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1. 腫瘍壊死因子α（TNF-α）阻害剤：副作用の概要tumor necrosis factor alpha inhibitors an overview of adverse effects [show details]
… “absence of a relevant difference in the parameter of interest.” Infliximab and adalimumab both bind monomeric and trimeric TNF-alpha. Infliximab is a chimeric antibody with human constant region of immunoglobulin …
2. 腫瘍壊死因子α阻害剤：細菌、ウイルス、および真菌感染tumor necrosis factor alpha inhibitors bacterial viral and fungal infections [show details]
… receptor fusion protein; Certolizumab pegol – A pegylated Fab fragment of a humanized monoclonal antibody; Golimumab – A human monoclonal anti-TNF-alpha antibody; These agents are discussed in detail elsewhere …
3. 腫瘍壊死因子α（TNF-α）阻害剤：悪性腫瘍のリスクtumor necrosis factor alpha inhibitors risk of malignancy [show details]
… antibody; Certolizumab pegol – An antigen-binding fragment (Fab') of a humanized monoclonal antibody coupled to polyethylene glycol; Golimumab – A fully human anti-TNF-alpha monoclonal antibody; Etanercept …
4. 腫瘍壊死因子α（TNF-α）阻害剤：抗体、自己抗体、および自己免疫疾患の誘導tumor necrosis factor alpha inhibitors induction of antibodies autoantibodies and autoimmune diseases [show details]
… Neutralizing anti-adalimumab ADA pose similar problems to those seen with infliximab, including lower or absent circulating levels of the drug and reduced clinical responsiveness, despite adalimumab being a humanized …
5. 腫瘍壊死因子α阻害剤および抗酸菌感染tumor necrosis factor alpha inhibitors and mycobacterial infections [show details]
… receptor fusion protein; Certolizumab pegol – A pegylated Fab fragment of a humanized monoclonal antibody; Golimumab – A human monoclonal anti-TNF-alpha antibody; These agents are discussed in detail elsewhere …

Japanese Journal

トシリズマブが奏功した難治性小児高安動脈炎の女子例

藤田円,丹代諭,大谷勝記,田中完,高橋徹,伊藤悦朗,湯澤健太郎,三浦文武,相澤知美,嶋田淳,北川陽介,渡邊祥二郎,津川浩二,敦賀和志
弘前医学 70(1), 56-61, 2019
… ステロイド薬, 各種免疫抑制剤薬, 抗TNFα抗体のインフリキシマブを併用しても寛解が得られなかった. …
NAID 130007757488

Development of Allergic Bronchopulmonary Aspergillosis in a Patient with Crohn's Disease

Sasaki Hisashi,Miyata Jun,Maki Yohei,Kimizuka Yoshifumi,Hayashi Nobuyoshi,Fujikura Yuji,Kawana Akihiko
Internal Medicine 58(19), 2835-2838, 2019
… A 66-year-old man with CD treated with an anti-tumor necrosis factor-α antibody presented with dyspnea. …
NAID 130007722385

アダリムマブが奏功した潰瘍性大腸炎術後の難治性回腸囊炎の1例

加藤聖也,三田英治,榊原祐子,石原朗雄,岩﨑哲也,田中聡司,長谷川裕子,赤坂智史,中水流正一,石田永
日本消化器病学会雑誌 116(9), 732-738, 2019
… <p>症例は40歳男性．潰瘍性大腸炎術後で回腸囊炎の再燃と寛解を繰り返し，経過中に肛門周囲膿瘍と痔瘻を合併した．痔瘻根治術後に抗TNF-α抗体製剤であるアダリムマブを投与し，寛解導入および寛解維持が得られている．潰瘍性大腸炎術後の回腸囊炎に対するアダリムマブ投与の報告はまれであり，貴重な症例と考え報告する．</p> …
NAID 130007704997