8-ブロモサイクリックAMP
- 関
- 8-bromo cyclic adenosine monophosphate、8-bromo-cAMP
WordNet
- of a compound having atoms arranged in a ring structure
- recurring in cycles (同)cyclical
- conforming to the Carnot cycle
- forming a whorl or having parts arranged in a whorl; "cyclic petals"; "cyclic flowers"
- marked by repeated cycles
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
PrepTutorEJDIC
- answer / ampere
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/01/07 06:24:08」(JST)
[Wiki en表示]
8-Bromoadenosine 3',5'-cyclic monophosphate[1] |
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IUPAC name
(1S,6R,8R,9R)-8-(6-amino-8-bromopurin-9-yl)-3-hydroxy-3-oxo-2,4,7-trioxa-3λ5-phosphabicyclo[4.3.0]nonan-9-ol
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Other names
8-Br-cAMP; BCAMP; 8-Bromo-cyclic AMP; 8-Bromo-cyclic 3',5'-AMP
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Identifiers |
CAS number |
23583-48-4 |
PubChem |
32014 |
ChemSpider |
29689 |
ChEMBL |
CHEMBL85519 Y |
Jmol-3D images |
Image 1 |
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Brc2nc1c(ncnc1n2[C@@H]3O[C@@H]4COP(=O)(O[C@H]4[C@H]3O)O)N
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InChI=1S/C10H11BrN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/t3-,5-,6-,9-/m1/s1
Key: DVKQVRZMKBDMDH-UUOKFMHZSA-N
InChI=1/C10H11BrN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/t3-,5-,6-,9-/m1/s1
Key: DVKQVRZMKBDMDH-UUOKFMHZBM
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Properties |
Molecular formula |
C10H11BrN5O6P |
Molar mass |
408.10 g mol−1 |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) |
Y (verify) (what is: Y/N?) |
Infobox references |
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8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) is a brominated derivative of cyclic adenosine monophosphate (cAMP). 8-Br-cAMP is an activator of cyclic AMP-dependent protein kinase, and it is long-acting because it is resistant to degradation by cyclic AMP phosphodiesterase.[2]
See also
- 8-Bromoguanosine 3',5'-cyclic monophosphate (8-Br-cGMP)
References
- ^ 8-Bromoadenosine 3′,5′-cyclic monophosphate at Sigma-Aldrich
- ^ 8-Bromo Cyclic Adenosine Monophosphate at PubChem
UpToDate Contents
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English Journal
- cAMP Promotes Cell Migration Through Cell Junctional Complex Dynamics and Actin Cytoskeleton Remodeling: Implications in Skin Wound Healing.
- Kim MO1,2, Ryu JM1,2, Suh HN1,2, Park SH3, Oh YM4, Lee SH5, Han HJ1,2.
- Stem cells and development.Stem Cells Dev.2015 Nov 1;24(21):2513-24. doi: 10.1089/scd.2015.0130. Epub 2015 Sep 2.
- Stem cells have attracted great interest for their therapeutic capacity in tissue regeneration. Cyclic adenosine 3',5'-monophosphate (cAMP), existing in high concentration at wound sites, mediated various signaling pathways such as cytoskeleton dynamics, cell adhesion, and cell migration in stem cel
- PMID 26192163
- SHC1 sensitizes cancer cells to the 8-Cl-cAMP treatment.
- Choi KY1, Cho YJ1, Kim JS2, Ahn YH3, Hong SH4.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Aug 7;463(4):673-8. doi: 10.1016/j.bbrc.2015.05.123. Epub 2015 Jun 1.
- 8-Chloro-cyclic AMP (8-Cl-cAMP) is a cyclic AMP analog that induces growth inhibition and apoptosis in a broad spectrum of cancer cells. Previously, we found that 8-Cl-cAMP-induced growth inhibition is mediated by AMP-activated protein kinase (AMPK) as well as p38 mitogen-activated protein kinase (p
- PMID 26043699
- Functional characterization of the human facilitative glucose transporter 12 (GLUT12) by electrophysiological methods.
- Pujol-Giménez J1, Pérez A2, Reyes AM2, Loo DD3, Lostao MP4.
