WordNet
- spread out; not concentrated in one place; "a large diffuse organization"
- move outward; "The soldiers fanned out" (同)spread, spread out, fan out
- lacking conciseness; "a diffuse historical novel"
- relating to or existing on or affecting the skin; "cutaneous nerves"; "a cutaneous infection" (同)cutaneal, dermal
- the 19th letter of the Roman alphabet (同)s
- (of light rays) subjected to scattering by reflection from a rough surface or transmission through a translucent material; "diffused light"
PrepTutorEJDIC
- 〈光・熱・液体など〉‘を'散らす,放散する,拡散させる / 〈学問・知識など〉‘を'広める,普及させる / 散る,放散する,拡散する / 広まる,普及する / 広く散った,広がった / 〈文体などが〉締まりのない,散漫な
- 皮膚の,皮膚を冒す
- sulfurの化学記号 / {略}South[ern]
UpToDate Contents
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- 1. 成人における全身性硬化症（強皮症）の臨床症状の概要 overview of the clinical manifestations of systemic sclerosis scleroderma in adults
- 2. 成人における全身性硬化症（強皮症）の治療および予後の概要 overview of the treatment and prognosis of systemic sclerosis scleroderma in adults
- 3. 強皮症の分類 classification of scleroderma disorders
- 4. 成人における全身性硬化症（強皮症）の診断および鑑別診断 diagnosis and differential diagnosis of systemic sclerosis scleroderma in adults
- 5. 全身性硬化症（強皮症）における肺疾患の評価および診断 evaluation for and diagnosis of lung disease in systemic sclerosis scleroderma
English Journal
- Recent advances in understanding the pathogenesis of scleroderma-interstitial lung disease.
- Akter T1, Silver RM, Bogatkevich GS.Author information 1Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, 114 Doughty Street, Charleston, SC, 29425, USA, akter@musc.edu.AbstractSystemic sclerosis (scleroderma, SSc) is a heterogeneous autoimmune connective tissue disease of unknown etiology. Interstitial lung disease (ILD) is a frequent complication, and a significant contributor to morbidity and mortality among SSc patients. SSc-ILD most commonly occurs within 10 years of diagnosis, and may be seen in patients with either the limited or diffuse cutaneous subset of SSc. SSc-ILD is a multifaceted disease process in which different factors and pathways are involved. Aberrant function of a variety of lung cells, cytokines, growth factors, peptides, and bioactive proteins, in combination with genetic and epigenetic regulators, have crucial functions in the pathogenesis of this disease. Here we present our view on recent advances regarding the pathogenesis of SSc-ILD.
- Current rheumatology reports.Curr Rheumatol Rep.2014 Apr;16(4):411. doi: 10.1007/s11926-014-0411-1.
- Systemic sclerosis (scleroderma, SSc) is a heterogeneous autoimmune connective tissue disease of unknown etiology. Interstitial lung disease (ILD) is a frequent complication, and a significant contributor to morbidity and mortality among SSc patients. SSc-ILD most commonly occurs within 10 years of
- PMID 24523015
- Radiological thymus alterations in systemic sclerosis: our experience and a review of the literature.
- Colaci M1, Giuggioli D, Manfredi A, Vacchi C, Della Casa G, Ferri C.Author information 1Rheumatology Unit, University of Modena & Reggio Emilia, Policlinico di Modena, Via del Pozzo, 71, 41100 Modena, Italy. michelecolaci@virgilio.it.AbstractObjective. Thymus alterations have been related to several autoimmune disorders. In particular, previous studies identified a significant frequency of gland abnormalities by chest high-resolution CT (HRCT) in SSc patients. In this study we aimed to investigate the prevalence of radiological thymic alterations and their correlation with clinical and serological features in a large SSc series. Methods. We retrospectively evaluated thymic shape on CT scans of 200 consecutive, unselected SSc patients aged over 30 years The presence of radiological abnormalities, i.e. enlarged gland >13 mm or nodular lesions >7 mm, was correlated with SSc clinico-serological features. Moreover, the patients were also classified using a second thickness cut-off of 7 mm in order to identify incomplete thymic involution. Results. Twenty-four of 200 (12%) SSc patients presented an abnormal thymus at HRCT, including hyperplasic (19/24) and nodular (5/24) glands. Otherwise, using the cut-off of 7 mm for gland thickness and excluding subjects with nodular thymus, 50/195 (25.6%) patients presented an incomplete thymic involution. Thymic radiological alterations are significantly correlated with younger age and diffuse cutaneous SSc. Moreover, an abnormally enlarged thymus tended to be more common in patients with shorter disease duration. Conclusion. The present report on a large series of SSc patients further reinforces previous data present in the literature that includes other cohort studies and a number of anecdotal observations. Even though the actual role of thymus radiological abnormalities remains unclear, possible involvement of the gland in the early phase of immune-mediated SSc pathogenesis might be supposed.
- Rheumatology (Oxford, England).Rheumatology (Oxford).2014 Apr;53(4):732-6. doi: 10.1093/rheumatology/ket419. Epub 2013 Dec 24.
- Objective. Thymus alterations have been related to several autoimmune disorders. In particular, previous studies identified a significant frequency of gland abnormalities by chest high-resolution CT (HRCT) in SSc patients. In this study we aimed to investigate the prevalence of radiological thymic a
- PMID 24369415
- Myopathy is a poor prognostic feature in systemic sclerosis: results from the Canadian Scleroderma Research Group (CSRG) cohort.
