脂肪酸結合蛋白質
WordNet
- executed with proper legal authority; "a binding contract"
- the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
- strip sewn over or along an edge for reinforcement or decoration
- the capacity to attract and hold something
- having an (over)abundance of flesh; "he hadnt remembered how fat she was"
- a soft greasy substance occurring in organic tissue and consisting of a mixture of lipids (mostly triglycerides); "pizza has too much fat"
- marked by great fruitfulness; "fertile farmland"; "a fat land"; "a productive vineyard"; "rich soil" (同)fertile, productive, rich
- lucrative; "a juicy contract"; "a nice fat job" (同)juicy
- having a relatively large diameter; "a fat rope"
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- containing or composed of fat; "fatty food"; "fat tissue" (同)fat
PrepTutorEJDIC
- 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
- 『脂肪』,脂肪分 / (動物の)あぶら身 / (料理用の)油,ヘット / 肥満,太り過ぎ / 『太った』,肥満した / 『脂肪の多い』 / たっぷりとはいった,分厚い / もうかる / (土地が)肥えた / …‘を'太らせる / ふとる,肥える
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
- 蛋白(たんばく)質
- 脂肪質の,脂肪の多い / でぶ,太っちょ
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/04/03 15:09:01」(JST)
[Wiki en表示]
The fatty-acid-binding proteins (FABPs) are a family of carrier proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids.[1][2] These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes.[3] Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR.[4] Levels of fatty-acid-binding protein have been shown to decline with ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity.[5]
Family members[edit]
Members of this family include:
Protein name |
Gene |
Tissue distribution |
Comment |
FABP 1 |
FABP1 |
liver |
|
FABP 2 |
FABP2 |
intestinal |
|
FABP 3 |
FABP3 |
muscle and heart |
mammary-derived growth inhibitor |
FABP 4 |
FABP4 |
adipocyte |
|
FABP 5 |
FABP5 |
epidermal |
psoriasis-associated |
FABP 6 |
FABP6 |
ileal |
gastrotropin |
FABP 7 |
FABP7 |
brain |
|
FABP 8 |
PMP2 |
peripheral nervous system |
peripheral myelin protein 2 |
FABP 9 |
FABP9 |
testis |
FABP 11 |
fabp11 |
restricted to fishes |
FABP 12 |
FABP12 |
presence shown in human retinoblastoma cell lines, rodent retina and testis (Liu et al. 2008). |
FABP 5-like 1 |
FABP5L1 |
|
|
FABP 5-like 2 |
FABP5L2 |
|
|
FABP 5-like 3 |
FABP5L3 |
|
|
FABP 5-like 4 |
FABP5L4 |
|
|
FABP 5-like 5 |
FABP5L5 |
|
|
FABP 5-like 6 |
FABP5L6 |
|
|
FABP 5-like 7 |
FABP5L7 |
|
|
References[edit]
- ^ Chmurzyńska A (2006). "The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism". J. Appl. Genet. 47 (1): 39–48. doi:10.1007/BF03194597. PMID 16424607.
- ^ Smathers RL, Petersen DR (2011). "The human fatty acid-binding protein family: evolutionary divergences and functions". Hum Genomics 5 (1): 170–191. doi:10.1186/1479-7364-5-3-170. PMID 21504868.
- ^ Weisiger RA (2002). "Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of their ligands". Mol. Cell. Biochem. 239 (1-2): 35–43. doi:10.1023/A:1020550405578. PMID 12479566.
- ^ Tan NS, Shaw NS, Vinckenbosch N, Liu P, Yasmin R, Desvergne B, Wahli W, Noy N (2002). "Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription". Mol. Cell. Biol. 22 (14): 5114–27. doi:10.1128/MCB.22.14.5114-5127.2002. PMC 139777. PMID 12077340.
- ^ Pu L, Igbavboa U, Wood WG, Roths JB, Kier AB, Spener F, Schroeder F (August 1999). "Expression of fatty acid binding proteins is altered in aged mouse brain". Mol. Cell. Biochem. 198 (1-2): 69–78. doi:10.1023/A:1006946027619. PMID 10497880.
