fatty acyl-CoA

• 脂肪酸アシル補酵素A、脂肪酸アシルCoA

関

acyl-CoA、acyl-coenzyme A

WordNet

1. having an (over)abundance of flesh; "he hadnt remembered how fat she was"
2. a soft greasy substance occurring in organic tissue and consisting of a mixture of lipids (mostly triglycerides); "pizza has too much fat"
3. marked by great fruitfulness; "fertile farmland"; "a fat land"; "a productive vineyard"; "rich soil" (同)fertile, productive, rich
4. lucrative; "a juicy contract"; "a nice fat job" (同)juicy
5. having a relatively large diameter; "a fat rope"
6. the 3rd letter of the Roman alphabet (同)c
7. (music) the keynote of the scale of C major
8. a general-purpose programing language closely associated with the UNIX operating system
9. containing or composed of fat; "fatty food"; "fat tissue" (同)fat
10. any group or radical of the form RCO- where R is an organic group; "an example of the acyl group is the acetyl group" (同)acyl_group

PrepTutorEJDIC

1. 『脂肪』,脂肪分 / (動物の)あぶら身 / (料理用の)油,ヘット / 肥満,太り過ぎ / 『太った』,肥満した / 『脂肪の多い』 / たっぷりとはいった,分厚い / もうかる / (土地が)肥えた / …‘を'太らせる / ふとる,肥える
2. carbonの化学記号
3. 脂肪質の,脂肪の多い / でぶ,太っちょ
4. cobaltの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/20 12:20:46」(JST)

wiki en

[Wiki en表示]

Fatty acyl-CoA esters are fatty acid derivatives formed of one fatty acid, a 3'-phospho-AMP linked to phosphorylated pantothenic acid (Vitamin B₅) and cysteamine.

Long-chain acyl-CoA esters are substrates for a number of important enzymatic reactions and play a central role in the regulation of metabolism as allosteric regulators of several enzymes. To participate in specific metabolic processes, fatty acids must first be activated by being joined in thioester linkage (R-CO-SCoA) to the -SH group of coenzyme A, where R is a fatty carbon chain. The thioester bond is a high energy bond.

The activation reaction normally occurs in the endoplasmic reticulum or the outer mitochondrial membrane. This is an ATP-requiring reaction (fatty acyl-CoA synthase), yielding AMP and pyrophosphate (PPi). Different enzymes are specific for fatty acids of different chain length. Then, the acyl CoA esters are transported in mitochondria. They are converted to fatty acyl carnitine by carnitine acyl transferase I, an enzyme of the inner leaflet of the outer mitochondrial membrane. Fatty acyl carnitine is then transported by an antiport in exchange for free carnitine to the inner surface of the inner mitochondrial membrane. There carnitine acyl transferase II reverses the process, producing fatty acyl-CoA and carnitine. This shuttle mechanism is required only for longer chain fatty acids. Once inside the mitochondrial matrix, the fatty acyl-CoA derivatives are degraded by a series of reactions that release acetyl-CoA and leads to the production of NADH and FADH2. There are four steps in fatty acid oxidation pathway; oxidation, hydration, oxidation, and thiolysis. It requires 7 rounds of this pathway to degrade palmitate (a C16 fatty acid).

References

UpToDate Contents

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• 1. 脂質およびプリン代謝障害による代謝性ミオパチー metabolic myopathies caused by disorders of lipid and purine metabolism
• 2. 先天性代謝異常：分類 inborn errors of metabolism classification
• 3. 妊娠時の急性脂肪肝 acute fatty liver of pregnancy
• 4. 乳児および小児における低血糖症の原因 causes of hypoglycemia in infants and children
• 5. ペルオキシソーム病 peroxisomal disorders

English Journal

• Gene Expression Patterns Associated with Peroxisome Proliferator-activated Receptor (PPAR) Signaling in the Longissimus dorsi of Hanwoo (Korean Cattle).

