
- Naloxone#
- Naltrexone
|
|
|
Reversal of
neuromuscular blockade
|
|
|
|
Circulatory
system |
|
Beta blocker
|
|
|
|
Digoxin toxicity
|
|
|
|
Heparin
|
|
|
|
| Other |
|
Arsenic poisoning
|
|
|
|
Cyanide poisoning
|
- 4-Dimethylaminophenol
- Hydroxocobalamin
- nitrite
- Amyl nitrite
- Sodium nitrite#
- Sodium thiosulfate#
|
|
|
Hydrofluoric acid
|
|
|
Methanol /
Ethylene glycol
poisoning |
|
|
|
Paracetamol toxicity
(Acetaminophen)
|
- Acetylcysteine#
- Glutathione
- Methionine#
|
|
|
|
- Dimercaprol#
- Edetates
- Prussian blue#
|
|
|
Other
|
- iodine-131
- Methylthioninium chloride#
- oxidizing agent
- Prednisolone/promethazine
|
|
|
| Emetic |
- Copper sulfate
- Ipecacuanha
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
|
Anxiolytics (N05B)
|
|
GABAA
PAMs |
|
non-N05B
|
- Alcohols (2M2B, Ethanol (beverage), Ethchlorvynol, Methylpentynol)
- Chlormezanone
- Etifoxine
- Inhalants
- Kavalactones (Kava)
- Skullcap
- Valerenic acid (Valerian)
|
|
|
Benzodiazepine
|
- Adinazolam
- Alprazolam
- Bretazenil
- Bromazepam
- Camazepam
- Chlordiazepoxide
- Clobazam
- Clonazepam
- Clorazepate
- Clotiazepam
- Cloxazolam
- Diazepam#
- Ethyl Loflazepate
- Etizolam
- Fludiazepam
- Halazepam
- Imidazenil
- Ketazolam
- Lorazepam#
- Medazepam
- Nordazepam
- Oxazepam
- Pinazepam
- Prazepam
|
|
|
Carbamates
|
- Difebarbamate
- Emylcamate
- Febarbamate
- Mebutamate
- Meprobamate (Carisoprodol, Tybamate)
- Phenprobamate
- Procymate
|
|
|
Nonbenzodiazepines
|
- Abecarnil
- Adipiplon
- Alpidem
- CGS-8216
- CGS-9896
- CGS-13767
- CGS-20625
- Divaplon
- ELB-139
- Fasiplon
- GBLD-345
- Gedocarnil
- L-838,417
- NS-2664
- NS-2710
- Ocinaplon
- Pagoclone
- Panadiplon
- Pipequaline
- RWJ-51204
- SB-205,384
- SL-651,498
- Taniplon
- TP-003
- TP-13
- TPA-023
- Y-23684
- ZK-93423
|
|
|
Pyrazolopyridines
|
- Cartazolate
- Etazolate
- ICI-190,622
- Tracazolate
|
|
|
| α2δ VDCC Blockers |
- Atagabalin
- Gabapentin
- Imagabalin
- PD-217,014
- Pregabalin
- 4-methylpregabalin
|
|
| 5-HT1A Agonists |
- Azapirones: Buspirone
- Gepirone
- Tandospirone; Others: Flesinoxan
- Naluzotan
- Oxaflozane
|
|
| H1 Antagonists |
- Diphenylmethanes: Captodiame
- Hydroxyzine; Others: Brompheniramine
- Chlorphenamine
- Pheniramine
|
|
| CRH1 Antagonists |
- Antalarmin
- CP-154,526
- Pexacerfont
- Pivagabine
|
|
| NK2 Antagonists |
- GR-159,897
- Saredutant
- Ibodutant
|
|
| MCH1 antagonists |
|
|
| mGluR2/3 Agonists |
- Biphenylindanone A
- DCG-IV
- Eglumegad
- HYDIA
- LY-379,268
- LY-404,039
|
|
| mGluR5 NAMs |
- Fenobam
- GRN-529
- MPEP
- MTEP
|
|
| TSPO agonists |
- DAA-1097
- DAA-1106
- Emapunil
- FGIN-127
- FGIN-143
|
|
| σ1 agonists |
- Afobazole
- BD1031
- BD1052
- L-687,384
- Opipramol
- Pentoxyverine
- PRE-084
- SA-4503
- 4-PPBP
|
|
| Antidepressants |
- Clomipramine
- Duloxetine
- Escitalopram
- Fluoxetine
- Fluvoxamine
- Imipramine
- Lofepramine
- Maprotiline
- Moclobemide
- Nefazodone
- Paroxetine
- Phenelzine
- Sertraline
- Venlafaxine
|
|
| Others |
- Benzoctamine
- Cannabidiol
- Carbetocin
- Clozapine
- Cycloserine
- Demoxytocin
- Emoxypine
- Kava
- Mephenoxalone
- Mepiprazole
- Oxanamide
- Oxytocin
- Periciazine
- Promoxolane
- Quetiapine
- Risperidone
- Tofisopam
- Tramadol
- Trimetozine
- Valproate
- WAY-267,464
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
|
dsrd (o, p, m, p, a, d, s), sysi/epon, spvo
|
proc (eval/thrp), drug (N5A/5B/5C/6A/6B/6D)
|
|
|
|
|
Euphoriants
|
|
| Cannabinoids |
- AM-2201
- JWH-018
- THC (found in Cannabis)
- UR-144
|
|
| Depressants |
|
General
|
- Barbiturates
- Benzodiazepines
- GHB
- Methaqualone
- Pregabalin
- Z-drugs
|
|
|
Alcohols
|
- 2M2B
- Ethanol
- Ethchlorvynol
- Methylpentynol
- UMB68
|
|
|
Opioids
|
- 7-Hydroxymitragynine (Kratom)
- Buprenorphine
- Codeine
- Dipipanone
- Fentanyl
- Heroin
- Heterocodeine
- Hydromorphone
- Methadone
- Morphine
- Opium
- Oxycodone
- Oxymorphone
- Pethidine
|
|
|
| Drugs with mixed mechanism of actions (MoA) |
- Cocaine
- Dimethyltryptamine (DMT)
- Ibogaine
- Methadone
- Pentazocine
- Tramadol
|
|
| Stimulants |
|
General
|
Nicotine (found in Tobacco)
|
|
|
Releasing agents (RA)
|
- 4-Methylaminorex
- Amphetamine
- MDMA
- Mephedrone
- Methamphetamine
- Methylone
|
|
|
Reuptake inhibitors (RI)
|
- Cocaine
- Ethylphenidate
- Methylphenidate
|
|
|
| Hallucinogens |
|
Deliriants
|
- Atropine
- Cyclizine
- Diphenhydramine
- Orphenadrine
- Scopolamine
- Trihexyphenidyl
|
|
|
Dissociatives
|
- Dextromethorphan (DXM)
- Ketamine (K)
- Methoxetamine (MXE)
- Nitrous oxide (N2O)
- Phencyclidine (PCP)
|
|
|
Psychedelics
|
- 2C-B
- 2C-I
- DMT
- LSD
- Mescaline
- Psilocybin
|
|
|
|
Hypnotics/sedatives (N05C)
|
|
GABAA
agonists/PAMs |
|
|
GABAB
agonists |
- 1,4-Butanediol
- Aceburic acid
- GABOB
- GHB (Sodium oxybate)
- GBL
- GVL
|
|
H1 inverse
agonists |
| Antihistamines: |
- Captodiame
- Cyproheptadine
- Diphenhydramine
- Doxylamine
- Hydroxyzine
- Methapyrilene
- Pheniramine
- Promethazine
- Propiomazine
|
|
| Antidepressants |
- Tricyclic antidepressants
- Amitriptyline
- Doxepin
- Trimipramine, etc.
- Tetracyclic antidepressants
- Mianserin
- Mirtazapine, etc.
|
|
| Antipsychotics |
- Typical antipsychotics
- Chlorpromazine
- Thioridazine, etc.
- Atypical antipsychotics
- Olanzapine
- Quetiapine
- Risperidone, etc.
|
|
|
α1-Adrenergic
antagonists |
| Antidepressants |
- Serotonin antagonists and reuptake inhibitors
- Tricyclic antidepressants
- Amitriptyline
- Doxepin
- Trimipramine, etc.
- Tetracyclic antidepressants
|
|
| Antipsychotics |
- Typical antipsychotics
- Chlorpromazine
- Thioridazine, etc.
