PAF receptor

• 血小板活性化因子受容体、血小板活性化因子レセプター、PAF受容体、PAFレセプター

WordNet

1. the 16th letter of the Roman alphabet (同)p
2. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. personal assistant個人秘書 / public address [system]
2. parking
3. phosphorusの化学記号
4. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/08 11:33:46」(JST)

wiki en

[Wiki en表示]

Platelet-activating factor receptor
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2B0X
Identifiers
Symbols	PTAFR ; PAFR
External IDs	OMIM: 173393 MGI: 106066 HomoloGene: 20260 IUPHAR: 334 ChEMBL: 250 GeneCards: PTAFR Gene
Gene ontology Molecular function • lipopolysaccharide binding • lipopolysaccharide receptor activity • G-protein coupled receptor activity • platelet activating factor receptor activity • phospholipid binding Cellular component • plasma membrane • integral component of plasma membrane • membrane • integral component of membrane Biological process • cytokine production • chemotaxis • inflammatory response • immune response • G-protein coupled receptor signaling pathway • cytokine-mediated signaling pathway • lipopolysaccharide-mediated signaling pathway • inositol trisphosphate biosynthetic process • phosphatidylinositol-mediated signaling • interferon-gamma-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5724	19204
Ensembl	ENSG00000169403	ENSMUSG00000056529
UniProt	P25105	Q62035
RefSeq (mRNA)	NM_000952	NM_001081211
RefSeq (protein)	NP_000943	NP_001074680
Location (UCSC)	Chr 1: 28.47 – 28.52 Mb	Chr 4: 132.56 – 132.58 Mb
PubMed search	[1]	[2]

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.

The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM] Its pathogenetic role in chronic kidney failure has also been reported recently.

Ligands

Agonists

• Platelet activating factor

Antagonists

• Israpafant (Y-24180)
• WEB 2086

References

Further reading

• Shukla SD (1992). "Platelet-activating factor receptor and signal transduction mechanisms.". FASEB J. 6 (6): 2296–301. PMID 1312046. 
• Sugimoto T, Tsuchimochi H, McGregor CG et al. (1993). "Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.". Biochem. Biophys. Res. Commun. 189 (2): 617–24. doi:10.1016/0006-291X(92)92245-S. PMID 1281995.  CS1 maint: Explicit use of et al. (link)
• Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1.". Genomics 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356. 
• Kunz D, Gerard NP, Gerard C (1992). "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.". J. Biol. Chem. 267 (13): 9101–6. PMID 1374385. 
• Ye RD, Prossnitz ER, Zou AH, Cochrane CG (1991). "Characterization of a human cDNA that encodes a functional receptor for platelet activating factor.". Biochem. Biophys. Res. Commun. 180 (1): 105–11. doi:10.1016/S0006-291X(05)81261-6. PMID 1656963. 
• Nakamura M, Honda Z, Izumi T et al. (1991). "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.". J. Biol. Chem. 266 (30): 20400–5. PMID 1657923.  CS1 maint: Explicit use of et al. (link)
• Haslam RJ, Williams KA, Davidson MM (1986). "Receptor-effector coupling in platelets: roles of guanine nucleotides.". Adv. Exp. Med. Biol. 192: 265–80. PMID 3010668. 
• Valone FH (1984). "Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine.". Immunology 52 (1): 169–74. PMC 1454573. PMID 6325330. 
• Cundell DR, Gerard NP, Gerard C et al. (1995). "Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor.". Nature 377 (6548): 435–8. doi:10.1038/377435a0. PMID 7566121.  CS1 maint: Explicit use of et al. (link)
• Izumi T, Kishimoto S, Takano T et al. (1995). "Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation.". Biochem. J. 305. ( Pt 3): 829–35. PMC 1136334. PMID 7848283.  CS1 maint: Explicit use of et al. (link)
• Bito H, Honda Z, Nakamura M, Shimizu T (1994). "Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA.". Eur. J. Biochem. 221 (1): 211–8. doi:10.1111/j.1432-1033.1994.tb18731.x. PMID 8168510. 
• Chase PB, Halonen M, Regan JW (1993). "Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region.". Am. J. Respir. Cell Mol. Biol. 8 (3): 240–4. doi:10.1165/ajrcmb/8.3.240. PMID 8383507. 
• Mutoh H, Bito H, Minami M et al. (1993). "Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor.". FEBS Lett. 322 (2): 129–34. doi:10.1016/0014-5793(93)81552-B. PMID 8387031.  CS1 maint: Explicit use of et al. (link)
• Nakamura M, Honda Z, Matsumoto T et al. (1993). "Isolation and properties of platelet-activating factor receptor cDNAs.". Journal of lipid mediators 6 (1-3): 163–8. PMID 8395240.  CS1 maint: Explicit use of et al. (link)
• Kishimoto S, Shimadzu W, Izumi T et al. (1996). "Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils.". J. Immunol. 157 (9): 4126–32. PMID 8892648.  CS1 maint: Explicit use of et al. (link)
• Chase PB, Yang JM, Thompson FH et al. (1997). "Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35→p34.3 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 72 (2-3): 205–7. doi:10.1159/000134190. PMID 8978777.  CS1 maint: Explicit use of et al. (link)
• Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J (1997). "Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor.". FEBS Lett. 402 (2-3): 203–8. doi:10.1016/S0014-5793(96)01531-1. PMID 9037196. 
• Ahmed A, Dearn S, Shams M et al. (1998). "Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125.". FASEB J. 12 (10): 831–43. PMID 9657523.  CS1 maint: Explicit use of et al. (link)
• Cargill M, Altshuler D, Ireland J et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209.  CS1 maint: Explicit use of et al. (link)