- Jung M1, Bonner A, Hudson M, Baron M, Pope J, On Behalf Of The Canadian Scleroderma Research Group Csrg.Author information 1University of Western Ontario, Schulich School of Medicine and Dentistry, Department of Medicine, Division of Rheumatology, St Joseph's Health Care , London, ON , Canada.AbstractObjective: To determine the clinical impact of muscle involvement in a large systemic sclerosis (SSc) cohort. Method: Using the Canadian Scleroderma Research Group (CSRG) database, SSc patients with either elevated creatine kinase (CK) or a prior history of myositis/myopathy were identified. Regression and Kaplan-Meier analyses were performed to determine characteristics associated with muscle involvement in SSc and survival outcome. Results: In 1145 patients with SSc, 5.6% had an elevated CK. This subset was more likely to be male (24.5% in elevated CK vs. 12.6% in normal CK, p < 0.013), younger (52 vs. 56 years, p < 0.045), have diffuse cutaneous SSc (dcSSc; 40.4% vs. 37.9%, p < 0.002), tendon friction rubs (30.0% vs. 13.4%, p < 0.001), and forced vital capacity (FVC) < 70% (23.9% vs. 13.1%, p < 0.039), be ribonucleoprotein (RNP) antibody positive (12.0% vs. 5.0%, p < 0.032), topoisomerase1 (topo1)-antibody positive (26.0% vs. 14.4%, p < 0.026), have a higher modified Rodnan skin score (MRSS; 16.14 vs. 9.81, p < 0.001), and a higher Health Assessment Questionnaire (HAQ) score (0.98 vs. 0.79, p < 0.011). Survival was reduced for patients with elevated CK (p < 0.025). Nearly 10% of patients in the CSRG cohort had a prior history of myositis/myopathy. This subset also had findings similar to those with elevated CK and increased mortality (p < 0.003). Conclusions: Muscle involvement in SSc has a poor prognosis impacting survival, especially in men with early dcSSc with topo1 and RNP autoantibodies and interstitial lung disease (ILD).
- Scandinavian journal of rheumatology.Scand J Rheumatol.2014 Mar 21. [Epub ahead of print]
- Objective: To determine the clinical impact of muscle involvement in a large systemic sclerosis (SSc) cohort. Method: Using the Canadian Scleroderma Research Group (CSRG) database, SSc patients with either elevated creatine kinase (CK) or a prior history of myositis/myopathy were identified. Regress
- PMID 24650305
Japanese Journal
- Serum levels of soluble carbonic anhydrase IX are decreased in patients with diffuse cutaneous systemic sclerosis compared to those with limited cutaneous systemic sclerosis
- Makino Katsunari,Jinnin Masatoshi,Makino Takamitsu,Kajihara Ikko,Fukushima Satoshi,Inoue Yuji,Ihn Hironobu
- BioScience Trends 8(3), 144-148, 2014
- … Hypoxia may play an important role in the pathogenesis of systemic sclerosis (SSc). … However, the clinical significance of serum CA IX levels in SSc is still unknown. … The aim of this study is to evaluate the possibility that serum CA IX levels can be a specific disease marker of SSc. … Serum samples were obtained from SSc patients and healthy controls. …
- NAID 130004572597
- A Patient with Diffuse Cutaneous Systemic Sclerosis Complicated by Antineutrophil-cytoplasmic Antibody-associated Vasculitis Exhibiting Honeycomb Lung without Volume Loss
- Yamashita Hiroyuki,Takahashi Yuko,Kaneko Hiroshi,Kano Toshikazu,Mimori Akio
- Internal Medicine 53(7), 801-804, 2014
- … We herein report the case of a 72-year-old woman with diffuse cutaneous systemic sclerosis (SSc) complicated by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis who exhibited honeycomb lung without volume loss. … It is necessary to recognise that vasculitis may develop in SSc patients who exhibit honeycomb lung without volume loss. …
- NAID 130003392746
- A portable dermatoscope for easy, rapid examination of periungual nailfold capillary changes in patients with systemic sclerosis.
- Muroi Eiji,Hara Toshihide,Yanaba Koichi,Ogawa Fumihide,Yoshizaki Ayumi,Takenaka Motoi,Shimizu Kazuhiro,Sato Shinichi
- Rheumatology international 31(12), 1601-1606, 2011-12
- … Microvascular lesions are a predominant feature in systemic sclerosis (SSc) and seem to play a central pathogenic role. … The presence of nailfold capillary abnormalities is useful in diagnosing SSc. … To assess the practical utility of dermatoscope for assessment of capillary morphology in patients with SSc, 83 Japanese patients with SSc (68 women, 15 men) and 68 healthy controls were examined in the study. …
- NAID 120002223828
Related Links
- 欧米では全身性強皮症はlimited cutaneous SSc(lcSSc)とdiffuse cutaneous SSc(dcSSc)に分類されていますが、これに対応する適切な日本語訳については今後検討していくことが決定されました。 ...
- 190 12 章 膠原病および類縁疾患 12 膨化，浮腫やリンパ球浸潤がみられる．硬化が進むと，表皮萎 縮と付属器の減少や消失がみられ，膠原線維の均質化（表皮に 平行に走る），ムチン沈着が観察される．SSc単独では，皮膚
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| 関連記事 | 「SS」「diffuse」「cutaneous」「S」「SSc」 |
「SS」
- セザリー症候群 Sézary syndrome
- ソマトスタチン somatostatin
- シェーグレン症候群 Sjögren syndrome
- 全身性強皮症 systemic sclerosis
- 浮遊物質 suspended solid
- ソトス症候群 Sotos syndrome
- 漿膜下層 subserosa
「diffuse」
- vt.
- (気体・液体など)を放散する
- vi.
- adj.
- 広汎性の、びまん性の
「cutaneous」
- adj.
- 皮膚の、皮膚性の
「S」