ヒトTリンパ球向性ウイルス2型、ヒトTリンパ好性ウイルス2型、ヒトT細胞白血病ウイルス2型

関: HTLV-II、human T-cell leukemia virus II、human T-cell leukemia virus type 2、human T-cell leukemia virus type II、human T-cell lymphotropic virus type 2、human T-lymphotropic virus 2、human T-lymphotropic virus type 2、human T-lymphotropic virus type II

同: human T-cell lymphotropic viruses type II

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/29 20:28:47」(JST)

wiki en

A virus closely related to HTLV-I, Human T-lymphotropic virus 2 (HTLV-II) shares approximately 70% genomic homology (structural similarity) with HTLV-I.

It is found predominantly in Native Americans,^[1] and South American Indian groups. And also in Asian countries. More common in Japan and Korea. It can be passed down from mother to child through breastmilk and genetically as well from either parent.

HTLV-II entry in target cells is mediated by the glucose transporter GLUT1.^[2]

Clinical significance

HTLV-II has not been clearly linked to any disease, but has been associated with several cases of myelopathy/tropical spastic paraparesis (HAM/TSP)- like neurological disease.

An impact on platelet count has been observed.^[3]

In the 1980s, HTLV-2 was identified in a patient with an unidentified T cell lymphoproliferative disease that was described as having characteristics similar to the B cell disorder, hairy cell leukemia.^[4] HTLV-2 was identified in a second patient with a T cell lymphoproliferative disease; this patient later developed hairy cell leukemia, but HTLV-2 was not found in the hairy cell clones.^[5] The cause of hairy cell leukemia is not known, but it is no longer believed to be related to viral infections.

References

^ Roucoux DF, Murphy EL. The epidemiology and disease outcomes of human T-lymphotropic virus type II.
^ Manel N, Kim FJ, Kinet S, Taylor N, Sitbon M, Battini JL (November 2003). "The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV". Cell 115 (4): 449–59. doi:10.1016/S0092-8674(03)00881-X. PMID 14622599.
^ Bartman MT, Kaidarova Z, Hirschkorn D, et al. (November 2008). "Long-term increases in lymphocytes and platelets in human T-lymphotropic virus type II infection". Blood 112 (10): 3995–4002. doi:10.1182/blood-2008-05-155960. PMC 2581993. PMID 18755983.
^ Kalyanaraman VS, Sarngadharan MG, Robert-Guroff M, Miyoshi I, Golde D, Gallo RC (November 1982). "A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia". Science 218 (4572): 571–3. doi:10.1126/science.6981847. PMID 6981847.
^ Rosenblatt JD, Giorgi JV, Golde DW, et al. (February 1988). "Integrated human T-cell leukemia virus II genome in CD8 + T cells from a patient with "atypical" hairy cell leukemia: evidence for distinct T and B cell lymphoproliferative disorders". Blood 71 (2): 363–9. PMID 2827811.

External links

International Retrovirology Association
Human T-lymphotropic virus 2 at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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Expert review of molecular diagnostics.Expert Rev Mol Diagn.2016 Feb;16(2):135-45. doi: 10.1586/14737159.2016.1123622. Epub 2016 Jan 11.
As the first US FDA-approved assay for supplemental HTLV testing, the MP Diagnostics HTLV Blot 2.4 is an effective and efficient method for confirming and differentiating HTLV type infection in repeatedly reactive samples. Novel and patented antigens added increased sensitivity in identifying specim
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Human T-cell leukemia virus type 1 (HTLV-1) is a causative retrovirus of adult T-cell leukemia and HTLV-1-associated myelopathy. Unlike HTLV-1, the same group of retrovirus HTLV-2 has not been found to be associated with these diseases. HTLV-1 and HTLV-2 encode transforming proteins Tax1 and Tax2, a
PMID 26739459

Functional Comparison of HBZ and the Related APH-2 Protein Provide Insight into HTLV-1 Pathogenesis.

Panfil AR1, Dissinger NJ1, Howard CM1, Murphy BM1, Landes K1, Fernandez SA2, Green PL3.
Journal of virology.J Virol.2016 Jan 27. pii: JVI.03113-15. [Epub ahead of print]
Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are highly related retroviruses that transform T-cells in vitro, but have distinct pathological outcomes in vivo. HTLV-1 encodes a protein from the antisense strand of its proviral genome, the HTLV-1 basic leucine zipper factor (HBZ), w
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B'-protein phosphatase 2A is a functional binding partner of delta-retroviral integrase.

