Heberden node

ヘバーデン結節

WordNet

1. used to express refusal or denial or disagreement etc or especially to emphasize a negative statement; "no, you are wrong"
2. a negative; "his no was loud and clear"
3. referring to the degree to which a certain quality is present; "he was no heavier than a child" (同)no more
4. not in any degree or manner; not at all; "he is no better today"
5. quantifier; used with either mass nouns or plural count nouns for indicating a complete or almost complete lack or zero quantity of; "we have no bananas"; "no eggs left and no money to buy any"; "have you no decency?"; "did it with no help"; "Ill get you there in no time"
6. sway gently back and forth, as in a nodding motion; "the flowers were nodding in the breeze"
7. be almost asleep; "The old man sat nodding by the fireplace"
8. let the head fall forward through drowsiness; "The old man was nodding in his chair"
9. the act of nodding the head
10. a sign of assent or salutation or command
11. express or signify by nodding; "He nodded his approval"
12. lower and raise the head, as to indicate assent or agreement or confirmation; "The teacher nodded when the student gave the right answer"
13. any thickened enlargement (同)knob, thickening
14. (botany) the small swelling that is the part of a plant stem from which one or more leaves emerge (同)leaf node
15. a connecting point at which several lines come together
16. (computer science) any computer that is hooked up to a computer network (同)client, guest
17. (astronomy) a point where an orbit crosses a plane
18. (physics) the point of minimum displacement in a periodic system
19. any bulge or swelling of an anatomical structure or part

PrepTutorEJDIC

1. 《名詞の前に置いて》『一つも』(『一人も,少しも』)・・・『ない』 / 《補語につけて》『決して・・・でない』 / 《省略文で》・・・なし;・・・お断り / 《話》少ししか(あまり)・・・ない / (肯定の問いに対して)『いいえ』;(否定の問いに対して)はい,ええ / 《not, norの前に挿入して》『いや』,否 / 《形容詞の前に置その形容詞を否定して》…どころではない / 《比較級の前に置いて》ちっとも…でない,…と全く同じ / 《… or no の形で》…であってもなくても / 《驚き・困惑・不信などを表して》とんでもない / 《単数形で》『拒否』,「『いいえ』」という返事 / 《複数形で》反対[投]票
2. (承諾・あいさつ・合図などで)『うなずく』,会釈する / (眠くて)『こっくりする』,(油断して)うとうとする《+off》 / 〈草木・穂などが〉揺れる / (承諾・あいさつなどで)〈頭〉‘を'『うなずかせる』 / …‘を'うなずいて示す / 《副詞[句]を伴って》〈人〉‘に'うなずいて示す / 《同意・承諾・あいさつ・命令など,また時には拒絶を表して》(…に対する)『うなずき』,『会釈』《+『to』+『名』》;(眠気による)こっくり
3. (茎・幹の)節(ふし) / (体組織にできた)結節,こぶ(リンパ瘤(りゅう)など) / (天体の軌道の)交点 / (物事の)中心点

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/02 21:50:50」(JST)

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Heberden's node
Classification and external resources
Heberden's nodes on the 2nd (index) finger of the right hand
ICD-10	M15.1
ICD-9	715.04
OMIM	140600
DiseasesDB	29319

Heberden's nodes are hard or bony swellings that can develop in the distal interphalangeal joints (DIP) (the joints closest to the end of the fingers and toes). They are a sign of osteoarthritis and are caused by formation of osteophytes (calcific spurs) of the articular (joint) cartilage in response to repeated trauma at the joint.

Heberden's nodes typically develop in middle age, beginning either with a chronic swelling of the affected joints or the sudden painful onset of redness, numbness, and loss of manual dexterity. This initial inflammation and pain eventually subsides, and the patient is left with a permanent bony outgrowth that often skews the fingertip sideways. Bouchard's nodes may also be present; these are similar bony growths in the proximal interphalangeal (PIP) joints (middle joints of the fingers), and are also associated with osteoarthritis.

Heberden's nodes are more common in women than in men, and there seems to be a genetic component involved in predisposition to the condition.

They are named after William Heberden (1710–1801).