External links

• "Platelet-Activating Factor Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• platelet activating factor receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 肺炎連鎖球菌の微生物学および病因 microbiology and pathogenesis of streptococcus pneumoniae
• 2. 鎌状赤血球症の臨床症状の概要 overview of the clinical manifestations of sickle cell disease
• 3. アナフィラキシーの病態生理 pathophysiology of anaphylaxis
• 4. 好中球運動の決定要因 determinants of neutrophil movement
• 5. 食物アレルギーに対する今後の治療法 future therapies for food allergy

English Journal

• Platelet-Activating Factor Receptor Blockade Ameliorates Aggregatibacter actinomycetemcomitans-Induced Periodontal Disease in Mice.

• Madeira MF, Queiroz-Junior CM, Costa GM, Werneck SM, Cisalpino D, Garlet GP, Teixeira MM, Silva TA, Souza DG.SourceDepartment of Microbiology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
• Infection and immunity.Infect Immun.2013 Nov;81(11):4244-51. doi: 10.1128/IAI.01046-13. Epub 2013 Sep 3.
• Periodontal disease (PD) is a chronic inflammatory and alveolar bone destructive disease triggered by oral biofilm-producing microorganisms, such as Aggregatibacter actinomycetemcomitans. The levels of the phospholipid platelet-activating factor (PAF) in the saliva, gingival crevicular fluid, and pe
• PMID 24002061

• Staphylococcus aureus Lipoteichoic Acid Inhibits Platelet Activation and Thrombus Formation via the Paf Receptor.

• Waller AK, Sage T, Kumar C, Carr T, Gibbins JM, Clarke SR.SourceSchool of Biological Sciences.
• The Journal of infectious diseases.J Infect Dis.2013 Oct 21. [Epub ahead of print]
• Impaired healing is common in wounds infected with the major human pathogen Staphylococcus aureus, although the underlying mechanisms are poorly understood. Here, we show that S. aureus lipoteichoic acid (LTA) inhibits platelet aggregation caused by physiological agonists and S. aureus and reduced p
• PMID 23911710

• Rapid desensitization of mice with anti-FcγRIIb/FcγRIII mAb safely prevents IgG-mediated anaphylaxis.

