- 同
- ARS
WordNet
- determine the order of constituents in; "They sequenced the human genome"
- a following of one thing after another in time; "the doctor saw a sequence of patients" (同)chronological sequence, succession, successiveness, chronological succession
- film consisting of a succession of related shots that develop a given subject in a movie (同)episode
- serial arrangement in which things follow in logical order or a recurrent pattern; "the sequence of names was alphabetical"; "he invented a technique to determine the sequence of base pairs in DNA"
- several repetitions of a melodic phrase in different keys
- arrange in a sequence
- existing as an independent entity; "the partitioning of India created two separate and autonomous jute economies"
- (of political bodies) not controlled by outside forces; "an autonomous judiciary"; "a sovereign state" (同)independent, self-governing, sovereign
- (of persons) free from external control and constraint in e.g. action and judgment (同)self-directed, self-reliant
PrepTutorEJDIC
- 〈U〉〈C〉(時間の上の,また因果関係のつながりによる)『連続』,続き / 〈C〉《a~》(…の)一連のもの《+『of』+『名』》 / 〈U〉(起こる)『順序』(order),筋道 / 〈C〉(…に対する)結果《+『to』+『名』》
- 自治の,自治権のある
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/12/09 11:16:55」(JST)
[Wiki en表示]
An autonomously replicating sequence (ARS) contains the origin of replication in the yeast genome. It contains four regions (A, B1, B2, and B3), named in order of their effect on plasmid stability; when these regions are mutated, replication does not initiate.
Element A is highly conserved, consisting of the consensus sequence:
5'- T/A T T T A Y R T T T T/A -3'
(where Y is either pyrimidine and R is either purine). When this element is mutated, the ARS loses all activity.
As seen above the ARS are considerably A-T rich which makes it easy for replicative proteins to disrupt the H-bonding in that area. ORC protein complex (Origin Recognition Complex) is bound at the ARS throughout the cell cycle, allowing replicative proteins access to the ARS.
Mutational analysis for the yeast ARS elements have shown that any mutation in the B1, B2 and B3 regions result in a reduction of function of the ARS element. A mutation in the A region results in a complete loss of function.
Melting of dna occurs within domain B2, induced by attachment of ARS Binding factor 1 to B3. A1 and B1 domain binds with Origin Recognition Complex.
DNA replication (comparing Prokaryotic to Eukaryotic)
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|
Initiation |
Prokaryotic
(initiation) |
|
|
Eukaryotic
(preparation in
G1 phase) |
- Origin recognition complex
- ORC1
- ORC2
- ORC3
- ORC4
- ORC5
- ORC6
- Minichromosome maintenance
- MCM2
- MCM3
- MCM4
- MCM5
- MCM6
- MCM7
- Autonomously replicating sequence
- Single-strand binding protein
|
|
Both |
- Origin of replication/Ori/Replicon
- Replication fork
- Lagging and leading strands
- Okazaki fragment
- Primer
|
|
|
Replication |
Prokaryotic
(elongation) |
- DNA polymerase III holoenzyme
- dnaC
- dnaE
- dnaH
- dnaN
- dnaQ
- dnaT
- dnaX
- holA
- holB
- holC
- holD
- holE
- Replisome
- DNA ligase
- DNA clamp
- Topoisomerase
- Prokaryotic DNA polymerase: DNA polymerase I
|
|
Eukaryotic
(synthesis in
S phase) |
- Replication factor C
- Flap endonuclease
- Topoisomerase
- Replication protein A
- Eukaryotic DNA polymerase: delta
|
|
Both |
- Movement: Processivity
- DNA ligase
|
|
|
Termination |
|
|
See also: DNA replication and repair-deficiency disorder B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
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UpToDate Contents
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English Journal
- The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substrates.
- Voth DE, Beare PA, Howe D, Sharma UM, Samoilis G, Cockrell DC, Omsland A, Heinzen RA.SourceDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, AR 72205, USA. dvoth@uams.edu
- Journal of bacteriology.J Bacteriol.2011 Apr;193(7):1493-503. Epub 2011 Jan 7.
- The intracellular bacterial pathogen Coxiella burnetii directs biogenesis of a phagolysosome-like parasitophorous vacuole (PV), in which it replicates. The organism encodes a Dot/Icm type IV secretion system (T4SS) predicted to deliver to the host cytosol effector proteins that mediate PV formation
- PMID 21216993
- Amplification of a Zygosaccharomyces bailii DNA segment in wine yeast genomes by extrachromosomal circular DNA formation.
- Galeote V, Bigey F, Beyne E, Novo M, Legras JL, Casaregola S, Dequin S.SourceINRA, UMR1083 Sciences Pour l'?nologie, Montpellier, France.
- PloS one.PLoS One.2011 Mar 10;6(3):e17872.
- We recently described the presence of large chromosomal segments resulting from independent horizontal gene transfer (HGT) events in the genome of Saccharomyces cerevisiae strains, mostly of wine origin. We report here evidence for the amplification of one of these segments, a 17 kb DNA segment from
- PMID 21423766
Japanese Journal
- Identification and Application of Novel Autonomously Replicating Sequences (ARSs) for Promoter-Cloning and Co-Transformation in Candida utilis
- IKUSHIMA Shigehito,MINATO Toshiko,KONDO Keiji
- Bioscience, biotechnology, and biochemistry 73(1), 152-159, 2009-01-23
- … In order to develop practical recombinant DNA techniques in the industrially important yeast Candida utilis, at least six plasmids harboring autonomously replicating sequences (ARSs) were isolated from a C. … Sequences of 1.9 and 1.8 kb were found to be necessary to exert ARS activity in a plasmid as assessed by transformation efficiency and mitotic stability. …
- NAID 10027536293
- Transformation of Acremonium chrysogenum and Saccharomyces cerevisiae Using an Antibiotic Resistance Marker
- ISOGAI Takao,YOSHIDA Masaru,TANAKA Miho,AOKI Hatsuo
- Agricultural and Biological Chemistry 51(9), 2321-2329, 1987
- … chrysogenum functions as an autonomously replicating sequence (ARS) in Saccharomyces cerevisiae. … The fragment contains multiple copies of sequences that have at least 10 out of 11 bases of homology to a previously reported core consensus sequence of S. …
- NAID 130000024865
Related Links
- An autonomously replicating sequence (ARS) contains the origin of replication in the yeast genome. It contains four regions (A, B1, B2, and B3), named in order of their effect on plasmid stability; when these regions are mutated, ...
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- 関
- autonomic、autonomously、autonomy
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