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1. 不安症状および不安障害に対する補完代替療法：漢方薬および栄養補助食品complementary and alternative treatments for anxiety symptoms and disorders herbs and medications [show details]
…make pills, eg, stems, leaves, peelings, and bark with an ethanol or acetone solvent. The principal active ingredients of kava remedies are called kavalactones; 15 have been identified, all with psychoactive…
2. 成人における腎移植：腎移植後の骨疾患kidney transplantation in adults bone disease after kidney transplantation [show details]
… topic would treat with an active vitamin D analog. However, other authors and editors of this topic do not use bisphosphonates or active vitamin D analogs to prevent… We give vitamin D3 to target a serum 25-hydroxyvitamin D level of >30 ng/mL. There are few data concerning the effectiveness of vitamin D3 alone in the prevention…
3. 成人における腎移植：腎移植後の持続性副甲状腺機能亢進症kidney transplantation in adults persistent hyperparathyroidism after kidney transplantation [show details]
…per day. Serum calcium should be checked frequently (ie, every month) while titrating up the active vitamin D3 derivative dose. This approach is effective in most patients. Patients who develop hypercalcemia …
4. ビタミンDの概要overview of vitamin d [show details]
… does not produce toxic amounts of vitamin D3 because of photoconversion of previtamin D3 and vitamin D3 to inactive metabolites (lumisterol; tachysterol; 5,6-transvitamin… biologically inactive and requires enzymatic conversion to active metabolites Vitamin D is converted enzymatically in the liver to 25-hydroxyvitamin D (25[OH]D),…
5. 成人におけるビタミンD欠乏症：定義、臨床症状、および治療vitamin d deficiency in adults definition clinical manifestations and treatment [show details]
…doses of vitamin D3 increase serum 25(OH)D levels, we do not use them in patients with normal absorptive capacity. In one trial, a large, annual oral dose of 500,000 international units of vitamin D3 had… It requires hepatic 25-hydroxylation prior to becoming therapeutically active.…

English Journal

Protective effects of 1,25 dihydroxyvitamin D and its analogs on ultraviolet radiation-induced oxidative stress: a review.

Jagoda SV, Dixon KM.
Redox report : communications in free radical research. 2020 Dec;25(1)11-16.
The active vitamin D compound, 1,25-dihydroxyvitamin D3 (1,25D) is produced in skin cells following exposure to ultraviolet radiation (UV) from the sun. However, there are many harmful effects of UV which include DNA damage caused by direct absorption of UV, as well as that caused indirectly via UV-
PMID 32093585

Vitamin D modulates yellow catfish (Pelteobagrus fulvidraco) immune function in vivo and in vitro and this involves the vitamin D/VDR-type I interferon axis.

Cheng K, Ma C, Guo X, Huang Y, Tang R, Karrow NA, Wang C.
Developmental and comparative immunology. 2020 Jun;107()103644.
Vitamin D (VD) has been shown to regulate immune function in mammals. 1,25-dihydroxyvitamin (1,25(OH)D) is the active form of vitamin D, which is also known as calcitriol. The current study investigated the immunomodulatory effects of 1,25(OH)D on the innate immune response of yellow catfish (Pelteo
PMID 32061641

Ezh2-dependent H3K27me3 modification dynamically regulates vitamin D3-dependent epigenetic control of CYP24A1 gene expression in osteoblastic cells.

Moena D, Nardocci G, Acevedo E, Lian J, Stein G, Stein J, Montecino M.
Journal of cellular physiology. 2020 Jun;235(6)5404-5412.
Epigenetic control is critical for the regulation of gene transcription in mammalian cells. Among the most important epigenetic mechanisms are those associated with posttranslational modifications of chromosomal histone proteins, which modulate chromatin structure and increased accessibility of prom
PMID 31907922

Japanese Journal

Micro-CT imaging analysis for the effects of ibandronate and eldecalcitol on secondary osteoporosis and arthritis in adjuvant-induced arthritis rats

ONO Yuichi,SATO Chiaki,KAWATANI Masahito,SHIMADA Yoichi,MIYAKOSHI Naohisa,KASUKAWA Yuji,IMAI Yuuki,NAGASAWA Hiroyuki,TSUCHIE Hiroyuki,AKAGAWA Manabu,NAGAHATA Itsuki,YUASA Yusuke
Biomedical Research 40(5), 197-205, 2019
… eldecalcitol, an active vitamin D3 analogue; …
NAID 130007724878

Severe hypocalcemia following denosumab treatment in a patient with secondary osteoporosis associated with primary sclerosing cholangitis

Yasuda Yoshinori,Iwama Shintaro,Arima Hiroshi
Endocrine Journal 66(3), 271-275, 2019
… Despite replacements with calcium and active vitamin D (alfacalcidol; … After that, the corrected serum calcium levels were controlled within the normal range with 0.75 μg of eldecalcitol (1α,25-dihydroxy-2β-(3-hydroxypropyloxy)vitamin D3) and increased doses of calcium (1,500 mg daily) and phosphate (900 mg daily) without denosumab. …
NAID 130007626250

1,25(OH)₂D₃ Activates Autophagy to Protect against Oxidative Damage of INS-1 Pancreatic Beta Cells

He Dawei,Wang Yubin,Liu Ruijiang,He Aolin,Li Shasha,Fu Xuejie,Zhou Zhengyu
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 42(4), 561-567, 2019
… Vitamin D (Vit D) is a well-characterized regulator of calcium-phosphorus metabolism that also exerts other biological effects extending far beyond mineral homeostasis. … In this study, the protective effect of 1,25(OH)<sub>2</sub>D<sub>3</sub>, the physiologically active metabolite of Vit D, against streptozotocin-induced cytotoxicity in rat insulinoma cell line (INS-1) cells was explored. …
NAID 130007622153