- Atypical antipsychotics
- Olanzapine
- Quetiapine
- Risperidone, etc.
|
|
| Others: |
|
|
|
α2-Adrenergic
agonists |
- 4-NEMD
- Clonidine
- Detomidine
- Dexmedetomidine
- Lofexidine
- Medetomidine
- Romifidine
- Tizanidine
- Xylazine
|
|
5-HT2A
antagonists |
| Antidepressants |
- Serotonin antagonists and reuptake inhibitors
- Tricyclic antidepressants
- Amitriptyline
- Doxepin
- Trimipramine, etc.
- Tetracyclic antidepressants
- Mianserin
- Mirtazapine, etc.
|
|
| Antipsychotics |
- Typical antipsychotics
- Chlorpromazine
- Thioridazine, etc.
- Atypical antipsychotics
- Olanzapine
- Quetiapine
- Risperidone, etc.
|
|
| Others: |
- Eplivanserin
- Niaprazine
- Pruvanserin
- Volinanserin
|
|
|
Melatonin
agonists |
- Agomelatine
- LY-156,735
- Melatonin
- Ramelteon
- Tasimelteon
|
|
Orexin
antagonists |
- Almorexant
- SB-334,867
- SB-408,124
- SB-649,868
- Suvorexant
- TCS-OX2-29
|
|
| Others |
- Acecarbromal
- Apronal
- Bromisoval
- Cannabidiol
- Carbromal
- Embutramide
- Evoxine
- Fenadiazole
- Gabapentin
- Kavalactones
- Mephenoxalone
- Opioids
- Passion flower
- Scopolamine
- UMB68
- Valnoctamide
|
|
|
Physical dependants
|
|
| µ-opioids |
All µ-opioids with any (even slight) agonist effect, such as (partial list) morphine, heroin, codeine, oxycodone, buprenorphine, nalbuphine, methadone, and fentanil, but not agonists specific to non-µ opioid receptors, such as salvinorin A (a k-opioid agonist), nor opioid antagonists or inverse agonists, such as naltrexone (a universal opioid inverse agonist)
|
|
| GABAergics |
All GABA agonists and positive allosteric modulators of both the GABA-A ionotropic receptor and GABA-B metabotropic receptor subunits, of which the following drugs are examples (partial list):
- Alcohols
- barbiturates
- benzodiazepines
- nonbenzodiazepines (z-drugs)
- GHB
- carbamates
- baclofen
- chloral hydrate
- glutethimide
- clomethiazole
- methaqualone
|
|
Other
drug groups |
- antiepileptic
- blood pressure medications
- androgenic-anabolic steroids
- glucocorticoids
|
|
| Other drugs |
- Cocaine
- gabapentin
- Nicotine
|
|
|
Neurotoxins
|
|
| Animal |
- Batrachotoxin
- Bestoxin
- Birtoxin
- Bungarotoxin
- Charybdotoxin
- Conotoxin
- Saxitoxin
- Tetrodotoxin
- Vanillotoxin
- Huwentoxin
|
|
| Bacterial |
- Botulinum toxin
- Tetanospasmin
|
|
| Plant |
- Penitrem A
- Picrotoxin
- Bicuculline
|
|
| Pesticides |
|
|
| Nerve agents |
- Cyclosarin
- EA-3148
- Novichok agent
- Sarin
- Soman
- Tabun
- VE
- VG
- VM
- VR
- VX
|
|
| Neurotoxic drugs |
- 1,4-BD
- 5,7-DHT
- 6-OHDA
- αET
- αMT
- Dizocilpine (MK-801)
- DSP-4
- Ethanol
- GBL
- GHB
- Ibotenic acid
- Ketamine
- Methamphetamine
- MBDB
- MDA
- MDEA
- MDMA (Ecstasy)
- MPP+
- MPTP
- Norsalsolinol
- PBA
- PCA
- PIA
- Phencyclidine (PCP)
|
|
| Denaturants |
Methanol
|
|
Pharmacology of ethanol
|
Adenosinergics
|
|
Receptor
ligands |
|
Agonists
|
- 2-(1-Hexynyl)-N-methyladenosine
- 2-Cl-IB-MECA
- 2'-MeCCPA
- 5'-N-ethylcarboxamidoadenosine
- ATL-146e
- BAY 60–6583
- CCPA
- CGS-21680
- CP-532,903
- GR 79236
- LUF-5835
- LUF-5845
- N6-Cyclopentyladenosine
- Regadenoson
- SDZ WAG 994
- UK-432,097
|
|
|
Antagonists
|
- 8-Phenyl-1,3-dipropylxanthine
- Acefylline
- Aminophylline
- Bamifylline
- Caffeine
- CGS-15943
- 8-Chlorotheophylline
- CPX
- CVT-6883
- Dimethazan
- DPCPX
- Fenethylline
- Istradefylline
- KF-26777
- MRE3008F20
- MRS-1220
- MRS-1334
- MRS-1706
- MRS-1754
- MRS-3777
- Paraxanthine
- Pentoxifylline
- Preladenant
- Propentofylline
- PSB-10
- PSB-11
- PSB 36
- PSB-603
- PSB-788
- PSB-1115
- Rolofylline
- SCH-442,416
- SCH-58261
- Theobromine
- Theophylline
- VUF-5574
- ZM-241,385
|
|
|
Reuptake
inhibitors |
|
Plasmalemmal
|
|
ENT inhibitors
|
- Dilazep
- Dipyridamole
- Hexobendine
- Pentoxifylline
- Propentofylline
- Barbiturates
- Ethanol
- Benzodiazepines
|
|
|
|
Vesicular
|
|
|
|
|
Adrenergics
|
|
|
Receptor ligands
|
|
|
α1
|
- Agonists: 5-FNE
- 6-FNE
- Amidephrine
- Anisodamine
- Anisodine
- Cirazoline
- Dipivefrine
- Dopamine
- Ephedrine
- Epinephrine
- Etilefrine
- Ethylnorepinephrine
- Indanidine
- Levonordefrin
- Metaraminol
- Methoxamine
- Methyldopa
- Midodrine
- Naphazoline
- Norepinephrine
- Octopamine
- Oxymetazoline
- Phenylephrine
- Phenylpropanolamine
- Pseudoephedrine
- Synephrine
- Tetrahydrozoline
Antagonists: Abanoquil
- Adimolol
- Ajmalicine
- Alfuzosin
- Amosulalol
- Arotinolol
- Atiprosin
- Benoxathian
- Buflomedil
- Bunazosin
- Carvedilol
- CI-926
- Corynanthine
- Dapiprazole
- DL-017
- Domesticine
- Doxazosin
- Eugenodilol
- Fenspiride
- GYKI-12,743
- GYKI-16,084
- Hydroxyzine
- Indoramin
- Ketanserin
- L-765,314
- Labetalol
- Mephendioxan
- Metazosin
- Monatepil
- Moxisylyte
- Naftopidil
- Nantenine
- Neldazosin
- Nicergoline
- Niguldipine
- Pelanserin
- Phendioxan
- Phenoxybenzamine
- Phentolamine
- Piperoxan
- Prazosin
- Quinazosin
- Ritanserin
- RS-97,078
- SGB-1,534
- Silodosin
- SL-89.0591
- Spiperone
- Talipexole
- Tamsulosin
- Terazosin
- Tibalosin
- Tiodazosin
- Tipentosin
- Tolazoline
- Trimazosin
- Upidosin
- Urapidil
- Zolertine
* Note that many TCAs, TeCAs, antipsychotics, ergolines, and some piperazines like buspirone and trazodone all antagonize α1-adrenergic receptors as well, which contributes to their side effects such as orthostatic hypotension.
|
|
|
α2
|
- Agonists: (R)-3-Nitrobiphenyline
- 4-NEMD
- 6-FNE
- Amitraz
- Apraclonidine
- Brimonidine
- Cannabivarin
- Clonidine
- Detomidine
- Dexmedetomidine
- Dihydroergotamine
- Dipivefrine
- Dopamine
- Ephedrine
- Ergotamine
- Epinephrine
- Esproquin
- Etilefrine
- Ethylnorepinephrine
- Guanabenz
- Guanfacine
- Guanoxabenz
- Levonordefrin
- Lofexidine
- Medetomidine
- Methyldopa
- Mivazerol
- Naphazoline
- Norepinephrine
- Oxymetazoline
- Phenylpropanolamine
- Piperoxan
- Pseudoephedrine
- Rilmenidine
- Romifidine
- Talipexole
- Tetrahydrozoline
- Tizanidine
- Tolonidine
- Urapidil
- Xylazine
- Xylometazoline
Antagonists: 1-PP
- Adimolol
- Aptazapine
- Atipamezole
- BRL-44408
- Buflomedil
- Cirazoline
- Efaroxan
- Esmirtazapine
- Fenmetozole
- Fluparoxan
- GYKI-12,743
- GYKI-16,084
- Idazoxan
- Mianserin
- Mirtazapine
- MK-912
- NAN-190
- Olanzapine
- Phentolamine
- Phenoxybenzamine
- Piperoxan
- Piribedil
- Rauwolscine
- Rotigotine
- SB-269,970
- Setiptiline
- Spiroxatrine
- Sunepitron
- Tolazoline
- Yohimbine
* Note that many atypical antipsychotics and azapirones like buspirone (via metabolite 1-PP) antagonize α2-adrenergic receptors as well.