• Lim D1, Chai HH1, Lee SH1, Cho YM1, Choi JW1, Kim NK1.
• Asian-Australasian journal of animal sciences.Asian-Australas J Anim Sci.2015 Aug;28(8):1075-83. doi: 10.5713/ajas.14.0811.
• Adipose tissue deposited within muscle fibers, known as intramuscular fat (IMF or marbling), is a major determinant of meat quality and thereby affects its economic value. The biological mechanisms that determine IMF content are therefore of interest. In this study, 48 genes involved in the bovine p
• PMID 26104514

• Chlamydia trachomatis growth depends on eukaryotic cholesterol esterification and is affected by Acyl-CoA:cholesterol acyltransferase inhibition.

• Peters J1, Byrne GI2.
• Pathogens and disease.Pathog Dis.2015 Aug;73(6). pii: ftv028. doi: 10.1093/femspd/ftv028. Epub 2015 Apr 15.
• Chlamydia trachomatis is auxotrophic for a variety of essential metabolites. Inhibitors that interrupt host cell catabolism may inhibit chlamydial growth and reveal Chlamydia metabolite requirements. We used the known indoleamine-2,3-dioxygenase (IDO)-inhibitor 4-phenyl imidazole (4-PI) to reverse I
• PMID 25883118

• Functional characterization of two single nucleotide polymorphisms of acyl-coenzyme A:cholesterol acyltransferase 2.

• He X1, Leow KY2, Yang H3, Heng CK4.
• Gene.Gene.2015 Jul 25;566(2):236-41. doi: 10.1016/j.gene.2015.04.061. Epub 2015 Apr 24.
• BACKGROUND: Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) plays a critical role in the formation of cholesteryl esters from cholesterol and fatty acids, and is a potential target for treating hypercholesterolemia. We recently reported the significant effects of two human ACAT2 gene polymorph
• PMID 25917363

Japanese Journal

• Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases

• Scientific reports 6, 25469, 2016-05-03
• NAID 120005819300

• Comparative Genomics of Syntrophic Branched-Chain Fatty Acid Degrading Bacteria

• Microbes and Environments advpub(0), 288-292, 2016
• NAID 130005164817

• Expression of Lipid Metabolism-Associated Genes in Male and Female White Feather Chicken

• The Journal of Poultry Science 53(2), 118-123, 2016
• NAID 130005147705

Related Links

• Fatty acyl-CoA assay - Cyberlipid Center-Resource site for ...

FATTY ACYL CoA Because the acyl-CoA are present in nanomole amounts in tissues, and the common glycerol esters are present in micromole amounts, a very selective assay procedure is required to determine specifically the ...

• Fatty-acyl-CoA synthaseとは - goo Wikipedia (ウィキペディア)

Fatty-acyl-CoA Synthase, or more commonly known as yeast fatty acid synthase (and not to be confused with Long Chain fatty acyl-CoA synthetase), is an enzyme complex responsible for fatty acid biosynthesis, and is of Type I ...

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★リンクテーブル★

リンク元	「acyl-coenzyme A」「acyl-CoA」「脂肪酸アシル補酵素A」
関連記事	「C」「fatty」「CoA」「COA」「fat」

「acyl-coenzyme A」

　　[★]

アシル補酵素A、アシルコエンザイムA、アシルCoA

関

acyl-CoA、fatty acyl-CoA

「acyl-CoA」

　　[★]

• アシルCoA、アシル補酵素A

関

acyl-coenzyme A、fatty acyl-CoA

「脂肪酸アシル補酵素A」

　　[★]

英

fatty acyl-CoA

関

脂肪酸アシルCoA

「C」

　　[★]

• 炭素 carbon
• シトシン cytosine
• システイン cysteine
• シチジン
• セルシウス度 摂氏 degrees Celsius degree C
• 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語

　 　 　 　

「fatty」

　　[★]

• adj.

• 脂肪性の、脂肪質の

関

adipose、aliphatic、lipogenous

　 　

「CoA」

　　[★]

• 大動脈縮窄症 coactation of the aorta
• 補酵素A coenzyme A

「COA」

　　[★] 補酵素A coenzyme A CoA

「fat」

　　[★] 脂肪