出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/25 02:29:27」(JST)
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The term human blood group systems is defined by International Society of Blood Transfusion as systems in the human species where cell-surface antigens—in particular, those on blood cells—are "controlled at a single gene locus or by two or more very closely linked homologous genes with little or no observable recombination between them",[1] and include the common ABO and Rh- (Rhesus) antigen systems, as well as many others; thirty-five major human systems are identified as of November 2014.[2] In addition to the ABO and Rh systems, the antigens expressed on blood cell membrane surfaces include 346 red blood cell antigens and 33 platelet antigens, as defined serologically.[3][better source needed] The genetic basis for most of these antigens lie in 45 red blood cell and 6 platelet genes.[citation needed] An individual, for example, can be AB RhD positive, and at the same time M and N positive in the MNS system, K positive in the Kell system, and Lea or Leb positive in the Lewis system,[citation needed] where these and many of the systems are named for patients in whom the corresponding antibodies were first detected.[citation needed]
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Blood is composed of cells suspended in a liquid called plasma. Suspended in the plasma are three types of cells:
The most common type of grouping is the ABO (either uppercase or lowercase) grouping. The varieties of glycoprotein coating on red blood cells divides blood into four groups:
There are subtypes under this grouping (listed as A1, A2, A1B or A2B…) some of which are quite rare. Apart from this there is a protein which plays an important part in the grouping of blood. This is called the Rh factor. If this is present, the particular blood type is called positive. If it is absent, it is called negative. Thus we have the following broad categories:[4][dubious – discuss][better source needed]
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In the "ABO" system, (and Rhesus D system) all blood belongs to one of four major groups: A+/−, B+/−, AB+/−, or O+/−. The presence (+) or absence (−) of the RhD (Rhesus D) antigen is indicated by the plus or minus following the ABO type. But there are more than two hundred minor blood groups that can complicate blood transfusions. These are known as rare blood types. Whereas common blood types are expressed in a letter or two, which may be a plus or a minus, a smaller number of people express their blood type in an extensive series of letters in addition to their 'AB-' type designation. The h/h blood group, also known as Oh or the Bombay blood group, is a rare blood type.[5][citation needed]
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This table was borrowed in significant part from a tabular ISBT document available via the web (columns 1, 2, 3 and 5),[2] with column 4, regarding epitopes and entry notes, being largely unsourced (and therefore suspect material not in compliance with Wikipedia policies).[6] That and other unsourced information—i.e., not appearing in the ISBT table cited, or new to the table since publication of the ISBT table—should be considered as currently unverifiable by this encyclopedia's standards.
| ISBT №[2] | System name | System symbol | Epitope or carrier, notes[citation needed] | Chromosome |
|---|---|---|---|---|
| 001 | ABO | ABO | Carbohydrate (N-Acetylgalactosamine, galactose). A, B and H antigens mainly elicit IgM antibody reactions, although anti-H is very rare, see the Hh antigen system (Bombay phenotype, ISBT #18). | 9q34.2 |
| 002 | MNS | MNS | GPA / GPB (glycophorins A and B). Main antigens M, N, S, s. | 4q31.21 |
| 003 | P | P | Glycolipid. Three antigens: P1, P, and Pk | 22q13.2 |