|
|
|
β
|
|
|
|
|
|
Reuptake inhibitors
|
|
|
NET
|
- Selective norepinephrine reuptake inhibitors: Amedalin
- Atomoxetine (Tomoxetine)
- Ciclazindol
- Daledalin
- Edivoxetine
- Esreboxetine
- Lortalamine
- Mazindol
- Nisoxetine
- Reboxetine
- Talopram
- Talsupram
- Tandamine
- Viloxazine; Norepinephrine-dopamine reuptake inhibitors: Amineptine
- Bupropion (Amfebutamone)
- Fencamine
- Fencamfamine
- Lefetamine
- Levophacetoperane
- LR-5182
- Manifaxine
- Methylphenidate
- Nomifensine
- O-2172
- Radafaxine; Serotonin-norepinephrine reuptake inhibitors: Bicifadine
- Desvenlafaxine
- Duloxetine
- Eclanamine
- Levomilnacipran
- Milnacipran
- Sibutramine
- Venlafaxine; Serotonin-norepinephrine-dopamine reuptake inhibitors: Brasofensine
- Diclofensine
- DOV-102,677
- DOV-21,947
- DOV-216,303
- JNJ-7925476
- JZ-IV-10
- Methylnaphthidate
- Naphyrone
- NS-2359
- PRC200-SS
- SEP-225,289
- SEP-227,162
- Tesofensine; Tricyclic antidepressants: Amitriptyline
- Butriptyline
- Cianopramine
- Clomipramine
- Desipramine
- Dosulepin
- Doxepin
- Imipramine
- Lofepramine
- melitracen
- Nortriptyline
- Protriptyline
- Trimipramine; Tetracyclic antidepressants: Amoxapine
- Maprotiline
- Mianserin
- Oxaprotiline
- Setiptiline; Others: Cocaine
- CP-39,332
- Ethanol
- EXP-561
- Fezolamine
- Ginkgo biloba
- Indeloxazine
- Nefazodone
- Nefopam
- Pridefrine
- Tapentadol
- Tedatioxetine
- Teniloxazine
- Tofenacin
- Tramadol
- Ziprasidone
|
|
|
VMAT
|
- Ibogaine
- Reserpine
- Tetrabenazine
|
|
|
|
|
|
|
|
Enzyme inhibitors
|
|
|
Anabolism
|
|
PAH
|
|
|
|
TH
|
- 3-Iodotyrosine
- Aquayamycin
- Bulbocapnine
- Metirosine
- Oudenone
|
|
|
AAAD
|
- Benserazide
- Carbidopa
- DFMD
- Genistein
- Methyldopa
|
|
|
DBH
|
- Bupicomide
- Disulfiram
- Dopastin
- Fusaric acid
- Nepicastat
- Phenopicolinic acid
- Tropolone
|
|
|
PNMT
|
- CGS-19281A
- SKF-64139
- SKF-7698
|
|
|
|
Catabolism
|
|
MAO
|
- Nonselective: Benmoxin
- Caroxazone
- Echinopsidine
- Furazolidone
- Hydralazine
- Indantadol
- Iproclozide
- Iproniazid
- Isocarboxazid
- Isoniazid
- Linezolid
- Mebanazine
- Metfendrazine
- Nialamide
- Octamoxin
- Paraxazone
- Phenelzine
- Pheniprazine
- Phenoxypropazine
- Pivalylbenzhydrazine
- Procarbazine
- Safrazine
- Tranylcypromine; MAO-A selective: Amiflamine
- Bazinaprine
- Befloxatone
- Brofaromine
- Cimoxatone
- Clorgiline
- Eprobemide
- Esuprone
- Harmala alkaloids (Harmine,
- Harmaline
- Tetrahydroharmine
- Harman
- Norharman, etc)
- Methylene blue
- Metralindole
- Minaprine
- Moclobemide
- Pirlindole
- Sercloremine
- Tetrindole
- Toloxatone
- Tyrima; MAO-B selective:
- Ladostigil
- Lazabemide
- Milacemide
- Mofegiline
- Pargyline
- Rasagiline
- Safinamide
- Selegiline (also D-Deprenyl)
* Note that MAO-B inhibitors also influence norepinephrine/epinephrine levels since they inhibit the breakdown of their precursor dopamine.
|
|
|
COMT
|
- Entacapone
- Nitecapone
- Tolcapone
|
|
|
|
|
|
Others
|
|
|
Precursors
|
- L-Phenylalanine → L-Tyrosine → L-DOPA (Levodopa) → Dopamine
- L-DOPS (Droxidopa)
|
|
|
Cofactors
|
- Ferrous Iron (Fe2+)
- S-Adenosyl-L-Methionine
- Vitamin B3 (Niacin
- Nicotinamide → NADPH)
- Vitamin B6 (Pyridoxine
- Pyridoxamine
- Pyridoxal → Pyridoxal Phosphate)
- Vitamin B9 (Folic acid → Tetrahydrofolic acid)
- Vitamin C (Ascorbic acid)
- Zinc (Zn2+)
|
|
|
Others
|
- Activity enhancers: BPAP
- PPAP; Release blockers: Bethanidine
- Bretylium
- Guanadrel
- Guanazodine
- Guanclofine
- Guanethidine
- Guanoxan; Toxins: 6-OHDA
|
|
|
|
|
List of adrenergic drugs
|
|
|
Dopaminergics
|
|
|
Receptor ligands
|
|
|
Agonists
|
- Adamantanes: Amantadine
- Memantine
- Rimantadine; Aminotetralins: 7-OH-DPAT
- 8-OH-PBZI
- Rotigotine
- UH-232; Benzazepines: 6-Br-APB
- Fenoldopam
- SKF-38,393
- SKF-77,434
- SKF-81,297
- SKF-82,958
- SKF-83,959; Ergolines: Bromocriptine
- Cabergoline
- Dihydroergocryptine
- Epicriptine
- Lisuride
- LSD
- Pergolide; Dihydrexidine derivatives: 2-OH-NPA
- A-86,929
- Ciladopa
- Dihydrexidine
- Dinapsoline
- Dinoxyline
- Doxanthrine; Others: A-68,930
- A-77636
- A-412,997
- ABT-670
- ABT-724
- Aplindore
- Apomorphine
- Aripiprazole
- Bifeprunox
- BP-897
- CY-208,243
- Dizocilpine
- Etilevodopa
- Flibanserin
- Ketamine
- Melevodopa
- Modafinil
- Pardoprunox
- Phencyclidine
- PD-128,907
- PD-168,077
- PF-219,061
- Piribedil
- Pramipexole
- Propylnorapomorphine
- Pukateine
- Quinagolide
- Quinelorane
- Quinpirole
- RDS-127
- Ro10-5824
- Ropinirole
- Rotigotine
- Roxindole
- Salvinorin A
- SKF-89,145
- Sumanirole
- Terguride
- Umespirone
- WAY-100,635
|
|
|
Antagonists
|
- Typical antipsychotics: Acepromazine
- Azaperone
- Benperidol
- Bromperidol
- Clopenthixol
- Chlorpromazine
- Chlorprothixene
- Droperidol
- Flupentixol
- Fluphenazine
- Fluspirilene
- Haloperidol
- Levosulpiride
- Loxapine
- Mesoridazine
- Methotrimeprazine
- Nemonapride
- Penfluridol
- Perazine
- Periciazine
- Perphenazine
- Pimozide
- Prochlorperazine
- Promazine
- Sulforidazine
- Sulpiride
- Sultopride
- Thioridazine
- Thiothixene
- Trifluoperazine
- Triflupromazine
- Trifluperidol
- Zuclopenthixol; Atypical antipsychotics: Amisulpride
- Asenapine
- Blonanserin
- Cariprazine
- Carpipramine
- Clocapramine
- Clorotepine
- Clozapine
- Gevotroline
- Iloperidone
- Lurasidone
- Melperone
- Molindone
- Mosapramine
- Olanzapine
- Paliperidone
- Perospirone
- Piquindone
- Quetiapine
- Remoxipride
- Risperidone
- Sertindole
- Tiospirone
- Zicronapine
- Ziprasidone
- Zotepine; Antiemetics: AS-8112
- Alizapride
- Bromopride
