WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
having an (over)abundance of flesh; "he hadnt remembered how fat she was"
a soft greasy substance occurring in organic tissue and consisting of a mixture of lipids (mostly triglycerides); "pizza has too much fat"
marked by great fruitfulness; "fertile farmland"; "a fat land"; "a productive vineyard"; "rich soil" (同)fertile, productive, rich
lucrative; "a juicy contract"; "a nice fat job" (同)juicy
having a relatively large diameter; "a fat rope"
the act of determining the properties of something, usually by research or calculation; "the determination of molecular structures" (同)finding
the quality of being determined to do or achieve something; firmness of purpose; "his determination showed in his every movement"; "he is a man of purpose" (同)purpose
deciding or controlling somethings outcome or nature; "the determination of grammatical inflections"
the syllable naming the fourth (subdominant) note of the diatonic scale in solmization

PrepTutorEJDIC

(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
『脂肪』,脂肪分 / (動物の)あぶら身 / (料理用の)油,ヘット / 肥満,太り過ぎ / 『太った』,肥満した / 『脂肪の多い』 / たっぷりとはいった,分厚い / もうかる / (土地が)肥えた / …‘を'太らせる / ふとる,肥える
〈U〉『決心』,決意,決断力 / 〈U〉(…の)『決定』,決着《+『of』+『名』》 / 〈C〉(法律上の)(…の)判決,裁決,終結《+『of』+『名』》 / 〈U〉(…の)測定[法]《+『of』+『名』》
〈U〉『運命』,宿命 / 〈U〉(運命として定められた)最期,破滅,(特に)死 / 《the Fates》(ギリシア・ローマ神話の)運命の三女神(Clotho,Lachesis,Atropes) / …‘を'運命づける
ファ(全音階の第4音)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/25 03:38:57」(JST)

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Within the field of developmental biology one goal is to understand how a particular cell (or embryo) develops into the final cell type (or organism), essentially how a cell’s fate is determined. Within an embryo, 4 processes play out at the cellular and tissue level to essentially create the final organism. These processes are cell proliferation, cell specialization, cell interaction and cell movement. Each cell in the embryo receives and gives cues to its neighboring cells and retains a cell memory of its own cell proliferation history. Almost all animals undergo a similar sequence of events during embryogenesis and have, at least at this developmental stage, the three germ layers and undergo gastrulation. While embryogenesis has been studied for more than a century, it was only recently (the past 15 years or so) that scientists discovered that a basic set of the same proteins and mRNAs are involved in all of embryogenesis. This is one of the reasons that model systems such as the fly (Drosophila melanogaster), the mouse (Muridae), and the leech (Helobdella), can all be used to study embryogenesis and developmental biology relevant to other animals, including humans. What continues to be discovered and investigated is how the basic set of proteins (and mRNAs) are expressed differentially between cells types, temporally and spatially; and whether this is responsible for the vast diversity of organisms produced. This leads to one of the key questions of developmental biology of how is cell fate determined.

Cell Fate

In the past 15 years or so, the development of new molecular tools (see GFP) and major advances in optical microscopy (see microscopy) have made cell lineageication in the C. elegans embryo.^[1]^[2] This technique is used to study cells as they are differentiating into their final cell fates. Merely observing a cell as it becomes differentiated (see Cell differentiation) during embryogenesis provides no indication of the mechanisms that drive the specification. Therefore, the addition of molecular manipulation techniques, including gene and protein knock downs, knock outs and overexpression, along with live cell imaging techniques has been transformational in understanding what mechanisms are involved with cell fate determination.^[3]^[4]^[5]^[6]^[7] Transplantation experiments are commonly used in conjunction with the genetic manipulation and lineage tracing. Transplantation experiments are the only way to determine what state the cell is in on its way to being differentiated.

For a number of cell cleavages (the specific number depends on the type of organism) all the cells of an embryo will be morphologically and developmentally equivalent. This means, each cell has the same development potential and all cells are essentially interchangeable, thus establishing an equivalence group. The developmental equivalence of these cells is usually established via transplantation and cell ablation experiments.

