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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/06/17 15:20:58」(JST)

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Drug-induced autoimmune hemolytic anemia is a form of hemolytic anemia.

In some cases, a drug can cause the immune system to mistakenly think the body's own red blood cells are dangerous, foreign substances. Antibodies then develop against the red blood cells. The antibodies attach to red blood cells and cause them to break down too early. Drugs that can cause this type of hemolytic anemia include:

Cephalosporins (a class of antibiotics) – most common cause^{[citation needed]}
Dapsone
Levodopa
Levofloxacin
Methyldopa
Nitrofurantoin
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Phenazopyridine (pyridium)
Quinidine^[1]

Penicillin in high doses can induce immune mediated hemolysis^[2] via the hapten mechanism in which antibodies are targeted against the combination of penicillin in association with red blood cells. Complement is activated by the attached antibody leading to the removal of red blood cells by the spleen.^{[citation needed]}

The drug itself can be targeted by the immune system, e.g. by IgE in a Type I hypersensitivity reaction to penicillin, rarely leading to anaphylaxis.^{[citation needed]}

References

^ MedlinePlus Encyclopedia Drug-induced immune hemolytic anemia
^ Stroncek, David; Procter, Jo L.; Johnson, Judy (2000). "Drug-induced hemolysis: Cefotetan-dependent hemolytic anemia mimicking an acute intravascular immune transfusion reaction". American Journal of Hematology. 64 (1): 67–70. doi:10.1002/(SICI)1096-8652(200005)64:1<67::AID-AJH12>3.0.CO;2-Z. PMID 10815791.

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1. 自己免疫性溶血性貧血の病因：温暖凝集素と薬剤pathogenesis of autoimmune hemolytic anemia warm agglutinins and drugs [show details]
…spherocyte , which is ultimately destroyed in the spleen. Drug-induced AIHA – A number of drugs elicit immune reactions that result in hemolysis The drug may alter antigens on the red cell, resulting in the …
2. 薬物および毒素による溶血性貧血hemolytic anemia due to drugs and toxins [show details]
… diminishes rapidly, the rate depending upon the clearance of the drug. The direct Coombs test in the immune complex type of drug-induced AIHA is usually positive with anti-C3 antisera but negative with anti-IgG …
3. 小児の自己免疫性溶血性貧血：分類、臨床的特徴、診断autoimmune hemolytic anemia in children classification clinical features and diagnosis [show details]
… pneumoniae and Epstein-Barr virus (in patients with cold AIHA only) Review of the patient medications to identify potential drugs that may induce AIHA Determination of the antigenic specificity of erythrocyte …
4. 小児の自己免疫性溶血性貧血：治療と転帰autoimmune hemolytic anemia in children treatment and outcome [show details]
…autoimmune disease-induced AIHA may benefit from earlier initiation of rituximab therapy. In patients with suspected drug-induced AIHA , it is imperative that the offending drug be discontinued. In …
5. 寒冷凝集素症cold agglutinin disease [show details]
…anemia include warm AIHA, drug-induced hemolytic anemia, hemolytic transfusion reactions (HTRs), and paroxysmal cold hemoglobinuria (PCH). Warm AIHA and drug-induced hemolytic anemia – Warm AIHA is the most …

English Journal

Management of Select Thrombocytopenias.

, V V, T T, T T, .
AACN advanced critical care. 2019 ;30(2)165-180.
Evaluating, diagnosing, and managing patients with consumptive thrombocytopenia is challenging because of the overlapping nature of many of the diseases that reduce platelet counts. Immune thrombocytopenia (and its variations), drug-induced immune thrombocytopenia, and heparin-induced thrombocytopen
PMID 31151947

Artesunate-Induced Severe Autoimmune Hemolytic Anemia in Complicated Malaria.

Singh S, Singh SK, Tentu AK, Kumar A, Shahbabu B, Singh V, Singh N.
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine. 2018 Oct;22(10)753-756.
Autoimmune hemolytic anemia (AIHA) is a very rare cause of anemia in a case of malaria and drug-induced AIHA is even rarer. A 50-year old patient with a history of fever for 8 days was diagnosed with a case of complicated malaria with mixed infection having initial parasite index of 45%. He showed g
PMID 30405291

A patient with oxaliplatin immune-induced syndrome (OIIS) who also developed leucovorin and palonosetron-associated thrombocytopenia.