Maertens GN1.
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Japanese Journal

Comparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2

FEUER G
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新潟医学会雑誌 118(11), 601-606, 2004-11-10
… Human T-cell leukemia virus type 1 (HTLV-1) is an etiologic agent of adult T-cell leukemia (ATL). … Around 5% HTLV-1-infected individuals develop ATL averagely 50-60 years after the infection. … Thus, in addition to HTLV-1, multiple host factors are involved in the development of ATL. … Unlike to HTLV-1, an allied virus HTLV-2 is not associated with ATL or similar leukemia. …
NAID 110004717173

Differences in the ability of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 tax to inhibit p53 function

MAHIEUX R.
J. Virol. 74, 6866-6874, 2000
NAID 30020794847

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リンク元	「ヒトT細胞白血病ウイルス」「ヒトTリンパ球向性ウイルス2型」「HTLV-II」「ヒトTリンパ好性ウイルス2型」「human T-lymphotropic virus type 2」
拡張検索	「HTLV-2感染症」
関連記事	「HT」「HTLV」

「ヒトT細胞白血病ウイルス」

　　[★]

英: human T-lymphotropic virus, human T-cell leukemia virus, human T cell leukemia virus, HTLV
同: ヒトTリンパ球好性ウイルスヒトTリンパ好性ウイルス human T-lymphotropic virus、ヒトTリンパ球向性ウイルス
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ヒトTリンパ好性ウイルス : 約 29,900 件
ヒトTリンパ球向性ウイルス : 約 74,200 件
ヒトT細胞白血球ウイルス : 15 件
ヒトT細胞白血病ウイルス : 約 171,000 件

ウイルス学

レトロウイルス科デルタレトロウイルス属
エンベロープ有り
一本鎖+鎖RNA

種類

ヒトT細胞白血病ウイルス1型 HTLV-1

成人T細胞白血病（ATL）やHTLV-I関連脊髄症(HTLV-I-associated myelopathy；HAM)の原因

ヒトT細胞白血病ウイルス2型 HTLV-2
レトロウイルス科デルタレトロウイルス属
一本鎖RNA(+)ゲノムを2分子有する
コアがエンベロープで包まれている

感染症

1. 白血病/リンパ腫

成人T細胞白血病

2. 自己免疫病

痙性脊髄麻痺
HTLV関連ぶどう膜炎 HTLV associated uveitis

「ヒトTリンパ球向性ウイルス2型」

　　[★]

英: human T-cell leukemia virus type 2、human T-cell leukemia virus type II、human T-lymphotropic virus type 2、human T-lymphotropic virus type II、human T-lymphotropic virus 2、human T-cell leukemia virus II、human T-cell lymphotropic virus type 2、HTLV-2、HTLV-II
関: ヒトT細胞白血病ウイルスII型、ヒトT細胞白血病ウイルス2型、ヒトTリンパ球向性ウイルス2、ヒトTリンパ好性ウイルス2型、ヒトTリンパ好性ウイルスII型、ヒトTリンパ球好性ウイルス2型、ヒトTリンパ球向性ウイルスII型

「HTLV-II」

　　[★]

ヒトTリンパ球向性ウイルスII型、ヒトTリンパ球向性ウイルス2型、ヒトTリンパ好性ウイルスII型、ヒトTリンパ好性ウイルス2型、ヒトT細胞白血病ウイルスII型、ヒトT細胞白血病ウイルス2型

関: HTLV-2、human T-cell leukemia virus II、human T-cell leukemia virus type 2、human T-cell leukemia virus type II、human T-cell lymphotropic virus type 2、human T-lymphotropic virus 2、human T-lymphotropic virus type 2、human T-lymphotropic virus type II

「ヒトTリンパ好性ウイルス2型」

　　[★]

英: human T-lymphotropic virus type 2、human T-lymphotropic virus type II、human T-lymphotropic virus 2、HTLV-2、HTLV-II
関: ヒトT細胞白血病ウイルスII型、ヒトT細胞白血病ウイルス2型、ヒトTリンパ球向性ウイルス2、ヒトTリンパ好性ウイルスII型、ヒトTリンパ球好性ウイルス2型、ヒトTリンパ球向性ウイルス2型、ヒトTリンパ球向性ウイルスII型

「human T-lymphotropic virus type 2」

　　[★]

ヒトTリンパ球向性ウイルス2型、ヒトTリンパ好性ウイルス2型

関: HTLV-2、HTLV-II、human T-cell leukemia virus II、human T-cell leukemia virus type 2、human T-cell leukemia virus type II、human T-cell lymphotropic virus type 2、human T-lymphotropic virus 2、human T-lymphotropic virus type II