References

External links

• Diagram of Heberden's and Bouchard's nodes at WebMD

UpToDate Contents

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• 1. 変形性関節症の診断および分類 diagnosis and classification of osteoarthritis
• 2. 変形性関節症の臨床症状 clinical manifestations of osteoarthritis
• 3. 関節リウマチの診断および鑑別診断 diagnosis and differential diagnosis of rheumatoid arthritis
• 4. 成人における関節吸引または注射：手技および適応 joint aspiration or injection in adults technique and indications
• 5. 変形性関節症の危険因子および考えられる原因 risk factors for and possible causes of osteoarthritis

English Journal

• Heberden's nodes and what Heberden could not see: the pivotal role of ligaments in the pathogenesis of early nodal osteoarthritis and beyond.

• McGonagle D, Tan AL, Grainger AJ, Benjamin M.SourceAcademic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK. d.g.mcgonagle@leeds.ac.uk
• Rheumatology (Oxford, England).Rheumatology (Oxford).2008 Sep;47(9):1278-85. Epub 2008 Apr 4.
• Despite its relatively high prevalence, polyarticular nature, limited treatment options and recognized genetic contribution, the study of generalized OA (GOA) has lagged behind that of isolated knee OA. Whilst the pathogenesis of OA has been viewed in relation to either articular cartilage or bone d
• PMID 18390583

• Meclofenamate sodium in the treatment of degenerative joint disease of the hand (Heberden nodes).

• Seiler V.Abstract41 patients with radiographically verified degenerative joint disease of the hand who had at least one acutely inflamed Heberden node entered into the study. 22 patients were treated with 300 mg N-(2,6-dichloro-m-tolyl)anthranilic acid, sodium salt (meclofenamate sodium, Meclomen) per day for 4 weeks and 19 patients received placebo. Measures of efficacy were: the number of painful joints on both hands, an index of pain, the number of inflamed Heberden nodes and the grip strength (mmHg). Disease activity was similar in both groups at the beginning of the study. Analyses after one week of treatment and at the last observation at the conclusion of the study revealed significant differences in favor of meclofenamate sodium. This indicates that meclofenamate sodium treatment of degenerative joint disease of the hands is significantly superior to placebo. The reduction of the number of inflamed Heberden nodes demonstrates the anti-inflammatory effect of meclofenamate sodium, while the reduction of painful joints and the decreased pain index is evidence of the analgesic effect of this drug. The increase in grip strength indicates an improvement of function. The results further demonstrate the early onset of treatment effect with meclofenamate sodium. Meclofenamate sodium was well tolerated.
• Arzneimittel-Forschung.Arzneimittelforschung.1983;33(4A):656-9.
• 41 patients with radiographically verified degenerative joint disease of the hand who had at least one acutely inflamed Heberden node entered into the study. 22 patients were treated with 300 mg N-(2,6-dichloro-m-tolyl)anthranilic acid, sodium salt (meclofenamate sodium, Meclomen) per day for 4 week
• PMID 6349652

Japanese Journal

• 手術 Heberden結節に対する小切開関節固定法

• 整形・災害外科 55(2), 207-212, 2012-02
• NAID 40019193162

• 症例 Heberden結節に伴った多発性指端粘液嚢腫の1例

• 皮膚科の臨床 50(8), 1013-1016, 2008-08
• NAID 40016196419

• Heberden結節の検討 : 第1報 : 臨床所見を含めた新しい病期分類

• 日本手の外科学会雑誌 = The Journal of Japanese Society for Surgery of the Hand 18(6), 842-845, 2002-02-28
• NAID 10010062098

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★リンクテーブル★

リンク元	「ヘバーデン結節」
関連記事	「node」「nod」

「ヘバーデン結節」

　　[★]

英

Heberden's node, Heberden node, Heberden's nodes, Heberden nodes, Heberden nodules

同

指曲がり症、Heberden結節

関

変形性関節症、ブシャール結節 Bouchard結節

• DIP関節の変形性関節症

「node」

　　[★]

• n.

• 結節、リンパ節、節、ノード

関

clause、ganglia、ganglion、ganglionic、knot、lymph node、nodal、nodose、nodulate、section、tubercle、tubercular、tuberosity

　 　 　 　 　 　 　 　

「nod」

　　[★]