関: SCF ubiquitin ligase、Skp1-cullin-F-box protein

WordNet

the quantity contained in a box; "he gave her a box of chocolates" (同)boxful
evergreen shrubs or small trees (同)boxwood
a rectangular drawing; "the flowchart contained many boxes"
hit with the fist; "Ill box your ears!"
the drivers seat on a coach; "an armed guard sat in the box with the driver" (同)box_seat
private area in a theater or grandstand where a small group can watch the performance; "the royal box was empty" (同)loge
a (usually rectangular) container; may have a lid; "he rummaged through a box of spare parts"
a blow with the hand (usually on the ear); "I gave him a good box on the ear"
any one of several designated areas on a ball field where the batter or catcher or coaches are positioned; "the umpire warned the batter to stay in the batters box"
separate partitioned area in a public place for a few people; "the sentry stayed in his box to avoid the cold"
put into a box; "box the gift, please" (同)package
engage in a boxing match
remove something that has been rejected; "cull the sick members of the herd"
the person or thing that is rejected or set aside as inferior in quality (同)reject
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
enclosed in or set off by a border or box; "boxed sections of the report"; "boxed announcements in the newspaper"
enclosed in or as if in a box; "boxed cigars"; "a confining boxed-in space"; "felt boxed in by the traffic" (同)boxed-in, boxed in
the 19th letter of the Roman alphabet (同)s

PrepTutorEJDIC

『箱』 / (の…)『1箱』《+『of』+『名』》 / (劇場などの)さじき席ます席 / 番小屋,詰め所 / (野球で)バッターボックス;コーチャーズボックス;ピッチャーズマウンド;キャッチャーの定位置 / (線で囲った)四角のわく,囲み;(新聞・雑誌の) / (郵便の)私書箱 / 《the box》《英俗》テレビ / …'を'箱に入れる,箱詰めにする
〈C〉(平手・こぶしの)びんた,張り手,ひと打ち / 〈人〉‘と'ボクシングをする / …'を'平手で打つ,こぶしでなぐる / (…と)ボクシングをする《+『with』(『against』)+『名』》
〈C〉〈U〉ツゲ(常緑低木) / 〈U〉=boxwood
〈花など〉'を'摘む / 〈最上のもの〉'を'選び取る / 〈粗悪なもの〉'を'淘汰(とうた)する,〈劣っているもの〉'を'えり分けて殺す / えり出された劣等品(きず物の果物など)
蛋白(たんばく)質
sulfurの化学記号 / {略}South[ern]

UpToDate Contents

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1. T-B-NK+ SCID：病因および遺伝学 t b nk scid pathogenesis and genetics
2. Protein S deficiency
3. Protein C deficiency
4. Factor V Leiden and activated protein C resistance
5. Hypertrophic cardiomyopathy: Gene mutations and clinical genetic testing

English Journal

Hepatitis B virus X protein enhances Myc stability by inhibiting SCFSkp2 ubiquitin E3 ligase-mediated Myc ubiquitination and contributes to oncogenesis.

Lee S1, Kim W1, Ko C1, Ryu WS1.
Oncogene.Oncogene.2015 Jul 13. doi: 10.1038/onc.2015.251. [Epub ahead of print]
The stability of Myc oncoprotein is regulated by Skp/cullin/F-box (SCF) ubiquitin E3 ligase, in particular, via either SCFSkp2 or SCFFbw7 ubiquitin E3 ligases. An earlier study has shown that hepatitis B virus X protein (HBx) augments Myc stability via a mechanism involving the inhibition of Myc ubi
PMID 26165841

BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.

Coyaud E1, Mis M2, Laurent EM1, Dunham WH3, Couzens AL3, Robitaille M2, Gingras AC4, Angers S5, Raught B6.
Molecular & cellular proteomics : MCP.Mol Cell Proteomics.2015 Jul;14(7):1781-95. doi: 10.1074/mcp.M114.045658. Epub 2015 Apr 21.
The identification of ubiquitin E3 ligase substrates has been challenging, due in part to low-affinity, transient interactions, the rapid degradation of targets and the inability to identify proteins from poorly soluble cellular compartments. SCF(β-TrCP1) and SCF(β-TrCP2) are well-studied ubiquiti
PMID 25900982

Circulating E3 ligases are novel and sensitive biomarkers for diagnosis of acute myocardial infarction.

Han QY1, Wang HX1, Liu XH2, Guo CX3, Hua Q4, Yu XH5, Li N1, Yang YZ5, Du J1, Xia YL5, Li HH1.
Clinical science (London, England : 1979).Clin Sci (Lond).2015 Jun;128(11):751-60. doi: 10.1042/CS20140663.
Ubiquitin ligase (E3) is a decisive element of the ubiquitin-proteasome system (UPS), which is the main pathway for intracellular protein turnover. Recently, circulating E3 ligases have been increasingly considered as cancer biomarkers. In the present study, we aimed to determine if cardiac-specific
PMID 25599194