グルココルチコイド応答エレメント、GREs
WordNet
- a straight line that generates a cylinder or cone
- one of four substances thought in ancient and medieval cosmology to constitute the physical universe; "the alchemists believed that there were four elements"
- the situation in which you are happiest and most effective; "in your element"
- the most favorable environment for a plant or animal; "water is the element of fishes"
- a result; "this situation developed in response to events in Africa"
- a phrase recited or sung by the congregation following a versicle by the priest or minister
- the manner in which an electrical or mechanical device responds to an input signal or a range of input signals
- a steroid hormone that is produced by the adrenal cortex of animals; affects functioning of gonads and has anti-inflammatory activity
- violent or severe weather (viewed as caused by the action of the four elements); "they felt the full fury of the elements"
PrepTutorEJDIC
- 〈C〉(物質を構成する)元素 / 〈C〉《修飾語[句]を伴って》(…の)(基本的な)『要素』,『成分』;《しばしば複数形で》構成分子 / 〈C〉(生物に固有の)生息場所,環境;(人の)適所,本領 / 〈C〉《古》四大(しだい)[元素](自然界の基本的構成要素と考えられていた地(earth)・水(water)・風(air)・火(fire)の4大要素の一つ) / 《the elements》(雨・風・雪などの)自然力・風雨,(特に)悪天候 / 《the elements》(学問の)原理,初歩,概論
- 〈C〉(…に対する)『返事』,『返答』《+『to』+『名』》 / 〈C〉〈U〉(…に対する)『反応』,『反響』《『to』+『名』》 / 〈C〉応答歌,応唱(牧師にならって合唱隊・会衆が短い祈り・歌を応答すること)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/08 13:41:54」(JST)
[Wiki en表示]
A hormone response element (HRE) is a short sequence of DNA within the promoter of a gene that is able to bind a specific hormone receptor complex and therefore regulate transcription.[1] The sequence is most commonly a pair of inverted repeats separated by three nucleotides, which also indicates that the receptor binds as a dimer. Specifically, HRE responds to steroid hormones, as the activated steroid receptor is the transcription factor binding HRE. This regulates the transcription of genes signaled by the steroid hormone.
A gene may have many different response elements, allowing complex control to be exerted over the level and rate of transcription.[2]
HRE are used in transgenic animal cells as inducers of gene expression.
References
- ^ "Steroid Hormone Receptors and their Response Elements". Retrieved 2006-11-09.
- ^ Monty Krieger; Matthew P Scott; Matsudaira, Paul T.; Lodish, Harvey F.; Darnell, James E.; Lawrence Zipursky; Kaiser, Chris; Arnold Berk (2003). Molecular Cell Biology, Fifth Edition. San Francisco: W. H. Freeman. p. 973 pages. ISBN 0-7167-4366-3.
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Histone H3 K27 acetylation marks a potent enhancer element on the adipogenic master regulator gene Pparg2.
- Ramlee MK1, Zhang Q, Idris M, Peng X, Sim CK, Han W, Xu F.
- Cell cycle (Georgetown, Tex.).Cell Cycle.2014 Nov 1;13(21):3414-22. doi: 10.4161/15384101.2014.953424.
- PPARγ2 is expressed almost exclusively in adipose tissue and plays a central role in adipogenesis. Despite intensive studies over the last 2 decades, the mechanism regulating the expression of the Pparg2 gene, especially the role of cis-regulatory elements, is still not completely understood. Here,
- PMID 25485585
- Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers.
- Miller GE1, Murphy ML2, Cashman R3, Ma R3, Ma J4, Arevalo JM4, Kobor MS5, Cole SW4.
- Brain, behavior, and immunity.Brain Behav Immun.2014 Oct;41:191-9. doi: 10.1016/j.bbi.2014.05.016. Epub 2014 Jun 2.
- Chronic stress is associated with morbidity and mortality from numerous conditions, many of whose pathogenesis involves persistent inflammation. Here, we examine how chronic stress influences signaling pathways that regulate inflammation in monocytes. The sample consisted of 33 adults caring for a f
- PMID 25242587
- Rapid fluorescent detection of (anti)androgens with spiggin-gfp medaka.
- Sébillot A1, Damdimopoulou P, Ogino Y, Spirhanzlova P, Miyagawa S, Du Pasquier D, Mouatassim N, Iguchi T, Lemkine GF, Demeneix BA, Tindall AJ.
- Environmental science & technology.Environ Sci Technol.2014 Sep 16;48(18):10919-28. doi: 10.1021/es5030977. Epub 2014 Aug 29.
- Widespread environmental antiandrogen contamination has been associated with negative impacts on biodiversity and human health. In particular, many pesticides are antiandrogenic, creating a need for robust and sensitive environmental monitoring. Our aim was to develop a sensitive and specific transg
- PMID 25171099
Japanese Journal
- Fibroblast growth factor 2 regulates bone sialoprotein gene transcription in human breast cancer cells
- Li Zhengyang,Wang Zhitao,Li Xinyue,Sasaki Yoko,Wang Shuang,Araki Shouta,Mezawa Masaru,Takai Hideki,Nakayama Youhei,Ogata Yorimasa
- Journal of Oral Science 52(1), 125-132, 2010
- … We previously reported that FGF2 regulates BSP gene transcription through the FGF2 response element (FRE) and activator protein 1 (AP1) binding site overlapping with the glucocorticoid response element in the rat BSP gene promoter. … These studies demonstrate that FGF2 stimulates BSP transcription in MCF7 human breast cancer cells by targeting the AP1 and CRE2 elements in the human BSP gene promoter. …
- NAID 130000253615
- Gastroprotective Role of Glucocorticoid Hormones
- FILARETOVA Ludmila,PODVIGINA Tatiana,BAGAEVA Tatiana,BOBRYSHEV Peter,TAKEUCHI Koji
- Journal of pharmacological sciences 104(3), 195-201, 2007-07-20
- … The findings overviewed here support the idea that glucocorticoid hormones released in response to acute stress or NSAIDs act as gastroprotective substances and exert many of the same actions in the stomach as prostaglandins (PGs) and nitric oxide (NO) as well as capsaicin-sensitive afferent neurons. …
- NAID 10024314567
Related Links
- In cells that have not been exposed to steroid, this receptor exists in the cytoplasm complexed to a 90-kDa heat-inducible protein, hsp90. The association with hsp90 anchors the glucocorticoid receptor in the cytoplasm and prevents ...
- 1. J Invest Dermatol. 1997 Jun;108(6):938-42. Identification of novel glucocorticoid-response elements in human elastin promoter and demonstration of nucleotide sequence specificity of the receptor binding. Del Monaco M(1), Covello ...
★リンクテーブル★
[★]
グルココルチコイド応答エレメント、glucocorticoid response elements
[★]
- 要素、成分、素。(構成)分子。(科学)元素、(数)(集合の)要素、元素、素。(行列の)要素、成分。(図形を火tが千都来る)要素。(文法の)要素
- (電子)素子、(光学)素子
- 関
- basal、bases、basic、basis、component、composition、constituent、elementary、factor、fundamentals、ingredient、moiety
[★]
[★]
糖質コルチコイド