- 関
- paratope
WordNet
- serve in a specific professional capacity; "the priest sat for confession"; "she sat on the jury"
- be around, often idly or without specific purpose; "The object sat in the corner"; "We sat around chatting for another hour" (同)sit around
- be seated (同)sit_down
- be in session; "When does the court of law sit?"
- be located or situated somewhere; "The White House sits on Pennsylvania Avenue"
- executed with proper legal authority; "a binding contract"
- the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
- strip sewn over or along an edge for reinforcement or decoration
- the capacity to attract and hold something
- the piece of land on which something is located (or is to be located); "a good site for the school" (同)land site
- physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides" (同)situation
- any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response
PrepTutorEJDIC
- (…に)『座る』,座っている《+『at』(『on, in』)+『名』》・着席する《+『down』》・(…に)〈鳥などが〉『止まる』,休む《+『on』+『名』》・〈めんどりが〉卵を抱く,巣に就く / 《場所の副詞[句]を伴って》(ある場所に)『位置する』・ (画家・写真家のために)ポーズをとる・しっとしている,動かないでいる・(議員・委員などの)職に就いている《+『on』+『名』》・〈議会・法廷などが〉開会(開廷)される・(…に)負担となる,重荷となる《+『on』(『upon』)+『名』》・〈衣服などが〉(…に)合う,似合う《+『on』+『名』》・〈人〉‘を'座らせる,着席させる《+『down』+『名,』+『名』+『down』》・〈馬〉‘に'乗る・《英》〈試験〉‘を'受ける
- 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
- (町・建物などの)『場所』;敷地,用地 / 遺跡;(事件などの)現場 / 〈建物など〉‘を'位置させる(locate)
- 抗体,免疫体,抗毒素
- =ti
UpToDate Contents
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English Journal
- HIV-1 V3 loop crown epitope-focused mimotope selection by patient serum from random phage display libraries: implications for the epitope structural features.
- Gazarian KG, Palacios-Rodríguez Y, Gazarian TG, Huerta L.SourceDepartment of Medicine Genomics and Environmental Toxicology, Institute of the Biomedical Research, Mexican National University, Ciudad Universitaria, 3er Circuito Exterior S/N, Mexico-City 04510, Mexico. karlen@unam.mx
- Molecular immunology.Mol Immunol.2013 Jun;54(2):148-56. doi: 10.1016/j.molimm.2012.11.016. Epub 2012 Dec 25.
- The crown region of the V3 loop in HIV-1 that contains the conserved amino acid sequence GPGR/G is known as the principal neutralizing determinant due to the extraordinary ability of antibodies to this region to neutralize the virus. To complement the existing peptide models of this epitope, we desc
- PMID 23270686
- Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab.
- Ultsch M, Bevers J, Nakamura G, Vandlen R, Kelley RF, Wu LC, Eigenbrot C.SourceDepartment of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- Journal of molecular biology.J Mol Biol.2013 Apr 26;425(8):1330-9. doi: 10.1016/j.jmb.2013.01.024. Epub 2013 Jan 25.
- The cytokine interleukin 13 (IL-13) is a major effector molecule for T-helper type 2 inflammation and is pathogenic in allergic diseases such as asthma. The effects of IL-13 are mediated via a pathway that is initiated by binding to a heterodimeric receptor consisting of IL-13Rα1 and IL-4Rα. Antib
- PMID 23357170
- With an antibody whose duty's double, a step towards ending asthma trouble?
- Sundberg EJ.SourceInstitute of Human Virology, Department of Medicine, Department of Microbiology and Immunology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, U.S.A.
- The Biochemical journal.Biochem J.2013 Apr 15;451(2):e1-3. doi: 10.1042/BJ20130305.
- Asthma is a debilitating chronic inflammatory disease of the airways that results in shortness of breath, wheezing and coughing, often triggered by inhalation of common allergens. The prevalence and severity of asthma has increased dramatically over the last several decades to the point where severa
- PMID 23535171
Japanese Journal
- 自己免疫性脳炎―最近の知見―抗体の病態へのかかわり
- 田中 惠子
- 臨床神経学 54(12), 1107-1109, 2014
- 抗NMDAR脳炎は,若年女性に精神症状で初発する特徴的な臨床像を呈するが,様々な臨床亜型が報告され,その臨床像は拡大を見せている.NMDARは,グルタミン酸のイオンチャネル型受容体として,シナプス後膜表面にGluN1とGluN2の4量体で形成される受容体で,抗体は細胞表面構造に結合する.本抗体を培養海馬細胞に作用させると,NMDARのendocytosisを生じ,NMDAR関連膜電位変化を生じる. …
- NAID 130004921211
- 二重濾過血漿交換を用いたインスリン抗体の除去により長期にわたり良好なコントロールを得た2型糖尿病症例
- 西川 真那,寺西 哲也,森澤 俊英,山内 健史,日並 義統,関 保道,上山 茂充,三木 隆
- 日本透析医学会雑誌 47(2), 159-165, 2014
- 52歳男性.30歳頃に糖尿病を指摘,40歳から経口血糖降下薬が,51歳よりインスリンが開始となった.インスリン開始約8か月後から,インスリンを増量しても血糖値が300~600mg/dL台に上昇しインスリンの作用不全を呈した.また同時期にインスリン注射部位の皮疹も出現した.当科に紹介となり,紹介時IRI(immunoreactive insulin)は5,182.6μU/mLと著明高値であった.イ …
- NAID 130003395193
- インスリン抗体による低血糖症に対しリラグルチドとインスリン併用療法が著効した1例
- 岡田 裕子,小林 寛和,白木 里織,西澤 昭彦,高田 政文,鎮西 忠信,石川 雄一,永田 正男
- 糖尿病 56(8), 570-577, 2013
- … )より2相性アスパルト注射が開始されたが,2009年より夜間,早朝の低血糖と日中の高血糖が出現し2010年6月に当科入院した.インスリン抗体価,抗体結合率が高値であり,スキャッチャード解析ではhigh affinity siteの低親和性と高結合能を認めた.インスリン製剤の変更を行ったが改善せず,インスリン中止のうえ分割食とミグリトール内服を開始したが,早朝の低血糖は遷延し日中の高血糖は悪化した.このためリラグ …
- NAID 130004905418
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- 抗原結合部位
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- lie、locate、location、loci、locus、map、position、rank、seat、situated、situation、stand、topo
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- location、loci、locus、place、topo