WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/28 10:23:11」(JST)

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Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in DNA and RNA. It is an ester of phosphoric acid and the nucleoside adenosine. AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine. As a substituent it takes the form of the prefix adenylyl-.

Production and degradation

AMP can be produced during ATP synthesis by the enzyme adenylate kinase by combining two ADP molecules:

2 ADP → ATP + AMP

'

Or AMP may be produced by the hydrolysis of one high energy phosphate bond of ADP:

ADP → AMP + P_i

AMP can also be formed by hydrolysis of ATP into AMP and pyrophosphate:

ATP → AMP + PP_i

When RNA is broken down by living systems, nucleoside monophosphates, including adenosine monophosphate, are formed.

AMP can be regenerated to ATP as follows:

AMP + ATP → 2 ADP (adenylate kinase in the opposite direction)

ADP + P_i → ATP (this step is most often performed in aerobes by the ATP synthase during oxidative phosphorylation)

AMP can be converted into IMP by the enzyme myoadenylate deaminase, freeing an ammonia group.

In a catabolic pathway, adenosine monophosphate can be converted to uric acid, which is excreted from the body.

cAMP

AMP can also exist as a cyclic structure known as cyclic AMP (or cAMP). Within certain cells the enzyme adenylate cyclase makes cAMP from ATP, and typically this reaction is regulated by hormones such as adrenaline or glucagon. cAMP plays an important role in intracellular signaling.

References

External links

GMD MS Spectrum
Ming D, Ninomiya Y, Margolskee RF (1999). "Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds". Proc. Natl. Acad. Sci. USA 96 (17): 9903–9908. doi:10.1073/pnas.96.17.9903. PMC 22308. PMID 10449792.

UpToDate Contents

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English Journal

Effects of different concentrations of metal ions on degradation of adenosine triphosphate in common carp (Cyprinus carpio) fillets stored at 4°C: An in vivo study.

Li D1, Qin N1, Zhang L1, Lv J1, Li Q1, Luo Y2.
Food chemistry.Food Chem.2016 Nov 15;211:812-8. doi: 10.1016/j.foodchem.2016.05.120. Epub 2016 May 18.
The impact of different concentrations of Na(+), K(+), Ca(2+), Mg(2+), Fe(2+), and Zn(2+) on the degradation of adenosine triphosphate (ATP) and the influence of these ions on the activity of adenosine monophosphate deaminase (AMP-deaminase) and acid phosphatase (ACP) in common carp fillets (in vivo
PMID 27283700

Rapid effects of aldosterone in primary cultures of cardiomyocytes - do they suggest the existence of a membrane-bound receptor?

Araujo CM1, Hermidorff MM1, Amancio Gde C1, Lemos Dda S2, Silva ME3, de Assis LV4, Isoldi MC1.
Journal of receptor and signal transduction research.J Recept Signal Transduct Res.2016 Oct;36(5):435-44. doi: 10.3109/10799893.2015.1122042. Epub 2015 Dec 20.
Aldosterone acts on its target tissue through a classical mechanism or through the rapid pathway through a putative membrane-bound receptor. Our goal here was to better understand the molecular and biochemical rapid mechanisms responsible for aldosterone-induced cardiomyocyte hypertrophy. We have ev
PMID 27305962

Differential Neuronal Plasticity of Dental Pulp Stem Cells From Exfoliated Deciduous and Permanent Teeth Towards Dopaminergic Neurons.

Majumdar D1, Kanafi M1, Bhonde R1, Gupta P2, Datta I3.
Journal of cellular physiology.J Cell Physiol.2016 Sep;231(9):2048-63. doi: 10.1002/jcp.25314. Epub 2016 Feb 4.
Based on early occurrence in chronological age, stem-cells from human exfoliated deciduous teeth (SHED) has been reported to possess better differentiation-potential toward certain cell-lineage in comparison to stem-cells from adult teeth (DPSCs). Whether this same property between them extends for
PMID 26773559

Japanese Journal

Conformational Variation Revealed by the Crystal Structure of RNase U2A Complexed with Ca Ion and 2'-Adenylic Acid at 1.03 Å Resolution

Noguchi Shuji
Protein & Peptide Letters 17(12), 1559-1561, 2010
… The crystal structure of ribonuclease U2A complexed with 2'-adenylic acid and calcium ions wasdetermined at 1.03 Å resolution. …
NAID 120002696073

環状ビス(3'-5')ジグアニル酸(c-di-GMP)および類縁体の有機合成, 化学的性質, および生物活性

兵藤守,早川芳宏,Karaolis David K. R.
有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN 64(4), 359-370, 2006-04-01
… This paper describes efficient synthesis, chemical behaviors, and biological activities of cyclic bis (3'-5') diguanylic acid (c-di-GMP) and its analogs, including cyclic bis (3'-5') guanylic-inosinic acid (c-GpIp), cyclic bis (3'-5') guanylic-adenylic acid (c-GpAp), and bis (3'-5') diguanylic acid monophosphorothioate (c-GpGps). …
NAID 10018131558

非平衡熱水環境下におけるアデニル酸のリン酸化反応

今井栄一,小澤慶太,本多元,羽鳥晋由,松野孝一郎
生物物理 43(SUPPLEMENT_1), S205, 2003-08-25
NAID 110001158453

Related Pictures

★リンクテーブル★

リンク元	「アデノシン一リン酸」「adenylate」
拡張検索	「5'-adenylic acid」

「アデノシン一リン酸」

Adenosine monophosphate
	IUPAC name 5'-Adenylic acid
Identifiers
CAS number	61-19-8
ChemSpider	5858
UNII	415SHH325A
DrugBank	DB00131
KEGG	C00020
MeSH	Adenosine+monophosphate
ChEBI	CHEBI:16027
ChEMBL	CHEMBL752
IUPHAR ligand	2455
Jmol-3D images	Image 1; Image 2
	SMILES O=P(O)(O)OC[C@H]3O[C@@H](n2cnc1c(ncnc12)N)[C@H](O)[C@@H]3O c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)N ;
	InChI InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 ; Key: UDMBCSSLTHHNCD-KQYNXXCUSA-N InChI=1/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1; Key: UDMBCSSLTHHNCD-KQYNXXCUBP ;
Properties
Molecular formula	C10H14N5O7P
Molar mass	347.22 g/mol
Appearance	white crystalline powder
Density	2.32 g/mL
Melting point	178 to 185 °C (352 to 365 °F; 451 to 458 K)
Boiling point	798.5 °C (1,469.3 °F; 1,071.7 K)
Acidity (pKa)	0.9, 3.8, 6.1
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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	Infobox references