WordNet

the quantity contained in a box; "he gave her a box of chocolates" (同)boxful
evergreen shrubs or small trees (同)boxwood
a rectangular drawing; "the flowchart contained many boxes"
hit with the fist; "Ill box your ears!"
the drivers seat on a coach; "an armed guard sat in the box with the driver" (同)box_seat
private area in a theater or grandstand where a small group can watch the performance; "the royal box was empty" (同)loge
a (usually rectangular) container; may have a lid; "he rummaged through a box of spare parts"
a blow with the hand (usually on the ear); "I gave him a good box on the ear"
any one of several designated areas on a ball field where the batter or catcher or coaches are positioned; "the umpire warned the batter to stay in the batters box"
separate partitioned area in a public place for a few people; "the sentry stayed in his box to avoid the cold"
put into a box; "box the gift, please" (同)package
engage in a boxing match
enclosed in or set off by a border or box; "boxed sections of the report"; "boxed announcements in the newspaper"
enclosed in or as if in a box; "boxed cigars"; "a confining boxed-in space"; "felt boxed in by the traffic" (同)boxed-in, boxed in
fighting with the fists (同)pugilism, fisticuffs

PrepTutorEJDIC

『箱』 / (の…)『1箱』《+『of』+『名』》 / (劇場などの)さじき席ます席 / 番小屋,詰め所 / (野球で)バッターボックス;コーチャーズボックス;ピッチャーズマウンド;キャッチャーの定位置 / (線で囲った)四角のわく,囲み;(新聞・雑誌の) / (郵便の)私書箱 / 《the box》《英俗》テレビ / …'を'箱に入れる,箱詰めにする
〈C〉(平手・こぶしの)びんた,張り手,ひと打ち / 〈人〉‘と'ボクシングをする / …'を'平手で打つ,こぶしでなぐる / (…と)ボクシングをする《+『with』(『against』)+『名』》
〈C〉〈U〉ツゲ(常緑低木) / 〈U〉=boxwood
『ボクシング』

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/29 11:10:52」(JST)

wiki en

The TATA box (also called Goldberg-Hogness box)^[1] is a DNA sequence (cis-regulatory element) found in the promoter region of genes in archaea and eukaryotes;^[2] approximately 24% of human genes contain a TATA box within the core promoter.^[3]

Considered to be the core promoter sequence, it is the binding site of either general transcription factors or histones (the binding of a transcription factor blocks the binding of a histone and vice versa) and is involved in the process of transcription by RNA polymerase.

Overview

The TATA box has the core DNA sequence 5'-TATAAA-3' or a variant, which is usually followed by three or more adenine bases^{[citation needed]}. It is usually located 25-35 base pairs upstream of the transcription start site. The sequence is believed to have remained consistent throughout much of the evolutionary process, possibly originating in an ancient eukaryotic organism.^[4]^[5]

During the process of transcription, the TATA binding protein (TBP) normally binds to the TATA-box sequence, which unwinds the DNA and bends it through 80°. The AT-rich sequence of the TATA-box facilitates easy unwinding, due to weaker base-stacking interactions between A and T bases, as compared to between G and C. The TBP is an unusual protein in that it binds to the minor groove and binds with a β sheet.^[6]

The TATA box is usually found at the binding site of RNA polymerase II. TFIID, a transcription factor, binds to the TATA box, followed by TFIIA binding to the upstream part of the TFIID protein. TFIIB then binds to the downstream part of TFIID. RNA polymerase can then recognize this multi-protein complex and bind to it, along with various other transcription factors such as TFIIF, TFIIE and TFIIH. Transcription is then initiated, and the polymerase moves along the DNA strand, leaving TFIID and TFIIA bound to the TATA box. These can then facilitate the binding of additional RNA polymerase II molecules.

This cluster of RNA polymerase II and various transcription factors is known as a basal transcriptional complex or BTC. In this state, it only gives a low level of transcription. Other factors must stimulate the BTC to increase transcription levels. One such example of a BTC stimulating region of DNA is the CAAT box.

Most genes lack a TATA box and use an initiator element or downstream core promoter instead.^[7] Nevertheless, TBP is always involved and is forced to bind without sequence specificity. A genome-wide study put the fraction of TATA-dependent human promoters at ~10%.^[8] An earlier study of ~1,000 genes found 32% of the promoters had a TATA box.^[9]

References

^ Lifton RP, Goldberg ML, Karp RW, Hogness DS (1978). "The organization of the histone genes in Drosophila melanogaster: functional and evolutionary implications". Cold Spring Harb Symp Quant Biol 42: 1047–1051. doi:10.1101/sqb.1978.042.01.105. PMID 98262.
^ Smale, ST; Kadonaga, JT (2003). "The RNA polymerase II core promoter." (PDF). Annual review of biochemistry 72: 449–79. doi:10.1146/annurev.biochem.72.121801.161520. PMID 12651739.
^ Yang, C; Bolotin, E; Jiang, T; Sladek, FM; Martinez, E (2007). "Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters.". Gene 389 (1): 52–65. doi:10.1016/j.gene.2006.09.029. PMC 1955227. PMID 17123746.
^ Patikoglou, G. A.; Kim, J. L.; Sun, L.; Yang, S.-H.; Kodadek, T.; Burley, S. K. (15 December 1999). "TATA element recognition by the TATA box-binding protein has been conserved throughout evolution". Genes & Development 13 (24): 3217–3230. doi:10.1101/gad.13.24.3217. PMID 10617571. |access-date= requires |url= (help)
^ Bernard, Virginie; Brunaud, Véronique; Lecharny, Alain (2010). "TC-motifs at the TATA-box expected position in plant genes: a novel class of motifs involved in the transcription regulation". BMC Genomics 11 (1): 166. doi:10.1186/1471-2164-11-166. |access-date= requires |url= (help)
^ Kutyavin, IV; Afonina, IA; Mills, A; Gorn, VV; Lukhtanov, EA; Belousov, ES; Singer, MJ; Walburger, DK; Lokhov, SG; Gall, AA; Dempcy, R; Reed, MW; Meyer, RB; Hedgpeth, J (15 January 2000). "3'-minor groove binder-DNA probes increase sequence specificity at PCR extension temperatures.". Nucleic Acids Research 28 (2): 655–61. doi:10.1093/nar/28.2.655. PMC 102528. PMID 10606668. Retrieved 6 March 2015.
^ Yang, C; Bolotin, E; Jiang, T; Sladek, FM; Martinez, E (1 March 2007). "Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters.". Gene 389 (1): 52–65. doi:10.1016/j.gene.2006.09.029. PMC 1955227. PMID 17123746. Retrieved 6 March 2015.
^ Carninci P, Sandelin A, Lenhard B, et al. (June 2006). "Genome-wide analysis of mammalian promoter architecture and evolution". Nat. Genet. 38 (6): 626–35. doi:10.1038/ng1789. PMID 16645617.
^ Suzuki Y, Tsunoda T, Sese J, et al. (May 2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMC 311086. PMID 11337467.

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