結合部位
WordNet
- serve in a specific professional capacity; "the priest sat for confession"; "she sat on the jury"
- be around, often idly or without specific purpose; "The object sat in the corner"; "We sat around chatting for another hour" (同)sit around
- be seated (同)sit_down
- be in session; "When does the court of law sit?"
- be located or situated somewhere; "The White House sits on Pennsylvania Avenue"
- executed with proper legal authority; "a binding contract"
- the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
- strip sewn over or along an edge for reinforcement or decoration
- the capacity to attract and hold something
- the piece of land on which something is located (or is to be located); "a good site for the school" (同)land site
- physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides" (同)situation
PrepTutorEJDIC
- (…に)『座る』,座っている《+『at』(『on, in』)+『名』》・着席する《+『down』》・(…に)〈鳥などが〉『止まる』,休む《+『on』+『名』》・〈めんどりが〉卵を抱く,巣に就く / 《場所の副詞[句]を伴って》(ある場所に)『位置する』・ (画家・写真家のために)ポーズをとる・しっとしている,動かないでいる・(議員・委員などの)職に就いている《+『on』+『名』》・〈議会・法廷などが〉開会(開廷)される・(…に)負担となる,重荷となる《+『on』(『upon』)+『名』》・〈衣服などが〉(…に)合う,似合う《+『on』+『名』》・〈人〉‘を'座らせる,着席させる《+『down』+『名,』+『名』+『down』》・〈馬〉‘に'乗る・《英》〈試験〉‘を'受ける
- 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
- (町・建物などの)『場所』;敷地,用地 / 遺跡;(事件などの)現場 / 〈建物など〉‘を'位置させる(locate)
- =ti
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/03/21 13:17:14」(JST)
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This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (July 2009) (Learn how and when to remove this template message)
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In biochemistry, a binding site is a region on a protein or piece of DNA or RNA to which ligands (specific molecules and/or ions) may form a chemical bond. An equilibrium exists between unbound ligands and bound ligands.
Saturation is the fraction of total binding sites that are occupied at any given time. When more than one type of ligand can bind to a binding site, the ligands can compete with each other.
Binding sites also exhibit chemical specificity, a measure of the types of ligands that will bond, and affinity, which is a measure of the strength of the chemical bond.
Binding sites are often an important component of the functional characterization of biomolecules. For example, the characterization of the active site of a substrate to an enzyme is essential to model the reaction mechanism responsible for the chemical change from substrate to product.
Binding sites on proteins can sometimes recognize other proteins. When a binding site of one protein identifies with another protein's surface, a non-covalent bond is formed between the two polypeptide (peptide) chains and a combined new protein is formed.[1]
A more specific type of binding site is the transcription factor binding site present on DNA. Short, recurring patterns in DNA often indicate sequence-specific binding sites for proteins such as nucleases and transcription factors; ribosome binding, mRNA processing, and transcription termination are also signaled by these sequence motifs.[2]. Prediction of protein (esp. transcription factors) binding sites on DNA has recently become an area of active research and different tools have been produced for it [3]. With the advent of deep learning, newer and more accurate methods have been produced [4]; these methods often benefit from the large volume of available data which is generated from high-throughput technologies, such as the protein binding microarrays [5] and use deep learning modules such as the convolutional neural networks (CNNs) and the recurrent neural nets (RNNs).
Binding sites also exist on antibodies as specifically coded regions that bind antigens based upon their structure.[6] Several supervised machine learning models and applications were suggested to identify the binding sites,[7] including techniques involving 3D convolutional neural networks .[8]
See also
References
- ^ Alberts B, Bray D, Hopkin K, Johnson AD, Lewis J, Raff M, Roberts K, Walter P. (2010) Essential Cell Biology third edition.
- ^ D'haeseleer, Patrik. "What are DNA sequence motifs?". Nature Biotechnology. Nature. Retrieved 29 April 2017.
- ^ Hassanzadeh, Hamid Reza, et al. "MotifMark: Finding regulatory motifs in DNA sequences." Engineering in Medicine and Biology Society (EMBC), 2017 39th Annual International Conference of the IEEE. IEEE, 2017.
- ^ Hassanzadeh, Hamid Reza, and May D. Wang. "DeeperBind: enhancing prediction of sequence specificities of DNA binding proteins." Bioinformatics and Biomedicine (BIBM), 2016 IEEE International Conference on. IEEE, 2016.