- Clebopride
- Domperidone
- Metoclopramide
- Thiethylperazine; Others: Amoxapine
- Buspirone
- Butaclamol
- Ecopipam
- EEDQ
- Eticlopride
- Fananserin
- Hydroxyzine
- L-745,870
- Nafadotride
- Nuciferine
- PNU-99,194
- Raclopride
- Sarizotan
- SB-277,011-A
- SCH-23,390
- SKF-83,959
- Sonepiprazole
- Spiperone
- Spiroxatrine
- Stepholidine
- Tetrahydropalmatine
- Tiapride
- UH-232
- Yohimbine
|
|
|
|
|
Reuptake inhibitors
|
|
|
Plasmalemmal
|
|
DAT inhibitors
|
- Piperazines: DBL-583
- GBR-12,935
- Nefazodone
- Vanoxerine; Piperidines: BTCP
- Desoxypipradrol
- Dextromethylphenidate
- Difemetorex
- Ethylphenidate
- Methylnaphthidate
- Methylphenidate
- Phencyclidine
- Pipradrol; Pyrrolidines: Diphenylprolinol
- MDPV
- Naphyrone
- Prolintane
- Pyrovalerone; Tropanes: Altropane
- Brasofensine
- CFT
- Cocaine
- Dichloropane
- Difluoropine
- FE-β-CPPIT
- FP-β-CPPIT
- Ioflupane (123I)
- Iometopane
- RTI-112
- RTI-113
- RTI-121
- RTI-126
- RTI-150
- RTI-177
- RTI-229
- RTI-336
- Tenocyclidine
- Tesofensine
- Troparil
- Tropoxane
- WF-11
- WF-23
- WF-31
- WF-33; Others: Adrafinil
- Armodafinil
- Amfonelic acid
- Amphetamine
- Amineptine
- Benzatropine
- Bromantane
- BTQ
- BTS-74,398
- Bupropion
- Ciclazindol
- Diclofensine
- Dimethocaine
- Diphenylpyraline
- Dizocilpine
- DOV-102,677
- DOV-21,947
- DOV-216,303
- Etybenzatropine
- EXP-561
- Fencamine
- Fencamfamine
- Fezolamine
- Fluorenol
- GYKI-52,895
- Indatraline
- Ketamine
- Lefetamine
- Levophacetoperane
- LR-5182
- Manifaxine
- Mazindol
- Medifoxamine
- Mesocarb
- Modafinil
- Nefopam
- Nomifensine
- NS-2359
- O-2172
- Pridefrine
- Propylamphetamine
- Radafaxine
- SEP-225,289
- SEP-227,162
- Sertraline
- Sibutramine
- Tametraline
- Tedatioxetine
- Tripelennamine
|
|
|
|
Vesicular
|
|
VMAT inhibitors
|
- Deserpidine
- Ibogaine
- Reserpine
- Tetrabenazine
|
|
|
|
|
|
|
|
|
Allosteric modulators
|
|
- Quinazolinamines: SoRI-9804
- SoRI-20040
- SoRI-20041
|
|
|
|
Enzyme inhibitors
|
|
|
Anabolism
|
|
PAH inhibitors
|
|
|
|
TH inhibitors
|
- 3-Iodotyrosine
- Aquayamycin
- Bulbocapnine
- Metirosine
- Oudenone
|
|
|
AAAD/DDC inhibitors
|
- Benserazide
- Carbidopa
- DFMD
- Genistein
- Methyldopa
|
|
|
|
Catabolism
|
|
MAO inhibitors
|
- Nonselective: Benmoxin
- Caroxazone
- Echinopsidine
- Furazolidone
- Hydralazine
- Indantadol
- Iproclozide
- Iproniazid
- Isocarboxazid
- Isoniazid
- Linezolid
- Mebanazine
- Metfendrazine
- Nialamide
- Octamoxin
- Paraxazone
- Phenelzine
- Pheniprazine
- Phenoxypropazine
- Pivalylbenzhydrazine
- Procarbazine
- Safrazine
- Tranylcypromine; MAO-A selective: Amiflamine
- Bazinaprine
- Befloxatone
- Brofaromine
- Cimoxatone
- Clorgiline
- Eprobemide
- Esuprone
- Harmala alkaloids
- Methylene Blue
- Metralindole
- Minaprine
- Moclobemide
- Pirlindole
- Sercloremine
- Tetrindole
- Toloxatone
- Tyrima; MAO-B selective: D-Deprenyl
- Ethanol
- L-Deprenyl (Selegiline)
- Ladostigil
- Lazabemide
- Milacemide
- Nicotine
- Pargyline
- Rasagiline
- Safinamide
|
|
|
COMT inhibitors
|
- Entacapone
- Nitecapone
- Tolcapone
|
|
|
DBH inhibitors
|
- Disulfiram
- Dopastin
- Fusaric acid
- Nepicastat
- Tropolone
|
|
|
|
|
|
Others
|
|
|
Precursors
|
- L-Phenylalanine → L-Tyrosine → L-DOPA (Levodopa)
|
|
|
Cofactors
|
- Ferrous iron (Fe2+)
- Tetrahydrobiopterin
- Vitamin B3 (Niacin
- Nicotinamide → NADPH)
- Vitamin B6 (Pyridoxine
- Pyridoxamine
- Pyridoxal → Pyridoxal phosphate)
- Vitamin B9 (Folic acid → Tetrahydrofolic acid)
- Vitamin C (Ascorbic acid)
- Zinc (Zn2+)
|
|
|
Others
|
- Activity enhancers: BPAP * PPAP; Toxins: 6-OHDA; Steroids: Anabolic-androgenic steroids
|
|
|
|
|
List of dopaminergic drugs
|
|
|
Glutamatergics
|
|
| Ionotropic |
|
AMPA
|
- Agonists: 5-Fluorowillardiine
- AMPA
- Domoic acid
- Quisqualic acid; Positive allosteric modulators: Aniracetam
- Cyclothiazide
- CX-516
- CX-546
- CX-614
- CX-691
- CX-717
- Diazoxide
- HCTZ
- IDRA-21
- LY-392,098
- LY-404,187
- LY-451,395
- LY-451,646
- LY-503,430
- Org 26576
- Oxiracetam
- PEPA
- Piracetam
- Pramiracetam
- S-18986
- Sunifiram
- Unifiram
Antagonists: ATPO
- Barbiturates
- BGG492
- Caroverine
- CNQX
- DNQX
- GYKI-52466
- NBQX
- Perampanel
- Talampanel
- Tezampanel
- Topiramate; Negative allosteric modulators: GYKI-53,655
|
|
|
NMDA
|
- Agonists: Glutamate/acite site competitive agonists: Aspartate
- Glutamate
- Homoquinolinic acid
- Ibotenic acid
- NMDA
- Quinolinic acid
- Tetrazolylglycine; Glycine site agonists: ACBD
- ACPC
- ACPD
- Alanine
- CCG
- Cycloserine
- DHPG
- Fluoroalanine
- Glycine
- GLYX-13
- HA-966
- L-687,414
- Milacemide
- Sarcosine
- Serine
- Tetrazolylglycine; Polyamine site agonists: Acamprosate
- Spermidine
- Spermine
Antagonists: Competitive antagonists: AP5 (APV)
- AP7
- CGP-37849
- CGP-39551
- CGP-39653
- CGP-40116
- CGS-19755
- CPP
- LY-233,053
- LY-235,959
- LY-274,614
- MDL-100,453
- Midafotel (d-CPPene)
- NPC-12,626
- NPC-17,742
- PBPD
- PEAQX
- Perzinfotel
- PPDA
- SDZ-220581
- Selfotel; Noncompetitive antagonists: ARR-15,896
- Caroverine
- Dexanabinol
- FPL-12495
- FR-115,427
- Hodgkinsine
- Magnesium
- MDL-27,266
- NPS-1506
- Psychotridine
- Zinc; Uncompetitive pore blockers: 2-MDP
- 3-MeO-PCP
- 8A-PDHQ
- Alaproclate
- Amantadine
- Aptiganel
- ARL-12,495
- ARL-15,896-AR
- ARL-16,247
- Budipine
- Delucemine
- Dexoxadrol
- Dextrallorphan
- Dieticyclidine
- Dizocilpine
- Endopsychosin
- Esketamine
- Etoxadrol
- Eticyclidine
- Gacyclidine
- Ibogaine
- Indantadol
- Ketamine
- Ketobemidone
- Lanicemine
- Loperamide
- Memantine
