急性汎発性発疹性膿疱症
WordNet
- of critical importance and consequence; "an acute (or critical) lack of research funds"
- having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
- extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
- having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
- of an angle; less than 90 degrees
- draw from specific cases for more general cases (同)generalise, extrapolate, infer
- become systemic and spread throughout the body; "this kind of infection generalizes throughout the immune system" (同)generalise
- speak or write in generalities (同)generalise
- not biologically differentiated or adapted to a specific function or environment; "the hedgehog is a primitive and generalized mammal" (同)generalised
PrepTutorEJDIC
- (先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/13 14:17:19」(JST)
[Wiki en表示]
Acute generalized exanthematous pustulosis (AGEP) (also known as "Pustular drug eruption," and "Toxic pustuloderma") is a common cutaneous reaction pattern that in 90% of cases is related to medication administration, characterized by a sudden eruption that appears on average five days after the medication is started.[1]:124
Acute generalized exanthematous pustulosis
It is mediated by T cells.[2]
Contents
- 1 Presentation
- 2 Treatment
- 3 See also
- 4 References
Presentation
AGEP is an acute febrile drug eruption characterized by numerous small, primarily non-follicular, sterile pustules, arising within large areas of edematous erythema.[3]
The eruption follows a self-limiting course and will end before a week provided the causative agent (e.g. medication) is discarded. It is accompanied by fever, neutrophilia, and sometimes by facial edema, hepatitis and eosinophilia. The mortality rate is about 5% and the differential diagnosis includes Stevens–Johnson syndrome (SJS). Contrary to SJS, in AGEP, mucosa are not affected, which means that there are no blisters in the mouth or vagina.
Treatment
The treatment is (1) stop the offending drug (antibiotics), (2) symptomatic (fever) and (3) for complications (hepatitis).[4]
See also
- List of cutaneous conditions
- Skin lesion
- Pustulosis
References
- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- ^ Halevy S (August 2009). "Acute generalized exanthematous pustulosis". Curr Opin Allergy Clin Immunol 9 (4): 322–8. doi:10.1097/ACI.0b013e32832cf64e. PMID 19458527.
- ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 297, 303, 308, 309, 470. ISBN 1-4160-2999-0.
- ^ Canadian Medical Association Journal, September 15, 2009, pp 393-396
Urticaria and erythema (L50–L54, 695, 708)
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Urticaria
(acute/chronic) |
Allergic urticaria |
- Urticarial allergic eruption
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Physical urticaria |
- Cold urticaria
- Primary cold contact urticaria
- Secondary cold contact urticaria
- Reflex cold urticaria
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- Heat urticaria
- Localized heat contact urticaria
- Solar urticaria
|
|
- Dermatographic urticaria
- Vibratory angioedema
- Pressure urticaria
- Cholinergic urticaria
- Aquagenic urticaria
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|
|
Other urticaria |
- Acquired C1 esterase inhibitor deficiency
- Adrenergic urticaria
- Exercise urticaria
- Galvanic urticaria
- Schnitzler syndrome
- Urticaria-like follicular mucinosis
|
|
Angioedema |
- Episodic angioedema with eosinophilia
- Hereditary angioedema
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Erythema |
Erythema multiforme/
drug eruption |
- Erythema multiforme minor
- Erythema multiforme major (Stevens–Johnson syndrome, Toxic epidermal necrolysis)
- panniculitis (Erythema nodosum)
- Acute generalized exanthematous pustulosis
|
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Figurate erythema |
- Erythema annulare centrifugum
- Erythema marginatum
- Erythema migrans
- Erythema gyratum repens
|
|
Other erythema |
- Necrolytic migratory erythema
- Erythema toxicum
- Erythroderma
- Palmar erythema
- Generalized erythema
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UpToDate Contents
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English Journal
- Acute generalized exanthematous pustulosis induced by iodixanol (Visipaque): a serious reaction to a commonly used drug.
- Ozturk U1, Sungur MA1, Karakas T2, Mulayim K2, Ozturk P2.
- Cutaneous and ocular toxicology.Cutan Ocul Toxicol.2015 Dec;34(4):344-6. doi: 10.3109/15569527.2014.961071. Epub 2014 Nov 3.