• Khodoun MV, Kucuk ZY, Strait RT, Krishnamurthy D, Janek K, Clay CD, Morris SC, Finkelman FD.SourceDepartment of Research, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio; Division of Immunology, Allergy and Rheumatology, Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio.
• The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2013 Oct 18. pii: S0091-6749(13)01429-2. doi: 10.1016/j.jaci.2013.09.008. [Epub ahead of print]
• BACKGROUND: Stimulatory IgG receptors (FcγRs) on bone marrow-derived cells contribute to the pathogenesis of several autoimmune and inflammatory disorders. Monoclonal antibodies that block FcγRs might suppress these diseases, but they can induce anaphylaxis.OBJECTIVE: We wanted to determine whethe
• PMID 24139828

Japanese Journal

• Platelet-Activating Factor and Pain

• Tsuda Makoto,Tozaki-Saitoh Hidetoshi,Inoue Kazuhide
• Biological & Pharmaceutical Bulletin 34(8), 1159-1162, 2011
• … Platelet-activating factor (PAF) is a phospholipid mediator that regulates the functions of a variety of cells in the peripheral tissues and in the nervous system. … Findings that injection of PAF exogenously at the skin or in the spinal cord induced pain hypersensitivity gave us much attention to its role in pain signaling. …
• NAID 130000936580

• PAFレセプターによるマスト細胞の活性化 (特集 マスト細胞・好塩基球の活性化をめぐって)

• 岡山 吉道,権 寧博,浅野 正岳 [他]
• 臨床免疫・アレルギー科 54(2), 149-154, 2010-08
• NAID 40017285241

• PI-36 Immunohistochemical Localization of PAF-receptor and Cross-talk between PAF-and ACTH-induced aldosterone secretion in Guinea Pig Adrenals

• Shimada Toshio,Matsumoto Itsuro,Aikawa Tadaomi
• 日本組織細胞化学会総会プログラムおよび抄録集 (50), 80, 2009-09-26
• NAID 110007384838

• Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection.

• Seki Masafumi,Kosai Kosuke,Hara Atsuko [他]
• Japanese journal of infectious diseases 62(1), 6-10, 2009-01
• … Platelet-activating factor (PAF) is a critical mediator of severe inflammatory diseases such as pneumonia, and the PAF-receptor (PAFR) is known to be an anchor for Streptococcus pneumoniae attachment to lung epithelial cells. …
• NAID 120001253656

Related Links

• Platelet-activating factor receptor - Wikipedia, the free encyclopedia

The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0- alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a ...

---

★リンクテーブル★

リンク元	「PAFレセプター」「血小板活性化因子受容体」「血小板活性化因子レセプター」「PAF受容体」
関連記事	「PA」「P」「PAF」

「PAFレセプター」

　　[★]

英

PAF receptor

関

血小板活性化因子受容体、血小板活性化因子レセプター、PAF受容体

「血小板活性化因子受容体」

　　[★]

英

PAF receptor

関

血小板活性化因子レセプター、PAFレセプター、PAF受容体

「血小板活性化因子レセプター」

　　[★]

英

PAF receptor

関

血小板活性化因子受容体、PAFレセプター、PAF受容体

「PAF受容体」

　　[★]

英

PAF receptor

関

血小板活性化因子

「PA」

　　[★]

• 肺動脈弁閉鎖症 pulmonary atresia
• 肺動脈 pulmonary artery、肺動脈幹
• 原発性アルドステロン症 primary aldosteronism

• 微生物学：粒子凝集法(particle agglutination test)
• 薬理学：

　

「P」

　　[★]

• プロリン proline
• P波 P wave
• リン phosphorus

　 　 　

「PAF」

　　[★] 血小板活性化因子, platelet activating factor, platelet-activating factor