ドパミンおよびサイクリックAMP調節性リン酸化タンパク質32
- 関
- DARPP-32
WordNet
- give an artificially banal or sexual quality to
- temporary living quarters specially built by the army for soldiers; "wherever he went in the camp the men were grumbling" (同)encampment, cantonment, bivouac
- shelter for persons displaced by war or political oppression or for religious beliefs (同)refugee camp
- a site where care and activities are provided for children during the summer months; "city kids get to see the country at a summer camp" (同)summer camp
- a penal institution (often for forced labor); "China has many camps for political prisoners"
- temporary lodgings in the country for travelers or vacationers; "level ground is best for parking and camp areas"
- a group of people living together in a camp; "the whole camp laughed at his mistake"
- something that is considered amusing not because of its originality but because of its unoriginality; "the living room was pure camp"
- establish or set up a camp (同)camp down
- providing sophisticated amusement by virtue of having artificially (and vulgarly) mannered or banal or sentimental qualities; "they played up the silliness of their roles for camp effect"; "campy Hollywood musicals of the 1940s" (同)campy
- live in or as if in a tent; "Can we go camping again this summer?"; "The circus tented near the town"; "The houseguests had to camp in the living room" (同)encamp, camp out, bivouac, tent
- bring into conformity with rules or principles or usage; impose regulations; "We cannot regulate the way people dress"; "This town likes to regulate" (同)regularize, regularise, order, govern
- fix or adjust the time, amount, degree, or rate of; "regulate the temperature"; "modulate the pitch" (同)modulate
- a monoamine neurotransmitter found in the brain and essential for the normal functioning of the central nervous system; as a drug (trade names Dopastat and Intropin) it is used to treat shock and hypotension (同)Dopastat, Intropin
PrepTutorEJDIC
- 〈C〉(軍隊・登山隊・探検隊などの)『野営地』 / 〈C〉〈U〉野営のテント,仮設小屋 / 〈U〉野営,キャンプ[生活];軍隊生活 / 〈C〉夏季キャンプ場,サマーキャンプ / 《集合的に》野営する人たち,キャンプする人たち / 〈C〉(主義・信条などを同じくする)同志たち,同じ陣営;同じ立場 / 『野営する』,キャンプ生活を送る《+『out』》
- =homosexual / (男性が)女々しい / すたれた,古めかしい
- 《語・句・節を対等に結んで》…『と』…,…や…,および / 《数詞を結合して》…『足す』…,…に加えて / …『しかも』…,…して,同時に… / 《時間的に》『そして』,それから,すると(and then) / 《当然の帰結として》…『ので』,…だから(and so) / 《おもに話》《命令文などの後で》『そうすれば』,そうしたら / 《追加・強調して》それに,しかも / 《対照的な内容を導いて》ところが,しかし(but) / 《譲歩的に》それなのに,それでいながら / 《A and Bで一体の関係を表して》《単数扱い》 / 《同一語を反復して多数・継続などを表して》 / 《同一の複数名詞を結合して変化・種類などを表して》 / 《話》《「形容詞+and+形容詞」の形で前の形容詞が後に副詞的に働く》 / 《話》《「動詞come, goなど+and+動詞」の形でandとその後の動詞が不定詞の働きをして》 / 《「動詞+and+動詞」の形で後の動詞が現在分詞の意を表して》 / 《話》《文頭において前の質問・意見などに同意を示して》そうとも,そして(Yes!and) / 《話》《文頭に置いて驚き・疑念・非難などを表して》ほんとうに;…なのに
- (規則などで)…‘を'『規制する』,『統制する』 / 〈機械など〉‘を'『調整する』 / 〈量や率など〉‘を'ある限度内におさえる
- (次にくる語の発音が母音で始まるときに用いる) / (子音[h]で始まり第1音節に強勢のない語の場合はanを用いることがある.ただし,この場合は[h]を発音しない)
UpToDate Contents
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English Journal
- LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
- Beccano-Kelly DA1, Volta M1, Munsie LN1, Paschall SA1, Tatarnikov I1, Co K1, Chou P1, Cao LP1, Bergeron S1, Mitchell E1, Han H1, Melrose HL2, Tapia L1, Raymond LA3, Farrer MJ4, Milnerwood AJ5.
