脂肪酸結合蛋白質 fatty acid-binding protein
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/01/28 23:42:02」(JST)
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The fatty-acid-binding proteins (FABPs) are a family of carrier proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids.[1][2] These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes.[3] Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR.[4] Levels of fatty-acid-binding protein have been shown to decline with ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity.[5]
Family members
Members of this family include:
Protein name |
Gene |
Tissue distribution |
Comment |
FABP 1 |
FABP1 |
liver |
|
FABP 2 |
FABP2 |
intestinal |
|
FABP 3 |
FABP3 |
muscle and heart |
mammary-derived growth inhibitor |
FABP 4 |
FABP4 |
adipocyte |
|
FABP 5 |
FABP5 |
adipocyte |
psoriasis-associated |
FABP 6 |
FABP6 |
ileal |
gastrotropin |
FABP 7 |
FABP7 |
brain |
|
FABP 8 |
PMP2 |
peripheral nervous system |
peripheral myelin protein 2 |
FABP 9 |
FABP9 |
testis |
FABP 11 |
fabp11 |
restricted to fishes |
FABP 12 |
FABP12 |
presence shown in human retinoblastoma cell lines, rodent retina and testis (Liu et al. 2008). |
FABP 5-like 1 |
FABP5L1 |
|
|
FABP 5-like 2 |
FABP5L2 |
|
|
FABP 5-like 3 |
FABP5L3 |
|
|
FABP 5-like 4 |
FABP5L4 |
|
|
FABP 5-like 5 |
FABP5L5 |
|
|
FABP 5-like 6 |
FABP5L6 |
|
|
FABP 5-like 7 |
FABP5L7 |
|
|
References
- ^ Chmurzyńska A (2006). "The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism". J. Appl. Genet. 47 (1): 39–48. doi:10.1007/BF03194597. PMID 16424607. http://jag.igr.poznan.pl/2006-Volume-47/1/abstracts/313.html.
- ^ Smathers RL, Petersen DR (2011). "The human fatty acid-binding protein family: evolutionary divergences and functions". Hum Genomics 5 (1): 170-191. doi:10.1186/1479-7364-5-3-170. PMID 21504868. http://www.humgenomics.com/content/5/3/170.
- ^ Weisiger RA (2002). "Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of their ligands". Mol. Cell. Biochem. 239 (1-2): 35–43. doi:10.1023/A:1020550405578. PMID 12479566.
- ^ Tan NS, Shaw NS, Vinckenbosch N, Liu P, Yasmin R, Desvergne B, Wahli W, Noy N (2002). "Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription". Mol. Cell. Biol. 22 (14): 5114–27. doi:10.1128/MCB.22.14.5114-5127.2002. PMC 139777. PMID 12077340. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139777/.
- ^ Pu L, Igbavboa U, Wood WG, Roths JB, Kier AB, Spener F, Schroeder F (August 1999). "Expression of fatty acid binding proteins is altered in aged mouse brain". Mol. Cell. Biochem. 198 (1-2): 69–78. doi:10.1023/A:1006946027619. PMID 10497880.
External links
- Fatty+Acid-Binding+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
Proteins: carrier proteins
|
|
Fatty acid |
- FABP1
- FABP2
- FABP3
- FABP4
- FABP5
- FABP6
- FABP7
|
|
Hormone |
- peptide hormone: Follistatin
- Growth hormone binding protein
- Insulin-like growth factor binding protein
- IGFBP1
- IGFBP2
- IGFBP3
- IGFBP4
- IGFBP5
- IGFBP6
- IGFBP7
- Neurophysins
- steroid hormone: Sex hormone binding globulin/Androgen binding protein
- Transcortin
- Thyroxine-binding globulin
- Transthyretin
|
|
Metal/element |
- calcium
- Calcium-binding protein
- Calmodulin-binding proteins
- copper
- iron
- Iron-binding proteins
- Transferrin receptor
|
|
Vitamin |
- Retinol binding protein
- Transcobalamin
|
|
Other |
- Acyl carrier protein
- Adaptor protein
- Cholesterylester transfer protein
- F-box protein
- GTP-binding protein
- Latent TGF-beta binding protein
- Light-harvesting complex
- Major urinary proteins
- Membrane transport protein
- Odorant binding protein
|
|
B proteins: BY STRUCTURE: membrane, globular (en, ca, an), fibrous
|
|
UpToDate Contents
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English Journal
- Role of liver fatty acid binding protein in hepatocellular injury: Effect of CrPic treatment.
