- 関
- cutaneous
WordNet
- below the skin; "inject subcutaneously"
- relating to or existing on or affecting the skin; "cutaneous nerves"; "a cutaneous infection" (同)cutaneal, dermal
PrepTutorEJDIC
- 皮膚の,皮膚を冒す
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English Journal
- Topical immunotherapy with diphencyprone for in transit and cutaneously metastatic melanoma.
- Damian DL1, Saw RP, Thompson JF.Author information 1Department of Dermatology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia; The University of Sydney at Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; Melanoma Institute Australia, North Sydney, New South Wales, Australia.AbstractTopical diphencyprone (DPCP) can be used to treat in transit and cutaneously metastastatic melanoma. To date, 50 patients have received DPCP therapy for at least 1 month at our institution, with complete clearance of cutaneous disease in 46% and partial response in a further 38% of patients. Topical immunotherapy with DPCP is inexpensive and well-tolerated and should be considered in patients with skin metastases unsuitable for or refractory to other forms of therapy. J. Surg. Oncol. 2014 109:308-313. © 2013 Wiley Periodicals, Inc.
- Journal of surgical oncology.J Surg Oncol.2014 Mar;109(4):308-13. doi: 10.1002/jso.23506. Epub 2013 Nov 19.
- Topical diphencyprone (DPCP) can be used to treat in transit and cutaneously metastastatic melanoma. To date, 50 patients have received DPCP therapy for at least 1 month at our institution, with complete clearance of cutaneous disease in 46% and partial response in a further 38% of patients. Topical
- PMID 24522938
- A dihydro-pyrido-indole potently inhibits HSV-1 infection by interfering the viral immediate early transcriptional events.
- Bag P1, Ojha D1, Mukherjee H1, Halder UC2, Mondal S1, Biswas A1, Sharon A3, Van Kaer L4, Chakrabarty S1, Das G5, Mitra D6, Chattopadhyay D7.Author information 1ICMR Virus Unit, ID and BG Hospital, General Block 4, 57 Dr. Suresh Chandra Banerjee Road, Beliaghata, Kolkata 700010, India.2Virology Laboratory, National Institute of Cholera & Enteric Diseases, Kolkata, India.3Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi, India.4Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN, United States.5Department of Microbiology and Immunology, University of KwaZulu-Natal, 719 Umbilo Road, Durban 4001, South Africa.6National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune, India.7ICMR Virus Unit, ID and BG Hospital, General Block 4, 57 Dr. Suresh Chandra Banerjee Road, Beliaghata, Kolkata 700010, India. Electronic address: debprasadc@yahoo.co.in.AbstractIn our continued quest for identifying novel molecules from ethnomedicinal source we have isolated an alkaloid 7-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole, also known as Harmaline (HM), from an ethnomedicinal herb Ophiorrhiza nicobarica. The compound exhibited a potent anti-HSV-1 activity against both wild type and clinical isolates of HSV-1. Further we demonstrated that HM did not interfere in viral entry but the recruitment of lysine-specific demethylase-1 (LSD1) and the binding of immediate-early (IE) complex on ICP0 promoter. This leads to the suppression of viral IE gene synthesis and thereby the reduced expression of ICP4 and ICP27. Moreover, HM at its virucidal concentration is nontoxic and reduced virus yields in cutaneously infected Balb/C mice. Thus, the interference in the binding of IE complex, a decisive factor for HSV lytic cycle or latency by HM reveals an interesting target for developing non-nucleotide antiherpetic agent with different mode of action than Acyclovir.
- Antiviral research.Antiviral Res.2014 Feb 25. pii: S0166-3542(14)00050-3. doi: 10.1016/j.antiviral.2014.02.007. [Epub ahead of print]
- In our continued quest for identifying novel molecules from ethnomedicinal source we have isolated an alkaloid 7-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole, also known as Harmaline (HM), from an ethnomedicinal herb Ophiorrhiza nicobarica. The compound exhibited a potent anti-HSV-1 activity
- PMID 24576908
- Gas chromatographic-tandem mass spectrometric analysis of β-lyase metabolites of sulfur mustard adducts with glutathione in urine and its use in a rabbit cutaneous exposure model.
