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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2020/05/10 11:50:57」(JST)

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TLS may refer to:

Computing

Transport Layer Security, a cryptographic protocol for secure computer network communication
Thread level speculation, an optimisation on multiprocessor CPUs
Thread-local storage, a mechanism for allocating variables in computer science
Transparent LAN Service, a transparent data link connecting remote Ethernet networks

Media

Theaterlexikon der Schweiz, an encyclopedia about theatre in Switzerland
Thesaurus Linguae Sericae, a study of the Chinese language
The Times Literary Supplement, a British weekly literary review
Town Life Stuff, one of The Sims 3 Stuff packs

Organisations

Telstra (ASX code), an Australian telecommunications and media company
Trans Link Systems B.V., a company delivering the OV-chipkaart system to public-transport operators in the Netherlands.
Transmitter Location Systems, a US satellite radio interference geolocation company

Education

The Lindsey School, a secondary school in Cleethorpes, North East Lincolnshire, England
Tallinn Law School, in Estonia
Torrey Life Science, a biology organization of the University of Connecticut, US
Trinity Law School, in Santa Ana, California, US
Trinity Lutheran School (disambiguation), several schools in the US
Tulane University Law School, in New Orleans, Louisiana, US

Science, medicine and technology

Thüringer Landessternwarte Tautenburg, the Karl Schwarzschild Observatory, Germany
Total least squares, a statistical analysis
Translesion synthesis, a form of DNA repair
Transponder landing system, an airplane landing system
Tumor lysis syndrome, a group of metabolic complications that can occur after treatment of cancer
Tunable laser spectrometer, an instrument in the Mars rover suite Sample Analysis at Mars
Two-level system, a quantum system

Other uses

East Timor (IOC code)
Toulouse–Blagnac Airport (IATA code)
Typed Letter Signed, in auctions of autographs

This disambiguation page lists articles associated with the title TLS.
If an internal link led you here, you may wish to change the link to point directly to the intended article.

UpToDate Contents

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1. 腫瘍崩壊症候群：予防および治療tumor lysis syndrome prevention and treatment [show details]
… percent in those without evidence of clinical TLS). The major causes of death in patients with clinical TLS were hemorrhage and acute kidney injury, and clinical TLS was considered a major cause of death in …
2. 腫瘍崩壊症候群：定義、発病メカニズム、臨床症状、原因および危険因子tumor lysis syndrome definition pathogenesis clinical manifestations etiology and risk factors [show details]
…presentation of TLS will be reviewed here. Prevention and treatment of TLS are discussed elsewhere, as are issues related to treatment of the particular malignancies that are associated with TLS. In the …
3. 学会が公開する診療ガイドラインのリンク：腫瘍崩壊症候群society guideline links tumor lysis syndrome [show details]
…for the evaluation of risk and prophylaxis of tumour lysis syndrome (TLS) in adults and children with malignant diseases – An expert TLS panel consensus (2010) Guidelines for the management of pediatric…
4. 急性骨髄性白血病の分子遺伝学molecular genetics of acute myeloid leukemia [show details]
…blast crisis of CML, and MDS . In this translocation, the TLS/FUS gene at 16p11 fuses to the ERG gene at 21q22 to generate a chimeric protein. Both TLS/FUS and ERG are involved in chromosomal translocations …
5. 血液悪性腫瘍における白血球増多症および白血球症hyperleukocytosis and leukostasis in hematologic malignancies [show details]
…precipitate or exacerbate hyperuricemia and occasionally precipitate TLS, therefore such patients also need intravenous hydration and TLS prophylaxis. For patients with symptoms of leukostasis who must …

English Journal

Serum level of PCBs and OCPs and leukocyte telomere length among adults in Tehran, Iran.

Karimi B, Nabizadeh Nodehi R, Yunesian M.
Chemosphere. 2020 Jun;248()126092.
Exposure to polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) may change leukocyte telomere length (TL) at the end of the DNA sequence. The purpose of this study was to investigate the association between PCBs and OCPs exposure with TL in Tehran adult males. Whole-blood samples w
PMID 32041072

The response of stream ecosystems in the Adirondack region of New York to historical and future changes in atmospheric deposition of sulfur and nitrogen.

Shao S, Driscoll CT, Sullivan TJ, Burns DA, Baldigo B, Lawrence GB, McDonnell TC.
The Science of the total environment. 2020 May;716()137113.
The present-day acid-base chemistry of surface waters can be directly linked to contemporary observations of acid deposition; however, pre-industrial conditions are key to predicting the potential future recovery of stream ecosystems under decreasing loads of atmospheric sulfur (S) and nitrogen (N)
PMID 32059317

DUSP3 maintains genomic stability and cell proliferation through modulation of the NER pathway and cell cycle regulatory proteins.

Russo LC, Farias JO, Forti FL.
Cell cycle (Georgetown, Tex.). 2020 May;()1-17.
The DUSP3 phosphatase regulates cell cycle, proliferation, apoptosis and senescence of different cell types, lately shown as a mediator of DNA repair processes. This work evaluated the impact of DUSP3 loss of function () on DNA repair-proficient fibroblasts (MRC-5), NER-deficient cell lines (XPA and
PMID 32380926

Japanese Journal

secureTCP: Securing the TCP/IP stack using a Trusted Execution Environment

Keita Aihara,Pierre-Louis Aublin,Kenji Kono
コンピュータシステム・シンポジウム論文集 (2019), 9-14, 2019-12-03
NAID 170000180883

腫瘍崩壊症候群における高尿酸血症 : 治癒を目指しうる緊急疾患 (特集新しい『高尿酸血症・痛風の治療ガイドライン』を読み解く) -- (治療はどう変わったか)

山下浩平
診断と治療 = Diagnosis and treatment 107(12), 1481-1486, 2019-12
NAID 40022099478

SSL/TLSハンドシェイク時に取得可能な情報を用いたWebサーバの信用度算定に関する検討

大室高帆,新城靖,中井央,三宮秀次,佐藤聡
インターネットと運用技術シンポジウム論文集 (2019), 120-121, 2019-11-28
NAID 170000180880

「腫瘍崩壊症候群」

　　[★]

英: tumor lysis syndrome, TLS
同: 腫瘍融解症候群、腫瘍溶解症候群

[show details]

腫瘍崩壊症候群 : 約 3,630 件
腫瘍融解症候群 : 約 4,040 件
腫瘍溶解症候群 : 92 件

概念

腫瘍性疾患において化学療法を施行した後、腫瘍細胞の崩壊により細胞内成分が血液内に流入することにより生じる病態。
高尿酸血症、高カリウム血症、高リン血症、低カルシウム血症、高乳酸血症(乳酸アシドーシス)を呈する。

高乳酸血症をきたすのは腫瘍細胞もっぱら解糖系でエネルギーを産生するためか？(NADHの再生とピルビン酸の処理のために乳酸が産生される？)

白血病や悪性リンパ腫の治療の過程で起こりうる。すなわち、化学療法や放射線療法により腫瘍細胞が壊死に至った際、腫瘍細胞から核酸、尿酸、カリウム、リンが血液中に放出される。糸球体を通過した尿酸が尿細管内で結晶化し尿路を閉塞し急性腎障害を来すといわれている。
急性腎不全を来しやすいために尿量を保ち尿のアルカリ化を計るなどする。