WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees
an inflammation of bone and bone marrow (usually caused by bacterial infection)

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の

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1. 成人における骨髄炎の概要 overview of osteomyelitis in adults
2. 非結核性抗酸菌による骨髄炎の疫学、臨床症状、および診断 epidemiology clinical manifestations and diagnosis of osteomyelitis due to nontuberculous mycobacteria
3. 成人における非結核性抗酸菌による骨髄炎の治療 treatment of osteomyelitis due to nontuberculous mycobacteria in adults
4. 小児における血行性骨髄炎の治療 treatment of hematogenous osteomyelitis in children
5. 骨髄炎の疑いがある状況での画像検査法 approach to imaging modalities in the setting of suspected osteomyelitis

English Journal

[Pott's puffy tumor: A rare complication of frontal sinusitis].

Aínsa Laguna D1, Pons Morales S2, Muñoz Tormo-Figueres A2, Vega Senra MI2, Otero Reigada MC3.Author information 1Servicio de Pediatría, Hospital Universitario Doctor Peset, Valencia, España. Electronic address: davidainsa@gmail.com.2Servicio de Pediatría, Hospital Universitario Doctor Peset, Valencia, España.3Sección de Pediatría Infecciosa, Servicio de Pediatría, Hospital Universitario y Politécnico La Fe, Valencia, España.AbstractPott's puffy tumor is a rare complication of frontal sinusitis characterized by swelling and edema in the brow due to a subperiosteal abscess associated with frontal osteomyelitis. Added complications are cellulitis by extension to the orbit and intracranial infection by posterior extension, with high risk of meningitis, intracranial abscess, and venous sinus thrombosis. Early diagnosis and aggressive medical or surgical treatment are essential for optimal recovery of affected patients. In the antibiotic age it is extremely rare, with very few cases described in the recent literature. A case is presented of a Pott inflammatory tumor in a 7 year-old boy, as a complication of acute pansinusitis who presented with front preseptal swelling and intracranial involvement with thrombosis of ophthalmic and superior orbital veins and frontal epidural abscess extending to the subarachnoid space.
Anales de pediatría (Barcelona, Spain : 2003).An Pediatr (Barc).2014 May;80(5):317-20. doi: 10.1016/j.anpedi.2013.06.001. Epub 2013 Oct 6.
Pott's puffy tumor is a rare complication of frontal sinusitis characterized by swelling and edema in the brow due to a subperiosteal abscess associated with frontal osteomyelitis. Added complications are cellulitis by extension to the orbit and intracranial infection by posterior extension, with hi
PMID 24103248

Propionibacterium acnes and Staphylococcus lugdunensis Cause Pyogenic Osteomyelitis in an Intramedullary Nail Model in Rabbits.

Gahukamble AD1, McDowell A, Post V, Salavarrieta Varela J, Rochford ET, Richards RG, Patrick S, Moriarty TF.Author information 1AO Research Institute Davos, Davos, Switzerland.AbstractPropionibacterium acnes and coagulase-negative staphylococci (CoNS) are opportunistic pathogens implicated in prosthetic joint and fracture fixation device-related infections. The purpose of this study was to determine whether P. acnes and the CoNS species Staphylococcus lugdunensis, isolated from an "aseptically failed" prosthetic hip joint and a united intramedullary nail-fixed tibial fracture, respectively, could cause osteomyelitis in an established implant-related osteomyelitis model in rabbits in the absence of wear debris from the implant material. The histological features of P. acnes infection in the in vivo rabbit model were consistent with localized pyogenic osteomyelitis, and a biofilm was present on all explanted intramedullary (IM) nails. The animals displayed no outward signs of infection, such as swelling, lameness, weight loss, or elevated white blood cell count. In contrast, infection with S. lugdunensis resulted in histological features consistent with both pyogenic osteomyelitis and septic arthritis, and all S. lugdunensis-infected animals displayed weight loss and an elevated white blood cell count despite biofilm detection in only two out of six rabbits. The differences in the histological and bacteriological profiles of the two species in this rabbit model of infection are reflective of their different clinical presentations: low-grade infection in the case of P. acnes and acute infection for S. lugdunensis. These results are especially important in light of the growing recognition of chronic P. acnes biofilm infections in prosthetic joint failure and nonunion of fracture fixations, which may be currently reported as "aseptic" failure.
Journal of clinical microbiology.J Clin Microbiol.2014 May;52(5):1595-606. doi: 10.1128/JCM.03197-13. Epub 2014 Mar 5.
Propionibacterium acnes and coagulase-negative staphylococci (CoNS) are opportunistic pathogens implicated in prosthetic joint and fracture fixation device-related infections. The purpose of this study was to determine whether P. acnes and the CoNS species Staphylococcus lugdunensis, isolated from a
PMID 24599975