- ^ Newburger, Daniel E., and Martha L. Bulyk. "UniPROBE: an online database of protein binding microarray data on protein–DNA interactions." Nucleic acids research 37.suppl_1 (2008): D77-D82.
- ^ Binding Site - definition from Biology-Online.org
- ^ Grau J.; Ben-Gal I.; Posch S.; Grosse I. (2006). "VOMBAT: Prediction of Transcription Factor Binding Sites using Variable Order Bayesian Trees" (PDF). Nucleic Acids Research. 34 (W529–W533).
- ^ Jiménez, J; Doerr, S; Martínez-Rosell, G; Rose, AS; De Fabritiis, G (2017). "DeepSite: Protein binding site predictor using 3D-convolutional neural networks". Bioinformatics. 33: 3036–3042. doi:10.1093/bioinformatics/btx350. PMID 28575181.
External links
- Drawing the active site of an enzyme
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Enzymes
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| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
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| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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| Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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| Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
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UpToDate Contents
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English Journal
- Lack of HLA predominance and HLA shared epitopes in biliary Atresia.
- Mack CL, Anderson KM, Aubrey MT, Rosenthal P, Sokol RJ, Freed BM.SourceDepartments of Medicine and Immunology, Division of Allergy and Clinical Immunology, University of Colorado School of Medicine, 80045 Aurora, CO USA ; Department of Pediatrics, Division of Pediatric Gastroenterology, Digestive Health Institute, Children's Hospital Colorado, Hepatology and Nutrition, 13123 East 16th Ave. B290, 80045 Aurora, CO USA.
- SpringerPlus.Springerplus.2013 Dec;2(1):42. Epub 2013 Feb 8.
- Biliary atresia (BA) is characterized by progressive inflammation and fibrosis of bile ducts. A theory of pathogenesis entails autoimmune-mediated injury targeting bile duct epithelia. One of the strongest genetic associations with autoimmunity is with HLA genes. In addition, apparently dissimilar H
- PMID 23505615
- The Bcl6 target gene microRNA-21 promotes Th2 differentiation by a T cell intrinsic pathway.
- Sawant DV, Wu H, Kaplan MH, Dent AL.SourceDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
- Molecular immunology.Mol Immunol.2013 Jul;54(3-4):435-42. doi: 10.1016/j.molimm.2013.01.006. Epub 2013 Feb 13.
- The transcriptional repressor Bcl6 is a critical regulator of T helper cell fate, and inhibits Th2-type inflammation. We have found that microRNA-21 (miR-21) is a novel target gene for Bcl6 in Treg cells. Bcl6 represses and Stat3 activates miR-21 transcription through a Stat3 binding element in the
- PMID 23416424
- YY1 and a unique DNA repeat element regulates the transcription of mouse CS1 (CD319, SLAMF7) gene.
- Dongre P, Mathew S, Akopova I, Gryczynski I, Mathew P.SourceDepartment of Molecular Biology and Immunology and Institute for Cancer Research, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107-2699, USA.
- Molecular immunology.Mol Immunol.2013 Jul;54(3-4):254-63. doi: 10.1016/j.molimm.2012.12.017. Epub 2013 Jan 11.
- CS1 (CD319, CRACC, SLAMF7, novel Ly9) activates NK cell-mediated cytotoxicity and proliferation of B lymphocytes during immune responses. The expression of CS1 is up regulated on B cells in multiple myeloma and systemic lupus erythematosus. In this study we describe the transcriptional regulation of
- PMID 23318224
Japanese Journal
- High-level production of valine by expression of the feedback inhibition-insensitive acetohydroxyacid synthase in Saccharomyces cerevisiae.
- A fungal Argonaute interferes with RNA interference
- Floquet Engineered Quadri-partite Lattice System as an Extension of the Topological Haldane Model
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★リンクテーブル★
[★]
- 関
- active site、binding site、combining site
[★]
結合部位
- 関
- active site、binding site、reactive site
[★]
- 英
- binding site
- 関
- 結合部位
[★]
- 英
- binding site, combining site
[★]
[★]
- 関
- paratope
[★]
- 関
- affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union
[★]
- 関
- lie、locate、location、loci、locus、map、position、rank、seat、situated、situation、stand、topo
[★]
- 関
- location、loci、locus、place、topo