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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/28 23:42:02」(JST)

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The fatty-acid-binding proteins (FABPs) are a family of carrier proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids.^[1]^[2] These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes.^[3] Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR.^[4] Levels of fatty-acid-binding protein have been shown to decline with ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity.^[5]

Family members

Members of this family include:

Protein name	Gene	Tissue distribution	Comment
FABP 1	FABP1	liver
FABP 2	FABP2	intestinal
FABP 3	FABP3	muscle and heart	mammary-derived growth inhibitor
FABP 4	FABP4	adipocyte
FABP 5	FABP5	adipocyte	psoriasis-associated
FABP 6	FABP6	ileal	gastrotropin
FABP 7	FABP7	brain
FABP 8	PMP2	peripheral nervous system	peripheral myelin protein 2
FABP 9	FABP9	testis
FABP 11	fabp11	restricted to fishes
FABP 12	FABP12	presence shown in human retinoblastoma cell lines, rodent retina and testis (Liu et al. 2008).
FABP 5-like 1	FABP5L1
FABP 5-like 2	FABP5L2
FABP 5-like 3	FABP5L3
FABP 5-like 4	FABP5L4
FABP 5-like 5	FABP5L5
FABP 5-like 6	FABP5L6
FABP 5-like 7	FABP5L7

References

^ Chmurzyńska A (2006). "The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism". J. Appl. Genet. 47 (1): 39–48. doi:10.1007/BF03194597. PMID 16424607. http://jag.igr.poznan.pl/2006-Volume-47/1/abstracts/313.html.
^ Smathers RL, Petersen DR (2011). "The human fatty acid-binding protein family: evolutionary divergences and functions". Hum Genomics 5 (1): 170-191. doi:10.1186/1479-7364-5-3-170. PMID 21504868. http://www.humgenomics.com/content/5/3/170.
^ Weisiger RA (2002). "Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of their ligands". Mol. Cell. Biochem. 239 (1-2): 35–43. doi:10.1023/A:1020550405578. PMID 12479566.
^ Tan NS, Shaw NS, Vinckenbosch N, Liu P, Yasmin R, Desvergne B, Wahli W, Noy N (2002). "Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription". Mol. Cell. Biol. 22 (14): 5114–27. doi:10.1128/MCB.22.14.5114-5127.2002. PMC 139777. PMID 12077340. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139777/.
^ Pu L, Igbavboa U, Wood WG, Roths JB, Kier AB, Spener F, Schroeder F (August 1999). "Expression of fatty acid binding proteins is altered in aged mouse brain". Mol. Cell. Biochem. 198 (1-2): 69–78. doi:10.1023/A:1006946027619. PMID 10497880.

External links

Fatty+Acid-Binding+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

Role of liver fatty acid binding protein in hepatocellular injury: Effect of CrPic treatment.

Fan W, Chen K, Zheng G, Wang W, Teng A, Liu A, Ming D, Yan P.SourceShandong Key Laboratory of Storage and Transportation Technology of Agricultural Products, National Engineering Research Center for Agricultural Products Logistics, Shandong Institute of Commerce and Technology, Jinan 250103, China; Key Laboratory for Food Nutrition and Safety of Ministry of Education, Tianjin University of Science and Technology, Tianjin, 300457, China.
Journal of inorganic biochemistry.J Inorg Biochem.2013 Jul;124:46-53. doi: 10.1016/j.jinorgbio.2013.03.015. Epub 2013 Mar 29.
This study was designed to investigate the molecular mechanisms of chromium picolinate (CrPic, Fig. 1) hepatoprotective activity from alloxan-induced hepatic injury. Diabetes is induced by alloxan-treatment concurrently with the hepatic injury in mice. In this study, we investigate the protective e
PMID 23603011

Relationship of cardiac biomarkers and reversible and irreversible myocardial injury following acute myocardial infarction as determined by cardiovascular magnetic resonance.

Mather AN, Fairbairn TA, Artis NJ, Greenwood JP, Plein S.SourceMultidisciplinary Cardiovascular Research Centre, University of Leeds, United Kingdom.
International journal of cardiology.Int J Cardiol.2013 Jun 20;166(2):458-64. doi: 10.1016/j.ijcard.2011.11.004. Epub 2011 Nov 26.
BACKGROUND: Cardiovascular magnetic resonance (CMR) can accurately depict myocardial oedema, haemorrhage, infarction and microvascular obstruction. The purpose of this study was to establish the relationships between cardiac biomarkers and reversible and irreversible myocardial injury following AMI,
PMID 22119118