- Meperidine (Pethidine)
- Methadone (Levomethadone)
- Methorphan (Dextromethorphan
- Levomethorphan)
- Methoxetamine
- Milnacipran
- Morphanol (Dextrorphan
- Levorphanol)
- NEFA
- Neramexane
- Nitromemantine
- Nitrous oxide
- Noribogaine
- Orphenadrine
- PCPr
- Phencyclamine
- Phencyclidine
- Propoxyphene
- Remacemide
- Rhynchophylline
- Riluzole
- Rimantadine
- Rolicyclidine
- Sabeluzole
- Tenocyclidine
- Tiletamine
- Tramadol
- Xenon; Glycine site antagonists: ACEA-1021
- ACEA-1328
- ACC
- Carisoprodol
- CGP-39653
- CKA
- DCKA
- Felbamate
- Gavestinel
- GV-196,771
- Kynurenic acid
- L-689,560
- L-701,324
- Lacosamide
- Licostinel
- LU-73,068
- MDL-105,519
- Meprobamate
- MRZ 2/576
- PNQX
- ZD-9379; NR2B subunit antagonists: Besonprodil
- CO-101,244 (PD-174,494)
- CP-101,606
- Eliprodil
- Haloperidol
- Ifenprodil
- Isoxsuprine
- Nylidrin
- Ro8-4304
- Ro25-6981
- Traxoprodil; Polyamine site antagonists: Arcaine
- Co 101676
- Diaminopropane
- Acamprosate
- Diethylenetriamine
- Huperzine A
- Putrescine
- Ro 25-6981; Unclassified/unsorted antagonists: Chloroform
- Diethyl ether
- Diphenidine
- Enflurane
- Ethanol (alcohol)
- Halothane
- Isoflurane
- Methoxyflurane
- Toluene
- Trichloroethane
- Trichloroethanol
- Trichloroethylene
- Xylene
|
|
|
Kainate
|
- Agonists: 5-Iodowillardiine
- ATPA
- Domoic acid
- Kainic acid
- LY-339,434
- SYM-2081
Antagonists: BGG492
- CNQX
- DNQX
- LY-382,884
- NBQX
- NS102
- Tezampanel
- Topiramate
- UBP-302; Negative allosteric modulators: NS-3763
|
|
|
| Metabotropic |
|
Group I
|
- Agonists: Non-selective: ACPD
- DHPG
- Quisqualic acid; mGlu1-selective: Ro01-6128
- Ro67-4853
- Ro67-7476
- VU-71; mGlu5-selective: ADX-47273
- CDPPB
- CHPG
- DFB
- VU-1545
Antagonists: Non-selective: MCPG
- NPS-2390; mGlu1-selective: BAY 36-7620
- CPCCOEt
- LY-367,385
- LY-456,236; mGlu5-selective: CTEP
- Dipraglurant
- DMeOB
- LY-344,545
- SIB-1757
- SIB-1893; Negative allosteric modulators: Fenobam
- MPEP
- MTEP
- GRN-529
|
|
|
Group II
|
- Agonists: Non-selective: CBiPES
- DCG-IV
- Eglumegad
- LY-379,268
- LY-404,039
- LY-487,379
- MGS-0028; mGlu2-selective: BINA
- LY-566,332
Antagonists: Non-selective: APICA
- EGLU
- HYDIA
- LY-307,452
- LY-341,495
- MCPG
- MGS-0039; mGlu2-selective: PCCG-4
- mGlu3-selective: CECXG; Negative allosteric modulators: RO4491533
|
|
|
Group III
|
- Agonists: Non-selective: L-AP4; mGlu4-selective: PHCCC
- VU-001,171
- VU-0155,041; mGlu7-selective: AMN082; mGlu8-selective: DCPG
Antagonists: Non-selective: CPPG
- MAP4
- MSOP
- MPPG
- MTPG
- UBP-1112; mGlu7-selective: MMPIP
|
|
|
Transporter
inhibitors |
|
|
| Others |
|
Precursors
|
|
|
|
Cofactors
|
- α-Ketoglutaric acid
- Iron
- Sulfur
- Vitamin B2 (as FAD and FMN)
- Vitamin B3 (as NADPH)
|
|
|
Others
|
|
|
|
|
Opioids
|
|
Opium and
poppy straw
derivatives |
Crude opiate
extracts /
whole opium
products |
- B&O Supprettes
- Diascordium
- Dover's powder
- Kendal Black Drop
- Laudanum
- Mithridate
- Opium
- Paregoric
- Polish heroin (compote/kompot)
- Poppy straw
- Poppy tea
- Smoking opium
- Theriac
|
|
| Natural opiates |
Opium
alkaloids |
- Codeine
- Morphine
- Oripavine
- Pseudomorphine
- Thebaine
|
|
Alkaloid
salts mixtures |
- Pantopon
- Papaveretum (Omnopon)
|
|
|
Semisynthetics
including
Bentley
compounds |
Morphine
family |
- 2,4-Dinitrophenylmorphine
- 6-MDDM
- Azidomorphine
- Chlornaltrexamine
- Desocodeine
- Desomorphine
- Dihydromorphine
- Hydromorphinol
- Methyldesorphine
- N-Phenethylnormorphine
- RAM-378
|
|
3,6-diesters
of morphine |
- Acetylpropionylmorphine
- Diacetyldihydromorphine
- Dibenzoylmorphine
- Dipropanoylmorphine
- Heroin
- Nicomorphine
|
|
Codeine-dionine
family |
- 6-Monoacetylcodeine
- Benzylmorphine
- Codeine methylbromide
- Ethylmorphine
- Heterocodeine
- Isocodeine
- Myrophine
- Pholcodine
|
|
Morphinones
and morphols |
- 14-Cinnamoyloxycodeinone
- 14-Ethoxymetopon
- 14-Methoxymetopon
- 14-Phenylpropoxymetopon
- 3-Acetyloxymorphone
- 3,14-Diacetyloxymorphone
- 6-MDDM
- 7-Spiroindanyloxymorphone
- Acetylmorphone
- Codeinone
- Codoxime
- Conorfone
- Hydrocodone
- Hydromorphone
- IBNtxA
- Methyldihydromorphine
- Metopon
- Morphinone
- N-Phenethyl-14-ethoxymetopon
- Nalmexone
- Oxycodone
- Oxymorphol
- Oxymorphone
- Pentamorphone
- Semorphone
- Thebacon
|
|
| Morphides |
- α-Chlorocodide
- Chloromorphide
|
|
Dihydrocodeine
series |
- 14-Hydroxydihydrocodeine
- Acetyldihydrocodeine
- Dihydrocodeine
- Nicocodeine
- Nicodicodeine
|
|
Nitrogen
morphine
derivatives |
- Codeine-N-oxide
- Morphine-N-oxide
|
|
| Hydrazones |
|
|
Halogenated
morphine
derivatives |
|
|
|
Active opiate
metabolites |
- 6-Monoacetylmorphine
- Morphine-6-glucuronide
- Norcodeine
- Normorphine
|
|
|
| Morphinans |
- 3-Hydroxymorphinan
- Butorphanol
- Cyclorphan
- Cyprodime
- Dextrallorphan
- Drotebanol
- Ketorfanol
- Levallorphan
- Levomethorphan
- Levophenacylmorphan
- Levorphanol
- Nalbuphine
- Norlevorphanol
- Oxilorphan
- Phenomorphan
- Proxorphan
- Racemethorphan/Methorphan
- Racemorphanol/Morphanol
- Ro4-1539
- Sinomenine/Cocculine
- Xorphanol
|
|
| Benzomorphans |
- 8-CAC
- Alazocine
- Anazocine
- Bremazocine
- Butinazocine
- Carbazocine
- Cogazocine
- Dezocine
- Eptazocine
- Etazocine
- Ethylketazocine
- Fluorophen
- Ibazocine
- Ketazocine
- Metazocine
- Moxazocine
- Pentazocine
- Phenazocine
- Tonazocine
- Volazocine
- Zenazocine
|
|
| 4-Phenylpiperidines |
Pethidines
(Meperidines) |
- 4-Fluoropethidine
- Allylnorpethidine
- Anileridine
- Benzethidine
- Carperidine
