WordNet

direct the flow of; "channel information towards a broad audience" (同)canalize, canalise
a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels" (同)television channel, TV channel
a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"
(often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms" (同)communication channel, line
a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company" (同)transmission channel
a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"
a positively charged ion
official routes of communication; "you have to go through channels"

PrepTutorEJDIC

〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す
陽イオン,正イオン

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Intracellular spermine blocks TRPC4 channel via electrostatic interaction with C-terminal negative amino acids.

Kim J1,2, Moon SH3, Shin YC2, Jeon JH2, Park KJ3, Lee KP4, So I5.
Pflugers Archiv : European journal of physiology.Pflugers Arch.2015 Dec 2. [Epub ahead of print]
Transient receptor potential canonical (TRPC) 4 channels are calcium-permeable, nonselective cation channels and are widely expressed in mammalian tissue, especially in the GI tract and brain. TRPC4 channels are known to be involved in neurogenic contraction of ileal smooth muscle cells via generati
PMID 26631167

Developmental changes in the expression and function of TRPC6 channels related the F-actin organization during differentiation in podocytes.

Liu Z1, Yang J2, Zhang X1, Xu P1, Zhang T3, Yang Z4.
Cell calcium.Cell Calcium.2015 Dec;58(6):541-8. doi: 10.1016/j.ceca.2015.09.001. Epub 2015 Sep 3.
The transient receptor potential canonical (TRPC) 6 channel is an important ion channel located in podocytes, which plays an essential role in regulating calcium homeostasis of the cell signaling. Podocytes are specialized, terminally differentiated cells surrounding glomerular capillaries, and are
PMID 26363733

Sun Y1, Birnbaumer L2, Singh BB1.
Journal of cellular physiology.J Cell Physiol.2015 Nov;230(11):2848-56. doi: 10.1002/jcp.25017.
Calcium-activated chloride channel (CaCC) plays an important role in modulating epithelial secretion. It has been suggested that in salivary tissues, sustained fluid secretion is dependent on Ca(2+) influx that activates ion channels such as CaCC to initiate Cl(-) efflux. However direct evidence as
PMID 25899321

New Molecular Mechanisms for Cardiovascular Disease : Transcriptional Pathways and Novel Therapeutic Targets in Heart Failure

Kuwahara Koichiro,Nakao Kazuwa
Journal of pharmacological sciences 116(4), 337-342, 2011-08-20
… channel. … In the pathological calcineurin – nuclear factor of activated T-cells (NFAT) signaling pathway, transient receptor potential cation channel, subfamily C, member 6 (TRPC6) is a key component of a Ca2+-dependent regulatory loop. … Indeed, inhibition of TRPC significantly ameliorates this pathological process in a mouse model of cardiac hypertrophy. …
NAID 10029895482

Dual Signaling Pathways of Arterial Constriction by Extracellular Uridine 5'-Triphosphate in the Rat

Sugihara Megumi,Morita Hiromitsu,Matsuda Miho [他],UMEBAYASHI Hisanori,KAJIOKA Shunichi,ITO Shinichi,NISHIDA Motohiro,INOUE Ryosuke,FUTATSUKI Toshiko,YAMAZAKI Jun,MORI Yasuo,INOUE Ryuji,ITO Yushi,ABE Kihachiro,HIRATA Masato
Journal of pharmacological sciences 115(3), 293-308, 2011-03-20
… The UTP-activated current was insensitive to G-protein modulators, TRPC3 inhibitors, or TRPC3 antibody, but was sensitive to P2-receptor inhibitors or P2X1-receptor antibody. … Both UTP (1 mM) and α,β-methylene ATP (10 μM) elicited similar conductance single channel activities. … In contrast to the low expression of TRPC3, significant expression of P2X1 …
NAID 10029892471

神田祥一郎,張田豊
Nihon Shoni Jinzobyo Gakkai Zasshi 24(2), 187-197, 2011
… その機序としてAngiotensinII受容体刺激の下流でTRPC6を介した細胞内へのCa2＋の流入と，その結果としてcalcineurin-NFAT経路の活性化が明らかになってきた。 …
NAID 130002114185