- American journal of physiology. Cell physiology.Am J Physiol Cell Physiol.2015 Jun 15;308(12):C1008-22. doi: 10.1152/ajpcell.00343.2014. Epub 2015 Apr 8.
- GLUT12 is a member of the facilitative family of glucose transporters. The goal of this study was to characterize the functional properties of GLUT12, expressed in Xenopus laevis oocytes, using radiotracer and electrophysiological methods. Our results showed that GLUT12 is a facilitative sugar trans
- PMID 25855082
Japanese Journal
- Inactivation of Membrane Surface Ecto-5'-nucleotidase by Sodium Nitroprusside in C6 Glioma Cells
- Kumasaka Tadanori,Matsuoka Isao,Mashiko Hirobumi [他],NIWA Shin-ichi,KIMURA Junko
- Journal of pharmacological sciences 117(1), 45-53, 2011-09-20
- … Ecto-5′-nucleotidase (NT5E), a predominant enzyme that produces extracellular adenosine from AMP, plays an important role in a variety of physiological and pathophysiological processes. … and its action was not mimicked by nitric oxide generating agents, 8-bromo cyclic GMP, ferricyanide, ferrocyanide, or sodium cyanide. …
- NAID 10029895939
- Possible Roles of Intracellular Cyclic AMP, Protein Kinase C and Calcium Ion in the Apoptotic Signaling Pathway in Bovine Luteal Cells
- Tatsukawa Yuko,Bowolaksono Anom,Nishimura Ryo [他],KOMIYAMA Junichi,ACOSTA Tomas J.,OKUDA Kiyoshi
- The Journal of reproduction and development 52(4), 517-522, 2006-08-01
- … Cultured bovine mid luteal cells were treated for 24 h with a cyclic AMP analogue (8-bromo cyclic AMP; … 8br-cAMP; … mRNA expression was inhibited by 8br-cAMP and PMA but was increased by A23187 (P …
- NAID 10020351661
- Homologous and heterologous phosphorylations of human histamine H-1 receptor in intact cells
- Miyoshi Katsuhiro,Kawakami Nozomi,Horio Shuhei [他],Fukui H
- Journal of pharmacological sciences 96(4), 474-482, 2004-12-01
- … Maximum phosphorylation of H1R by 8-fold over the basal level was induced 1 min after the stimulation, and the increased phosphorylation level was maintained over 40 min. M3 receptor-mediated heterologous phosphorylation of H1R reached maximum by 2-fold over the basal level at 5 min after the stimulation and then rapidly returned to the basal level by 40 min after the stimulation. …
- NAID 10014076047
Related Links
- ライフサイエンスシソーラス: 8-ブロモサイクリックアデノシン一リン酸 8-Bromo Cyclic Adenosine Monophosphate
- Influence of follicular maturation on the deposition of fibronectin by chicken granulosa cells in vitro:- Effect of 8-bromo cyclic AMP
Related Pictures
![bromo-,cyclic 3',5'-(hydrogen phosphate](https://1mg.info/0/d/r/0291.jpg)
![Bromo Amp Cyclique (AMPc(8-bromo))](https://1mg.info/0/d/r/0292.jpg)
![Bromo Cyclic Adenosine Monophosphate; 8](https://1mg.info/0/d/r/0293.jpg)
![Bromo Cyclic Adenosine Monophosphate; 8](https://1mg.info/0/d/r/0294.jpg)
![Thumbnail for version as of 15:53, 20](https://1mg.info/0/d/r/0295.jpg)
★リンクテーブル★
[★]
- 英
- 8-bromo cyclic AMP、8-bromo-cAMP
- 関
- 8-ブロモサイクリックアデノシン一リン酸
[★]
8-ブロモサイクリックアデノシン一リン酸
- 関
- 8-bromo cyclic AMP、8-bromo-cAMP
[★]
- 関
- annular、circular、cyclical、cyclicity、cyclo、periodic、periodicity
[★]
[★]
[★]
アデノシン一リン酸 adenosine monophosphate adenosine 5'-monophosphate
[★]
環状アデノシン一リン酸
- 同
- cAMP&GPCR signal pathways