- Difenoxin
- Diphenoxylate
- Etoxeridine (Carbetidine)
- Furethidine
- Hydroxypethidine (Bemidone)
- Morpheridine
- Oxpheneridine (Carbamethidine)
- Pethidine (Meperidine)
- Pethidine intermediate A
- Pethidine intermediate B (Norpethidine)
- Pethidine intermediate C (Pethidinic Acid)
- Pheneridine
- Phenoperidine
- Piminodine
- Properidine (Ipropethidine)
- Sameridine
|
|
| Prodines |
- Allylprodine
- Meprodine (α-meprodine / β-meprodine)
- MPPP (Desmethylprodine)
- PEPAP
- Prodine (α-prodine / β-prodine)
- Prosidol
- Trimeperidine (Promedol)
|
|
| Ketobemidones |
- Acetoxyketobemidone
- Droxypropine
- Ketobemidone
- Methylketobemidone
- Propylketobemidone
|
|
| Others |
- Alvimopan
- Loperamide
- Picenadol
|
|
|
Open chain
opioids |
| Amidones |
- Dipipanone
- Isomethadone
- Levomethadone
- Methadone
- Normethadone
- Norpipanone
- Phenadoxone (Heptazone)
|
|
| Methadols |
- Acetylmethadol
- Alphacetylmethadol
- Alphamethadol
- Betacetylmethadol
- Betamethadol
- Dimepheptanol (methadol)
- Isomethadol
- Levacetylmethadol
- Noracymethadol
|
|
| Moramides |
- Desmethylmoramide
- Dextromoramide
- Levomoramide
- Moramide/Racemoramide
|
|
| Thiambutenes |
- Diethylthiambutene
- Dimethylthiambutene
- Ethylmethylthiambutene
- Piperidylthiambutene
- Pyrrolidinylthiambutene
- Tipepidine
|
|
| Phenalkoxams |
- Dextropropoxyphene
- Dimenoxadol
- Dioxaphetyl butyrate
- Levopropoxyphene
- Norpropoxyphene
|
|
| Ampromides |
- Diampromide
- Phenampromide
- Propiram
|
|
| Others |
- Alimadol
- IC-26
- Isoaminile
- Lefetamine
- R-4066
|
|
|
| Anilidopiperidines |
- 3-Allylfentanyl
- 3-Methylfentanyl
- 3-Methylthiofentanyl
- 4-Phenylfentanyl
- α-Methylacetylfentanyl
- α-Methylfentanyl
- α-methylthiofentanyl
- β-hydroxyfentanyl
- β-hydroxythiofentanyl
- β-methylfentanyl
- Alfentanil
- Brifentanil
- Carfentanil
- Fentanyl
- Lofentanil
- Mirfentanil
- Ocfentanil
- Ohmefentanyl
- Parafluorofentanyl
- Phenaridine
- Remifentanil
- Sufentanil
- Thiofentanyl
- Trefentanil
|
|
Oripavine
derivatives |
- 7-PET
- Acetorphine
- Alletorphine
- BU-48
- Buprenorphine
- Cyprenorphine
- Dihydroetorphine
- Etorphine
- Homprenorphine
- Norbuprenorphine
|
|
| Phenazepanes |
- Ethoheptazine
- Meptazinol
- Metethoheptazine
- Metheptazine
- Proheptazine
|
|
| Pirinitramides |
|
|
| Benzimidazoles |
|
|
| Indoles |
- 18-MC
- 7-Hydroxymitragynine
- Akuammine
- Eseroline
- Hodgkinsine
- Ibogaine
- Mitragynine
- Noribogaine
- Pericine
|
|
Diphenylmethyl-
piperazines |
- BW373U86
- DPI-221
- DPI-287
- DPI-3290
- SNC-80
|
|
| Opioid peptides |
- Adrenorphin
- Amidorphin
- Biphalin
- Casokefamide
- Casomorphin
- Cytochrophin
- DADLE
- DAMGO
- Deltorphin
- Dermorphin
- Dynorphin
- Endomorphin
- Endorphins
- Enkephalin
- Frakefamide
- Gliadorphin
- Hemorphin
- Leumorphin
- Metkefamide
- Morphiceptin
- Neoendorphin
- Nociceptin
- Octreotide
- Opiorphin
- Rubiscolin
- Spinorphin
- TRIMU 5
- Tynorphin
- Valorphin
|
|
| Others |
- AD-1211
- AH-7921
- Azaprocin
- BRL-52537
- Bromadol
- Bromadoline
- C-8813
- Ciprefadol
- Ciramadol
- Doxpicomine
- Enadoline
- Faxeladol
- GR-89696
- Herkinorin
- ICI-199,441
- ICI-204,448
- J-113,397
- JTC-801
- LPK-26
- MCOPPB
- Metofoline
- MT-45
- N-Desmethylclozapine
- NNC 63-0532
- Nortilidine
- O-Desmethyltramadol
- Phenadone
- Phencyclidine
- Prodilidine
- Profadol
- Ro64-6198
- Salvinorin A
- SB-612,111
- SC-17599
- RWJ-394,674
- TAN-67
- Tapentadol
- Tifluadom
- Tilidine
- Tramadol
- Trimebutine
- U-50,488
- U-69,593
- Viminol
- W-18
|
|
Opioid
antagonists &
inverse agonists |
- 5'-Guanidinonaltrindole
- Alvimopan
- Chlornaltrexamine
- Chloroxymorphamine
- Conorfone
- Cyclazocine
- Cyprodime
- Diacetylnalorphine
- Difenamizole
- Diprenorphine (M5050)
- Gemazocine
- JDTic
- Levallorphan
- LY-255,582
- Methylnaltrexone
- Nalbuphine
- Naldemedine
- Nalmefene
- Nalmexone
- Nalorphine
- Nalorphine dinicotinate
- Naloxazone
- Naloxegol
- Naloxonazine
- Naloxone
- Naltrexol-d4
- Naltrexone
- Naltriben
- Naltrindole
- Norbinaltorphimine
- Oxilorphan
- Quadazocine
- Samidorphan
- Tonazocine
- Zenazocine
|
|
| Biased ligands |
- TRV130
- Herkinorin
- 6'-GNTI
|
|
Uncategorized
opioids |
- Anilopam
- Asimadoline
- Axomadol
- FE 200665
- Fedotozine
- Nalfurafine
- Nalorphine
- Nalorphine dinicotinate
- SoRI-9409
|
|
|
|
|
|
Serotonergics
|
|
|
5-HT1 receptor ligands
|
|
|
5-HT1A
|
- Agonists: Azapirones: Alnespirone
- Binospirone
- Buspirone
- Enilospirone
- Eptapirone
- Gepirone
- Ipsapirone
- Perospirone
- Revospirone
- Tandospirone
- Tiospirone
- Umespirone
- Zalospirone; Antidepressants: Etoperidone
- Nefazodone
- Trazodone
- Vortioxetine; Antipsychotics: Aripiprazole
- Asenapine
- Clozapine
- Quetiapine
- Ziprasidone; Ergolines: Dihydroergotamine
- Bromocriptine
- Ergotamine
- Lisuride
- Methysergide
- LSD; Tryptamines: 5-CT
- 5-MeO-DMT
- 5-MT
- Bufotenin
- DMT
- Indorenate
- Psilocin
- Psilocybin; Others: 8-OH-DPAT
- Adatanserin
- Bay R 1531
- Befiradol
- BMY-14802
- Cannabidiol
- Dimemebfe
- Ebalzotan
- Eltoprazine
- F-11,461
- F-12,826
- F-13,714
- F-14,679
- F-15,063
- F-15,599
- Flesinoxan
- Flibanserin
- Lesopitron
- LY-293,284
- LY-301,317
- MKC-242
- Naluzotan
- NBUMP
- Osemozotan
- Oxaflozane
- Pardoprunox
- Piclozotan
- Rauwolscine
- Repinotan
- Roxindole
- RU-24,969
- S 14,506
- S-14,671
- S-15,535
- Sarizotan
- SSR-181,507
- Sunepitron
- U-92,016-A
- Urapidil
- Vilazodone
- Xaliproden
- Yohimbine
Antagonists: Antipsychotics: Iloperidone
- Risperidone
- Sertindole; Beta blockers: Alprenolol
