グリシン輸送体1、グリシントランスポーター1

関: glycine plasma membrane transport protein、glycine transporter、glycine transporter 2、GlyT1

WordNet

move something or somebody around; usually over long distances
an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
transport commercially (同)send, ship
a long truck for carrying motor vehicles (同)car transporter
a crane for moving material with dispatch as in loading and unloading ships
the simplest amino acid found in proteins and the principal amino acid in sugar cane
genus of Asiatic erect or sprawling herbs: soya bean (同)genus Glycine

PrepTutorEJDIC

(ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
自動車運搬用大型トラック

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/18 02:21:16」(JST)

wiki en

[Wiki en表示]

Sodium- and chloride-dependent glycine transporter 1 is a protein that in humans is encoded by the SLC6A9 gene.^[1]^[2]^[3]

Selective inhibitors

Elevation of extracellular synaptic glycine concentration by blockade of GlyT1 has been hypothesized to potentiate NMDA receptor function in vivo and to represent a rational approach for the treatment of schizophrenia and cognitive disorders.

ASP2535^[4]
Bitopertin (RG1678), which has entered phase II trials for the treatment of schizophrenia^[5]
Org 25935

References

^ Kim KM, Kingsmore SF, Han H, Yang-Feng TL, Godinot N, Seldin MF, Caron MG, Giros B (Jun 1994). "Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes". Mol Pharmacol 45 (4): 608–17. PMID 8183239.
^ Jones EM, Fernald A, Bell GI, Le Beau MM (Nov 1995). "Assignment of SLC6A9 to human chromosome band 1p33 by in situ hybridization". Cytogenet Cell Genet 71 (3): 211. doi:10.1159/000134110. PMID 7587377.
^ "Entrez Gene: SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9".
^ Harada K, Nakato K, Yarimizu J, Yamazaki M, Morita M, Takahashi S, Aota M, Saita K, Doihara H, Sato Y, Yamaji T, Ni K, Matsuoka N. A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease. European Journal of Pharmacology. 2012 Apr 20. PMID 22542656
^ Pinard E, Alanine A, Alberati D, Bender M, Borroni E, Bourdeaux P, Brom V, Burner S, Fischer H, Hainzl D, Halm R, Hauser N, Jolidon S, Lengyel J, Marty HP, Meyer T, Moreau JL, Mory R, Narquizian R, Nettekoven M, Norcross RD, Puellmann B, Schmid P, Schmitt S, Stalder H, Wermuth R, Wettstein JG, Zimmerli D (June 2010). "Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia". J. Med. Chem. 53 (12): 4603–14. doi:10.1021/jm100210p. PMID 20491477.

UpToDate Contents

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1. Congenital disorders of creatine metabolism
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4. 先天性および後天性鉄芽球性貧血の原因 causes of congenital and acquired sideroblastic anemias
5. 鉄のバランス調節 regulation of iron balance

English Journal

A novel liquid chromatography/tandem mass spectrometry method for the quantification of glycine as biomarker in brain microdialysis and cerebrospinal fluid samples within 5min.

Voehringer P, Fuertig R, Ferger B.SourceCNS Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397 Biberach, Germany.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2013 Nov 15;939:92-7. doi: 10.1016/j.jchromb.2013.09.011. Epub 2013 Sep 14.
Glycine is an important amino acid neurotransmitter in the central nervous system (CNS) and a useful biomarker to indicate biological activity of drugs such as glycine reuptake inhibitors (GRI) in the brain. Here, we report how a liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for t
PMID 24121745

Psychopharmacology of the negative symptoms: Current status and prospects for progress.

Davis MC, Horan WP, Marder SR.SourceDepartment of Veterans Affairs, VISN 22 Mental Illness Research, Education, and Clinical Center, Los Angeles, CA, USA; UCLA Semel Institute of Neuroscience and Human Behavior, Los Angeles, CA, USA.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.Eur Neuropsychopharmacol.2013 Nov 4. pii: S0924-977X(13)00307-6. doi: 10.1016/j.euroneuro.2013.10.010. [Epub ahead of print]
The past decade has witnessed a resurgence of interest in the development of novel pharmacological agents to treat the negative symptoms of schizophrenia. This review provides an overview of pharmacological approaches that have been evaluated as potential treatments and describes the emergence of se
PMID 24252823

SSR504734 enhances basal expression of prepulse inhibition but exacerbates the disruption of prepulse inhibition by apomorphine.

