WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees
malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
staining readily with basic dyes
a leukocyte with basophilic granules easily stained by basic stains (同)basophile

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
白血病

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/08 11:25:05」(JST)

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Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by abnormal basophils in all stages of differentiation. It would most likely be classified as M0 without electron microscopic confirmation of basophil lineage.^[1]

Presentation[edit]

Differentiated (basophilic granules by light microscopy) and poorly differentiated cases ; Majority are poorly differentiated. MPO negative by light microscopy; granules positive in a speckled pattern by electron microscopy. Myeloid antigens are expressed. Diagnosis of poorly differentiated cases made by electron microscopy. May manifest basophil and mast cell granules by EM. Cytogenetically heterogeneous but frequently associated with Philadelphia chromosome. There is no clinically distinguishing features but may be more common in children and young adults and carry a poor prognosis.^[2]

References[edit]

^ Liu, P.P.; A. Hajara, C. Wijmengac and F.S. Collins (1995). "Molecular pathogenesis of chromosome 16 inversion in the M4E0 subtypes of acute myeloid leukemia". Blood 85 (9): 2289–2302. PMID 7727763.
^ Duchayne, E.; H. Rubier, A. Robert, and N. Dastugue (1999). "Diagnosis of acute basophilic leukemia". Leukemia & Lymphoma 32 (3–4): 269–278. doi:10.3109/10428199909167387. PMID 10037024.

UpToDate Contents

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1. 急性骨髄性白血病の分類 classification of acute myeloid leukemia
2. 急性骨髄性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of acute myeloid leukemia

English Journal

Dysmegakaryopoiesis, a Clue for an Early Diagnosis of Familial Platelet Disorder With Propensity to Acute Myeloid Leukemia in Case of Unexplained Inherited Thrombocytopenia Associated With Normal-sized Platelets.

Latger-Cannard V, Philippe C, Jonveaux P, Lecompte T, Favier R.Source*Service d'Hematologie Biologique ‡Laboratoire de Genetique §EA 4368, Centre Hospitalier Universitaire de Nancy †Centre de Competence Nord-Est des Pathologies plaquettaires '∥Publique-Hopitaux de Paris, Service dHematologie Biologique, Hopital A. Trousseau ¶Inserm U1009, Villejuif, Paris ♯Centre de Reference des Pathologies Plaquettaires, France.
Journal of pediatric hematology/oncology.J Pediatr Hematol Oncol.2011 Oct;33(7):e264-6.
We report dysmegakaryopoiesis in a case of familial platelet disorder with predisposition to acute myeloid leukemia (familial platelet disorder/acute myeloid leukemia phenotype Mendelian Inheritance in Man number 601 399). Slight reduction of the number of megakaryocytes with high nucleocytoplasmic
PMID 21900832

Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms.

Diamond HR, Ornellas MH, Orfao A, Gomes BE, Campos MM, Fernandez TD, Silva RI, Alves G, Lage C, Silva DA, Moellmann-Coelho A, Cruz GS, Bouzas LF, Abdelhay E.AbstractABSTRACT: A 54-year-old woman was diagnosed with infiltrative ductal breast carcinoma. Two years after treatment, the patient developed an acute myeloid leukemia (AML) which harbored del(11q23) in 8% of the blast cells. The patient was submitted for allogeneic stem cell transplantation (aSCT) from her HLA-compatible sister. Ten months after transplantation, she relapsed with an AML with basophilic maturation characterized by CD45low CD33high, CD117+, CD13-/+, HLA Drhigh, CD123high, and CD203c+ blast cells lacking expression of CD7, CD10, CD34, CD15, CD14, CD56, CD36, CD64, and cytoplasmic tryptase. Karyotype analysis showed the emergence of a new clone with t(2;14) and FISH analysis indicated the presence of MLL gene rearrangement consistent with del(11q23). Interestingly, AML blast cell DNA tested with microsatellite markers showed the same pattern as the donor's, suggesting that this AML emerged from donor cells. Additionally, polymorphisms of the XPA, XPD, XRCC1, XRCC3 and RAD51 DNA repair genes revealed three unfavorable alleles with low DNA repair capacity. In summary, we report the first case of AML involving XPD and XRCC3 polymorphism from donor origin following allogeneic stem cell transplantation and highlight the potential need for careful analysis of DNA repair gene polymorphisms in selecting candidate donors prior to allogeneic stem cell transplantation.
Journal of hematology & oncology.J Hematol Oncol.2011 Sep 27;4(1):39. [Epub ahead of print]
ABSTRACT: A 54-year-old woman was diagnosed with infiltrative ductal breast carcinoma. Two years after treatment, the patient developed an acute myeloid leukemia (AML) which harbored del(11q23) in 8% of the blast cells. The patient was submitted for allogeneic stem cell transplantation (aSCT) from h
PMID 21951951

Japanese Journal

Acute Myeloid Leukemia with Mastocytic and Megakaryocytic Differentiation in a Calf

IKEHATA Tsutomu,WADA Yoshihiro,ISHIKAWA Yoshiharu,KADOTA Koichi
Journal of Veterinary Medical Science 73(4), 467-470, 2011
… A diagnosis of acute myeloid leukemia was made in a 10-month-old Holstein female calf. … The leukemia was macroscopically characterized by great enlargement of the spleen and moderate enlargement of some lymph nodes. … The granules, which were positive for naphthol AS-D chloroacetate esterase and did not have particulate contents, were distinct from those of basophilic leukemia cells. …
NAID 130000444380

3-O-(2,3-Dimethylbutanoyl)-13-O-decanoylingenol from Euphorbia kansui Suppresses IgE-Mediated Mast Cell Activation(Pharmacology)

NUNOMURA Satoshi,KITANAKA Susumu,RA Chisei
Biological & pharmaceutical bulletin 29(2), 286-290, 2006-02-01
… Aggregation of the high affinity receptor for IgE (FcεRI) on mast cells by antigen and IgE complex induces release of chemical mediators, leading to acute allergic inflammation. … We recently found that 3-O-(2, 3-dimethylbutanoyl)-13-O-decanoylingenol (DBDI), purified from the Euphorbia kansui L., inhibits degranulation in rat basophilic leukemia 2H3 cells upon aggregation of the FcεRI. …
NAID 110005663960