glucocorticoid response element

グルココルチコイド応答エレメント GRE

WordNet

1. a straight line that generates a cylinder or cone
2. one of four substances thought in ancient and medieval cosmology to constitute the physical universe; "the alchemists believed that there were four elements"
3. the situation in which you are happiest and most effective; "in your element"
4. the most favorable environment for a plant or animal; "water is the element of fishes"
5. a result; "this situation developed in response to events in Africa"
6. a phrase recited or sung by the congregation following a versicle by the priest or minister
7. the manner in which an electrical or mechanical device responds to an input signal or a range of input signals
8. a steroid hormone that is produced by the adrenal cortex of animals; affects functioning of gonads and has anti-inflammatory activity
9. violent or severe weather (viewed as caused by the action of the four elements); "they felt the full fury of the elements"

PrepTutorEJDIC

1. 〈C〉(物質を構成する)元素 / 〈C〉《修飾語[句]を伴って》(…の)(基本的な)『要素』,『成分』;《しばしば複数形で》構成分子 / 〈C〉(生物に固有の)生息場所,環境;(人の)適所,本領 / 〈C〉《古》四大(しだい)[元素](自然界の基本的構成要素と考えられていた地(earth)・水(water)・風(air)・火(fire)の4大要素の一つ) / 《the elements》(雨・風・雪などの)自然力・風雨,(特に)悪天候 / 《the elements》(学問の)原理,初歩,概論
2. 〈C〉(…に対する)『返事』,『返答』《+『to』+『名』》 / 〈C〉〈U〉(…に対する)『反応』,『反響』《『to』+『名』》 / 〈C〉応答歌,応唱(牧師にならって合唱隊・会衆が短い祈り・歌を応答すること)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/14 09:44:37」(JST)

wiki en

[Wiki en表示]

A hormone response element (HRE) is a short sequence of DNA within the promoter of a gene that is able to bind a specific hormone receptor complex and therefore regulate transcription. The sequence is most commonly a pair of inverted repeats separated by three nucleotides, which also indicates that the receptor binds as a dimer. Specifically, HRE responds to steroid hormones, as the activated steroid receptor is the transcription factor binding HRE. This regulates the transcription of genes signaled by the steroid hormone.

A gene may have many different response elements, allowing complex control to be exerted over the level and rate of transcription.

HRE are used in transgenic animal cells as inducers of gene expression.

Examples of HREs include estrogen response elements (EREs) and androgen response elements (AREs).

References

UpToDate Contents

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• 1. ステロイド抵抗性喘息 glucocorticoid resistant asthma
• 2. ステロイドの中断 glucocorticoid withdrawal
• 3. ステロイドの全身投与の主な副作用 major side effects of systemic glucocorticoids
• 4. 早産リスクのある女性における出産前のステロイドの使用 antenatal use of corticosteroids in women at risk for preterm delivery
• 5. 免疫系に対するステロイドの影響 glucocorticoid effects on the immune system

English Journal

• Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation.

• Yehuda R1, Daskalakis NP2, Bierer LM2, Bader HN2, Klengel T3, Holsboer F4, Binder EB3.
• Biological psychiatry.Biol Psychiatry.2016 Sep 1;80(5):372-80. doi: 10.1016/j.biopsych.2015.08.005. Epub 2015 Aug 12.
• BACKGROUND: The involvement of epigenetic mechanisms in intergenerational transmission of stress effects has been demonstrated in animals but not in humans.METHODS: Cytosine methylation within the gene encoding for FK506 binding protein 5 (FKBP5) was measured in Holocaust survivors (n = 32), their a
• PMID 26410355

• Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin Architecture Changes.

• Dong C1, Virtucio C2, Zemska O2, Baltazar G2, Zhou Y2, Baia D2, Jones-Iatauro S2, Sexton H2, Martin S2, Dee J2, Mak Y2, Meewan M2, Rock F2, Akama T2, Jarnagin K2.
• The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2016 Sep;358(3):413-22. doi: 10.1124/jpet.116.232819. Epub 2016 Jun 27.
• Psoriasis and atopic dermatitis are skin diseases affecting millions of patients. Here, we characterize benzoxaborole phosphodiesterase (PDE)-4 inhibitors, a new topical class that has demonstrated therapeutic benefit for psoriasis and atopic dermatitis in phase 2 or phase 3 studies. Crisaborole [AN
• PMID 27353073

• Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity.

• Schöne S1, Jurk M1, Helabad MB2, Dror I3, Lebars I4, Kieffer B4, Imhof P2, Rohs R3, Vingron M1, Thomas-Chollier M5, Meijsing SH1.
• Nature communications.Nat Commun.2016 Sep 1;7:12621. doi: 10.1038/ncomms12621.
• The glucocorticoid receptor (GR) binds as a homodimer to genomic response elements, which have particular sequence and shape characteristics. Here we show that the nucleotides directly flanking the core-binding site, differ depending on the strength of GR-dependent activation of nearby genes. Our st
• PMID 27581526

Japanese Journal

• Molecular regulation of corticotropin-releasing hormone gene expression in parvocellular neurons of the hypothalamic paraventricular nucleus (Special issue : proceedings of parvo- and magnocellular symposium in Sendai : creating a new stream of neuroendocrinology)

• Interdisciplinary Information Sciences 21(3), 273-282, 2015-09
• NAID 110009966537

• Kaposi's sarcoma-associated herpesvirus-encoded LANA associates with glucocorticoid receptor and enhances its transcriptional activities

• Biochemical and biophysical research communications 463(3), 395-400, 2015-07-31
• NAID 120005820702

• ステロイド薬の作用機序

• 皮膚の科学 13(Suppl.21), 15-20, 2014
• NAID 130005078472

Related Links

• Glucocorticoid Response Element (Molecular Biology)

The glucocorticoid response element (GRE) is found in a number of different target genes that respond to glucocorticoid. It is a short element with the sequence where R = purine, (ie, A or G), Y = pyrimidine (ie, C or T), and N ...

• Identification of a functional glucocorticoid response element ...

Identification of a functional glucocorticoid response element in the promoter of the cyclin-dependent kinase inhibitor p57Kip2 K Alheim1,2, J Corness 1,MKRSamuelsson 1, L-G Bladh , T Murata , T Nilsson and S Okret1 1Department ...

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★リンクテーブル★

リンク元	「GRE」「グルココルチコイド応答エレメント」
拡張検索	「glucocorticoid response elements」
関連記事	「element」「response」「glucocorticoid」

「GRE」

　　[★]

• グルココルチコイド応答エレメント glucocorticoid response element
• グラディエントエコー法 gradient echo

「グルココルチコイド応答エレメント」

　　[★]

英

glucocorticoid response element GRE

同

グルココルチコイド応答配列

「glucocorticoid response elements」

　　[★] グルココルチコイド応答エレメント、GREs

「element」

　　[★]

• n.

• 要素、成分、素。(構成)分子。(科学)元素、(数)(集合の)要素、元素、素。(行列の)要素、成分。(図形を火ｔが千都来る)要素。(文法の)要素
• (電子)素子、(光学)素子

関

basal、bases、basic、basis、component、composition、constituent、elementary、factor、fundamentals、ingredient、moiety

　 　 　 　 　

「response」

　　[★]

• n.

• 返答、応答
• 反応、感応、反響。(刺激に対する)反応

　 　 　 　

「glucocorticoid」

　　[★] 糖質コルチコイド