- Lin Y1, Dong Y1, Chen J1, Li CZ1, Nie ZY1, Guo L1, Liu Q2, Xie JW3.Author information 1Laboratory of Toxicant Analysis, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, 27 Taiping Road, Haidian District, 100850 Beijing, China.2Laboratory of Toxicant Analysis, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, 27 Taiping Road, Haidian District, 100850 Beijing, China. Electronic address: liuq920@126.com.3Laboratory of Toxicant Analysis, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, 27 Taiping Road, Haidian District, 100850 Beijing, China. Electronic address: xiejw@bmi.ac.cn.AbstractA method for quantitation of β-lyase metabolites of sulfur mustard (SM) adducts with glutathione has been developed and validated using gas chromatography-tandem mass spectrometry (GC-MS/MS). The linear range of quantitation was 0.1-1000ng/mL in urine with a method detection limit of 0.02ng/mL. The method was applied in a rabbit exposure model. Domestic rabbits were cutaneously exposed to neat liquid SM in three dosage levels, and the β-lyase metabolites in urine were determined as 1,1'-sulfonylbis[2-(methylthio)ethane] (SBMTE). The study showed that even though more than 99% of the total amount of β-lyase metabolites was excreted in the first week after exposure, the β-lyase metabolites of SM adducts with glutathione could be detected in urine from rabbits for up to 3 or 4 weeks after the SM cutaneous exposure. For high dosage group (15mg/kg, 0.15 LD50), the mean concentration of SBMTE detected was 0.32ng/mL on day 28. For middle (5mg/kg, 0.05 LD50) and low (2mg/kg, 0.02 LD50) dosage groups, the mean concentrations of SBMTE were 0.07ng/mL and 0.02ng/mL on day 21, respectively. The data from this study indicate that the method is sensitive and provides a relatively long time frame for the retrospective detection of SM exposure.
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2014 Jan 15;945-946:233-9. doi: 10.1016/j.jchromb.2013.11.058. Epub 2013 Dec 8.
- A method for quantitation of β-lyase metabolites of sulfur mustard (SM) adducts with glutathione has been developed and validated using gas chromatography-tandem mass spectrometry (GC-MS/MS). The linear range of quantitation was 0.1-1000ng/mL in urine with a method detection limit of 0.02ng/mL. The
- PMID 24361979
Japanese Journal
- S14-5 Filaggrin deficiency impairs viral containment in mice cutaneously inoculated with Vaccinia virus
- The effect of omeprazole on gastric myoelectrical activity and emptying
- Journal of smooth muscle research = 日本平滑筋学会機関誌 47(3), 79-87, 2011-08-01
- NAID 10030497971
- 2A2-K05 振動刺激を用いた摩擦感呈示法 : 皮膚によって知覚する摩擦感と固着・滑り振動の関係
Related Links
- Define cutaneously. cutaneously synonyms, cutaneously pronunciation, cutaneously translation, English dictionary definition of cutaneously. adj. Of, relating to, or affecting the skin. cu·ta′ne·ous·ly adv. adj 1. of, relating to, or ...
- Looking for online definition of cutaneously in the Medical Dictionary? cutaneously explanation free. What is cutaneously? Meaning of cutaneously medical term. What does cutaneously mean? Cutaneously | definition of Search / ...
★リンクテーブル★
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- 英
- cutaneous、cutaneously
- 関
- 皮膚
[★]
- 関
- dermally、percutaneous、transcutaneous、transcutaneously、transdermal、transdermally
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- 関
- dermally、percutaneous、percutaneously、transcutaneous、transdermal、transdermally
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- 関
- endodermic、intracutaneous、intradermal、intradermally
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- 関
- s.c.、subcutaneous、subdermal
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- 関
- cutaneously、cutis、dermal、skin