- Acute generalized exanthematous pustulosis (AGEP) is an acute sterile pustular eruption most commonly induced by medications. Although antibiotics are the most commonly accused drugs in AGEP, non-antibiotic agents may also cause this disease. We present a case of AGEP following use of iodixanol for
- PMID 25363067
- Acute generalized exanthematous pustulosis (AGEP): A review and update.
- Szatkowski J1, Schwartz RA2.
- Journal of the American Academy of Dermatology.J Am Acad Dermatol.2015 Nov;73(5):843-8. doi: 10.1016/j.jaad.2015.07.017. Epub 2015 Sep 6.
- Acute generalized exanthematous pustulosis is a severe cutaneous adverse reaction characterized by the rapid development of nonfollicular, sterile pustules on an erythematous base. It is attributed to drugs in the majority of cases. Antibiotics are the most common cause of acute generalized exanthem
- PMID 26354880
- Acute Generalized Exanthematous Pustulosis Induced by Amoxicillin/Clavulanic Acid: Report of a Case Presenting With Generalized Lymphadenopathy.
- Syrigou E1, Grapsa D2, Charpidou A3, Syrigos K3.
- Journal of cutaneous medicine and surgery.J Cutan Med Surg.2015 Nov;19(6):592-4. doi: 10.1177/1203475415588003. Epub 2015 May 21.
- Drug-induced acute generalized exanthematous pustulosis is a rare pustular skin reaction, most commonly triggered by antibiotics. Although its diagnosis is based primarily on the presence of specific clinical and histopathologic features, additional in vivo (patch testing) or in vitro testing may be
- PMID 25997755
Japanese Journal
- 川崎病との鑑別を要した急性汎発性発疹性膿疱症の1女児例
- 真部 哲治,奥 典宏,相原 雄幸
- 日本小児アレルギー学会誌 29(1), 93-98, 2015
- 川崎病との鑑別を要した急性汎発性発疹性膿疱症の8歳女児例を経験した.入院時発熱,全身の紅斑,両側眼球結膜充血,口唇紅潮,四肢浮腫をみとめた.炎症反応が高値で,血清アルブミン,ナトリウム値が低下していた.川崎病も疑われたが発熱2日目であり,細菌感染症を考慮し抗菌薬の静注を開始した.翌日より全身の紅斑上に多数の小膿疱を認め診断に至った.入院3日目に解熱し,入院4日目に抗菌薬を中止した.紅斑・膿疱は徐々 …
- NAID 130005074488
- 塩酸ジルチアゼムによる急性汎発性発疹性膿疱症の1例 (特集 薬疹・薬物障害・中毒疹)
- 症例報告 肺真菌症患者に生じた急性汎発性発疹性膿疱症(AGEP)の1例
- 佐藤 洋平,平原 和久,狩野 葉子 [他]
- 臨床皮膚科 = Japanese journal of clinical dermatology 68(10), 775-780, 2014-09
- NAID 40020201420
Related Links
- Acute generalized exanthematous pustulosis (AGEP) is a rare, acute eruption characterized by the development of numerous nonfollicular sterile pustules on a background of edematous erythema (). Fever and peripheral blood ... ...
- Extensive formation of nonfollicular sterile pustules on erythematous background combined with fever and peripheral blood leukocytosis are the characteristics of acute generalized exanthematous pustulosis. This uncommon eruption ...
Related Pictures
★リンクテーブル★
[★]
- 英
- acute generalized exanthematous pustulosis、AGEP
- 関
- 薬疹。急性全身性発疹性膿疱症。スティーブンス・ジョンソン症候群、中毒性表皮壊死症、薬剤性過敏症症候群
参考
- http://www.mhlw.go.jp/shingi/2009/03/dl/s0325-10f_0002.pdf
[★]
- 英
- acute generalized exanthematous pustulosis
- 関
- 急性汎発性発疹性膿疱症
[★]
急性汎発性発疹性膿疱症
- 関
- acute generalized exanthematous pustulosis
[★]
- (疾患)急性の、急性型の、急性的な。(形状が)鋭い、鋭角の。(感覚、才知などが)鋭い。明敏な、鋭い眼識のある。
- 関
- acutely、quick、sharp
[★]
- 関
- generalisation、generalise、generalization
[★]
- 関
- generalization、systemic、systemically