WordNet

determine the order of constituents in; "They sequenced the human genome"
a following of one thing after another in time; "the doctor saw a sequence of patients" (同)chronological sequence, succession, successiveness, chronological succession
film consisting of a succession of related shots that develop a given subject in a movie (同)episode
serial arrangement in which things follow in logical order or a recurrent pattern; "the sequence of names was alphabetical"; "he invented a technique to determine the sequence of base pairs in DNA"
several repetitions of a melodic phrase in different keys
arrange in a sequence
existing as an independent entity; "the partitioning of India created two separate and autonomous jute economies"
(of political bodies) not controlled by outside forces; "an autonomous judiciary"; "a sovereign state" (同)independent, self-governing, sovereign
(of persons) free from external control and constraint in e.g. action and judgment (同)self-directed, self-reliant

PrepTutorEJDIC

〈U〉〈C〉(時間の上の,また因果関係のつながりによる)『連続』,続き / 〈C〉《a~》(…の)一連のもの《+『of』+『名』》 / 〈U〉(起こる)『順序』(order),筋道 / 〈C〉(…に対する)結果《+『to』+『名』》
自治の,自治権のある
配列,接続;(特に時間の)調整

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/03 15:58:51」(JST)

wiki en

[Wiki en表示]

An autonomously replicating sequence (ARS) contains the origin of replication in the yeast genome. It contains four regions (A, B1, B2, and B3), named in order of their effect on plasmid stability. The A-Domain is highly conserved, any mutation abolishes origin function. Mutations on B1, B2, and B3 will diminish, but not prevent functioning of the origin.

Element A is highly conserved, consisting of the consensus sequence:

5'- T/A T T T A Y R T T T T/A -3'

(where Y is either pyrimidine and R is either purine). When this element is mutated, the ARS loses all activity.

As seen above the ARS are considerably A-T rich which makes it easy for replicative proteins to disrupt the H-bonding in that area. ORC protein complex (Origin Recognition Complex) is bound at the ARS throughout the cell cycle, allowing replicative proteins access to the ARS.

Mutational analysis for the yeast ARS elements have shown that any mutation in the B1, B2 and B3 regions result in a reduction of function of the ARS element. A mutation in the A region results in a complete loss of function.

Melting of DNA occurs within domain B2, induced by attachment of ARS Binding factor 1 to B3. A1 and B1 domain binds with Origin Recognition Complex.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 遺伝性感覚自律神経ニューロパチー hereditary sensory and autonomic neuropathies
2. 糖尿病性自律神経障害 diabetic autonomic neuropathy
3. 三叉神経・自律神経性頭痛の病態生理 pathophysiology of the trigeminal autonomic cephalalgias
4. 起立性低血圧のメカニズム、原因、および評価 mechanisms causes and evaluation of orthostatic hypotension
5. 遺伝性ニューロパチーの概要 overview of hereditary neuropathies

English Journal

Mcm10 interacts with Rad4/Cut5(TopBP1) and its association with origins of DNA replication is dependent on Rad4/Cut5(TopBP1).

Taylor M, Moore K, Murray J, Aves SJ, Price C.SourceSchool of Health and Medicine, Division of Biomedical and Life Sciences, Biological Sciences Building, Lancaster University, Lancaster LA1 4YQ, UK.
DNA repair.DNA Repair (Amst).2011 Nov 10;10(11):1154-63. Epub 2011 Sep 23.
Initiation of DNA replication in eukaryotes is a highly conserved and ordered process involving the co-ordinated, stepwise association of distinct proteins at multiple origins of replication throughout the genome. Here, taking Schizosaccharomyces pombe as a model, the role of Rad4(TopBP1) in the ass
PMID 21945095

Protein switches identified from diverse insertion libraries created using S1 nuclease digestion of supercoiled-form plasmid DNA.

Tullman J, Guntas G, Dumont M, Ostermeier M.SourceDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400N. Charles St., Baltimore, Maryland 21218, Telephone: +1-410-516-7144; Fax: +1-410-516-5510.
Biotechnology and bioengineering.Biotechnol Bioeng.2011 Nov;108(11):2535-43. doi: 10.1002/bit.23224. Epub 2011 Jun 15.
We demonstrate that S1 nuclease converts supercoiled plasmid DNA to unit-length, linear dsDNA through the creation of a single, double-stranded break in a plasmid molecule. These double-stranded breaks occur not only in the origin of replication near inverted repeats but also at a wide variety of lo
PMID 21618478

Japanese Journal

Identification and Application of Novel Autonomously Replicating Sequences (ARSs) for Promoter-Cloning and Co-Transformation in Candida utilis

IKUSHIMA Shigehito,MINATO Toshiko,KONDO Keiji
Bioscience, biotechnology, and biochemistry 73(1), 152-159, 2009-01-23
… In order to develop practical recombinant DNA techniques in the industrially important yeast Candida utilis, at least six plasmids harboring autonomously replicating sequences (ARSs) were isolated from a C. … utilis with an integrating DNA fragment and a replicating plasmid yielded plasmid-free transformants harboring the fragment integrated into the C. …
NAID 10027536293

Organization and Localization of the dnaA and dnaK Gene Regions on the Multichromosomal Genome of Burkholderia multivorans ATCC 17616(Genetics, Molecular Biology, and Gene Engineering)

NAGATA YUJI,MATSUDA MUNEAKI,KOMATSU HARUNOBU,IMURA YOSHIYUKI,SAWADA HIROYUKI,OHTSUBO YOSHIYUKI,TSUDA MASATAKA
Journal of bioscience and bioengineering 99(6), 603-610, 2005-06-25
… This intergenic region, however, did not work as an autonomously replicating sequence in ATCC 17616. … A putative heat-shock promoter that showed good homology to the σ^<32>-dependent promoter consensus sequence in Escherichia coli was found upstream of the grpE gene, suggesting that these five genes constitute an operon. …
NAID 110002695708