- 関
- tumor necrosis factor-β, TNF-β, lymphotoxin-α, LT-α
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/04/11 23:15:37」(JST)
[Wiki en表示]
lymphotoxin alpha (TNF superfamily, member 1) |
Identifiers |
Symbol |
LTA |
Alt. symbols |
TNFB |
Entrez |
4049 |
HUGO |
6709 |
OMIM |
153440 |
RefSeq |
NM_000595 |
UniProt |
P01374 |
Other data |
Locus |
Chr. 6 p21.3 |
lymphotoxin beta (TNF superfamily, member 3) |
Identifiers |
Symbol |
LTB |
Alt. symbols |
TNFC |
Entrez |
4050 |
HUGO |
6711 |
OMIM |
600978 |
RefSeq |
NM_002341 |
UniProt |
Q06643 |
Other data |
Locus |
Chr. 6 p21.3 |
Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine.
It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them.[1] It is also known to be required for normal development of Peyer's patches.[2]
Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs.
See also
- lymphotoxin beta receptor
- Tumor necrosis factor-alpha#Discovery
References
- ^ Parham, Peter (2005). "Chapter 6: T-cell mediated immunity". The immune system (2nd ed.). New York: Garland Science. p. 172. ISBN 0-8153-4093-1.
- ^ Kumar. "Chapter 13 – Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus". In Kumar. Robbins and Cotran Pathologic Basis of Disease, Professional Edition (8th ed.).
External links
- Lymphotoxin at the US National Library of Medicine Medical Subject Headings (MeSH)
Cell signaling: cytokines
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UpToDate Contents
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English Journal
- Conditional Deletion of NF-κB-Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation.
- Brightbill HD1, Jackman JK2, Suto E3, Kennedy H4, Jones C 3rd4, Chalasani S4, Lin Z3, Tam L5, Roose-Girma M5, Balazs M3, Austin CD4, Lee WP3, Wu LC1.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Aug 1;195(3):953-64. doi: 10.4049/jimmunol.1401514. Epub 2015 Jun 26.
- NF-κB-inducing kinase (NIK) is a primary regulator of the noncanonical NF-κB signaling pathway, which plays a vital role downstream of BAFF, CD40L, lymphotoxin, and other inflammatory mediators. Germline deletion or inactivation of NIK in mice results in the defective development of B cells and se
- PMID 26116508
- The TNF Family Molecules LIGHT and Lymphotoxin αβ Induce a Distinct Steroid-Resistant Inflammatory Phenotype in Human Lung Epithelial Cells.
- da Silva Antunes R1, Madge L2, Soroosh P3, Tocker J2, Croft M4.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Jul 24. pii: 1500356. [Epub ahead of print]
- Lung epithelial cells are considered important sources of inflammatory molecules and extracellular matrix proteins that contribute to diseases such as asthma. Understanding the factors that stimulate epithelial cells may lead to new insights into controlling lung inflammation. This study sought to i
- PMID 26209626
- LTβR signalling preferentially accelerates oncogenic AKT-initiated liver tumours.
- Scarzello AJ1, Jiang Q1, Back T1, Dang H2, Hodge D1, Hanson C1, Subleski J1, Weiss JM1, Stauffer JK1, Chaisaingmongkol J3, Rabibhadana S3, Ruchirawat M3, Ortaldo J1, Wang XW2, Norris PS4, Ware CF4, Wiltrout RH1.
- Gut.Gut.2015 Jul 23. pii: gutjnl-2014-308810. doi: 10.1136/gutjnl-2014-308810. [Epub ahead of print]
- OBJECTIVES: The relative contributions of inflammatory signalling and sequential oncogenic dysregulation driving liver cancer pathogenesis remain incompletely understood. Lymphotoxin-β receptor (LTβR) signalling is critically involved in hepatitis and liver tumorigenesis. Therefore, we explored th
- PMID 26206664
Japanese Journal
- B細胞の反応におけるリンパ節髄質領域のリモデリングの意義 (特集 B細胞の分化と機能制御)
- Lymphotoxin beta Receptor Regulates the Development of CCL21-Expressing Subset of Postnatal Medullary Thymic Epithelial Cells
Related Pictures
★リンクテーブル★
[★]
[★]
- 英
- lymphotoxin
- 関
- リンホトキシン、腫瘍壊死因子β、リンホトキシンα
[★]
- 英
- lymphotoxin
- 関
- リンフォトキシン
-ロイコトリエン
- 同
- LT
[★]
腫瘍壊死因子β
- 関
- lymphotoxin、lymphotoxin-alpha
[★]
リンホトキシンα、リンホトキシン-α
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[★]
リンフォトキシンβ受容体、リンフォトキシンβレセプター