- Human molecular genetics.Hum Mol Genet.2014 Oct 24. pii: ddu543. [Epub ahead of print]
- Mutations in leucine-rich repeat kinase 2 (Lrrk2) are the most common genetic cause of Parkinson's disease (PD), a neurodegenerative disorder affecting 1-2% of those >65 years old. The neurophysiology of LRRK2 remains largely elusive, although protein loss suggests a role in glutamatergic synapse
- PMID 25343991
- Dyskinesia in Parkinson's disease: mechanisms and current non-pharmacological interventions.
- Heumann R1, Moratalla R, Herrero MT, Chakrabarty K, Drucker-Colín R, Garcia-Montes JR, Simola N, Morelli M.
- Journal of neurochemistry.J Neurochem.2014 Aug;130(4):472-89. doi: 10.1111/jnc.12751. Epub 2014 Jun 7.
- Dopamine replacement therapy in Parkinson's disease is associated with several unwanted effects, of which dyskinesia is the most disabling. The development of new therapeutic interventions to reduce the impact of dyskinesia in Parkinson's disease is therefore a priority need. This review summarizes
- PMID 24773031
- G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease.
- Oeckl P1, Hengerer B1, Ferger B2.
- Experimental neurology.Exp Neurol.2014 Jul;257:1-9. doi: 10.1016/j.expneurol.2014.04.010. Epub 2014 Apr 18.
- The orphan G-protein coupled receptor 6 (GPR6) is a constitutively active receptor which is positively coupled to the formation of cyclic adenosine-3',5'-monophosphate (cAMP). GPR6 is predominantly expressed in striatopallidal neurons. Here, we investigated neurochemical and behavioural effects of G
- PMID 24747358
Japanese Journal
- Colocalization of dopamine receptor subtypes with dopamine and cAMP-regulated phosphoprotein (DARPP-32) in rat brain
- RAJPUT Padmesh S.,KHARMATE Geetanjali,SOMVANSHI Rishi K.,KUMAR Ujendra
- Neuroscience research : the official journal of the Japan Neuroscience Society 65(1), 53-63, 2009-09-01
- NAID 10027500322
- Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling
- 高橋 悟,Ohshima T,Cho A,Sreenath T,Iadarola MJ,Pant HC,Kim Y,Nairn AC,Brady RO,Greengard P,Kulkarni AB
- Proceedings of the National Academy of Sciences 102(5), 1737-1742, 2005
- … Kulkarni, Proceedings of the National Academy of Sciences, 102(5), 2005, 1737-1742.authorCocaine, a drug of abuse, increases synaptic dopamine levels in the striatum by blocking dopamine reuptake at axon terminals. … Cyclin-dependent kinase 5 (Cdk5) and its activator p35, proteins involved in phosphorylation of substrates in postmitotic neurons, have been found to be up-regulated after chronic exposure to cocaine. …
- NAID 120003161764
- The Post-ischemic Administration of 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5, 6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e), a Novel Calmodulin Antagonist, Prevents Delayed Neuronal Death in Gerbil Hippocampus
- Hashiguchi Akihito,Yano Shigetoshi,Morioka Motohiro [他],HAMADA Junichiro,SHIRASAKI Yasufumi,KOCHI Masato,FUKUNAGA Kohji
- Journal of pharmacological sciences 96(1), 65-72, 2004-09-20
- NAID 10014166332
Related Links
- 1 Mar 2011 ... Striatal damage is associated with deficits in executive function, learning, and memory. Dopamine and cAMP regulated phosphoprotein 32 (DARPP-32) is expressed within striatal medium spiny neurons and regulates striatal ...
- Dopamine and cAMP regulated phosphoprotein 32 (DARPP-32), expressed within striatal medium spiny neurons, is known to regulate several substrates of cognition. We found that controlled cortical impact injury in rats produces a chronic ...
★リンクテーブル★
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- 関
- dopamine and cAMP-regulated phosphoprotein 32
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- 英
- dopamine and cAMP-regulated phosphoprotein 32、DARPP-32
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- 関
- accommodation、accommodative、adjust、adjustment、baffle、control、modulate、modulation、regulation、regulatory
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環状アデノシン一リン酸 サイクリックAMP 環状AMP adenosine 3',5'-cyclic monophosphate, cyclic AMP
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