優性遺伝性脊髄小脳失調症
- 関
- spinocerebellar ataxia、spinocerebellar ataxia type 1、spinocerebellar ataxia type 2、spinocerebellar ataxia type 4、spinocerebellar ataxia type 5、spinocerebellar ataxia type 6、spinocerebellar ataxia type 7、spinocerebellar atrophy
WordNet
- exercising influence or control; "television plays a dominant role in molding public opinion"; "the dominant partner in the marriage"
- (music) the fifth note of the diatonic scale
- (of genes) producing the same phenotype whether its allele is identical or dissimilar
- receive from a predecessor; "The new chairman inherited many problems from the previous chair"
- obtain from someone after their death; "I inherited a castle from my French grandparents"
- receive by genetic transmission; "I inherited my good eyesight from my mother"
- inability to coordinate voluntary muscle movements; unsteady movements and staggering gait (同)ataxy, dyssynergia, motor_ataxia
PrepTutorEJDIC
- 『支配的な』,最も有力な / (位置が)群を抜いて高い,そびえ立つ / (手・目など左右のいずれかが)力のある / (遺伝で)優性の / (音階で)第5度音の,属音の / (遺伝の)優性形質 / 第5度音,属音
- (…から)〈財産・権利・称号など〉‘を'『相続する』《+『名』+『from』+『名』》 / (…から)〈体質・性質など〉‘を'『受け継ぐ』《+『名』+『from』+『名』》 / (前任者・前代から)…‘を'受け継ぐ,継承ぐ,継承する《+『名』+『from』+『名』》 / 財産を相続する
UpToDate Contents
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English Journal
- Brain-specific knockdown of miR-29 results in neuronal cell death and ataxia in mice.
- Roshan R, Shridhar S, Sarangdhar MA, Banik A, Chawla M, Garg M, Singh VP, Pillai B.
- RNA (New York, N.Y.).RNA.2014 Aug;20(8):1287-97. doi: 10.1261/rna.044008.113. Epub 2014 Jun 23.
- Several microRNAs have been implicated in neurogenesis, neuronal differentiation, neurodevelopment, and memory. Development of miRNA-based therapeutics, however, needs tools for effective miRNA modulation, tissue-specific delivery, and in vivo evidence of functional effects following the knockdown o
- PMID 24958907
- Structural basis of the phosphorylation dependent complex formation of neurodegenerative disease protein Ataxin-1 and RBM17.
- Kim E1, Lee Y2, Choi S3, Song JJ4.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2014 Jul 11;449(4):399-404. doi: 10.1016/j.bbrc.2014.05.063. Epub 2014 May 22.
- Spinocerebellar Ataxia Type1 (SCA1) is a dominantly inherited neurodegenerative disease and belongs to polyglutamine expansion disorders. The polyglutamine expansion in Ataxin-1 (ATXN1) is responsible for SCA1 pathology. ATXN1 forms at least two distinct complexes with Capicua (CIC) or RNA-binding m
- PMID 24858692
- Repeat-Associated Non-AUG Translation and Its Impact in Neurodegenerative Disease.
- Kearse MG1, Todd PK.
- Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.Neurotherapeutics.2014 Jul 9. [Epub ahead of print]
- Nucleotide repeat expansions underlie numerous human neurological disorders. Repeats can trigger toxicity through multiple pathogenic mechanisms, including RNA gain-of-function, protein gain-of-function, and protein loss-of-function pathways. Traditionally, inference of the underlying pathogenic mec
- PMID 25005000
Japanese Journal
- シンポジウム０３‐４ 神経難病の克服‐単一遺伝子病からのアプローチ‐ ＳＣＡ６‐原因の同定から治療法の開発に向けて‐
Related Links
- Spinocerebellar ataxia, dominantly inherited forms is a rare disorder described in the database for rare diseases of the Swedish National Board of Health and Welfare. ... This is part of Rare diseases. Diagnosis: Spinocerebellar ...
- 1. Semin Neurol. 2007 Apr;27(2):133-42. Dominantly inherited ataxias: lessons learned from Machado-Joseph disease/spinocerebellar ataxia type 3. Paulson HL. Department of Neurology, University of Iowa College of Medicine, Iowa ...
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脊髄小脳失調症1型、脊髄小脳変性症1型
- 関
- dominantly-inherited spinocerebellar ataxia、SCA1、spinocerebellar ataxia、spinocerebellar ataxia type 2、spinocerebellar ataxia type 4、spinocerebellar ataxia type 5、spinocerebellar ataxia type 6、spinocerebellar ataxia type 7、spinocerebellar atrophy
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脊髄小脳失調症2型
- 関
- dominantly-inherited spinocerebellar ataxia、spinocerebellar ataxia、spinocerebellar ataxia type 1、spinocerebellar ataxia type 4、spinocerebellar ataxia type 5、spinocerebellar ataxia type 6、spinocerebellar ataxia type 7、spinocerebellar atrophy
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脊髄小脳失調症4型
- 関
- dominantly-inherited spinocerebellar ataxia、spinocerebellar ataxia、spinocerebellar ataxia type 1、spinocerebellar ataxia type 2、spinocerebellar ataxia type 5、spinocerebellar ataxia type 6、spinocerebellar ataxia type 7、spinocerebellar atrophy
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脊髄小脳失調症5型
- 関
- dominantly-inherited spinocerebellar ataxia、spinocerebellar ataxia、spinocerebellar ataxia type 1、spinocerebellar ataxia type 2、spinocerebellar ataxia type 4、spinocerebellar ataxia type 6、spinocerebellar ataxia type 7、spinocerebellar atrophy
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脊髄小脳失調症6型
- 関
- dominantly-inherited spinocerebellar ataxia、spinocerebellar ataxia、spinocerebellar ataxia type 1、spinocerebellar ataxia type 2、spinocerebellar ataxia type 4、spinocerebellar ataxia type 5、spinocerebellar ataxia type 7、spinocerebellar atrophy
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- 優性の、優位な、顕性の、優占の、支配的な、ドミナントな
- 関
- dominance、dominantly、manifest、overt、predominance、predominant、predominantly、predominately、prevailing、superior、superiorly
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- 関
- dominance、dominant、predominance、predominant、predominantly、predominately、superior、superiorly
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- 関
- hereditary、heredity、inheritance
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- 関
- hereditary、heritable、inheritable、inheritable character
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脊髄小脳変性症 spinocerebellar degeneration SCD = SCA