Singer P, Zhang W, Yee BK.SourceLaboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology (ETH) Zurich, Schorenstrasse 16, Schwerzenbach, 8603, Switzerland.
Psychopharmacology.Psychopharmacology (Berl).2013 Nov;230(2):309-17. doi: 10.1007/s00213-013-3160-3. Epub 2013 Jun 5.
RATIONALE: Inhibition of glycine transporter 1 (GlyT1) elevates extracellular glycine and can thus increase N-methyl-D-aspartate receptor (NMDAR) excitability in the brain. The potent GlyT1 inhibitor, SSR504734, has also been shown to potentiate the behavioral effects of direct and indirect dopamine
PMID 23736281

Japanese Journal

統合失調症のNMDA受容体仮説と新しい治療法 (特集 WFSBP2013シンポジウム)

橋本謙二
日本生物学的精神医学会誌 = Japanese journal of biological psychiatry 25(2), 109-112, 2014
NAID 40020158172

Immunohistochemical Localization of an Isoform of TRK-Fused Gene-Like Protein in the Rat Retina

, , , ,
ACTA HISTOCHEMICA ET CYTOCHEMICA 47(2), 75-83, 2014
… In addition, the rTFG-like immunopositive ACs were actually glycine transporter 1-positive glycinergic or glutamate decarboxylase-positive GABAergic ACs. …
NAID 130003390851

統合失調症のNMDA受容体機能低下仮説に基づいた新規治療薬の開発状況

橋本謙二
臨床精神医学 42(7), 927-934, 2013-07
NAID 40019730687

「glycine plasma membrane transport protein」

Solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Identifiers
Symbols	SLC6A9 ; GLYT1
External IDs	OMIM: 601019 MGI: 95760 HomoloGene: 5050 ChEMBL: 2337 GeneCards: SLC6A9 Gene
Gene ontology
Molecular function	• neurotransmitter:sodium symporter activity; • glycine:sodium symporter activity;
Cellular component	• plasma membrane; • integral component of plasma membrane; • membrane;
Biological process	• amino acid transmembrane transport; • transport; • neurotransmitter transport; • glycine transport; • transmembrane transport;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

細胞膜グリシントランスポーター、細胞膜グリシン輸送体、グリシントランスポーター、グリシン輸送体

関: glycine transporter、glycine transporter 1、glycine transporter 2

「グリシン輸送体1」

　　[★]

英: glycine transporter 1、GlyT1
関: 細胞膜グリシントランスポーター、グリシントランスポーター、グリシントランスポーター1、グリシン輸送体2

「glycine transporter 2」

　　[★]

グリシン輸送体2、グリシントランスポーター2

関: glycine plasma membrane transport protein、glycine transporter、glycine transporter 1、GlyT2

「glycine transporter」

　　[★]

グリシントランスポーター、グリシン輸送体

関: glycine plasma membrane transport protein、glycine transporter 1、glycine transporter 2

「グリシントランスポーター1」

　　[★]

英: glycine transporter 1
関: グリシン輸送体1

「transport」

　　[★]

n.

輸送、運搬

v.

輸送する、運搬する、運ぶ

関: bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation

「glycine transporter」

　　[★]

グリシントランスポーター、グリシン輸送体

関: glycine plasma membrane transport protein、glycine transporter 1、glycine transporter 2

「transporter」

　　[★] トランスポーター

関: translocator、transport protein、transporter protein

[pmid8183239-1] Kim KM, Kingsmore SF, Han H, Yang-Feng TL, Godinot N, Seldin MF, Caron MG, Giros B (Jun 1994). "Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes". Mol Pharmacol 45 (4): 608–17. PMID 8183239.

[pmid7587377-2] Jones EM, Fernald A, Bell GI, Le Beau MM (Nov 1995). "Assignment of SLC6A9 to human chromosome band 1p33 by in situ hybridization". Cytogenet Cell Genet 71 (3): 211. doi:10.1159/000134110. PMID 7587377.

[entrez-3] "Entrez Gene: SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9".

[4] Harada K, Nakato K, Yarimizu J, Yamazaki M, Morita M, Takahashi S, Aota M, Saita K, Doihara H, Sato Y, Yamaji T, Ni K, Matsuoka N. A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease. European Journal of Pharmacology. 2012 Apr 20. PMID 22542656

[pmid20491477-5] Pinard E, Alanine A, Alberati D, Bender M, Borroni E, Bourdeaux P, Brom V, Burner S, Fischer H, Hainzl D, Halm R, Hauser N, Jolidon S, Lengyel J, Marty HP, Meyer T, Moreau JL, Mory R, Narquizian R, Nettekoven M, Norcross RD, Puellmann B, Schmid P, Schmitt S, Stalder H, Wermuth R, Wettstein JG, Zimmerli D (June 2010). "Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia". J. Med. Chem. 53 (12): 4603–14. doi:10.1021/jm100210p. PMID 20491477.

リンク元	「glycine plasma membrane transport protein」「グリシン輸送体1」「glycine transporter 2」「glycine transporter」「グリシントランスポーター1」
関連記事	「transport」「glycine transporter」「transporter」

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案内

glycine transporter 1

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「glycine plasma membrane transport protein」

「グリシン輸送体1」

「glycine transporter 2」

「glycine transporter」

「グリシントランスポーター1」

「transport」

「glycine transporter」

「transporter」