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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/19 12:06:59」(JST)

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1. Fab region
2. Fc region
3. Heavy chain
4. Light chain with one variable (V_L) and one constant (C_L) domain
5. Fv region with paratope

6. Hinge regions

A paratope, also called an antigen-binding site, is a part of an antibody which recognizes and binds to an antigen. It is a small region (of 15 to 22 amino acids) of the antibody's Fv region, part of the fragment antigen-binding (Fab region), and contains parts of the antibody's heavy and light chains.^[1] Each arm of the Y shape of an antibody monomer is tipped with a paratope, which is a set of complementarity determining regions.

The part of the antigen to which the paratope binds is called an epitope. This can be mimicked by a mimotope. The figure given on the right hand side depicts the antibody commonly found on a B leukocyte. The engraved inner portions of idiotype (encircled region no.5) is the paratope where the epitope of the antigen binds.

References

^ Goldsby, Richard; Kindt, TJ; Osborne, BA; Kuby, Janis (2003). "Antigens (Chapter 3)". Immunology (Fifth ed.). New York: W. H. Freeman and Company. pp. 57–75. ISBN 0716749475.

This immunology article is a stub. You can help Wikipedia by expanding it.

English Journal

Proximity-dependent protein detection based on enzyme-assisted fluorescence signal amplification.

Tan Y, Guo Q, Zhao X, Yang X, Wang K, Huang J, Zhou Y.SourceState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Changsha 410082, PR China.
Biosensors & bioelectronics.Biosens Bioelectron.2014 Jan 15;51:255-60. doi: 10.1016/j.bios.2013.08.001. Epub 2013 Aug 9.
In this paper, we develop a sensitive fluorescence method for protein detection based on proximity extension and enzyme-assisted signal amplification. In this novel method, pairs of proximity probes are designed, and the recognition elements are integrated into the proximity probes. Then proteins ar
PMID 23973935

Methods for radiolabelling of monoclonal antibodies.

Tolmachev V, Orlova A, Andersson K.SourceUnit of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2014;1060:309-30. doi: 10.1007/978-1-62703-586-6_16.
The use of radionuclide labels allows to study the pharmacokinetics of monoclonal antibodies, to control the specificity of their targeting and to monitor the response to an antibody treatment with high accuracy. Selection of label depends on the processing of an antibody after binding to an antigen
PMID 24037848

Mediator and label free estimation of stress biomarker using electrophoretically deposited Ag@AgO-polyaniline hybrid nanocomposite.

Kaushik A, Vasudev A, Arya SK, Bhansali S.SourceBio-MEMS and Microsystems Laboratory, Department of Electrical and Computer Engineering, Florida International University, Miami, FL-33174, USA. Electronic address: ajeet.npl@gmail.com.
Biosensors & bioelectronics.Biosens Bioelectron.2013 Dec 15;50:35-41. doi: 10.1016/j.bios.2013.06.012. Epub 2013 Jun 14.
Cortisol, a steroid hormone, is an important biomarker for psychological stress and its detection is gaining prominence for personalized health monitoring. In present work, electrophoretically deposited nanocomposite films of polyaniline (PANI) and core-shell Ag@AgO nanoparticles (NP~5 nm) have been
PMID 23831854

Japanese Journal

歯周炎患者血清中の抗Porphyromonas gingivalis抗体に対する抗イディオタイプ抗体の解析

河井敬久
日本歯周病学会会誌 35(1), 63-83, 1993-03-27
Porphyromonas gingivalisと歯周炎患者の宿主寄生体間関係に関する理解を深める目的で,イディオタイプ(Id)調節機構の存在について基礎的検討を行った。P. gingivalisに反応する種々のマウスモノクローナル抗体(MoAb)を作製し,それらのMoAbの中で患者血清に存在する抗体(Ab 1)と同一のエピトープ特異性を有すると考えられたPF18のIdに対する抗Id抗体(Ab 2 …
NAID 110004725925

抗CEAモノクローナル抗体に対する抗イディオタイプモノクローナル抗体の解析

得地茂,辻崎正幸,今井浩三
1991-06-01
… These results indicate that all of these anti-Id MoAbs recognized private idiotopes at the paratope of MoAb MA208. …
NAID 120001796828