Curtis SA, Curtis BR, Lee AI, Hendrickson JE, Lacy J, Podoltsev NA.
Hematology (Amsterdam, Netherlands). 2018 Aug;23(7)429-432.
We report a case of an 83 year old man who developed oxaliplatin immune-induced syndrome (OIIS) after his 19th cycle of FOLFOX (5FU, leucovorin, oxaliplatin). When oxaliplatin was omitted from his next cycle of chemotherapy he continues to show signs of drug-induced immune thrombocytopenia (DITP) an
PMID 29281948

Japanese Journal

Levofloxacinによると推測される薬剤性免疫性溶血性貧血の1例

土手内靖,尾崎牧子,西山記子,長谷部淳,谷松智子,西山政孝
医学検査 64(1), 60-65, 2015
… 43病日に薬剤リンパ球刺激試験を施行したところ，LVFXに対し陽性であり，臨床経過と併せ，本例はLVFXによる薬剤性免疫性溶血性貧血（Drug-induced immune hemolytic anemia：DIIHA）と推測された。 …
NAID 130005057089

混合型自己免疫性溶血性貧血をともなうEvans症候群の1症例

天本貴広,岡村孝,佐川公矯,江頭弘一,川野洋之,東谷孝徳,石丸健,佐藤進一郎,奥英二郎,今村理恵,中島収
日本輸血細胞治療学会誌 58(4), 539-546, 2012
自己免疫性溶血性貧血（AIHA）は赤血球に対する自己抗体の産生を特徴とする．AIHAは，抗体が赤血球と最もよく反応する至適温度により分類され，その分類には，温式AIHA，冷式AIHA，発作性寒冷血色素尿症，混合型AIHA，そして薬剤依存性AIHAなども含まれる．<br> 今回，我々は混合型AIHAによる急速で重篤な溶血をともなうEvans症候群を経験し，赤血球に対する自己抗体解析を行っ …
NAID 130004542671

薬剤起因性と考えられる2度の無顆粒球症を発症した血管免疫芽球性T細胞リンパ腫

井上大地,木村隆治,下地園子 [他],森美奈子,永井雄也,田端淑恵,倉田雅之,松下章子,永井謙一,丸岡隼人,山下映子,高橋隆幸
臨床血液 50(2), 87-91, 2009-02-28
症例は73歳男性。2007年7月に発熱，紅斑，白血球減少のため入院。薬剤服用歴，白血球数1,400/μ<i>l</i>, 好中球0%, 骨髄顆粒球系細胞の著減より薬剤起因性無顆粒球症と考えられた。G-CSF製剤の投与により好中球数は正常化したが，表在リンパ節腫脹を認め，皮疹，発熱も持続し，自己免疫性溶血性貧血や2度目の薬剤性と考えられる無顆粒球症を来たしたため，リンパ …
NAID 10024958956

「薬剤性自己免疫性溶血性貧血」

Drug-induced autoimmune heamolytic anemia
Specialty	Hematology

　　[★]

英: drug-induced autoimmune hemolytic anemia
関: 自己免疫性溶血性貧血

キニジン quinidine

機序 (WCH.1175)

drug adsorption mechanism: penicillin type
neoantigen mechanism(immunne complex, innocent by stander mechanism): quinidine/stibophen type

薬物と特定の型の赤血球上に存在する抗原が新しい抗原を作り、これを自己抗体が認識する
薬単体や、薬と特定の型を持たない赤血球にたいしては自己抗体を作らない(特定の型の赤血球とはI,Rh)。

autoimmune mechanism: α-methyldopa type
nonimmunologic protein adsorption mechanism
multiple mechanism

「薬剤惹起性急性溶血」

　　[★]

英: drug-induced acute hemolysis
関: 薬剤性溶血性貧血 drug-induced hemolytic anemia、薬物誘発性自己免疫性溶血性貧血 drug-induced autoimmune hemolytic anemia

「induce」

　　[★]

v.

誘発する、誘導する、誘起する、導入する、引き起こす

関: cause、challenge、derivation、elicit、elicitation、evocation、evoke、guidance、induction、inductive、introduce、introduction、precipitate、provocation、provoke、spark

「induced」

　　[★]

v.

(induceの過去分詞)誘導される、引き起こされる

hypercalcaemia induced pancreatitis 高カルシウム血症による膵炎

「hemolytic」

　　[★]

adj.

溶血性の、溶血の

関: haemolysis、haemolytic、hemolysis、hemolyze

「drug」

　　[★]

同: drugs

[1] MedlinePlus Encyclopedia Drug-induced immune hemolytic anemia

[pmid10815791-2] Stroncek, David; Procter, Jo L.; Johnson, Judy (2000). "Drug-induced hemolysis: Cefotetan-dependent hemolytic anemia mimicking an acute intravascular immune transfusion reaction". American Journal of Hematology. 64 (1): 67–70. doi:10.1002/(SICI)1096-8652(200005)64:1<67::AID-AJH12>3.0.CO;2-Z. PMID 10815791.

リンク元	「薬剤性自己免疫性溶血性貧血」「薬剤惹起性急性溶血」
関連記事	「induce」「induced」「hemolytic」「drug」

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案内

drug-induced autoimmune hemolytic anemia