- Cyanopindolol
- Iodocyanopindolol
- Oxprenolol
- Pindobind
- Pindolol
- Propranolol
- Tertatolol; Others: AV965
- BMY-7,378
- CSP-2503
- Dotarizine
- Flopropione
- GR-46611
- Isamoltane
- Lecozotan
- Mefway
- Metitepine/Methiothepin
- MPPF
- NAN-190
- Robalzotan
- S-15535
- SB-649,915
- SDZ 216-525
- Spiperone
- Spiramide
- Spiroxatrine
- UH-301
- WAY-100,135
- WAY-100,635
- Xylamidine
|
|
|
5-HT1B
|
- Agonists: Lysergamides: Dihydroergotamine
- Ergotamine
- Methysergide; Piperazines: Eltoprazine
- TFMPP; Triptans: Avitriptan
- Eletriptan
- Sumatriptan
- Zolmitriptan; Tryptamines: 5-CT
- 5-MT; Others: CGS-12066A
- Bromocriptine
- CP-93,129
- CP-94,253
- CP-135,807
- RU-24,969
- Vortioxetine
Antagonists: Lysergamides: Metergoline; Others: AR-A000002
- Elzasonan
- GR-127,935
- Isamoltane
- Metitepine/Methiothepin
- SB-216,641
- SB-224,289
- SB-236,057
- Yohimbine
|
|
|
5-HT1D
|
- Agonists: Lysergamides: Dihydroergotamine
- Methysergide; Triptans: Almotriptan
- Avitriptan
- Eletriptan
- Frovatriptan
- Naratriptan
- Rizatriptan
- Sumatriptan
- Zolmitriptan; Tryptamines: 5-CT
- 5-Ethyl-DMT
- 5-MT
- 5-(Nonyloxy)tryptamine; Others: CP-135,807
- Bromocriptine
- CP-286,601
- GR-46611
- L-694,247
- L-772,405
- PNU-109,291
- PNU-142633
Antagonists: Lysergamides: Metergoline; Others: Alniditan
- BRL-15,572
- Elzasonan
- GR-127,935
- Ketanserin
- LY-310,762
- LY-367,642
- LY-456,219
- LY-456,220
- Metitepine/Methiothepin
- Ritanserin
- Yohimbine
- Ziprasidone
|
|
|
5-HT1E
|
- Agonists: Lysergamides: Methysergide; Triptans: Eletriptan; Tryptamines: BRL-54443
- Tryptamine
Antagonists: Metitepine/Methiothepin
|
|
|
5-HT1F
|
- Agonists: Triptans: Eletriptan
- Naratriptan
- Sumatriptan; Tryptamines: 5-MT; Others: BRL-54443
- Bromocriptine
- Lasmiditan
- LY-334,370
Antagonists: Metitepine/Methiothepin
|
|
|
|
|
5-HT2 receptor ligands
|
|
|
5-HT2A
|
|
|
|
5-HT2B
|
- Agonists: Oxazolines: 4-Methylaminorex
- Aminorex; Phenethylamines: Chlorphentermine
- Cloforex
- DOB
- DOC
- DOI
- DOM
- Fenfluramine (Dexfenfluramine, Levofenfluramine)
- MDA
- MDMA
- Norfenfluramine; Tryptamines: 5-CT
- 5-MT
- α-Methyl-5-HT; Others: BW-723C86
- Bromocriptine
- Cabergoline
- mCPP
- Pergolide
- PNU-22394
- Ro60-0175
Antagonists: Agomelatine
- Asenapine
- EGIS-7625
- Ketanserin
- Lisuride
- LY-272,015
- Metitepine/Methiothepin
- PRX-08066
- Rauwolscine
- Ritanserin
- RS-127,445
- Sarpogrelate
- SB-200,646
- SB-204,741
- SB-206,553
- SB-215,505
- SB-221,284
- SB-228,357
- SDZ SER-082
- Tegaserod
- Yohimbine
|
|
|
5-HT2C
|
- Agonists: Phenethylamines: 2C-B
- 2C-E
- 2C-I
- 2C-T-2
- 2C-T-7
- 2C-T-21
- DOB
- DOC
- DOI
- DOM
- MDA
- MDMA
- Mescaline; Piperazines: Aripiprazole
- mCPP
- TFMPP; Tryptamines: 5-CT
- 5-MeO-α-ET
- 5-MeO-α-MT
- 5-MeO-DET
- 5-MeO-DiPT
- 5-MeO-DMT
- 5-MeO-DPT
- 5-MT
- α-ET
- α-Methyl-5-HT
- α-MT
- Bufotenin
- DET
- DiPT
- DMT
- DPT
- Psilocin
- Psilocybin; Others: A-372,159
- AL-38022A
- Alstonine
- Bromocriptine
- CP-809,101
- Dimemebfe
- Lorcaserin
- Medifoxamine
- MK-212
- Org 12,962
- ORG-37,684
- Oxaflozane
- PHA-57378
- PNU-22394
- PNU-181731
- Ro60-0175
- Ro60-0213
- Vabicaserin
- WAY-629
- WAY-161,503
- YM-348
Antagonists: Atypical antipsychotics: Clorotepine
- Clozapine
- Iloperidone
- Melperone
- Olanzapine
- Paliperidone
- Quetiapine
- Risperidone
- Sertindole
- Ziprasidone
- Zotepine; Typical antipsychotics: Chlorpromazine
- Loxapine
- Pimozide
- Pipamperone; Antidepressants: Agomelatine
- Amitriptyline
- Amoxapine
- Aptazapine
- Etoperidone
- Fluoxetine
- Mianserin
- Mirtazapine
- Nefazodone
- Nortriptyline
- Tedatioxetine
- Trazodone; Others: Adatanserin
- CEPC
- Cinanserin
- Cyproheptadine
- Deramciclane
- Dotarizine
- Eltoprazine
- Esmirtazapine
- FR-260,010
- Ketanserin
- Ketotifen
- Latrepirdine
- Metitepine/Methiothepin
- Methysergide
- Pizotifen
- Ritanserin
- RS-102,221
- S-14,671
- SB-200,646
- SB-206,553
- SB-221,284
- SB-228,357
- SB-242,084
- SB-243,213
- SDZ SER-082
- Xylamidine
|
|
|
|
- 5-HT3
- 5-HT4
- 5-HT5
- 5-HT6
- 5-HT7 ligands
|
|
|
5-HT3
|
- Agonists: Piperazines: BZP
- Quipazine; Tryptamines: 2-Methyl-5-HT
- 5-CT; Others: Chlorophenylbiguanide
- Butanol
- Ethanol
- Halothane
- Isoflurane
- RS-56812
- SR-57,227
- SR-57,227-A
- Toluene
- Trichloroethane
- Trichloroethanol
- Trichloroethylene
- YM-31636
Antagonists: Antiemetics: AS-8112
- Alosetron
- Azasetron
- Batanopride
- Bemesetron
- Cilansetron
- Dazopride
- Dolasetron
- Galanolactone
- Granisetron
- Lerisetron
- Ondansetron
- Palonosetron
- Ramosetron
- Renzapride
- Tropisetron
- Zacopride
- Zatosetron; Atypical antipsychotics: Clozapine
- Olanzapine
- Quetiapine; Tetracyclic antidepressants: Amoxapine
- Mianserin
- Mirtazapine; Others: CSP-2503
- ICS-205,930
- MDL-72,222
- Memantine
- Nitrous Oxide
- Ricasetron
- Sevoflurane
- Tedatioxetine
- Thujone
- Tropanserin
- Vortioxetine
- Xenon
|
|
|
5-HT4
|
- Agonists: Gastroprokinetic Agents: Cinitapride
- Cisapride
- Dazopride
- Metoclopramide
- Mosapride
- Prucalopride
- Renzapride
- Tegaserod
- Velusetrag
- Zacopride; Others: 5-MT
- BIMU8
- CJ-033,466
- PRX-03140
- RS-67333
- RS-67506
- SL65.0155
- Antagonists: GR-113,808
- GR-125,487
- L-Lysine
- Piboserod
- RS-39604
- RS-67532
- SB-203,186
- SB-204,070
|
|
|
5-HT5A
|
- Agonists: Lysergamides: Ergotamine
- LSD; Tryptamines: 5-CT; Others: Valerenic Acid
Antagonists: Asenapine
- Latrepirdine
- Metitepine/Methiothepin
- Ritanserin
- SB-699,551
* Note that the 5-HT5B receptor is not functional in humans.
