同: LTB4

WordNet

the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/01 18:08:59」(JST)

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Leukotriene B4 is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue.^[1] In neutrophils, it is also a potent chemoattractant, and is able to induce the formation of reactive oxygen species and the release of lysosome enzymes by these cells.^[1] It is synthesized by leukotriene-A4 hydrolase from leukotriene A4.^[2]

Eicosanoid synthesis. (Leukotrienes at right.)

References

^ ^a ^b Cotran; Kumar, Collins. Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X.
^ http://www.uniprot.org/uniprot/P09960. Retrieved 9 April 2013. Missing or empty |title= (help)

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English Journal

Inhalation of two putative Gulf War toxins by mice.

Repine JE1, Wilson P1, Elkins N1, Klawitter J1, Christians U1, Peters B2, Smith DM2.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.J Environ Sci Health B.2016 Jun 2;51(6):366-73. doi: 10.1080/03601234.2016.1142318. Epub 2016 Mar 7.
We employed our inhalation methodology to examine whether biomarkers of inflammation and oxidative stress would be produced in mice following inhalation of aerosols containing carbonaceous particles or the vapor of pesticides prevalent during the first Gulf War. Exposure to two putative Gulf War Ill
PMID 26950528

Mast cells in rheumatic disease.

Suurmond J1, van der Velden D2, Kuiper J3, Bot I4, Toes RE5.
European journal of pharmacology.Eur J Pharmacol.2016 May 5;778:116-24. doi: 10.1016/j.ejphar.2015.03.085. Epub 2015 May 2.
Rheumatoid Arthritis is a chronic autoimmune disease with a complex disease pathogenesis leading to inflammation and destruction of synovial tissue in the joint. Several molecules lead to activation of immune pathways, including autoantibodies, Toll-Like Receptor ligands and cytokines. These pathway
PMID 25943290

Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation.

Siddiqui F1, Naqvi S2, Abidi L3, Faizi S4, Lubna5, Avesi L6, Mirza T7, Farooq AD8.
Journal of ethnopharmacology.J Ethnopharmacol.2016 Apr 22;182:221-34. doi: 10.1016/j.jep.2016.02.016. Epub 2016 Feb 18.
ETHANOPHARMACOLOGICAL RELEVANCE: Opuntia dillenii Haw (Nagphana) traditionally used against inflammation. The present study addressed the anti-inflammatory activity of O. dillenii derived methanol extract, fractions and pure compounds and their underlying mechanism of action.MATERIALS AND METHODS: O
PMID 26900126

Japanese Journal

10T024A, a New Phenazine Derivative, as a Radical Scavenger and a Prostaglandin, Leukotriene Release Suppressor

KOMODA Toshikazu,TAMIYA Yuta,NISHIKAWA Masazumi
Bioscience, biotechnology, and biochemistry 75(10), 2056-2058, 2011-10-23
… Moreover, it showed prostaglandin D2 (PGD2) and leukotriene B4 (LTB4) release suppressive activity in rat basophilic leukemia (RBL-2H3) cells, at IC50: 8 μM and 10 μM respectively. …
NAID 10029873355

JKCF1-5 The role of leukotriene B4-dependent migration of T cells in allergic airway inflammation and airway hyperresponsiveness(Inflammatory cells in allergic diseases,Free Paper Session 1,Japan-Korea-China Joint Symposium)

Ohnishi Hiroshi
アレルギー 60(9・10), 1313, 2011-10-10
NAID 110008912140

Related Pictures

★リンクテーブル★

リンク元	「leukotriene B」
拡張検索	「leukotriene B4 receptor」
関連記事	「B」「leukotriene」「leukotrienes」

「leukotriene B」

Leukotriene B4
	IUPAC name 5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
Identifiers
CAS number	71160-24-2
PubChem	169
MeSH	Leukotriene+B4
ChEMBL	CHEMBL65061
Jmol-3D images	Image 1
	SMILES CCCCCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O ;
	InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12- 17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24); Key: VNYSSYRCGWBHLG-UHFFFAOYSA-N ;
Properties
Molecular formula	C20H32O4
Molar mass	336.466 g/mol
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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	Infobox references