External links[edit]
- Fatty Acid-Binding Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
Proteins: carrier proteins
|
|
Fatty acid |
- FABP1
- FABP2
- FABP3
- FABP4
- FABP5
- FABP6
- FABP7
|
|
Hormone |
- peptide hormone: Follistatin
- Growth hormone binding protein
- Insulin-like growth factor binding protein
- IGFBP1
- IGFBP2
- IGFBP3
- IGFBP4
- IGFBP5
- IGFBP6
- IGFBP7
- Neurophysins
- steroid hormone: Sex hormone binding globulin/Androgen binding protein
- Transcortin
- Thyroxine-binding globulin
- Transthyretin
|
|
Metal/element |
- calcium
- Calcium-binding protein
- Calmodulin-binding proteins
- copper
- iron
- Iron-binding proteins
- Transferrin receptor
|
|
Vitamin |
- Retinol binding protein
- Transcobalamin
|
|
Other |
- Acyl carrier protein
- Adaptor protein
- Cholesterylester transfer protein
- F-box protein
- GTP-binding protein
- Latent TGF-beta binding protein
- Light-harvesting complex
- Major urinary proteins
- Membrane transport protein
- Odorant binding protein
|
|
B proteins: BY STRUCTURE: membrane, globular (en, ca, an), fibrous
|
|
UpToDate Contents
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English Journal
- Cardiodetect rapid test for the diagnosis of early acute myocardial infarction.
- Liang Y, Chan CP, Cheung KY, Cautherley GW, Glatz JF, Renneberg R, Zhu J.Sourcea Department of Emergency , Cardiovascular Institute & FuWai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , P. R. China.
- Journal of immunoassay & immunochemistry.J Immunoassay Immunochem.2011 Oct;32(4):342-52.
- Two hundreds patients suspected of acute myocardial infarction presenting to the hospital with a median symptom onset of 2.3?h (IQR 1.7-4.0?h) were enrolled in this study. The diagnostic performances of CardioDetectR, a one-step immunotest for heart-type fatty acid-binding protein (H-FABP), and i
- PMID 21728825
- Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression.
- Du R, Xue J, Wang HB, Zhang Y, Xie ML.SourceDepartment of Pharmacy, The Affiliated Children's Hospital of Soochow University, Suzhou 215003, Jiangsu Province, China; Department of Pharmacology, Medical College of Soochow University, Suzhou 215123, Jiangsu Province, China.
- European journal of pharmacology.Eur J Pharmacol.2011 Sep;666(1-3):183-8. Epub 2011 May 20.
- The objective of this study was to examine the therapeutic effect of osthol, an active constituent of Cnidium monnieri (L.) Cusson (Apiaceae), in hyperlipidemic fatty liver mice and investigate the potential mechanism of the osthol treatment. A mouse model with hyperlipidemic fatty liver was induced
- PMID 21620823
Japanese Journal
- Activation of peroxisome proliferator-activated receptor-α enhances fatty acid oxidation in human adipocytes.
- Lee Joo-Young,Hashizaki Hikari,Goto Tsuyoshi,Sakamoto Tomoya,Takahashi Nobuyuki,Kawada Teruo
- Biochemical and biophysical research communications 407(4), 818-822, 2011-04-22
- … Activation of PPARα by GW7647, a potent PPARα agonist, increased the mRNA expression levels of adipocyte differentiation marker genes such as PPARγ, adipocyte-specific fatty acid-binding protein, and lipoprotein lipase and increased both GPDH activity and insulin-dependent glucose uptake level. …
- NAID 120003018555
- 脂肪細胞型脂肪酸結合蛋白(A-FABP/FABP4/aP2) (脂肪細胞)
Related Links
- Box 1Crystal structure of ligand-bound FABPs Generally, one or two conserved basic amino-acid side chains are required to bind the carboxylate site of a fatty-acid ligand in the binding pocket of a fatty acid-binding ...
- 脂肪酸結合タンパク質(Fatty Acid Binding Protein: FABP)は、水に不溶な多価不飽和脂肪酸を可溶化する細胞内キャリアーであり、リガンドである脂肪酸の細胞内動態を制御し、脂質代謝の恒常性維持やシグナル伝達に関与すると考えられ ...
- FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It ...
Related Pictures
★リンクテーブル★
[★]
- 英
- fatty acid-binding protein, FABP
- 関
- ヒト心臓由来脂肪酸結合蛋白
- 心臓型(H-FABP)
[★]
脂肪酸結合蛋白質
- 同
- fatty acid-binding protein
[★]
脂肪酸結合蛋白質 fatty acid-binding protein
[★]
- 同
- FABPs
- 同
- FABPs
- 同
- FABPs
[★]
ヒト心臓由来脂肪酸結合蛋白
[★]
ヒト心臓由来脂肪酸結合蛋白
[★]
- 関
- affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union
[★]
- 関
- BP、carrier protein、transport protein
[★]
- 関
- adipose、aliphatic、lipogenous
[★]
脂肪