WordNet

the 4th letter of the Roman alphabet (同)d

PrepTutorEJDIC

deuteriumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/13 21:02:32」(JST)

wiki en

Leukotriene D4 is one of the leukotrienes. Its functions in the body are bronchoconstriction, vasoconstriction, contraction of smooth muscle, and increasing vascular permeability. Other leukotrienes that function in a similar manner are leukotrienes C4 and E4. Pharmacological agents that inhibit the function of these leukotrienes are leukotriene receptor antagonists (e.g. Zafirlukast, montelukast) and are useful for asthmatic individuals.

Eicosanoid synthesis. (Leukotrienes at right.)

This biochemistry article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 慢性蕁麻疹：標準的なマネージメントおよび患者教育 chronic urticaria standard management and patient education
2. Chronic rhinosinusitis: Management
3. アナフィラキシーの病態生理 pathophysiology of anaphylaxis
4. 喘息の治療において5-リポキシゲナーゼ経路に影響する薬剤 agents affecting the 5 lipoxygenase pathway in the treatment of asthma
5. 肥満細胞由来のメディエーター mast cell derived mediators

English Journal

Leukotriene receptor antagonist as a novel tocolytic in an in vitro model of human uterine contractility.

Corriveau S1, Rousseau E2, Blouin S3, Pasquier JC4.Author information 1Obstetrics and Gynecology, CHUS, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada; Physiology and Biophysics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.2Physiology and Biophysics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.3Obstetrics and Gynecology, CHUS, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.4Obstetrics and Gynecology, CHUS, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada. Electronic address: Jean-Charles.Pasquier@usherbrooke.ca.AbstractOBJECTIVE: This study analyzed the ability of montelukast, a cysteinyl-leukotrienes receptor antagonist and anti-inflammatory agent, to produce a consistent tocolytic effect alone or in combination with nifedipine, a calcium (Ca2+) channel blocker currently used in clinical practice.
European journal of obstetrics, gynecology, and reproductive biology.Eur J Obstet Gynecol Reprod Biol.2014 Mar 12. pii: S0301-2115(14)00114-6. doi: 10.1016/j.ejogrb.2014.02.042. [Epub ahead of print]
OBJECTIVE: This study analyzed the ability of montelukast, a cysteinyl-leukotrienes receptor antagonist and anti-inflammatory agent, to produce a consistent tocolytic effect alone or in combination with nifedipine, a calcium (Ca2+) channel blocker currently used in clinical practice.STUDY DESIGN: Ut
PMID 24735655

The inflammatory mediator leukotriene D₄ induces subcellular β-catenin translocation and migration of colon cancer cells.

Salim T1, Sand-Dejmek J2, Sjölander A3.Author information 1Division of Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Clinical Research Center, ;Skåne University Hospital, Malmö, Sweden.2Division of Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Clinical Research Center, ;Skåne University Hospital, Malmö, Sweden; Section of Surgery, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden; Bayer HealthCare, Pharmaceuticals Medical Affairs, Solna, Sweden.3Division of Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Clinical Research Center, ;Skåne University Hospital, Malmö, Sweden. Electronic address: anita.sjolander@med.lu.se.AbstractThe abnormal activation of the Wnt/β-catenin pathway frequently occurs in colorectal cancer. The nuclear translocation of β-catenin activates the transcription of target genes that promote cell proliferation, survival, and invasion. The pro-inflammatory mediator leukotriene D4 (LTD4) exerts its effects through the CysLT1 receptor. We previously reported an upregulation of CysLT1R in patients with colon cancer, suggesting the importance of leukotrienes in colon cancer. The aim of this study was to investigate the impact of LTD4 on Wnt/β-catenin signaling and its effects on proliferation and migration of colon cancer cells. LTD4 stimulation led to an increase in β-catenin expression, β-catenin nuclear translocation and the subsequent transcription of MYC and CCND1. Furthermore, LTD4 significantly reduced the expression of E-cadherin and β-catenin at the plasma membrane and increased the migration and proliferation of HCT116 colon cancer cells. The effects of LTD4 can be blocked by the inhibition of CysLT1R. Furthermore, LTD4 induced the inhibition of glycogen synthase kinase 3 (GSK)-3β activity, indicating a crosstalk between the G-protein-coupled receptor CysLT1 and the Wnt/β-catenin pathway. In conclusion, LTD4, which can be secreted from macrophages and leukocytes in the tumor microenvironment, induces β-catenin translocation and the activation of β-catenin target genes, resulting in the increased proliferation and migration of colon cancer cells.
Experimental cell research.Exp Cell Res.2014 Feb 15;321(2):255-66. doi: 10.1016/j.yexcr.2013.10.021. Epub 2013 Nov 5.
The abnormal activation of the Wnt/β-catenin pathway frequently occurs in colorectal cancer. The nuclear translocation of β-catenin activates the transcription of target genes that promote cell proliferation, survival, and invasion. The pro-inflammatory mediator leukotriene D4 (LTD4) exerts its ef
PMID 24211746