|
|
|
5-HT6
|
- Agonists: Lysergamides: Dihydroergotamine
- Ergotamine
- Lisuride
- LSD
- Mesulergine
- Metergoline
- Methysergide; Tryptamines: 2-Methyl-5-HT
- 5-BT
- 5-CT
- 5-MT
- Bufotenin
- E-6801
- E-6837
- EMD-386,088
- EMDT
- LY-586,713
- N-Methyl-5-HT
- Tryptamine; Others: WAY-181,187
- WAY-208,466
Antagonists: Antidepressants: Amitriptyline
- Amoxapine
- Clomipramine
- Doxepin
- Mianserin
- Nortriptyline; Atypical antipsychotics: Aripiprazole
- Asenapine
- Clorotepine
- Clozapine
- Fluperlapine
- Iloperidone
- Olanzapine
- Tiospirone; Typical antipsychotics: Chlorpromazine
- Loxapine; Others: BGC20-760
- BVT-5182
- BVT-74316
- Cerlapirdine
- EGIS-12,233
- GW-742,457
- Ketanserin
- Latrepirdine
- Lu AE58054
- Metitepine/Methiothepin
- MS-245
- PRX-07034
- Ritanserin
- Ro04-6790
- Ro 63-0563
- SB-258,585
- SB-271,046
- SB-357,134
- SB-399,885
- SB-742,457
|
|
|
5-HT7
|
- Agonists: Lysergamides: LSD; Tryptamines: 5-CT
- 5-MT
- Bufotenin; Others: 8-OH-DPAT
- AS-19
- Bifeprunox
- E-55888
- LP-12
- LP-44
- RU-24,969
- Sarizotan
Antagonists: Lysergamides: 2-Bromo-LSD
- Bromocriptine
- Dihydroergotamine
- Ergotamine
- Mesulergine
- Metergoline
- Methysergide; Antidepressants: Amitriptyline
- Amoxapine
- Clomipramine
- Imipramine
- Maprotiline
- Mianserin; Atypical antipsychotics: Amisulpride
- Aripiprazole
- Asenapine
- Clorotepine
- Clozapine
- Olanzapine
- Risperidone
- Sertindole
- Tiospirone
- Ziprasidone
- Zotepine; Typical antipsychotics: Chlorpromazine
- Loxapine;
- Pimozide; Others: Butaclamol
- EGIS-12,233
- Ketanserin
- LY-215,840
- Metitepine/Methiothepin
- Ritanserin
- SB-258,719
- SB-258,741
- SB-269,970
- SB-656,104
- SB-656,104-A
- SB-691,673
- SLV-313
- SLV-314
- Spiperone
- SSR-181,507
- Vortioxetine
|
|
|
|
|
Reuptake inhibitors
|
|
|
SERT
|
- Selective serotonin reuptake inhibitors (SSRIs): Alaproclate
- Citalopram
- Dapoxetine
- Desmethylcitalopram
- Desmethylsertraline
- Escitalopram
- Femoxetine
- Fluoxetine
- Fluvoxamine
- Indalpine
- Ifoxetine
- Litoxetine
- Lubazodone
- Omiloxetine
- Panuramine
- Paroxetine
- Pirandamine
- RTI-353
- Seproxetine
- Sertraline
- Vilazodone
- Vortioxetine
- Zimelidine; Serotonin-norepinephrine reuptake inhibitors (SNRIs): Bicifadine
- Desvenlafaxine
- Duloxetine
- Eclanamine
- Levomilnacipran
- Milnacipran
- Sibutramine
- Venlafaxine; Serotonin-norepinephrine-dopamine reuptake inhibitors (SNDRIs): Brasofensine
- Diclofensine
- DOV-102,677
- DOV-21,947
- DOV-216,303
- NS-2359
- SEP-225289
- SEP-227,162
- Tedatioxetine
- Tesofensine; Tricyclic antidepressants (TCAs): Amitriptyline
- Butriptyline
- Cianopramine
- Clomipramine
- Desipramine
- Dosulepin
- Doxepin
- Imipramine
- Lofepramine
- Nortriptyline
- Pipofezine
- Protriptyline
- Trimipramine; Tetracyclic antidepressants (TeCAs): Amoxapine; Piperazines: Nefazodone
- Trazodone; Antihistamines: Brompheniramine
- Chlorphenamine
- Diphenhydramine
- Mepyramine/Pyrilamine
- Pheniramine
- Tripelennamine; Opioids: Pethidine
- Methadone
- Propoxyphene; Others: Cocaine
- CP-39,332
- Cyclobenzaprine
- Dextromethorphan
- Dextrorphan
- EXP-561
- Fezolamine
- Mesembrine
- Nefopam
- PIM-35
- Pridefine
- Roxindole
- SB-649,915
- Tofenacin
- Ziprasidone
|
|
|
VMAT
|
- Ibogaine
- Reserpine
- Tetrabenazine
|
|
|
|
|
Releasing agents
|
|
- Aminoindanes: 5-IAI
- AMMI
- ETAI
- MDAI
- MDMAI
- MMAI
- TAI; Aminotetralins: 6-CAT
- 8-OH-DPAT
- MDAT
- MDMAT; Oxazolines: 4-Methylaminorex
- Aminorex
- Clominorex
- Fluminorex; Phenethylamines (also Amphetamines, Cathinones, Phentermines, etc): 2-Methyl-MDA
- 4-CAB
- 4-FA
- 4-FMA
- 4-HA
- 4-MTA
- 5-APDB
- 5-Methyl-MDA
- 6-APDB
- 6-Methyl-MDA
- AEMMA
- Amiflamine
- BDB
- BOH
- Brephedrone
- Butylone
- Chlorphentermine
- Cloforex
- Amfepramone
- Metamfepramone
- DCA
- DFMDA
- DMA
- DMMA
- EBDB
- EDMA
- Ethylone
- Etolorex
- Fenfluramine (Dexfenfluramine, Levofenfluramine)
- Flephedrone
- IAP
- IMP
- Iofetamine
- Lophophine
- MBDB
- MDA
- MDEA
- MDHMA
- MDMA
- MDMPEA
- MDOH
- MDPEA
- Mephedrone
- Methedrone
- Methylone
- MMA
- MMDA
- MMDMA
- MMMA
- NAP
- Norfenfluramine
- 4-TFMA
- pBA
- pCA
- pIA
- PMA
- PMEA
- PMMA
- TAP; Piperazines: 2C-B-BZP
- 3-MeOPP
- BZP
- DCPP
- MBZP
- mCPP
- MDBZP
- MeOPP
- Mepiprazole
- pCPP
- pFPP
- pTFMPP
- TFMPP; Tryptamines: 4-Methyl-αET
- 4-Methyl-αMT
- 5-CT
- 5-MeO-αET
- 5-MeO-αMT
- 5-MT
- αET
- αMT
- DMT
- Tryptamine (itself); Others: Indeloxazine
- Tramadol
- Viqualine
|
|
|
|
Enzyme inhibitors
|
|
|
Anabolism
|
|
TPH
|
|
|
|
AAAD
|
- Benserazide
- Carbidopa
- Genistein
- Methyldopa
|
|
|
|
Catabolism
|
|
MAO
|
- Nonselective: Benmoxin
- Caroxazone
- Echinopsidine
- Furazolidone
- Hydralazine
- Indantadol
- Iproclozide
- Iproniazid
- Isocarboxazid
- Isoniazid
- Linezolid
- Mebanazine
- Metfendrazine
- Nialamide
- Octamoxin
- Paraxazone
- Phenelzine
- Pheniprazine
- Phenoxypropazine
- Pivalylbenzhydrazine
- Procarbazine
- Safrazine
- Tranylcypromine; MAO-A Selective: Amiflamine
- Bazinaprine
- Befloxatone
- Brofaromine
- Cimoxatone
- Clorgiline
- Eprobemide
- Esuprone
- Harmala alkaloids (Harmine
- Harmaline
- Tetrahydroharmine
- Harman
- Norharman, etc)
- Methylene Blue
- Metralindole
- Minaprine
- Moclobemide
- Pirlindole
- Sercloremine
- Tetrindole
- Toloxatone
- Tyrima
|
|
|
|
|
|
Others
|
|
|
Precursors
|
|
|
|
Cofactors
|
- Ferrous iron (Fe2+)
- Magnesium (Mg2+)
- Tetrahydrobiopterin
- Vitamin B3 (Niacin
- Nicotinamide → NADPH)
- Vitamin B6 (Pyridoxine
- Pyridoxamine
- Pyridoxal → Pyridoxal phosphate)
- Vitamin B9 (Folic Acid → Tetrahydrofolic acid)
- Vitamin C (Ascorbic acid)
- Zinc (Zn2+)
|
|
|
Others
|
- Activity enhancers: BPAP * PPAP; Reuptake enhancers: Tianeptine; Steroids: Anabolic-androgenic steroids
|
|
|
|