| 004 | Rh | RH | Protein. C, c, D, E, e antigens (there is no "d" antigen; lowercase "d" indicates the absence of D). | 1p36.11 |
| 005 | Lutheran | LU | Protein (member of the immunoglobulin superfamily). Set of 21 antigens. | 19q13.32 |
| 006 | Kell | KEL | Glycoprotein. K1 can cause hemolytic disease of the newborn (anti-Kell), which can be severe. | 7q34 |
| 007 | Lewis | LE | Carbohydrate (fucose residue). Main antigens Lea and Leb — associated with tissue ABH antigen secretion. | 19p13.3 |
| 008 | Duffy | FY | Protein (chemokine receptor). Main antigens Fya and Fyb. Individuals lacking Duffy antigens altogether are immune to malaria caused by Plasmodium vivax and Plasmodium knowlesi. | 1q23.2 |
| 009 | Kidd | JK | Protein (urea transporter). Main antigens Jka and Jkb. | 18q12.3 |
| 010 | Diego | DI | Glycoprotein (band 3, AE 1, or anion exchange). Positive blood is found only among East Asians and Native Americans. | 17q21.31 |
| 011 | Yt | YT | Protein (AChE, acetylcholinesterase). | 7q22.1 |
| 012 | XG | XG | Glycoprotein. | Xp22.33 |
| 013 | Scianna | SC | Glycoprotein. | 1p34.2 |
| 014 | Dombrock | DO | Glycoprotein (fixed to cell membrane by GPI, or glycosyl-phosphatidyl-inositol). | 12p12.3 |
| 015 | Colton | CO | Aquaporin 1. Main antigens Co(a) and Co(b). | 7p14.3 |
| 016 | Landsteiner-Wiener | LW | Protein (member of the immunoglobulin superfamily). | 19p13.2 |
| 017 | Chido | CH | C4A C4B (complement fractions). | 6p21.3 |
| 018 | Hh | H | Carbohydrate (fucose residue). | 19q13.33 |
| 019 | XK | XK | Glycoprotein. | Xp21.1 |
| 020 | Gerbich | GE | GPC / GPD (Glycophorins C and D). | 2q14.3 |
| 021 | Cromer | CROM | Glycoprotein (DAF or CD55, regulates complement fractions C3 and C5, attached to the membrane by GPI). | 1q32.2 |
| 022 | Knops | KN | Glycoprotein (CR1 or CD35, immune complex receptor). | 1q32.2 |
| 023 | Indian | IN | Glycoprotein (CD44 adhesion function?). | 11p13 |
| 024 | Ok | OK | Glycoprotein (CD147). | 19p13.3 |
| 025 | Raph | RAPH | Transmembrane glycoprotein. | 11p15.5 |
| 026 | JMH | JMH | Protein (fixed to cell membrane by GPI). Also known as Semaphorin 7A or CD108. | 15q24.1 |
| 027 | Ii | I | Branched (I) / unbranched (i) polysaccharide. | 6p24.2 |
| 028 | Globoside | GLOB | Glycolipid. Antigen P. | 3q26.1 |
| 029 | GIL | GIL | Aquaporin 3.[citation needed] | 9p13.3 |
| 030 | Rh-associated glycoprotein | RHAg | Rh-associated glycoprotein.[citation needed] | 6p21-qter |
| 031 | Forssman | FORS | Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (GBGT1)[citation needed] | 9q34.13 |
| 032 | Langereis[7] | LAN | ABCB6, human ATP-binding cassette (ABC) transporter, mitochondrial porphyrin transporter.[7] | 2q36 |
| 033 | Junior | JR | ABCG2. Multi-drug transporter protein.[citation needed] | 4q22 |
| 034 | Vel | Vel | Human red cell antigens[citation needed] | 1p36.32 |
| 035 | CD59 | CD59 | — | 11p13 |
[Quoting Abstract: The human ATP-binding cassette (ABC) transporter ABCB6 has been described as a mitochondrial porphyrin transporter essential for heme biosynthesis, but it is also suspected to contribute to anticancer drug resistance, as do other ABC transporters located at the plasma membrane. We identified ABCB6 as the genetic basis of the Lan blood group antigen expressed on red blood cells but also at the plasma membrane of hepatocellular carcinoma (HCC) cells, and we established that ABCB6 encodes a new blood group system (Langereis, Lan). Targeted sequencing of ABCB6 in 12 unrelated individuals of the Lan(-) blood type identified 10 different ABCB6 null mutations. This is the first report of deficient alleles of this human ABC transporter gene. Of note, Lan(-) (ABCB6(-/-)) individuals do not suffer any clinical consequences, although their deficiency in ABCB6 may place them at risk when determining drug dosage.]
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| リンク元 | 「血液型」 |
| 関連記事 | 「group」「grouping」「blood」 |