Leukotriene D4 inhalation challenge for predicting short-term efficacy of montelukast: a pilot study.

Guan WJ1, Shi X, Zheng JP, Gao Y, Jiang CY, Xie YQ, Liu QX, Zhu Z, Guo E, An JY, Yu XX, Liu WT, Zhong NS.Author information 1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.AbstractINTRODUCTION: The convenient measure to predict efficacy of leukotriene receptor antagonist is lacking.
The clinical respiratory journal.Clin Respir J.2014 Feb 8. doi: 10.1111/crj.12117. [Epub ahead of print]
INTRODUCTION: The convenient measure to predict efficacy of leukotriene receptor antagonist is lacking.OBJECTIVES: To determine if leukotriene D4 inhalation challenge predicts short-term efficacy of montelukast in asthma.METHODS: In this open-labelled 28-day trial, 45 patients with asthma were alloc
PMID 24506412

Japanese Journal

ロイコトリエン(B4,C4,D4,E4) (広範囲血液・尿化学検査免疫学的検査(第7版・4)その数値をどう読むか) -- (プロスタノイド,サイトカイン,増殖因子,ケモカイン)

北村諭
日本臨床 68(-) (982), 38-43, 2010-07
NAID 40017200681

Pharmacological Analysis of Antigen-Induced Late Airway Response in Rats(Pharmacology)

MIYAGAWA Naoki,IWASAKI Hidenori,KATO Toshinobu,TANAKA Masaru,SHIBATA Tsutomu,WAKITANI Korekiyo
Biological & pharmaceutical bulletin 32(3), 394-398, 2009-03-01
… In this study, the pharmacological properties of rat ovalbumin (OVA)-induced LAR and effects of the clinically used anti-asthmatic drugs salbutamol (β_2-agonist), ketotifen (antihista-mine), pranlukast (anti-leukotriene C_4/D_4/E_4), and prednisolone (steroid) were examined. … Although β_2-agonist, antihistamine, and anti-leukotriene C_4/D_4/E_4 exhibited no effects on rat LAR, steroid attenuated LAR and decreased eosinophil number in BALF. …
NAID 110007122727

Related Pictures

★リンクテーブル★

リンク元	「leukotriene D」
関連記事	「D」「leukotriene」「leukotrienes」

「leukotriene D」

Leukotriene D4
Identifiers
CAS number	73836-78-9
PubChem	5280878
MeSH	Leukotriene+D4
ChEMBL	CHEMBL288943
Jmol-3D images	Image 1
	SMILES CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O ;
Properties
Molecular formula	C25H40N2O6S
Molar mass	496.661 g/mol
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references

　　[★]

ロイコトリエンD

関: leukotriene D4、LTD4

「D」

　　[★]

アスパラギン酸
ジヒドロウリジン
遠位の distal,
うつ病 depression
下行結腸 descending colon(大腸内視鏡検査の結果を記載するときに用いる)

「leukotriene」

　　[★] ロイコトリエン LT

「leukotrienes」