- Fan W, Chen K, Zheng G, Wang W, Teng A, Liu A, Ming D, Yan P.SourceShandong Key Laboratory of Storage and Transportation Technology of Agricultural Products, National Engineering Research Center for Agricultural Products Logistics, Shandong Institute of Commerce and Technology, Jinan 250103, China; Key Laboratory for Food Nutrition and Safety of Ministry of Education, Tianjin University of Science and Technology, Tianjin, 300457, China.
- Journal of inorganic biochemistry.J Inorg Biochem.2013 Jul;124:46-53. doi: 10.1016/j.jinorgbio.2013.03.015. Epub 2013 Mar 29.
- This study was designed to investigate the molecular mechanisms of chromium picolinate (CrPic, Fig. 1) hepatoprotective activity from alloxan-induced hepatic injury. Diabetes is induced by alloxan-treatment concurrently with the hepatic injury in mice. In this study, we investigate the protective e
- PMID 23603011
- Relationship of cardiac biomarkers and reversible and irreversible myocardial injury following acute myocardial infarction as determined by cardiovascular magnetic resonance.
- Mather AN, Fairbairn TA, Artis NJ, Greenwood JP, Plein S.SourceMultidisciplinary Cardiovascular Research Centre, University of Leeds, United Kingdom.
- International journal of cardiology.Int J Cardiol.2013 Jun 20;166(2):458-64. doi: 10.1016/j.ijcard.2011.11.004. Epub 2011 Nov 26.
- BACKGROUND: Cardiovascular magnetic resonance (CMR) can accurately depict myocardial oedema, haemorrhage, infarction and microvascular obstruction. The purpose of this study was to establish the relationships between cardiac biomarkers and reversible and irreversible myocardial injury following AMI,
- PMID 22119118
Japanese Journal
- 検尿検査・バイオマーカー (特集 急性腎障害(AKI) : 概念の確認から,さらなる予後改善を目指して) -- (AKIの診断)
Related Links
- L-FABPは、ヒト腎臓の近位尿細管細胞の細胞質に局在する分子量14kDaの「脂肪酸結合タンパク質」です。 L-FABPは、「組織障害が進行する前」の 尿細管の虚血(血流不全)や 尿細管への酸化ストレス により、尿中に排泄されます。
- 実施料: 150点 判断料: 生化学的検査(Ⅰ)判断料144点 区分: D007(39) レセプト名: 心臓由来脂肪酸結合蛋白(H-FABP ... 心臓由来脂肪酸結合蛋白(Heart type fatty acid-binding protein:H-FABP)は,心筋細胞の細胞質に存在する ...
Related Pictures
![FABP: Release Kinetics](https://1mg.info/0/6/j/0212.jpg)
![Essentially, we represent the protein](https://1mg.info/0/6/j/0213.jpg)
![Protein FABP5 PDB 1b56.png](https://1mg.info/0/6/j/0214.jpg)
![Human L-FABP ELISA Kit](https://1mg.info/0/6/j/0215.jpg)
![FABP nieuwe myocard infarct sneltest H](https://1mg.info/0/6/j/0216.jpg)
★リンクテーブル★
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- 英
- fatty acid-binding protein, FABP
- 関
- ヒト心臓由来脂肪酸結合蛋白
- 心臓型(H-FABP)
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ヒト心臓由来脂肪酸結合蛋白 heart-type fatty acid binding protein
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小腸脂質結合タンパク
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