The determination of a cell to a particular fate can be broken down into two states where the cell can be specified (committed) or determined. In the state of being committed or specified, the cell type is not yet determined and any bias the cell has toward a certain fate can be reversed or transformed to another fate. If a cell is in a determined state, the cell’s fate cannot be reversed or transformed. In general, this means that a cell determined to differentiate into a brain cell cannot be transformed into a skin cell. Determination is followed by differentiation, the actual changes in biochemistry, structure, and function that result in specific cell types. Differentiation often involves a change in appearance as well as function.

Modes of Determination

There are three general ways a cell can become specified for a particular fate; they are autonomous specification, conditional specification and syncytial specification.

Autonomous Specification

This type of specification results from cell-intrinsic properties; it gives rise to mosaic development. The cell-intrinsic properties arise from a cleavage of a cell with asymmetrically expressed maternal cytoplasmic determinants (proteins, small regulatory RNAs and mRNA). Thus, the fate of the cell depends on factors secreted into its cytoplasm during cleavage. Autonomous specification was demonstrated in 1887 by a French medical student, Laurent Chabry, working on tunicate embryos.^[8]^[9] This asymmetric cell division usually occurs early in embryogenesis.

Positive feedback can create asymmetry from homogeneity. In cases where the external or stimuli that would cause asymmetry are very weak or disorganized, through positive feedback the system can spontaneously pattern itself. Once the feedback has begun, any small initial signaling is magnified and thus produces an effective patterning mechanism.^[10] This is normally what occurs in the case of lateral inhibition in which neighboring cells induce specification via inhibitory or inducing signals (see Notch signaling). This kind of positive feedback at the single cell level and tissue level is responsible for symmetry breaking, which is an all-or-none process whereas once the symmetry is broken, the cells involved become very different. Symmetry breaking leads to a bistable or multistable system where the cell or cells involved are determined for different cell fates. The determined cells continue on their particular fate even after the initial stimulatory/inhibitory signal is gone, giving the cells a memory of the signal.^[11]

Conditional Specification

In contrast to the autonomous specification, this type of specification is a cell-extrinsic process that relies on cues and interactions between cells or from concentration-gradients of morphogens. Inductive interactions between neighboring cells is the most common mode of tissue patterning. In this mechanism, one or two cells from a group of cells with the same developmental potential are exposed to a signal (morphogen) from outside the group. Only the cells exposed to the signal are induced to follow a different developmental pathway, leaving the rest of the equivalence group unchanged. Another mechanism that determines the cell fate is regional determination (see Regional specification). As implied by the name, this specification occurs based on where within the embryo the cell is positioned, it is also known as positional value.^[12] This was first observed when mesoderm was taken from the prospective thigh region of a chick embryo, was grafted onto the wing region and did not transform to wing tissue, but instead into toe tissue.^[13]

Syncytial Specification

(See main article on Syncytium)

This type of a specification is a hybrid of the autonomous and conditional that occurs in insects. This method involves the action of morphogen gradients within the syncytium. As there are no cell boundaries in the syncytium, these morphogens can influence nuclei in a concentration-dependent manner.

References

^ Dev Dyn 2010, 239:1315-1329. Maduro, M. F. (2010). "Cell fate specification in the C. Elegans embryo". Developmental dynamics : an official publication of the American Association of Anatomists 239 (5): 1315–1329. doi:10.1002/dvdy.22233. PMID 20108317. edit
^ Zernicka-Goetz M: First cell fate decisions and spatial patterning in the early mouse embryo. Semin Cell Dev Biol 2004, 15:563-572.Zernicka-Goetz, M. (2004). "First cell fate decisions and spatial patterning in the early mouse embryo". Seminars in cell & developmental biology 15 (5): 563–572. doi:10.1016/j.semcdb.2004.04.004. PMID 15271302. edit
^ Artavanis-Tsakonas S, Rand MD, Lake RJ: Notch signaling: cell fate control and signal integration in development. Science 1999, 284:770-776.Artavanis-Tsakonas, S.; Rand, M. D.; Lake, R. J. (1999). "Notch Signaling: Cell Fate Control and Signal Integration in Development". Science 284 (5415): 770–6. Bibcode:1999Sci...284..770A. doi:10.1126/science.284.5415.770. PMID 10221902. edit
^ Schuurmans C, Guillemot F: Molecular mechanisms underlying cell fate specification in the developing telencephalon. Curr Opin Neurobiol 2002, 12:26-34.Schuurmans, C.; Guillemot, F. (2002). "Molecular mechanisms underlying cell fate specification in the developing telencephalon". Current Opinion in Neurobiology 12 (1): 26–34. doi:10.1016/S0959-4388(02)00286-6. PMID 11861161. edit
^ Rohrschneider MR, Nance J: Polarity and cell fate specification in the control of Caenorhabditis elegans gastrulation. Dev Dyn 2009, 238:789-796. Rohrschneider, M.; Nance, J. (2009). "Polarity and cell fate specification in the control of Caenorhabditis elegans gastrulation". Developmental dynamics : an official publication of the American Association of Anatomists 238 (4): 789–796. doi:10.1002/dvdy.21893. PMC 2929021. PMID 19253398. edit
^ Segalen M, Bellaiche Y: Cell division orientation and planar cell polarity pathways. Semin Cell Dev Biol 2009, 20:972-977. Segalen, M.; Bellaïche, Y. (2009). "Cell division orientation and planar cell polarity pathways". Seminars in cell & developmental biology 20 (8): 972–977. doi:10.1016/j.semcdb.2009.03.018. PMID 19447051. edit
^ Fazi F, Nervi C: MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination. Cardiovasc Res 2008, 79:553-561. Fazi, F.; Nervi, C. (2008). "MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination". Cardiovascular research 79 (4): 553–561. doi:10.1093/cvr/cvn151. PMID 18539629. edit
^ Gilbert, S. F. (2000). Developmental Biology (6th ed.).
^ Whittaker JR. Segregation during ascidian embryogenesis of egg cytoplasmic information for tissue-specific enzyme development. PNAS. 1973 Jul;70(7):2096-100. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC433673/?tool=pubmed
^ Xiong W, Ferrell JE, Jr.: A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature 2003, 426:460-465.Xiong, W.; Ferrell Jr, J. (2003). "A positive-feedback-based bistable 'memory module' that governs a cell fate decision". Nature 426 (6965): 460–465. doi:10.1038/nature02089. PMID 14647386. edit
^ Xiong W, Ferrell JE, Jr.: A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature 2003, 426:460-465.doi:10.1038/nature02089
^ Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P: Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell 2010, 18:675-685.Guo, G.; Huss, M.; Tong, G.; Wang, C.; Li Sun, L.; Clarke, N.; Robson, P. (2010). "Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst". Developmental cell 18 (4): 675–685. doi:10.1016/j.devcel.2010.02.012. PMID 20412781. edit
^ Cairns JM: Development of grafts from mouse embryos to the wing bud of the chick embryo. Dev Biol 1965, 12:36-52.Cairns, J. (1965). "Development of grafts from mouse embryos to the wing bud of the chick embryo". Developmental Biology 12 (1): 36–00. doi:10.1016/0012-1606(65)90019-9. PMID 5833110. edit
^ Lau S, Ehrismann JS, Schlereth A, Takada S, Mayer U, Jurgens G: Cell-cell communication in Arabidopsis early embryogenesis. Eur J Cell Biol 2010, 89:225-230. Lau, S.; Ehrismann, J.; Schlereth, A.; Takada, S.; Mayer, U.; Jürgens, G. (2010). "Cell-cell communication in Arabidopsis early embryogenesis". European journal of cell biology 89 (2–3): 225–230. doi:10.1016/j.ejcb.2009.11.010. PMID 20031252. edit
^ Briscoe J: Making a grade: Sonic Hedgehog signalling and the control of neural cell fate. EMBO J 2009, 28:457-465. doi:10.1038/emboj.2009.12

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Japanese Journal

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